List of works - Marialessandra Contino

1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Δ(8)-Δ(7) sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity

scientific article published on January 2011

4-(tetralin-1-yl)- and 4-(naphthalen-1-yl)alkyl derivatives of 1-cyclohexylpiperazine as sigma receptor ligands with agonist sigma2 activity

scientific article published on April 2004

4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators

scientific article published on 2 February 2008

4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes

scholarly article in RSC Advances, vol. 5 no. 58, 2015

4-[omega-[4-arylpiperazin-1-yl]alkoxy]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization

scientific article published on 12 September 2007

6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers

scientific article published on 01 December 2020

A benzopyrane derivative as a P-glycoprotein stimulator: a potential agent to decrease β-amyloid accumulation in Alzheimer's disease

scientific article

A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents

scientific article published on 13 November 2010

A new method for evaluating sigma(2) ligand activity in the isolated guinea-pig bladder

scientific article published on 17 July 2003

ABC pumps and their role in active drug transport

scientific article published on January 2009

ABC transporters in CSCs membranes as a novel target for treating tumor relapse

scientific article

Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments

scientific article published on 16 May 2013

Antiproliferative and cytotoxic effects of some sigma2 agonists and sigma1 antagonists in tumour cell lines

scientific article

Arylamides hybrids of two high-affinity σ2 receptor ligands as tools for the development of PET radiotracers

scientific article published on 30 May 2011

Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity.

scientific article

Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins

scientific article

Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration

scientific article published on 23 October 2020

Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer

scientific article published on 07 July 2005

Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents

scientific article published on 4 November 2014

Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells

scientific article published on 21 June 2019

Design, Biological Evaluation, and Molecular Modeling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-Glycoprotein Ligand Overcoming Multidrug Resistance in Cancer Stem Cells

scientific article published on 09 January 2019

Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II.

scientific article

Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET.

scientific article published on November 2005

EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives

scientific article published on January 2011

Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum

scientific article published on 20 May 2008

F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells

scientific article

First structure-activity relationship study on dopamine D3 receptor agents with N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamide structure

scientific article

From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: Small structural changes address the mechanism of interaction at the efflux pump

scientific article published on 30 October 2014

Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay

scientific article published on 11 September 2007

Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death

scientific article published on 22 April 2020

Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo

scholarly article by Enza Lacivita et al published 26 July 2012 in Journal of Medicinal Chemistry

Is the sigma2 receptor a histone binding protein?

scientific article

MRP1-Collateral Sensitizers as a Novel Therapeutic Approach in Resistant Cancer Therapy: An In Vitro and In Vivo Study in Lung Resistant Tumor

scientific article published on 08 May 2020

Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma(1) receptor

scientific article published in December 2005

Mucoadhesive Properties and Interaction with P-Glycoprotein (P-gp) of Thiolated-Chitosans and -Glycol Chitosans and Corresponding Parent Polymers: A Comparative Study

scientific article published on 24 February 2014

Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors

scientific article

Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters

scientific article

New Strategies to Overcome Resistance to Chemotherapy and Immune System in Cancer

scientific article published on 26 September 2019

New tetrahydroisoquinoline-based P-glycoprotein modulators: decoration of the biphenyl core gives selective ligands

scientific article published on 03 April 2018

Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties

scientific article published on 21 April 2011

PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma

scientific article published on 2 February 2008

PET radiotracers for imaging P-glycoprotein: the challenge for early diagnosis in AD.

scientific article published on 31 October 2013

Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure-Affinity Relationship (SAfiR) and Structure-Activity Relationship (SAR) Studies

scientific article

Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological, and diagnostic potentials

scientific article published on March 2010

Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp

scientific article published on 5 January 2013

SAR studies on tetrahydroisoquinoline derivatives: the role of flexibility and bioisosterism to raise potency and selectivity toward P-glycoprotein.

scientific article

SAR study on arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity

scientific article published on 21 February 2014

Sigma-2 Receptors as Potential Novel Biomarkers During the Progression of Benign Prostatic Hypertrophy (BPH) into Prostate Cancer

Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: hints for collateral sensitivity

scientific article published on 19 September 2013

Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives

scientific article

Small and Innovative Molecules as New Strategy to Revert MDR

scientific article

Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III.

scientific article

Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.

scientific article

Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents

scientific article

Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors

scientific article published on February 2004

Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes

scientific article published in Nature Communications

Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as σ1 receptor ligands

scientific article published on 17 October 2011

The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders

scientific article

The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line

scientific article published on 24 May 2013

The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells

scientific article

Tritium radiolabelling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization

scientific article published on 25 December 2007

miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives

scientific article published on 30 April 2014

List of works by Marialessandra Contino

1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Δ(8)-Δ(7) sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity

4-(tetralin-1-yl)- and 4-(naphthalen-1-yl)alkyl derivatives of 1-cyclohexylpiperazine as sigma receptor ligands with agonist sigma2 activity

4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators

4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes

4-[omega-[4-arylpiperazin-1-yl]alkoxy]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization

6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers

A benzopyrane derivative as a P-glycoprotein stimulator: a potential agent to decrease β-amyloid accumulation in Alzheimer's disease

A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents

A new method for evaluating sigma(2) ligand activity in the isolated guinea-pig bladder

ABC pumps and their role in active drug transport

ABC transporters in CSCs membranes as a novel target for treating tumor relapse

Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments

Antiproliferative and cytotoxic effects of some sigma2 agonists and sigma1 antagonists in tumour cell lines

Arylamides hybrids of two high-affinity σ2 receptor ligands as tools for the development of PET radiotracers

Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity.

Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins

Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration

Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer

Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents

Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells

Design, Biological Evaluation, and Molecular Modeling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-Glycoprotein Ligand Overcoming Multidrug Resistance in Cancer Stem Cells

Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II.

Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET.

EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives

Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum

F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells

First structure-activity relationship study on dopamine D3 receptor agents with N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamide structure

From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: Small structural changes address the mechanism of interaction at the efflux pump

Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay

Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death

Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo

Is the sigma2 receptor a histone binding protein?

MRP1-Collateral Sensitizers as a Novel Therapeutic Approach in Resistant Cancer Therapy: An In Vitro and In Vivo Study in Lung Resistant Tumor

Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma(1) receptor

Mucoadhesive Properties and Interaction with P-Glycoprotein (P-gp) of Thiolated-Chitosans and -Glycol Chitosans and Corresponding Parent Polymers: A Comparative Study

Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors

Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters

New Strategies to Overcome Resistance to Chemotherapy and Immune System in Cancer

New tetrahydroisoquinoline-based P-glycoprotein modulators: decoration of the biphenyl core gives selective ligands

Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties

PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma

PET radiotracers for imaging P-glycoprotein: the challenge for early diagnosis in AD.

Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure-Affinity Relationship (SAfiR) and Structure-Activity Relationship (SAR) Studies

Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological, and diagnostic potentials

Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp

SAR studies on tetrahydroisoquinoline derivatives: the role of flexibility and bioisosterism to raise potency and selectivity toward P-glycoprotein.

SAR study on arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity

Sigma-2 Receptors as Potential Novel Biomarkers During the Progression of Benign Prostatic Hypertrophy (BPH) into Prostate Cancer

Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: hints for collateral sensitivity

Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives

Small and Innovative Molecules as New Strategy to Revert MDR

Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III.

Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.

Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents

Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors

Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes

Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as σ1 receptor ligands

The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders

The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line

The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells

Tritium radiolabelling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization

miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives