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List of works by Francis Ka-Leung Chan

1,25-Dihydroxyvitamin D3 suppresses gastric cancer cell growth through VDR- and mutant p53-mediated induction of p21.

scientific article

17-Beta-estradiol induces neoplastic transformation in prostatic epithelial cells.

scientific article published on 25 February 2011

A protein kinase G-sensitive channel mediates flow-induced Ca(2+) entry into vascular endothelial cells

scientific article published on 01 May 2000

Abolition of endothelium-dependent relaxation in the rat aorta by tetraoctylammonium ions.

scientific article

Adipose-derived stem cells and cancer cells fuse to generate cancer stem cell-like cells with increased tumorigenicity

scientific article published on 29 January 2020

Altered expression of extracellular matrix and proteinases in Noble rat prostate gland after long-term treatment with sex steroids

scientific article

Analysis of glycoconjugate patterns of normal and hormone-induced dysplastic Noble rat prostates, and an androgen-independent Noble rat prostate tumor, by lectin histochemistry and protein blotting

scientific article

Assessing the effect of food mycotoxins on aromatase by using a cell-based system.

scientific article published on 7 February 2014

Association of androgen deprivation therapy with thromboembolic events in patients with prostate cancer: a systematic review and meta-analysis

scientific article published on 09 July 2018

Burden of nonsteroidal anti-inflammatory and antiplatelet drug use in Asia: a multidisciplinary working party report

scientific article published on 10 April 2012

Celecoxib increases miR-222 while deterring aromatase-expressing breast tumor growth in mice

scientific article

Characterization of glycoconjugates of guinea pig seminal vesicle by lectin histochemistry

scientific article published on June 1998

Characterization of the T-cell receptor repertoire by deep T cell receptor sequencing in tissues from patients with prostate cancer

scientific article published on 23 November 2017

Chemopreventive effect of PSP through targeting of prostate cancer stem cell-like population

scientific article

Chromogranin A is a predictor of prognosis in patients with prostate cancer: a systematic review and meta-analysis

article

Coadministrating luteolin minimizes the side effects of the aromatase inhibitor letrozole.

scientific article published on 19 August 2014

Collapsin response mediator protein-1 (CRMP1) acts as an invasion and metastasis suppressor of prostate cancer via its suppression of epithelial-mesenchymal transition and remodeling of actin cytoskeleton organization.

scientific article published on 20 June 2016

Comparative study of glycoconjugates of the rat prostatic lobes by lectin histochemistry

scientific article

Contribution of nitric oxide and K+ channel activation to vasorelaxation of isolated rat aorta induced by procaine.

scientific article published in February 1999

Cryofixation of basement membranes followed by freeze substitution or freeze drying demonstrates that they are composed of a tridimensional network of irregular cords

scientific article published on 01 February 1993

Cytochemical characterization of cuprolinic blue-stained proteoglycans in the epithelial-stromal interface of the guinea pig lateral prostate

scientific article published in January 1989

Detection of mRNA expression of gonadotropin-releasing hormone and its receptor in normal and neoplastic rat prostates

scientific article published on 01 December 2001

Determination of the complexity and diversity of the TCR β-chain CDR3 repertoire in bladder cancer using high-throughput sequencing

scientific article published on 05 February 2019

Development of a novel and economical agar-based non-adherent three-dimensional culture method for enrichment of cancer stem-like cells

article

Development of a three-dimensional culture model of prostatic epithelial cells and its use for the study of epithelial-mesenchymal transition and inhibition of PI3K pathway in prostate cancer

scientific article

Diet-Quality Scores and Prevalence of Nonalcoholic Fatty Liver Disease: A Population Study Using Proton-Magnetic Resonance Spectroscopy

scientific article published on 29 September 2015

Dietary administration of the licorice flavonoid isoliquiritigenin deters the growth of MCF-7 cells overexpressing aromatase.

scientific article

Difference in flavonoid and isoflavone profile between soybean and soy leaf

scientific article published in August 2002

Different role of endothelium/nitric oxide in 17beta-estradiol- and progesterone-induced relaxation in rat arteries.

scientific article

Differential effects of estrogen and progesterone on potassium channels expressed in Xenopus oocytes.

scientific article published on 4 November 2007

Differential expression of PSP94 in rat prostate lobes as demonstrated by an antibody against recombinant GST-PSP94

scientific article published on 01 September 1999

Differential regulation of K+ and Ca2+ channel gene expression by chronic treatment with estrogen and tamoxifen in rat aorta.

scientific article

ERRgamma suppresses cell proliferation and tumor growth of androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer.

scientific article published on May 2007

ERRα augments HIF-1 signalling by directly interacting with HIF-1α in normoxic and hypoxic prostate cancer cells

scientific article published on 5 February 2014

Effects of cis-4-hydroxy-L-proline on the androgen-induced growth of the lateral prostate of the prepubertally castrated guinea pig.

scientific article

Effects of p-nitrophenyl-beta-D-xylopyranoside (beta-D-xyloside) on the androgen-induced growth of the lateral prostate of the prepubertally castrated guinea pig.

scientific article published in January 1993

Efficacy of cap-assisted colonoscopy in comparison with regular colonoscopy: a randomized controlled trial

scientific article published on 01 January 2009

Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma.

scientific article published on February 2007

Epigenetic silencing of cellular retinol-binding proteins in nasopharyngeal carcinoma

scientific article

Establishment of a novel immortalized human prostatic epithelial cell line stably expressing androgen receptor and its application for the functional screening of androgen receptor modulators.

scientific article published on 24 March 2009

Estrogen and tamoxifen modulate cerebrovascular tone in ovariectomized female rats.

scientific article

Estrogen-related receptor α decreases RHOA stability to induce orientated cell migration

scientific article

Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues

scientific article

Expression of olfactory-type cyclic nucleotide-gated channel (CNGA2) in vascular tissues ⬇️

scientific article (publication date: December 2003)

Expression pattern of glycoconjugates in rat retina as analysed by lectin histochemistry

scientific article published on January 2002

Expression study of three secretory proteins (prostatic secretory protein of 94 amino acids, probasin, and seminal vesicle secretion II) in dysplastic and neoplastic rat prostates.

scientific article published on July 2003

FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells.

scientific article

FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer.

scientific article published in December 2005

Glycoconjugates of the lateral prostate of the guinea pig: a lectin histochemical study.

scientific article

Glycoconjugates of the rat ciliary body epithelium: a lectin histochemical and protein blotting study

scientific article

Hepatitis B virus genotype C takes a more aggressive disease course than hepatitis B virus genotype B in hepatitis B e antigen-positive patients

scientific article

Hepatitis B virus genotype has no impact on hepatitis B e antigen seroconversion after lamivudine treatment

scientific article

High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B.

scientific article

Higher estimated net endogenous Acid production may be associated with increased prevalence of nonalcoholic Fatty liver disease in chinese adults in Hong Kong

scientific article published on 23 April 2015

Hyaluronan and chondroitin sulfate proteoglycans are colocalized to the ciliary zonule of the rat eye: a histochemical and immunocytochemical study

scientific article published in April 1997

Hydroxychalcones exhibit differential effects on XRE transactivation.

scientific article

Identification of a specifically expressed modified form of novel PSP-94 protein in the secretion of benign prostatic hyperplasia

scientific article (publication date: April 2003)

Identification of differently expressed genes in chemical carcinogen-induced rat bladder cancers.

scientific article published on 28 April 2009

In situ hybridization study of PSP94 (prostatic secretory protein of 94 amino acids) expression in human prostates

scientific article published on 01 October 1999

Incidence and risk factors of suicide after a prostate cancer diagnosis: a meta-analysis of observational studies

scientific article published on 14 August 2018

Increased expression of activated endothelial nitric oxide synthase contributes to antiandrogen resistance in prostate cancer cells by suppressing androgen receptor transactivation.

scientific article

Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin.

scientific article published in November 2000

Inflammatory cytokine tumor necrosis factor alpha confers precancerous phenotype in an organoid model of normal human ovarian surface epithelial cells

scientific article published on June 2009

Involvement of endothelium/nitric oxide in vasorelaxation induced by purified green tea (-)epicatechin

scientific article published in April 1999

Ion channel TRPM8 promotes hypoxic growth of prostate cancer cells via an O2 -independent and RACK1-mediated mechanism of HIF-1α stabilization

scientific article

Isoproterenol amplifies 17 beta-estradiol-mediated vasorelaxation: role of endothelium/nitric oxide and cyclic AMP.

scientific article published in February 2002

Knockin of SV40 Tag oncogene in a mouse adenocarcinoma of the prostate model demonstrates advantageous features over the transgenic model

scientific article

LRH-1 drives hepatocellular carcinoma partially through induction of c-myc and cyclin E1, and suppression of p21

scientific article published on 01 August 2018

Lamina lucida of basement membrane: an artefact

scientific article

Localization of heparan sulfate proteoglycan in basement membrane by side chain staining with cuprolinic blue as compared with core protein labeling with immunogold

scientific article

Localization of heparan sulfate proteoglycan in basement membranes

scientific article published in November 1992

Localization of prostatic glycoconjugates by the lectin-gold method

scientific article

Machine learning model to predict recurrent ulcer bleeding in patients with history of idiopathic gastroduodenal ulcer bleeding

scientific article published on 13 February 2019

Modulatory effect of protein kinase C activator on contractility of rat vas deferens

scientific article

Molecular cloning and functional study of rat estrogen receptor-related receptor gamma in rat prostatic cells

scientific article published on 01 November 2006

Mouse PSP94 expression is prostate tissue-specific as demonstrated by a comparison of multiple antibodies against recombinant proteins.

scientific article

Nickel inhibits urocortin-induced relaxation in the rat pulmonary artery.

scientific article published in March 2004

Nuclear receptor ERRα and transcription factor ERG form a reciprocal loop in the regulation of TMPRSS2:ERG fusion gene in prostate cancer

scientific article published on 24 July 2018

Nuclear receptor LRH-1 functions to promote castration-resistant growth of prostate cancer via its promotion of intratumoral androgen biosynthesis.

scientific article published on 8 February 2018

Nuclear receptor profiling in prostatospheroids and castration-resistant prostate cancer

scientific article published on 17 October 2017

Orphan nuclear receptor TLX contributes to androgen insensitivity in castration-resistant prostate cancer via its repression of androgen receptor transcription

scientific article published on 20 March 2018

Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes.

scientific article published on 2 February 2015

Orphan nuclear receptor estrogen-related receptor-beta suppresses in vitro and in vivo growth of prostate cancer cells via p21(WAF1/CIP1) induction and as a potential therapeutic target in prostate cancer

scientific article published on 10 December 2007

PSP94 (or beta-microseminoprotein) is a secretory protein specifically expressed and synthesized in the lateral lobe of the rat prostate

Prejunctionally mediated inhibition of neurotransmission by isoprenaline in rat vas deferens

scientific article published on 01 January 1998

Prostate targeting: PSP94 gene promoter/enhancer region directed prostate tissue-specific expression in a transgenic mouse prostate cancer model

scientific article published in December 2002

Proteoglycans associated with the ciliary zonule of the rat eye: a histochemical and immunocytochemical study

scientific article published in November 1995

Raloxifene relaxes rat cerebral arteries in vitro and inhibits L-type voltage-sensitive Ca2+ channels.

scientific article

Rodent PSP94 gene expression is more specific to the dorsolateral prostate and less sensitive to androgen ablation than probasin

scientific article published in May 2001

Role of endothelium in thapsigargin-induced arterial responses in rat aorta

scientific article published in March 2000

Roles of cyclic AMP and Ca2+-activated K+ channels in endothelium-independent relaxation by urocortin in the rat coronary artery.

scientific article published in March 2003

Serum C-peptide concentration and prostate cancer: A meta-analysis of observational studies

scientific article published on 01 August 2018

Silencing of the retinoid response gene TIG1 by promoter hypermethylation in nasopharyngeal carcinoma

scientific article

Soy leaf lowers the ratio of non-HDL to HDL cholesterol in hamsters

scientific article

Tamoxifen and estrogen attenuate enhanced vascular reactivity induced by estrogen deficiency in rat carotid arteries

scientific article published on 21 December 2006

The basement membranes of cryofixed or aldehyde-fixed, freeze-substituted tissues are composed of a lamina densa and do not contain a lamina lucida

scientific article published on 01 July 1993

The citrus flavonone hesperetin inhibits growth of aromatase-expressing MCF-7 tumor in ovariectomized athymic mice.

scientific article

The citrus flavonone hesperetin prevents letrozole-induced bone loss in a mouse model of breast cancer

scientific article published on 11 December 2012

The emerging roles of orphan nuclear receptors in prostate cancer.

scientific article published on 2 June 2016

The nuclear tubular invaginations are dynamic structures inside the nucleus of HeLa cells.

scientific article published in March 2006

The nucleus of HeLa cells contains tubular structures for Ca2+ signaling with the involvement of mitochondria.

scientific article published in September 2003

The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase

scientific article

The red clover (Trifolium pratense) isoflavone biochanin A inhibits aromatase activity and expression ⬇️

scientific article published on 29 August 2007

The red wine polyphenol resveratrol displays bilevel inhibition on aromatase in breast cancer cells

scientific article

The relaxant effect of urocortin in rat pulmonary arteries

scientific article published in September 2004

Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells

scientific article

Ultrastructural and biochemical observations on the early changes in apoptotic epithelial cells of the rat prostate induced by castration

scientific article published on 01 October 1999

Ultrastructural localization of proteoglycans by cationic dyes in the epithelial-stromal interface of the guinea pig lateral prostate

scientific article published on January 1989

Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target

scientific article published on June 2005

Urocortin-induced endothelium-dependent relaxation of rat coronary artery: role of nitric oxide and K+ channels.

scientific article published in March 2002

Use of hepatitis B virus DNA quantitation to predict hepatitis B e antigen reversion in cases of chronic hepatitis B.

scientific article

Vasorelaxant effects of cardamonin and alpinetin from Alpinia henryi K. Schum.

scientific article

cDNA, genomic cloning, and gene expression analysis of mouse PSP94 (prostate secretory protein of 94 amino acids).

scientific article

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