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List of works by Anastasios Lymperopoulos

A case report: Pharmacology and resistance patterns of three generations of ALK inhibitors in metastatic inflammatory myofibroblastic sarcoma

scientific article published on 20 June 2018

Adrenal G protein-coupled receptor kinase-2 in regulation of sympathetic nervous system activity in heart failure

scientific article

Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure

scientific article published on 19 March 2010

Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure

scientific article published on 18 February 2007

Adrenal adrenoceptors in heart failure: fine-tuning cardiac stimulation

scientific article published on 5 November 2007

Adrenal beta-arrestin 1 inhibition in vivo attenuates post-myocardial infarction progression to heart failure and adverse remodeling via reduction of circulating aldosterone levels

scientific article

Adrenal βarrestin1 targeting for tobacco-associated cardiac dysfunction treatment: Aldosterone production as the mechanistic link

scientific article published on 18 June 2019

Adrenergic nervous system in heart failure: pathophysiology and therapy

scientific article published on August 2013

Alpha 2-adrenergic receptors decrease DNA replication and cell proliferation and induce neurite outgrowth in transfected rat pheochromocytoma cells.

scientific article

Alpha2-adrenergic receptor subtype-specific activation of NF-kappaB in PC12 cells

scientific article published on 24 May 2006

An adrenal beta-arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo

scientific journal article

Antagonistic Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Reveal GRK5-Mediated Cardioprotection via Mineralocorticoid Receptor Inhibition

scientific article published on 20 April 2020

Arrestins in the Cardiovascular System: An Update

scientific article published on 09 August 2018

Arrestins in the cardiovascular system

scientific article published on January 2013

Assays of adrenal GPCR signaling and regulation: Measuring adrenal β-arrestin activity in vivo through plasma membrane recruitment.

scientific article published on 4 September 2017

Beta-arrestin Biased Agonism/Antagonism at Cardiovascular Seven Transmembrane-spanning Receptors ⬇️

scientific article published on January 1, 2012

Biased Agonism/Antagonism of Cardiovascular GPCRs for Heart Failure Therapy

scientific article published on 26 March 2018

Blockade of β‐adrenoceptors restores the GRK2‐mediated adrenal α2‐adrenoceptor–catecholamine production axis in heart failure ⬇️

scientific article published on August 1, 2012

Cardiac βarrestin2 Improves Contractility and Adverse Remodeling in Heart Failure, But Is Underexpressed in Humans.

scientific article published in December 2017

Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation

scientific article

Caveolin-1 deficiency exacerbates cardiac dysfunction and reduces survival in mice with myocardial infarction

scientific article

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy

scientific article published on 03 January 2019

Clinical pharmacogenomics of carvedilol: the stereo-selective metabolism angle

scientific article published on 08 August 2018

Co-IP assays for measuring GPCR-arrestin interactions

scientific article published on 24 October 2018

Current and future G protein-coupled receptor signaling targets for heart failure therapy

scientific article published on 11 October 2013

Deletion of Osteopontin Enhances β₂-Adrenergic Receptor-Dependent Anti-Fibrotic Signaling in Cardiomyocytes ⬇️

scientific article published on 20 March 2019

Effect of sulfhydryl modification on rat kidney basolateral plasma membrane transport function

scientific article published on 02 August 2012

Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation

scientific article published on 08 June 2007

Future g protein-coupled receptor targets for treatment of heart failure.

scientific article

GPCRs of adrenal chromaffin cells & catecholamines: The plot thickens

scientific article published on 3 February 2016

GRK2 Regulates α2-Adrenergic Receptor-Dependent Catecholamine Release in Human Adrenal Chromaffin Cells

scientific article published on 01 March 2017

GRK2 Up-Regulation Creates a Positive Feedback Loop for Catecholamine Production in Chromaffin Cells

scientific article

GRK2 and Beta-Arrestins in Cardiovascular Disease: Established and Emerging Possibilities for Therapeutic Targeting

scientific article published on June 15, 2011

GRK2 and β-arrestins in cardiovascular disease: Something old, something new ⬇️

scientific article published on June 28, 2011

GRK2 as a novel gene therapy target in heart failure.

scientific article published on 25 August 2010

GRK2 inhibition in heart failure: something old, something new.

scientific article published on January 2012

GRK2-Mediated Crosstalk Between β-Adrenergic and Angiotensin II Receptors Enhances Adrenocortical Aldosterone Production In Vitro and In Vivo

scientific article published on 16 January 2020

Hypothesis: Paroxetine, a G Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor Reduces Morbidity and Mortality in Patients With Heart Failure.

scientific article

Impaired desensitization of a human polymorphic α2B-adrenergic receptor variant enhances its sympatho-inhibitory activity in chromaffin cells

scientific article

Ischemic emergency?: endothelial cells have their own "adrenaline shot" at hand

scientific article published on 04 June 2012

Lack of association between alpha2B-adrenergic receptor polymorphism and risk of restenosis following coronary angioplasty and stent implantation--preliminary report.

scientific article

Modulation of adrenal catecholamine secretion by in vivo gene transfer and manipulation of G protein-coupled receptor kinase-2 activity

scientific journal article

Myocardial adeno-associated virus serotype 6-betaARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure

scientific article

Myocardial β(2) -adrenoceptor gene delivery promotes coordinated cardiac adaptive remodelling and angiogenesis in heart failure.

scientific article

Negative impact of β-arrestin-1 on post-myocardial infarction heart failure via cardiac and adrenal-dependent neurohormonal mechanisms

scientific article

Novel Insights into the Crosstalk between Mineralocorticoid Receptor and G Protein-Coupled Receptors in Heart Adverse Remodeling and Disease

scientific article published on 27 November 2018

Pharmacogenetics of cardiac inotropy

scientific article

Pharmacogenomics of adrenoceptors.

scientific article published in October 2004

Pharmacogenomics of the heptahelical receptor regulators G-protein-coupled receptor kinases and arrestins: the known and the unknown

scientific article published on February 2012

Physiology and pharmacology of the cardiovascular adrenergic system

scientific article published on 04 September 2013

Reduction of sympathetic activity via adrenal-targeted GRK2 gene deletion attenuates heart failure progression and improves cardiac function after myocardial infarction

scientific article

Role of βarrestin1 in AT R-mediated MAPK Activation in Wistar and SHR Brainstem Astrocytes

scientific article published on 13 November 2018

Structure-activity relationship study of angiotensin II analogs in terms of β-arrestin-dependent signaling to aldosterone production

scientific article published on 8 March 2016

Suppression of adrenal βarrestin1-dependent aldosterone production by ARBs: head-to-head comparison

scientific article

Sustained GRK2-dependent CREB activation is essential for α2-adrenergic receptor-induced PC12 neuronal differentiation

scientific article published on 31 October 2019

Sympatholytic Mechanisms for the Beneficial Cardiovascular Effects of SGLT2 Inhibitors: A Research Hypothesis for Dapagliflozin’s Effects in the Adrenal Gland

scientific article published on 19 July 2021

Targeting the β-adrenergic receptor system through G-protein-coupled receptor kinase 2: a new paradigm for therapy and prognostic evaluation in heart failure: from bench to bedside

scientific article published on May 2012

The place of ARBs in heart failure therapy: is aldosterone suppression the key?

scientific article published on 01 January 2019

Transcription factor Sp1 expression is upregulated in human glomerulonephritis: correlation with pSmad2/3 and p300 expression and renal injury

scientific article published in January 2010

alpha(2)-Adrenergic receptors activate MAPK and Akt through a pathway involving arachidonic acid metabolism by cytochrome P450-dependent epoxygenase, matrix metalloproteinase activation and subtype-specific transactivation of EGFR.

scientific article published on 10 August 2005

β Adrenergic Receptor Kinase C-Terminal Peptide Gene-Therapy Improves β2-Adrenergic Receptor-Dependent Neoangiogenesis after Hindlimb Ischemia.

scientific article

β-Arrestin2 Improves Post-Myocardial Infarction Heart Failure via Sarco(endo)plasmic Reticulum Ca2+-ATPase-Dependent Positive Inotropy in Cardiomyocytes.

scientific article published on 5 September 2017

β1-adrenoceptor Arg389Gly polymorphism confers differential β-arrestin-binding tropism in cardiac myocytes.

scientific article published on 19 September 2016

βArrestins in cardiac G protein-coupled receptor signaling and function: partners in crime or "good cop, bad cop"?

scientific article published on 18 December 2013

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