List of works - Weining Lu

A Dominant Mutation in Nuclear Receptor Interacting Protein 1 Causes Urinary Tract Malformations via Dysregulation of Retinoic Acid Signaling

scientific article published on 5 April 2017

A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish

scientific article published in December 2002

A homozygous missense variant in VWA2, encoding an interactor of the Fraser-complex, in a patient with vesicoureteral reflux

scientific article

Assessing vesicoureteral reflux in live inbred mice via ultrasound with a microbubble contrast agent

scientific article

Blocking peptides and molecular mimicry as treatment for kidney disease.

scientific article published on 21 September 2016

Characterization of Apparently Balanced Chromosomal Rearrangements from the Developmental Genome Anatomy Project

scientific article published on 5 September 2008

Characterization of apparently balanced chromosomal rearrangements from the developmental genome anatomy project

scientific article published on March 2008

Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects

scientific article published on 01 October 2001

Crim1 regulates integrin signaling in murine lens development.

scientific article

Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux

scientific article

Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice

scientific article

Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis

scientific article published on 02 January 2002

Identification of direct negative crosstalk between the SLIT2 and Bone Morphogenetic Protein-Gremlin signaling pathways

scientific article published on 9 January 2018

Inhibition of HER-2(neu/ErbB2) restores normal function and structure to polycystic kidney disease (PKD) epithelia

scientific article

Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure

scientific article published on 12 July 2012

Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes

scientific article published on 01 February 1999

Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms

scientific journal article

Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease.

scientific article

Lower urinary tract development and disease

scientific article

MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus

scientific journal article

Models for microarray gene expression data.

scientific article

Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development

scientific article

Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract

scientific article published on 31 May 2015

Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations

scientific article published on 31 August 2020

NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects

scientific article published on 25 May 2007

Noninvasive assessment of antenatal hydronephrosis in mice reveals a critical role for Robo2 in maintaining anti-reflux mechanism

scientific article (publication date: 2011)

Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation ⬇️

scientific article published on October 1, 1997

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

scientific article

Roundabout receptor 2 maintains inhibitory control of the adult midbrain

scientific article

SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion.

scientific article published on 17 November 2016

The fate of Notch-deficient nephrogenic progenitor cells during metanephric kidney development

scientific article published on 26 January 2011

Tissue-specific reduction in splicing efficiency of IKBKAP due to the major mutation associated with familial dysautonomia.

scientific article

Whole-Exome Sequencing Identifies Causative Mutations in Families with Congenital Anomalies of the Kidney and Urinary Tract

scientific article published on 24 August 2018

List of works by Weining Lu

A Dominant Mutation in Nuclear Receptor Interacting Protein 1 Causes Urinary Tract Malformations via Dysregulation of Retinoic Acid Signaling

A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish

A homozygous missense variant in VWA2, encoding an interactor of the Fraser-complex, in a patient with vesicoureteral reflux

Assessing vesicoureteral reflux in live inbred mice via ultrasound with a microbubble contrast agent

Blocking peptides and molecular mimicry as treatment for kidney disease.

Characterization of Apparently Balanced Chromosomal Rearrangements from the Developmental Genome Anatomy Project

Characterization of apparently balanced chromosomal rearrangements from the developmental genome anatomy project

Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects

Crim1 regulates integrin signaling in murine lens development.

Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux

Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice

Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis

Identification of direct negative crosstalk between the SLIT2 and Bone Morphogenetic Protein-Gremlin signaling pathways

Inhibition of HER-2(neu/ErbB2) restores normal function and structure to polycystic kidney disease (PKD) epithelia

Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure

Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes

Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms

Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease.

Lower urinary tract development and disease

MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus

Models for microarray gene expression data.

Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development

Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract

Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations

NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects

Noninvasive assessment of antenatal hydronephrosis in mice reveals a critical role for Robo2 in maintaining anti-reflux mechanism

Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation ⬇️

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

Roundabout receptor 2 maintains inhibitory control of the adult midbrain

SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion.

The fate of Notch-deficient nephrogenic progenitor cells during metanephric kidney development

Tissue-specific reduction in splicing efficiency of IKBKAP due to the major mutation associated with familial dysautonomia.

Whole-Exome Sequencing Identifies Causative Mutations in Families with Congenital Anomalies of the Kidney and Urinary Tract