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List of works by Thomas Jenuwein

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse

scientific article

A chromosomal memory triggered by Xist regulates histone methylation in X inactivation

scientific article

A crack in histone lysine methylation.

scientific article

A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin

scientific article

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

scientific article

A transcription factor–based mechanism for mouse heterochromatin formation

scientific article published on 16 September 2012

ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes.

scientific article

Acetate Promotes T Cell Effector Function during Glucose Restriction.

scientific article

Activation of the beta globin locus by transcription factors and chromatin modifiers

scientific article

Active and repressive chromatin are interspersed without spreading in an imprinted gene cluster in the mammalian genome.

scientific article

An epigenetic road map for histone lysine methylation ⬇️

scientific article published on June 1, 2003

Arabidopsis REF6 is a histone H3 lysine 27 demethylase ⬇️

scientific article published on June 5, 2011

Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing

scientific article

Complete loss of H3K9 methylation dissolves mouse heterochromatin organization

scientific article published on 16 July 2021

Complex pattern of immunoglobulin mu gene expression in normal and transgenic mice: nonoverlapping regulatory sequences govern distinct tissue specificities

scientific article published on June 1991

Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development

scientific journal article

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

scientific article

Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair.

scientific article published on 9 December 2014

DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2.

scientific article published on June 2007

Dependence of enhancer-mediated transcription of the immunoglobulin mu gene on nuclear matrix attachment regions

scientific article published on August 1994

Di-methyl H4 lysine 20 targets the checkpoint protein Crb2 to sites of DNA damage

scientific article published on 29 September 2008

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

scientific journal article

Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3

scientific journal article

Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana.

scientific article

Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8

scientific journal article

Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3.

scientific article published on 30 September 2004

Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3.

scientific article published in May 2011

Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins

scientific article

Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin.

scientific article published on 19 April 2016

EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in Th1 cells

scientific article published on 11 July 2005

Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos.

scientific article published on July 2003

Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases

scientific article published on 14 December 2003

Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression

scientific article

Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes

scientific article published in April 2003

Extended life span and tumorigenicity of nonestablished mouse connective tissue cells transformed by the fos oncogene of FBR-MuSV.

scientific article published in June 1985

Extension of chromatin accessibility by nuclear matrix attachment regions.

scientific article published on January 1997

Formation of facultative heterochromatin in the absence of HP1

scientific article

Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31

scientific article

G9a and Glp methylate lysine 373 in the tumor suppressor p53

scientific article

G9a and Glp methylate lysine 373 in the tumor suppressor p53.

scientific article published in June 2010

Generation and characterization of methyl-lysine histone antibodies

scientific article published on January 2004

H1 linker histones silence repetitive elements by promoting both histone H3K9 methylation and chromatin compaction

scientific article published on 08 June 2020

H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome

scientific article

H3K9me3-heterochromatin loss at protein-coding genes enables developmental lineage specification

scientific article published on 03 January 2019

Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3

scientific article published on 29 June 2020

Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3

scientific article

Heterochromatin formation in Drosophila requires genome-wide histone deacetylation in cleavage chromatin before mid-blastula transition in early embryogenesis

scientific article published on 16 January 2020

Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component

scientific article published on 19 February 2002

Histone Demethylase UTX-1 Regulates C. elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway ⬇️

scientific article published on August 3, 2011

Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin.

scientific article published on 10 December 2001

Histone H3 lysine 9 methylation occurs rapidly at the onset of random X chromosome inactivation.

scientific article published on February 2002

Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes

scientific article published on 28 October 2004

Histone modification patterns associated with the human X chromosome

scientific article

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases ⬇️

scientific article published on June 28, 2012

Initiation of epigenetic reprogramming of the X chromosome in somatic nuclei transplanted to a mouse oocyte

scientific article

Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity.

scientific article published on 25 October 2017

Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression

scientific article

Isolation and structural analysis of a biologically active chicken c-fos cDNA: identification of evolutionarily conserved domains in fos protein

scientific article published on January 1987

Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells

scientific journal article

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

scientific article

Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability

scientific article (publication date: 2 November 2001)

MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output

scientific article

Maintenance of stable heterochromatin domains by dynamic HP1 binding

scientific article (publication date: 31 January 2003)

Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation.

scientific article

Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes

scientific journal article

Mammalian Su(var) genes in chromatin control.

scientific article published on January 2010

Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S.cerevisiae telomeres ⬇️

scientific article published on June 2, 1997

MeCP2 binds to methylated DNA independently of phase separation and heterochromatin organisation

scientific article published in 2024

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

scientific article (publication date: March 2001)

Mitotic phosphorylation of SUV39H1, a novel component of active centromeres, coincides with transient accumulation at mammalian centromeres

scientific article

Molecular biology. An RNA-guided pathway for the epigenome

scientific article published on 01 September 2002

Multiple regions of v-Fos protein involved in the activation of AP1-dependent transcription: is trans-activation crucial for transformation?

scientific article published in July 1991

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

scholarly article

Nuclear Architecture Organized by Rif1 Underpins the Replication-Timing Program

scientific article published on 23 December 2015

Nuclear matrix attachment regions confer long-range function upon the immunoglobulin mu enhancer

scientific article published on January 1998

Oncogene-induced senescence as an initial barrier in lymphoma development

scientific article published in August 2005

Over-expression of the SUV39H1 histone methyltransferase induces altered proliferation and differentiation in transgenic mice.

scientific article published in September 2001

PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation

scientific article

PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouse.

scientific article published on 22 August 2008

Partitioning and plasticity of repressive histone methylation states in mammalian chromatin

scientific article (publication date: December 2003)

Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis

scientific article

Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity.

scientific article published in August 2012

Rb targets histone H3 methylation and HP1 to promoters

scientific article (publication date: 2 August 2001)

Re-SET-ting heterochromatin by histone methyltransferases

scientific article

Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing

scientific article

Regulation of chromatin structure by site-specific histone H3 methyltransferases

scientific article

Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition

scientific article published on 14 November 2013

Repeat to gene expression ratios in leukemic blast cells can stratify risk prediction in acute myeloid leukemia

scientific article published on 26 June 2021

Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells

scientific article published on 28 October 2020

Repression of p53 activity by Smyd2-mediated methylation

scientific article

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase

scientific article

Role of enhancer sequences in regulating accessibility of DNA in nuclear chromatin

scientific article published on January 1993

Role of the OCTA site in regulation of IgH chain gene transcription during B cell activation

scientific article published on August 1995

Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin

scientific article

Role of the polycomb repressive complex 2 in acute promyelocytic leukemia

scientific article

SET domain proteins modulate chromatin domains in eu- and heterochromatin.

scientific article

SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway

scientific article published on 9 January 2018

Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression.

scientific article

Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins

scientific article

Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state

scientific article published on April 2006

Silencing by plant Polycomb-group genes requires dispersed trimethylation of histone H3 at lysine 27.

scientific article

Structure-function analysis of SUV39H1 reveals a dominant role in heterochromatin organization, chromosome segregation, and mitotic progression

scientific article

Structure-function analysis of fos protein: A single amino acid change activates the immortalizing potential of v-fos

scientific article published on 01 February 1987

Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila

scientific article

Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells.

scientific article published on 26 June 2014

Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin

scientific article (publication date: 15 July 2003)

Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination

scientific article

The chromatin remodelling factor ATRX suppresses R-loops in transcribed telomeric repeats

scientific article published on 9 May 2017

The epigenetic magic of histone lysine methylation

scientific article published in July 2006

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.

scientific article published on 31 March 2017

The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA

scientific article published on 01 July 2006

The histone methyltransferase Suv39h2 contributes to nonalcoholic steatohepatitis in mice.

scientific article

The immunoglobulin mu enhancer core establishes local factor access in nuclear chromatin independent of transcriptional stimulation

scientific article published in October 1993

The indexing potential of histone lysine methylation.

scientific article published on January 2004

The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation

scientific article published on February 1989

The many faces of histone lysine methylation

scientific article

The molecular hallmarks of epigenetic control

scientific article published on 27 June 2016

The murine polycomb-group genes Ezh1 and Ezh2 map close to Hox gene clusters on mouse chromosomes 11 and 6.

scientific article

The polycomb group protein EZH2 is required for mammalian circadian clock function

scientific article

The polycomb-group gene Ezh2 is required for early mouse development

scientific article (publication date: July 2001)

The profile of repeat-associated histone lysine methylation states in the mouse epigenome

scientific article

The role of histone modifications in epigenetic transitions during normal and perturbed development

scientific article

Translating the Histone Code

scientific article

Trilogies of histone lysine methylation as epigenetic landmarks of the eukaryotic genome

scientific article published in January 2004

Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity.

scientific article published on January 2016

Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence.

scientific article published in March 2010

p53 is regulated by the lysine demethylase LSD1

scientific article

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