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List of works by Ronny Drapkin

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

scientific article

A Study of High-Grade Serous Ovarian Cancer Origins Implicates the SOX18 Transcription Factor in Tumor Development

scientific article published on 01 December 2019

A candidate precursor to serous carcinoma that originates in the distal fallopian tube.

scientific article published in January 2007

A comprehensive analysis of PAX8 expression in human epithelial tumors

scientific article (publication date: June 2011)

A human RNA polymerase II complex associated with SRB and DNA-repair proteins

scientific article

A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs

scientific article published on 01 January 2019

A molecular signature of gastric metaplasia arising in response to acute parietal cell loss

scientific article

A novel breast cancer-associated BRIP1 (FANCJ/BACH1) germ-line mutation impairs protein stability and function

scientific article published on July 2008

A novel multiple biomarker panel for the early detection of high-grade serous ovarian carcinoma.

scientific article published on 20 March 2018

A recurrent mutation in PALB2 in Finnish cancer families.

scientific article

Aberrant expression of the dendritic cell marker TNFAIP2 by the malignant cells of Hodgkin lymphoma and primary mediastinal large B-cell lymphoma distinguishes these tumor types from morphologically and phenotypically similar lymphomas.

scientific article published on October 2011

Adenofibroma of the fimbria: a common entity that is indistinguishable from ovarian adenofibroma

scientific article published in July 2008

An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells

scientific article

An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma

scientific article

Angiogenic mRNA and microRNA gene expression signature predicts a novel subtype of serous ovarian cancer

scientific article (publication date: 2012)

Anti-CCR4 monoclonal antibody enhances antitumor immunity by modulating tumor-infiltrating Tregs in an ovarian cancer xenograft humanized mouse model

scientific article published on 10 December 2015

Association of BRCA1 with the inactive X chromosome and XIST RNA

scientific article

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

scientific article

Beyond genomics: critical evaluation of cell line utility for ovarian cancer research

scientific article

CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity.

scientific article published on 12 February 2018

CCNE1 amplification and centrosome number abnormality in serous tubal intraepithelial carcinoma: further evidence supporting its role as a precursor of ovarian high-grade serous carcinoma.

scientific article

CD151-α3β1 integrin complexes suppress ovarian tumor growth by repressing slug-mediated EMT and canonical Wnt signaling.

scientific article

CLIC1 and CLIC4 complement CA125 as a diagnostic biomarker panel for all subtypes of epithelial ovarian cancer ⬇️

scientific article published in Scientific Reports

Cdk-activating kinase complex is a component of human transcription factor TFIIH

scientific article

Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci

scientific article published on 24 March 2015

Chromosomal Instability and mTORC1 Activation through PTEN Loss Contribute to Proteotoxic Stress in Ovarian Carcinoma

scientific article published on 17 September 2019

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

scientific article published on 22 September 2015

Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness

scientific article published on 24 January 2019

Combined therapy with thrombospondin-1 type I repeats (3TSR) and chemotherapy induces regression and significantly improves survival in a preclinical model of advanced stage epithelial ovarian cancer.

scientific article

Coming into focus: the nonovarian origins of ovarian cancer.

scientific article

Correlation of serum HE4 with tumor size and myometrial invasion in endometrial cancer.

scientific article published on 28 October 2011

Creation of a Human Secretome: A Novel Composite Library of Human Secreted Proteins: Validation Using Ovarian Cancer Gene Expression Data and a Virtual Secretome Array

scientific article

Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference

article

Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube-derived high-grade serous ovarian cancers.

scientific article published on 23 December 2013

Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment

scientific article published on March 2016

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

scientific journal article

Distinctive cytogenetic profile in benign metastasizing leiomyoma: pathogenetic implications

scientific article

Does the fimbria have an embryologic origin distinct from that of the rest of the fallopian tube?

scientific article published on 18 March 2008

Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.

scientific article

Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II

scientific article

Early Loss of Histone H2B Monoubiquitylation Alters Chromatin Accessibility and Activates Key Immune Pathways That Facilitate Progression of Ovarian Cancer

scientific article published on 18 December 2018

Elafin drives poor outcome in high-grade serous ovarian cancers and basal-like breast tumors.

scientific article

Elafin: a double agent in breast and ovarian cancer.

scientific article published on 17 September 2015

Endosalpingiosis as it relates to tubal, ovarian and serous neoplastic tissues: an immunohistochemical study of tubal and Müllerian antigens

scientific article published on 13 December 2013

Epigenetic remodeling regulates transcriptional changes between ovarian cancer and benign precursors

scientific article published on August 2016

ErbB2, EphrinB1, Src kinase and PTPN13 signaling complex regulates MAP kinase signaling in human cancers

scientific article

Erratum: Corrigendum: Whole–genome characterization of chemoresistant ovarian cancer

scientific article published in Nature

Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics.

scientific article published on 29 August 2016

Expression of candidate tumor markers in ovarian carcinoma and benign ovary: evidence for a link between epithelial phenotype and neoplasia

scientific article published on 01 August 2004

Expression of the POTE gene family in human ovarian cancer

scientific article published in Scientific Reports

FOXO3a loss is a frequent early event in high-grade pelvic serous carcinogenesis

scientific article published on 30 September 2013

Further evidence for BRCA1 communication with the inactive X chromosome

scientific article published in March 2007

GATA3 Is a Sensitive and Specific Marker of Benign and Malignant Mesonephric Lesions in the Lower Female Genital Tract

scientific article

GATA3 expression in gestational trophoblastic tissues and tumours

scientific article published on 6 March 2015

Genome wide DNA copy number analysis of serous type ovarian carcinomas identifies genetic markers predictive of clinical outcome

scientific article

HE4 transcription- and splice variants-specific expression in endometrial cancer and correlation with patient survival.

scientific article

High grade serous ovarian carcinomas originate in the fallopian tube.

scientific article

High throughput interrogation of somatic mutations in high grade serous cancer of the ovary

scientific article (publication date: 2011)

Highlights from the 2014 American Association for Cancer Research Annual Meeting

scientific article published in July 2014

Human cyclin-dependent kinase-activating kinase exists in three distinct complexes

scientific article

Human epididymis protein 4 is up-regulated in gastric and pancreatic adenocarcinomas

scientific article published on 16 October 2012

Imaging Collagen Alterations in STICs and High Grade Ovarian Cancers in the Fallopian Tubes by Second Harmonic Generation Microscopy

scientific article published on 16 November 2019

Immunoaffinity purification of the human multisubunit transcription factor IIH

scientific article published on 01 March 1998

In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene

scientific article published on 02 January 2014

In vivo modeling of metastatic human high-grade serous ovarian cancer in mice

scientific article published on 04 June 2020

Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming

scientific article published on 01 June 2020

Inhibition of the integrin/FAK signaling axis and c-Myc synergistically disrupts ovarian cancer malignancy.

scientific article published on 30 January 2017

Innervation of cervical carcinoma is mediated by cancer-derived exosomes

scientific article published on 17 April 2019

Integrated Genomic, Epigenomic, and Expression Analyses of Ovarian Cancer Cell Lines

scientific article published on 01 November 2018

Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer

scientific article published on March 2017

It's Totally Tubular....Riding The New Wave of Ovarian Cancer Research.

scientific article

Lessons from BRCA: the tubal fimbria emerges as an origin for pelvic serous cancer.

scientific article published on March 2007

Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis

scientific article

Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance

scientific article

Modeling high-grade serous ovarian carcinogenesis from the fallopian tube

scientific article

Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment

scientific article published on 01 January 2020

Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition.

scientific article

PAX8 reliably distinguishes ovarian serous tumors from malignant mesothelioma

scientific article published on May 2010

PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth

scientific article

PRKCI promotes immune suppression in ovarian cancer

scientific article published on 11 July 2017

Pathogenesis and heterogeneity of ovarian cancer.

scientific article

Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer.

scientific article published on 6 January 2016

Precious GEMMs: emergence of faithful models for ovarian cancer research.

scientific article published in March 2018

Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy ⬇️

scientific article published on October 27, 2011

Primary culture and immortalization of human fallopian tube secretory epithelial cells

scientific article published on 30 August 2012

Primary ex vivo cultures of human fallopian tube epithelium as a model for serous ovarian carcinogenesis.

scientific article

Primordial germ cells as a potential shared cell of origin for mucinous cystic neoplasms of the pancreas and mucinous ovarian tumors

scientific article published on 19 October 2018

Prior appendectomy does not protect against subsequent development of malignant or borderline mucinous ovarian neoplasms.

scientific article published on 14 December 2013

Profiles of genomic instability in high-grade serous ovarian cancer predict treatment outcome

scientific article

Prognostically relevant gene signatures of high-grade serous ovarian carcinoma

scientific article

Promoter methylation of the SALL2 tumor suppressor gene in ovarian cancers

scientific article

Purification of human RNA polymerase II and general transcription factors

scientific article published on 01 January 1996

RNA polymerase II stalled at a thymine dimer: footprint and effect on excision repair

scientific article published on February 1997

Rationale for Developing a Specimen Bank to Study the Pathogenesis of High-Grade Serous Carcinoma: A Review of the Evidence

scientific article

Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin.

scientific article published on October 2008

Regulation of RNA polymerase II transcription

scientific article

Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

scientific article

Rethinking ovarian cancer: recommendations for improving outcomes

scientific article

Role of miR-182 in response to oxidative stress in the cell fate of human fallopian tube epithelial cells

scientific article published on 12 October 2015

STICS, SCOUTs and p53 signatures; a new language for pelvic serous carcinogenesis

scientific article published on January 2011

SUSD2 expression in high-grade serous ovarian cancer correlates with increased patient survival and defective mesothelial clearance.

scientific article published on 24 October 2016

Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition.

scientific article published on 23 September 2016

Serous carcinogenesis in the fallopian tube: a descriptive classification

scientific article published in January 2008

Stathmin 1 and p16(INK4A) are sensitive adjunct biomarkers for serous tubal intraepithelial carcinoma

scientific article

Stathmin 1, a marker of PI3K pathway activation and regulator of microtubule dynamics, is expressed in early pelvic serous carcinomas.

scientific article

Stathmin-1 expression as a complement to p16 helps identify high-grade cervical intraepithelial neoplasia with increased specificity

scientific article published on January 2013

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

scientific article

Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response.

scientific article published on 28 August 2017

Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4

scientific article published on August 2012

Testing ovarian cancer cell lines to train dogs to detect ovarian cancer from blood plasma: A pilot study

scientific article published on 08 May 2019

The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations

scientific article

The Epstein-Barr Virus Nuclear Protein 2 Acidic Domain Forms a Complex with a Novel Cellular Coactivator That Can Interact with TFIIE ⬇️

scientific article published on September 1, 1995

The RNA polymerase II general transcription factors: past, present, and future.

scientific article

The SETDB1-TRIM28 Complex Suppresses Antitumor Immunity

scientific article published on 01 December 2021

The distal fallopian tube: a new model for pelvic serous carcinogenesis.

scientific article

The essential twist

scientific article published in Nature

The hormonal composition of follicular fluid and its implications for ovarian cancer pathogenesis

scientific article

The multifunctional TFIIH complex and transcriptional control

scientific article published on November 1994

The new face of ovarian cancer modeling: better prospects for detection and treatment.

scientific article published on November 2011

The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC

scientific article

The role of peritoneal cytology at risk-reducing salpingo-oophorectomy (RRSO) in women at increased risk of familial ovarian/tubal cancer ⬇️

scientific article published on October 20, 2011

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

scientific article published on 2 May 2003

There is a need for routine peritoneal cytology at RRSO

scientific article published in January 2013

Traceback: A Proposed Framework to Increase Identification and Genetic Counseling of BRCA1 and BRCA2 Mutation Carriers Through Family-Based Outreach

scientific article published on 11 April 2017

Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models

scientific article

Tubal and ovarian pathways to pelvic epithelial cancer: a pathological perspective

scientific article published on 01 November 2009

Tumor-Targeted Synergistic Blockade of MAPK and PI3K from a Layer-by-Layer Nanoparticle.

scientific article

Unilateral transverse arm defect with subterminal digital nubbins

scientific article published on July 2003

Unraveling the mysteries of PAX8 in reproductive tract cancers

scientific article published on 23 December 2020

Urokinase-type plasminogen activator receptor: a beacon of malignancy?

scientific article published on September 2008

Use of CA125 and HE4 serum markers to predict ovarian cancer in elevated-risk women

scientific article

Use of yeast-secreted in vivo biotinylated recombinant antibodies (Biobodies) in bead-based ELISA. ⬇️

scientific article published on May 2008

Where transcription meets repair

scientific article published on April 1994

Whole-genome characterization of chemoresistant ovarian cancer

scientific article published in May 2015

YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells.

scientific article published on 14 September 2015

miR-181a initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling

scientific article published on 26 June 2020

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