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List of works by Dylan R. Edwards

A novel stratification framework for predicting outcome in patients with prostate cancer

scientific article published on 20 March 2020

A sequence-selective single-strand DNA-binding protein regulates basal transcription of the murine tissue inhibitor of metalloproteinases-1 (Timp-1) gene

scientific article published on August 1999

ADAM15 mediates upregulation of Claudin-1 expression in breast cancer cells

scientific article published on 29 August 2019

ADAMTS-1 and syndecan-4 intersect in the regulation of cell migration and angiogenesis

scientific article published on 08 April 2020

ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma

scientific article

ADAMs and protein disulfide isomerase: the key to regulated cell-surface protein ectodomain shedding?: Figure 1

scientific article published on 27 May 2010

Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k).

scientific article published on 11 February 2005

Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes.

scientific article published on 4 October 2007

Acute depletion of endothelial β3-integrin transiently inhibits tumor growth and angiogenesis in mice

scientific article published on 8 October 2013

Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of αvβ6 integrin in DCIS identifies high-risk patients and predicts recurrence

scientific article published on 22 October 2013

An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization.

scientific article

Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis.

scientific article

Avoiding spam in the proteolytic internet: future strategies for anti-metastatic MMP inhibition.

scientific article published on October 2009

Banking of fresh-frozen prostate tissue: methods, validation and use.

scientific article published in March 2003

Biology and genetics of implantation

scientific article published on January 1997

Brk protects breast cancer cells from autophagic cell death induced by loss of anchorage.

scientific article published on 06 August 2009

Cancer. Proteases--invasion and more

scientific article

Cell signalling and the control of gene transcription.

scientific article

Collagenase-2 Deficiency or Inhibition Impairs Experimental Autoimmune Encephalomyelitis in Mice

scientific article published in Journal of Biological Chemistry

Combination of Tumor Necrosis Factor-α Ablation and Matrix Metalloproteinase Inhibition Prevents Heart Failure After Pressure Overload in Tissue Inhibitor of Metalloproteinase-3 Knock-Out Mice

article

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

scientific article published on October 2013

Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3.

scientific article published on 29 March 2005

Development of a Novel Tumor-Targeted Vascular Disrupting Agent Activated by Membrane-Type Matrix Metalloproteinases ⬇️

scientific article published on July 27, 2010

Differential Expression of Matrix Metalloproteinases During Impaired Wound Healing of the Diabetes Mouse

scientific article published on 01 July 2002

Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-beta1 induced murine tissue inhibitor of metalloproteinases-1 gene expression

scientific article

Differential effects of transforming growth factor-β1 on the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in young and old human fibroblasts

scientific article published on 01 January 1996

Differential expression and localization of TIMP-1 and TIMP-4 in human gliomas

scientific article published on July 2001

Differential expression of the ccn3 (nov) proto-oncogene in human prostate cell lines and tissues.

scientific article

Differential regulation of TIMP-1 and TIMP-2 mRNA expression in normal and Ha-ras-transformed murine fibroblasts

scientific article published on August 1992

Distinct functionality of tumor cell-derived gelatinases during formation of liver metastases

scientific article

Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma.

scientific article

Diverse and potent activities of HGF/SF in skin wound repair

scientific article published in July 2004

Dysregulated expression of adamalysin-thrombospondin genes in human breast carcinoma

scientific article published on April 2004

Elevated plasma gelatinase A (MMP-2) activity is associated with quiescent Crohn's Disease

scientific article published in June 1999

Epithelial carcinogenesis: dynamic interplay between neoplastic cells and their microenvironment.

scientific article

Evaluation of effects caused by differentially spliced Ets-1 transcripts in fibroblasts

scientific article

Expression analysis of the entire MMP and TIMP gene families during mouse tissue development.

scientific article

Expression and Activity of Ovarian Tissue Inhibitors of Metalloproteinases during Pseudopregnancy in the Rat1

scientific article published on 01 September 1995

Expression of Sorsby's fundus dystrophy mutations in human retinal pigment epithelial cells reduces matrix metalloproteinase inhibition and may promote angiogenesis

scientific article published on 30 January 2002

Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the mouse uterus during the peri-implantation period

scientific article published on 01 January 1997

Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes

scientific article published on September 2004

Expression profile of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in mature human odontoblasts and pulp tissue.

scientific article

Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma

scientific article published on 21 March 2010

Expression profiling of metalloproteinases and their inhibitors in cartilage

scientific article (publication date: 2004)

Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon.

scientific article

Extracellular protease mRNAs are predominantly expressed in the stromal areas of microdissected mouse breast carcinomas.

scientific article published on 10 March 2005

G-helix of maspin mediates effects on cell migration and adhesion

scientific article

Genome-Wide Responses of Female Fruit Flies Subjected to Divergent Mating Regimes.

scientific article

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes.

scientific article published on 12 May 2010

HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia

scientific article published on 28 February 2018

High levels of gelatinase-B and active gelatinase-A in metastatic glioblastoma

scientific article published in January 1998

Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues

scientific article published in June 2005

Identification of novel peptide motifs in the serpin maspin that affect vascular smooth muscle cell function

scientific article published on 22 November 2016

Identification, regulation and role of tissue inhibitor of metalloproteinases-4 (TIMP-4) in human platelets

scientific article

Increase of anti-metastatic efficacy by selectivity- but not affinity-optimization of synthetic serine protease inhibitors

scientific article published on October 2003

Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia ⬇️

scientific article published on November 28, 1997

Insulin-like growth factor-II regulates PTEN expression in the mammary gland.

scientific article

Intradermal air pouch leukocytosis as an in vivo test for nanoparticles

scientific article published on 13 December 2013

Involvement of AP1 and PEA3 binding sites in the regulation of murine tissue inhibitor of metalloproteinases-1 (TIMP-1) transcription

scientific article

Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment.

scientific article

Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function

scientific article published on 23 March 2017

MMP and TIMP expression in quiescent, dividing, and differentiating human lens cells.

scientific article published in September 2007

MMP-1 drives immunopathology in human tuberculosis and transgenic mice.

scientific article

MMP2 activity is critical for TGFβ2-induced matrix contraction--implications for fibrosis

scientific article published on 26 June 2012

Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression

scientific article

Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion

scientific article

Matrix metalloproteinase-9 maps to the distal end of chromosome 2 in the mouse ⬇️

scientific article published on January 1, 1997

Matrix metalloproteinases mediate the dismantling of mesenchymal structures in the tadpole tail during thyroid hormone-induced tail resorption

scientific article published on 01 March 2002

Matrix metalloproteinases: protective roles in cancer.

scientific article

Membrane type matrix metalloproteinases (MMPs) show differential expression in non-small cell lung cancer (NSCLC) compared to normal lung: correlation of MMP-14 mRNA expression and proteolytic activity.

scientific article

Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases

scientific article published on May 2006

Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid.

scientific article published on 8 October 2003

Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration

article

Metalloproteinase inhibitors: biological actions and therapeutic opportunities.

scientific article

Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15

scientific article published on 18 August 2014

Metalloproteinases and their inhibitors in angiogenesis.

scientific article published on 22 September 2003

Metalloproteinases and their inhibitors in tumor angiogenesis

scientific article

Metalloproteinases are enriched in microglia compared with leukocytes and they regulate cytokine levels in activated microglia

article

Metalloproteinases in biology and pathology of the nervous system.

scientific article

Murine tissue inhibitor of metalloproteinases-4 (Timp-4): cDNA isolation and expression in adult mouse tissues

scientific article published in January 1997

Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and Activator Protein-1-dependent monocyte networks

scientific article

Mycobacterium tuberculosis, but not vaccine BCG, specifically upregulates matrix metalloproteinase-1.

scientific article

NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts.

scientific article

New insights into the plasticity of the endothelial phenotype

scientific article published on December 2011

Oncostatin M Stimulates c-Fos to Bind a Transcriptionally Responsive AP-1 Element within the Tissue Inhibitor of Metalloproteinase-1 Promoter

scientific article published in Journal of Biological Chemistry

PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment

scientific article published on 10 March 2017

Perivascular cells regulate endothelial membrane type-1 matrix metalloproteinase activity

scientific article published in March 2001

Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases

scientific article

Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice.

scientific article

Prostate Single Nucleotide Polymorphism Provides a Crucial Clue to Cancer Aggression in Active Surveillance Patients

scientific article published on 09 October 2015

Proteases in cancer drug delivery.

scientific article

Quantitative reverse transcription-polymerase chain reaction (RT-PCR): a comparison of primer-dropping, competitive, and real-time RT-PCRs

scientific article

Real-time PCR expression profiling of MMPs and TIMPs.

scientific article published in January 2010

Regulation of tissue inhibitor of metalloproteinases-1 gene expression by cytokines and dexamethasone in rat hepatocyte primary cultures

article

Reprogramming of TIMP-1 and TIMP-3 expression profiles in brain microvascular endothelial cells and astrocytes in response to proinflammatory cytokines

scientific article published in April 1999

Research tissue banking in otolaryngology: organization, methods and uses, with reference to practical, ethical and legal issues

scientific article published in June 2006

Reversible transdifferentiation of blood vascular endothelial cells to a lymphatic-like phenotype in vitro

scientific article published on 12 October 2010

Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP).

scientific article published on June 2003

Sorsby's fundus dystrophy tissue inhibitor of metalloproteinases-3 (TIMP-3) mutants have unimpaired matrix metalloproteinase inhibitory activities, but affect cell adhesion to the extracellular matrix

scientific article published on January 2002

Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer

scientific article

Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis

scientific article

Systemic Ablation of MMP-9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL6 Expression in the Bone Marrow.

scientific article published on 03 August 2016

TGF-[beta]1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apolipoprotein E-null mice.

scientific article published on 26 March 2009

TGF-β-elicited induction of tissue inhibitor of metalloproteinases (TIMP)-3 expression in fibroblasts involves complex interplay between Smad3, p38α, and ERK1/2.

scientific article

TIMP-1 enhancer sequence--real or bacterial?

scientific article published in November 2003

TIMP-3 and endocrine therapy of breast cancer: an apoptosis connection emerges

scientific article published in April 2004

TISSUE INHIBITOR OF METALLOPROTEINASE-3 IS UP-REGULATED BY TRANSFORMING GROWTH FACTOR-β1 IN VITRO AND EXPRESSED IN FIBROBLASTIC FOCI IN VIVO IN IDIOPATHIC PULMONARY FIBROSIS

article

Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates

scientific article published on April 2011

Tenascin-C stimulates glioma cell invasion through matrix metalloproteinase-12.

scientific article published on December 2006

The ADAM metalloproteinases

scientific article

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family

scientific article

The ADAMTS metalloproteinases

scientific article (publication date: 15 February 2005)

The activity of a designer tissue inhibitor of metalloproteinases (TIMP)-1 against native membrane type 1 matrix metalloproteinase (MT1-MMP) in a cell-based environment

scientific article published on 7 October 2009

The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1

scientific journal article

The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: a time-course study using real-time quantitative reverse transcription-polymerase chain reaction

scientific article published on April 2002

The regulation of matrix metalloproteinases and their inhibitors.

scientific article published on 24 December 2007

The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis

scientific article published on January 2011

The β3-integrin endothelial adhesome regulates microtubule-dependent cell migration.

scientific article published on 24 May 2018

Tissue inhibitor of metalloproteinases (TIMP, aka EPA): structure, control of expression and biological functions

scientific article published on September 1993

Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling.

scientific article

Tissue inhibitor of metalloproteinases-3 is the major metalloproteinase inhibitor in the decidualizing murine uterus

scientific article published on 01 December 1996

Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms

scientific article published on 30 April 2009

Variation in dermcidin expression in a range of primary human tumours and in hypoxic/oxidatively stressed human cell lines

scientific article

mRNA profiling of the cancer degradome in oesophago-gastric adenocarcinoma.

scientific article

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