A generative algorithm for de novo design of proteins with diverse pocket structures

Accurate single domain scaffolding of three non-overlapping protein epitopes using deep learning

Accuratede novodesign of high-affinity protein binding macrocycles using deep learning

Atomically accurate de novo design of antibodies with RFdiffusion

Author response: De novo design of a homo-trimeric amantadine-binding protein

Broadly applicable and accurate protein design by integrating structure prediction networks and diffusion generative models

COVID-19 Rehabilitation With Herbal Medicine and Cardiorespiratory Exercise: Protocol for a Clinical Study (Preprint)

Computational Design of Metallohydrolases

De Novo Design of Integrin α5β1 Modulating Proteins for Regenerative Medicine

De Novo Design of Miniprotein Inhibitors of Bacterial Adhesins

De Novo Design of Peptide Masks Enables Rapid Generation of Conditionally-Active Miniprotein Binders

De novo Design of All-atom Biomolecular Interactions with RFdiffusion3

De novo Design of Near Infrared Fluorescent Proteins

De novo design of Ras isoform selective binders

De novo design of allosterically switchable protein assemblies

De novo design of high-affinity protein binders to bioactive helical peptides

De novo protein design by deep network hallucination

De novodesign of buttressed loops for sculpting protein functions

Deep learning methods for designing proteins scaffolding functional sites

Design of Orthogonal Far-Red, Orange and Green Fluorophore-binding Proteins for Multiplex Imaging

Design of facilitated dissociation enables control over cytokine signaling duration

Design of stimulus-responsive two-state hinge proteins

Designed Soluble Notch Agonist Drives Human Ameloblast Maturation for Tooth Regeneration

F-domain valency determines outcome of signaling through the angiopoietin pathway

Formation, Chemical Evolution, and Solidification of the Calcium Carbonate Dense Liquid Phase

Hierarchical design of multi-scale protein complexes by combinatorial assembly of oligomeric helical bundle and repeat protein building blocks

Hierarchical design of multi-scale protein complexes by combinatorial assembly of oligomeric helical bundle and repeat protein building blocks

Hierarchical design of pseudosymmetric protein nanoparticles

Improved protein binder design using beta-pairing targeted RFdiffusion

Improved protein structure prediction using predicted inter-residue orientations

Increasing computational protein design literacy through cohort-based learning for undergraduate students

Joint Generation of Protein Sequence and Structure with RoseTTAFold Sequence Space Diffusion

LetA defines a structurally distinct transporter family involved in lipid trafficking

Multiplex design and discovery of proximity handles for programmable proteome editing

Multispectral live-cell imaging with uncompromised spatiotemporal resolution

Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive protection across divergent subgroups

Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive protection across divergent subgroups

Nucleation limited assembly and polarized growth of a de novo-designed allosterically modulatable protein filament

Nucleation limited assembly and polarized growth of a de novo-designed allosterically modulatable protein filament

Nucleation limited assembly and polarized growth of a de novo-designed allosterically modulatable protein filament

Peptide binding specificity prediction using fine-tuned protein structure prediction networks

Rapid Online Buffer Exchange: A Method for Screening of Proteins, Protein Complexes, and Cell Lysates by Native Mass Spectrometry

Rapid Online Buffer Exchange: A Method for Screening of Proteins, Protein Complexes, and Cell Lysates by Native Mass Spectrometry

Rapid Online Buffer Exchange: A Method for Screening of Proteins, Protein Complexes, and Cell Lysates by Native Mass Spectrometry

Rapid and accurate prediction of protein homo-oligomer symmetry with Seq2Symm

Stepwise design of pseudosymmetric protein hetero-oligomers

Structural and functional evaluation ofde novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

Tailored Design of Protein Nanoparticle Scaffolds for Multivalent Presentation of Viral Glycoprotein Antigens

Targeting HIV Env immunogens to B cell follicles in non-human primates through immune complex or protein nanoparticle formulations

The stability landscape ofde novoTIM barrels explored by a modular design approach

Tuning Insulin Receptor Signaling UsingDe NovoDesigned Agonists