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List of works by Pål Klepstad

A GTP cyclohydrolase 1 genetic variant delays cancer pain

scientific article

A controlled comparison between single doses of intravenous and intramuscular morphine with respect to analgesic effects and patient safety

scientific article published in August 2008

A cross-sectional study on prevalence of pain and breakthrough pain among an unselected group of outpatients in a tertiary cancer clinic

scientific article published on 5 March 2014

A double-blind, randomized, crossover comparison between single-dose and double-dose immediate-release oral morphine at bedtime in cancer patients

scientific article published on 27 May 2008

A multicenter study of attitudinal barriers to cancer pain management

scientific article

Antiplatelet effect of clopidogrel is reduced in patients treated with therapeutic hypothermia after cardiac arrest ⬇️

scientific article published on August 19, 2010

Are all patients that count included in palliative care studies?

scientific article

Assessment of the time-dependent need for stay in a high dependency unit (HDU) after major surgery by using data from an anesthesia information management system

scientific article

Authors' Reply to Davies et al.

scientific article

Bedside dressing changes for open abdomen in the intensive care unit is safe and time and staff efficient

scientific article published on 28 May 2016

Biological pathways and genetic variables involved in pain ⬇️

scientific article published on September 15, 2010

Biological pathways, candidate genes, and molecular markers associated with quality-of-life domains: an update

scientific article

COMBAT study - Computer based assessment and treatment - A clinical trial evaluating impact of a computerized clinical decision support tool on pain in cancer patients

scientific article published on 08 August 2017

Can cancer patients assess the influence of pain on functions? A randomised, controlled study of the pain interference items in the Brief Pain Inventory

scientific article

Classification of pain in cancer patients--a systematic literature review

scientific article published on 13 March 2009

Clinical Factors Associated With a Short Survival Time After Percutaneous Nephrostomy for Ureteric Obstruction in Cancer Patients: An Updated Model

scientific article published on 20 October 2015

Clinical and genetic factors associated with nausea and vomiting in cancer patients receiving opioids

Clinical and genetic factors related to cancer-induced bone pain and bone pain relief

scientific article

Clinically significant drug-drug interactions involving opioid analgesics used for pain treatment in patients with cancer: a systematic review

scientific article

Clopidogrel does not work following cardiopulmonary resuscitation

scientific article published on 11 May 2013

Cognitive dysfunction and health-related quality of life after a cardiac arrest and therapeutic hypothermia

scientific article published on 10 March 2010

Common sense won: engagement from experts repealed Norwegian restrictions for ICU research

Comparing the effect of hydroxyethyl starch 130/0.4 with balanced crystalloid solution on mortality and kidney failure, etc.

scientific article

Concentrations of remifentanil, propofol, fentanyl, and midazolam during rewarming from therapeutic hypothermia

scientific article

Confirming neuropathic pain in cancer patients: applying the NeuPSIG grading system in clinical practice and clinical research ⬇️

scientific article

Confusion with cerebral perfusion pressure in a literature review of current guidelines and survey of clinical practice

scientific article

Day-to-day variations during clinical drug monitoring of morphine, morphine-3-glucuronide and morphine-6-glucuronide serum concentrations in cancer patients. A prospective observational study

scientific article

Developing quality indicators for physician-staffed emergency medical services: a consensus process

scientific article

Do CYP2D6 genotypes reflect oxycodone requirements for cancer patients treated for cancer pain? A cross-sectional multicentre study

scientific article published on 7 July 2011

Early pharmacokinetics of nasal fentanyl: is there a significant arterio-venous difference?

scientific article published on 6 January 2008

Effects of hypothermia on the disposition of morphine, midazolam, fentanyl, and propofol in intensive care unit patients

scientific article published on 31 October 2012

Efficacy of methylprednisolone on pain, fatigue, and appetite loss in patients with advanced cancer using opioids: a randomized, placebo-controlled, double-blind trial

scientific article published on 7 July 2014

Erratum: Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients

article

Evidence of peripheral nerve blocks for cancer-related pain: a systematic review

scientific article

Expert conference on cancer pain assessment and classification--the need for international consensus: working proposals on international standards

scientific article published on 13 October 2011

Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene

scientific article

From "Breakthrough" to "Episodic" Cancer Pain? A European Association for Palliative Care Research Network Expert Delphi Survey Toward a Common Terminology and Classification of Transient Cancer Pain Exacerbations ⬇️

scientific article published on 24 February 2016

Genetic and Non-genetic Factors Associated With Constipation in Cancer Patients Receiving Opioids

scientific article published on 18 June 2015

Genetic clustering of European cancer patients indicates that opioid-mediated pain relief is independent of ancestry

scientific article

Genetic findings related to pain and analgesics–why are they so inconsistent?

Genetic variability of pain - A patient focused end-point.

scientific article published on 14 August 2015

Genetic variation and cognitive dysfunction in opioid-treated patients with cancer

scientific article published on 3 May 2016

Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain

scientific article published on 18 December 2008

Genetic, pathological and physiological determinants of transdermal fentanyl pharmacokinetics in 620 cancer patients of the EPOS study

scientific article published in April 2014

Health care providers underestimate symptom intensities of cancer patients: a multicenter European study

scientific article

Health-related quality of life in long term-survivors of thoracoabdominal aortic aneurysm repair.

scientific article published in September 2005

Health-related quality of life three years after coronary surgery: a comparison with the general population.

scientific article published in February 2006

Immediate- or sustained-release morphine for dose finding during start of morphine to cancer patients: a randomized, double-blind trial

scientific article published on January 2003

Improved Pain Control in Terminally Ill Cancer Patients by Introducing Low-Dose Oral Methadone in Addition to Ongoing Opioid Treatment

scientific article published on 9 August 2017

Inadequate symptom control in advanced cancer patients across Europe ⬇️

scientific article published on November 30, 2010

Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients

scientific article published on 12 March 2011

Influences on serum concentrations of morphine, M6G and M3G during routine clinical drug monitoring: a prospective survey in 300 adult cancer patients

scientific article

Influences on the pharmacokinetics of oxycodone: a multicentre cross-sectional study in 439 adult cancer patients

scientific article

Innate Immune Signalling Genetics of Pain, Cognitive Dysfunction and Sickness Symptoms in Cancer Pain Patients Treated with Transdermal Fentanyl

scientific article published on 2 September 2015

Intensity and treatment of symptoms in 3,030 palliative care patients: a cross-sectional survey of the EAPC Research Network.

scientific article

Intensive care of patients with acute liver failure

scientific article published on August 2010

Interviews with patients with advanced cancer--another step towards an international cancer pain classification system

scientific article published on 18 January 2012

Intracranial Pressure During Pressure Control and Pressure-Regulated Volume Control Ventilation in Patients with Traumatic Brain Injury: A Randomized Crossover trial.

scientific article published on 26 October 2015

Intranasal midazolam: a comparison of two delivery devices in human volunteers

scientific article published in October 2006

Is oxycodone efficacy reflected in serum concentrations? A multicenter, cross-sectional study in 456 adult cancer patients

scientific article

Is there a genetic cause for cancer cachexia? - a clinical validation study in 1797 patients

scientific article

Is there a genetic cause of appetite loss?-an explorative study in 1,853 cancer patients

scientific article

Lack of association between genetic variability and multiple pain-related outcomes in a large cohort of patients with advanced cancer: the European Pharmacogenetic Opioid Study (EPOS).

scientific article published on 28 September 2012

Long-Term Outcomes After ICU Admission Triage in Octogenarians

scientific article published on 9 September 2016

Long-term health-related quality of life and survival after cardiac surgery: A prospective study

article

Long-term survival and quality of life after intensive care for patients 80 years of age or older

scientific article published on 3 June 2015

Management of opioid-induced nausea and vomiting in cancer patients: systematic review and evidence-based recommendations

scientific article published on July 2011

Minimally invasive procedures for the management of vertebral bone pain due to cancer: The EAPC recommendations

scientific article published on 15 September 2015

Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy

scientific article published on 13 July 2002

Multiple Loci modulate opioid therapy response for cancer pain

scientific article

Nociceptive stimuli responses at different levels of general anaesthesia and genetic variability

scientific article

Norwegian trauma care: a national cross-sectional survey of all hospitals involved in the management of major trauma patients

scientific article

Opioid switching from morphine to methadone causes a minor but not clinically significant increase in QTc time: A prospective 9-month follow-up study

scientific article published in August 2006

Opioid switching from oral slow release morphine to oral methadone may improve pain control in chronic non-malignant pain: a nine-month follow-up study

scientific article published in January 2006

Opioids in pain management of mesothelioma and lung cancer patients

scientific article published on October 2012

Pain Intensity Factors Changing Breakthrough Pain Prevalence in Patients with Advanced Cancer: A Secondary Analysis of a Cross-Sectional Observational International Study

Pain and pain treatments in European palliative care units. A cross sectional survey from the European Association for Palliative Care Research Network

scientific article

Patterns of smoking behaviour in patients following cardiac surgery. A prospective study ⬇️

scientific article published on October 1, 2010

Predication of cancer patients' survival by pain interference items is not the same as evidence that pain intensity is a survival predictor

scientific article published in September 2008

Prediction of opioid dose in cancer pain patients using genetic profiling: not yet an option with support vector machine learning

scientific article published on 27 January 2018

Prevalence and predictors of cognitive dysfunction in opioid-treated patients with cancer: a multinational study

scientific article published on 28 February 2011

Propofol and remifentanil versus midazolam and fentanyl for sedation during therapeutic hypothermia after cardiac arrest: a randomised trial

scientific article

Quality of Life in Patients With Advanced Cancer: Differential Association With Performance Status and Systemic Inflammatory Response

scientific article published on 27 June 2016

Recovery patterns and health-related quality of life in older patients undergoing cardiac surgery: a prospective study

scientific article published on 4 April 2012

Renal function and symptoms/adverse effects in opioid-treated patients with cancer

scientific article published on 5 May 2015

Response to letter by Mercadante

Risk factors and early pharmacological interventions to prevent chronic postsurgical pain following cardiac surgery

scientific article

Routine drug monitoring of serum concentrations of morphine, morphine-3-glucuronide and morphine-6-glucuronide do not predict clinical observations in cancer patients

scientific article published in December 2003

Self-reports are not related to objective assessments of cognitive function and sedation in patients with cancer pain admitted to a palliative care unit

scientific article published in November 2002

Serum and cerebrospinal fluid morphine pharmacokinetics after single doses of intravenous and intramuscular morphine after hip replacement surgery

scientific article

Serum and urine concentrations of morphine and morphine metabolites in patients with advanced cancer receiving continuous intravenous morphine: an observational study

scientific article published on 27 October 2015

Start of oral morphine to cancer patients: effective serum morphine concentrations and contribution from morphine-6-glucuronide to the analgesia produced by morphine

scientific article

Starting step III opioids for moderate to severe pain in cancer patients: dose titration: a systematic review

scientific article published on July 2011

Survival and quality of life in an elderly cardiac surgery population: 5-year follow-up

scientific article published on 25 June 2013

Sympathetic blocks for visceral cancer pain management: A systematic review and EAPC recommendations

scientific article published on August 2015

Symptoms assessment in cancer patients on admission to a hospital

scientific article

The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease

scientific article published in November 2004

The Edmonton Classification System for Cancer Pain: comparison of pain classification features and pain intensity across diverse palliative care settings in eight countries

scientific article published on 24 April 2013

The European Union--not united in opioid use.

scientific article published in April 2005

The Norwegian brief pain inventory questionnaire: translation and validation in cancer pain patients

scientific article published in November 2002

The Palliative Radiotherapy and Inflammation Study (PRAIS) - protocol for a longitudinal observational multicenter study on patients with cancer induced bone pain

The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients

scientific article published in July 2005

The breath of life. Patients' experiences of breathing during and after mechanical ventilation

scientific article published on 21 March 2017

The characteristics of physical activity and gait in patients receiving radiotherapy in cancer induced bone pain

scientific article

The establishment of the GENEQOL consortium to investigate the genetic disposition of patient-reported quality-of-life outcomes

scientific article

The evidence of neuraxial administration of analgesics for cancer-related pain: a systematic review

scientific article

The importance and pitfalls of correlational science in palliative care research

scientific article published on December 2012

The rare Arg181Cys mutation in the μ opioid receptor can abolish opioid responses

scientific article

The relationship between pro-inflammatory cytokines and pain, appetite and fatigue in patients with advanced cancer

scientific article

The role of sex in health-related quality of life after cardiac surgery: a prospective study.

scientific article published in August 2008

Tromboelastography: variability and relation to conventional coagulation test in non-bleeding intensive care unit patients

scientific article

Underestimation of Patient Breathlessness by Nurses and Physicians during a Spontaneous Breathing Trial

scientific article published on December 2015

Undertreatment of pain in the prehospital setting: a comparison between trauma patients and patients with chest pain

scientific article published on December 2013

Use of National Early Warning Score for observation for increased risk for clinical deterioration during post-ICU care at a surgical ward

Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC.

scientific article

Use of opioids against severe cancer pain

scientific article published in February 2004

Validation of the brief pain inventory in patients six months after cardiac surgery

scientific article published on 16 July 2007

Variability in UDP-glucuronosyltransferase genes and morphine metabolism: observations from a cross-sectional multicenter study in advanced cancer patients with pain

scientific article published in March 2013

Variable response to opioid treatment: any genetic predictors within sight?

scientific article published on June 2008

Which domains should be included in a cancer pain classification system? Analyses of longitudinal data

scientific article

Which mini-mental state exam items can be used to screen for delirium and cognitive impairment?

scientific article published in July 2005

Which variables are associated with pain intensity and treatment response in advanced cancer patients?--Implications for a future classification system for cancer pain

scientific article published on 06 September 2010

Zopiclone versus placebo for short-term treatment of insomnia in patients with advanced cancer: study protocol for a double-blind, randomized, placebo-controlled, clinical multicenter trial

[Therapeutic hypothermia--pharmacology and pathophysiology]. ⬇️

scientific article published on 01 January 2007

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