List of works - Bart Vandekerckhove

A Murine Intestinal Intraepithelial NKp46-Negative Innate Lymphoid Cell Population Characterized by Group 1 Properties.

scientific article published on May 2017

A new transcript in the TCRB locus unveils the human ortholog of the mouse pre-Dß1 promoter.

scientific article published on 15 May 2017

Abnormal thymocyte development and generation of autoreactive T cells in mixed and cortical thymomas

scientific article published on 01 June 1998

Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function

scientific article

Active form of Notch imposes T cell fate in human progenitor cells

scientific article published on September 2002

Adapted NOD/SCID model supports development of phenotypically and functionally mature T cells from human umbilical cord blood CD34(+) cells

scientific article published in March 2002

An accelerated, clinical-grade protocol to generate high yields of type 1-polarizing messenger RNA-loaded dendritic cells for cancer vaccination

scientific article published on 16 August 2018

An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells

scientific article published on 3 December 2008

An increase of donor-specific T helper precursors resulting from blood transfusions

scientific article

Analysis of cytotoxic T cell precursor frequencies directed against individual HLA-A and -B alloantigens

scientific article published on 01 July 1989

Analysis of the donor-specific cytotoxic T lymphocyte repertoire in a patient with a long term surviving allograft. Frequency, specificity, and phenotype of donor-reactive T cell receptor (TCR)-alpha beta+ and TCR-gamma delta+ clones.

scientific article published on February 1990

Analysis of the donor-specific cytotoxic T-cell repertoire in a patient with a long-term surviving kidney allograft.

scientific article

Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities

scientific article published on 19 January 2017

Both CD34+38+ and CD34+38- cells home specifically to the bone marrow of NOD/LtSZ scid/scid mice but show different kinetics in expansion

scientific article

CD27-deficient mice show normal NK-cell differentiation but impaired function upon stimulation

scientific article published in February 2011

Can immunotherapy specifically target acute myeloid leukemic stem cells?

scientific article published on February 2013

Characterization of distinct stages during the differentiation of human CD69+CD3+ thymocytes and identification of thymic emigrants

scientific article

Clonal analysis of the peripheral T cell compartment of the SCID-hu mouse.

scientific article published in June 1991

Continuous CD27 triggering in vivo strongly reduces NK cell numbers

scientific article published in April 2010

Contribution of the Ly49E natural killer receptor in the immune response to Plasmodium berghei infection and control of hepatic parasite development

scientific article published on 30 January 2014

Cytotoxic T lymphocytes are the prime mediators of suppression of the mixed lymphocyte reaction by alloactivated cells

Delivering Type I Interferon to Dendritic Cells Empowers Tumor Eradication and Immune Combination Treatments.

scientific article published on 29 November 2017

Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial γδ T cells

scientific article

Differentiation assays of bone marrow-derived Multipotent Adult Progenitor Cell (MAPC)-like cells towards neural cells cannot depend on morphology and a limited set of neural markers

scientific article published on 31 October 2006

Differentiation to T helper cells in the thymus. Gradual acquisition of T helper cell function by CD3+CD4+ cells

scientific article

Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development

scientific article published on 07 April 2020

Endothelial outgrowth cells are not derived from CD133+ cells or CD45+ hematopoietic precursors

scientific article published on 10 May 2007

Endothelial progenitor cells: identity defined?

scientific article

Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours.

scientific article published on 29 July 2016

Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells

scientific article published on October 2009

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate

scientific article published on 6 April 2016

Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects.

scientific article published on 06 July 2016

Generation of T cells from human embryonic stem cell-derived hematopoietic zones

scientific article published in June 2009

Guidelines for the use of fresh frozen plasma

scientific article published on 01 November 2008

HES1 and HES4 have non-redundant roles downstream of Notch during early human T cell development

scientific article published on 09 January 2020

Human CD34+ fetal liver stem cells differentiate to T cells in a mouse thymic microenvironment.

scientific article published in September 1994

Human Ig production and isotype switching in severe combined immunodeficient-human mice

scientific article published on 01 July 1993

Human T lymphopoiesis. In vitro and in vivo study models.

scientific article

Human Thymic CD10+ PD-1+ Intraepithelial Lymphocyte Precursors Acquire Interleukin-15 Responsiveness at the CD1a- CD95+ CD28- CCR7- Developmental Stage

scientific article published on 20 November 2020

Human fetal liver cells differentiate into thymocytes in chimeric mouse fetal thymus organ culture.

scientific article published in January 1994

Human hematopoietic cells and thymic epithelial cells induce tolerance via different mechanisms in the SCID-hu mouse thymus

scientific article published on April 1992

Human intrathymic development: a selective approach.

scientific article published on 17 October 2008

Human thymocytes become lineage committed at an early postselection CD69+ stage, before the onset of functional maturation

scientific article published in December 1997

Humanized Mice to Study Human T Cell Development.

scientific article published in January 2016

IL-2 reverses human T cell unresponsiveness induced by thymic epithelium in SCID-hu mice

scientific article published on 01 March 1994

Immunological unresponsiveness induced by ultraviolet-B-irradiated and nonirradiated skin grafts.

scientific article published in March 1990

In vitro expanded cells contributing to rapid severe combined immunodeficient repopulation activity are CD34+38-33+90+45RA-.

scientific article published on 14 September 2006

In vitro generation of immune cells from pluripotent stem cells

scientific article published on January 2011

In vitro generation of mature, naive antigen-specific CD8(+) T cells with a single T-cell receptor by agonist selection

scientific article published on 4 October 2013

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis

scientific article published on 7 November 2014

In vitro intrathymic differentiation kinetics of human fetal liver CD34+CD38- progenitors reveals a phenotypically defined dendritic/T-NK precursor split

scientific article published in January 1999

In vivo cytokine expression in the thymus. CD3high human thymocytes are activated and already functionally differentiated in helper and cytotoxic cells

scientific article published on 01 February 1994

Increase of donor-specific cytotoxic T lymphocyte precursors after transfusion

scientific article published on 01 October 1989

Induction of isotype switching and Ig production by CD5+ and CD10+ human fetal B cells

scientific article published on 01 June 1992

Influence of TGF-beta on murine thymocyte development in fetal thymus organ culture.

scientific article published in June 1995

Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes

scientific article

Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes

scientific article published on 13 April 2020

Interleukin-7 is a critical growth factor in early human T-cell development.

scientific article

Intracoronary delivery of hematopoietic bone marrow stem cells and luminal loss of the infarct-related artery in patients with recent myocardial infarction

scientific article

Intracoronary injection of CD133-positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction: feasibility and safety

scientific article

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions

scientific article published on 3 March 2011

Langerhans cells are not required for epidermal Vgamma3 T cell homeostasis and function

scientific article published on 12 April 2011

Ly49E expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases

scientific article

Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator.

scientific article published on 10 September 2008

MHC class II molecules are required for initiation of positive selection but not during terminal differentiation of human CD4 single positive thymocytes.

scientific article published in April 1997

Nanobody Based Dual Specific CARs

scientific article published on 30 January 2018

Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway.

scientific article published on 4 November 2011

Notch signaling is required for proliferation but not for differentiation at a well-defined beta-selection checkpoint during human T-cell development

scientific article published on 23 October 2008

Notch3 activation is sufficient but not required for inducing human T-lineage specification

scientific article published on 7 November 2014

Phenotypic and functional maturation of TCR gammadelta cells in the human thymus

scientific article

Pluripotent stem cell based gene therapy for hematological diseases.

scientific article published on 14 September 2015

RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia

scientific article

Radiation Sensitivity of Human CD34(+) Cells Versus Peripheral Blood T Lymphocytes of Newborns and Adults: DNA Repair and Mutagenic Effects.

scientific article published on 19 May 2016

Rapid and Effective Generation of Nanobody Based CARs using PCR and Gibson Assembly

scientific article published on 30 January 2020

Recommendations in the event of a suspected transfusion-related acute lung injury (TRALI)

scientific article published on 01 May 2012

SCID-hu mice as a model to study tolerance after fetal stem cell transplantation

scientific article published on 01 January 1992

Safe eradication of large established tumors using neovasculature-targeted tumor necrosis factor-based therapies

scientific article published on 08 January 2020

Selecting cord blood units for storage by CD34+ cell counts

scientific article published on 01 March 2005

Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.

scientific article published on 25 March 2013

Specific suppression of mixed lymphocyte reactions by alloactivated cells is correlated with cytotoxicity

scientific article published on March 1989

Stem cell research in hematology

scientific article published in January 2003

Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase as pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunity

scientific article published in August 2005

T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources

scientific article published on 17 February 2020

T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38-/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells

scientific article published on 17 February 2011

TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment

scientific article published on 01 August 2019

TCR Sequencing Reveals the Distinct Development of Fetal and Adult Human Vγ9Vδ2 T Cells

scientific article published on 14 August 2019

The Ly49E Receptor Inhibits the Immune Control of Acute Trypanosoma cruzi Infection.

scientific article

The checkpoint for agonist selection precedes conventional selection in human thymus.

scientific article published on February 2017

The human fetal thymus generates invariant effector γδ T cells ⬇️

scientific article published on 01 March 2020

The role of Ly49E receptor expression on murine intraepithelial lymphocytes in intestinal cancer development and progression.

scientific article

The transcription factor ETS1 is an important regulator of human NK cell development and terminal differentiation

scientific article published on 29 April 2020

Thymic repopulation by CD34(+) human cord blood cells after expansion in stroma-free culture

scientific article published in December 1999

Thymic selection of the human T cell receptor V beta repertoire in SCID-hu mice

scientific article published on December 1992

Time-Dependent Effects on Coronary Remodeling and Epicardial Conductance after Intracoronary Injection of Enriched Hematopoietic Bone Marrow Stem Cells in Patients with Previous Myocardial Infarction

scientific article published on 01 January 2007

Treatment of a patient with severe cytomegalovirus (CMV) infection after haploidentical stem cell transplantation with donor-derived CMV-specific T cells

scientific article published on 14 April 2020

Viable CD34+ stem cell content of a cord blood graft: which measurement performed before transplantation is most representative?

scientific article published in April 2004

gamma delta T-cell receptor-positive T-cell clones derived from human heart transplants do not show donor-specific cytotoxicity

scientific article published in June 1990

iPSC-Based Modeling of RAG2 Severe Combined Immunodeficiency Reveals Multiple T Cell Developmental Arrests

scientific article published on 16 January 2020

List of works by Bart Vandekerckhove

A Murine Intestinal Intraepithelial NKp46-Negative Innate Lymphoid Cell Population Characterized by Group 1 Properties.

A new transcript in the TCRB locus unveils the human ortholog of the mouse pre-Dß1 promoter.

Abnormal thymocyte development and generation of autoreactive T cells in mixed and cortical thymomas

Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function

Active form of Notch imposes T cell fate in human progenitor cells

Adapted NOD/SCID model supports development of phenotypically and functionally mature T cells from human umbilical cord blood CD34(+) cells

An accelerated, clinical-grade protocol to generate high yields of type 1-polarizing messenger RNA-loaded dendritic cells for cancer vaccination

An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells

An increase of donor-specific T helper precursors resulting from blood transfusions

Analysis of cytotoxic T cell precursor frequencies directed against individual HLA-A and -B alloantigens

Analysis of the donor-specific cytotoxic T lymphocyte repertoire in a patient with a long term surviving allograft. Frequency, specificity, and phenotype of donor-reactive T cell receptor (TCR)-alpha beta+ and TCR-gamma delta+ clones.

Analysis of the donor-specific cytotoxic T-cell repertoire in a patient with a long-term surviving kidney allograft.

Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities

Both CD34+38+ and CD34+38- cells home specifically to the bone marrow of NOD/LtSZ scid/scid mice but show different kinetics in expansion

CD27-deficient mice show normal NK-cell differentiation but impaired function upon stimulation

Can immunotherapy specifically target acute myeloid leukemic stem cells?

Characterization of distinct stages during the differentiation of human CD69+CD3+ thymocytes and identification of thymic emigrants

Clonal analysis of the peripheral T cell compartment of the SCID-hu mouse.

Continuous CD27 triggering in vivo strongly reduces NK cell numbers

Contribution of the Ly49E natural killer receptor in the immune response to Plasmodium berghei infection and control of hepatic parasite development

Cytotoxic T lymphocytes are the prime mediators of suppression of the mixed lymphocyte reaction by alloactivated cells

Delivering Type I Interferon to Dendritic Cells Empowers Tumor Eradication and Immune Combination Treatments.

Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial γδ T cells

Differentiation assays of bone marrow-derived Multipotent Adult Progenitor Cell (MAPC)-like cells towards neural cells cannot depend on morphology and a limited set of neural markers

Differentiation to T helper cells in the thymus. Gradual acquisition of T helper cell function by CD3+CD4+ cells

Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development

Endothelial outgrowth cells are not derived from CD133+ cells or CD45+ hematopoietic precursors

Endothelial progenitor cells: identity defined?

Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours.

Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate

Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects.

Generation of T cells from human embryonic stem cell-derived hematopoietic zones

Guidelines for the use of fresh frozen plasma

HES1 and HES4 have non-redundant roles downstream of Notch during early human T cell development

Human CD34+ fetal liver stem cells differentiate to T cells in a mouse thymic microenvironment.

Human Ig production and isotype switching in severe combined immunodeficient-human mice

Human T lymphopoiesis. In vitro and in vivo study models.

Human Thymic CD10+ PD-1+ Intraepithelial Lymphocyte Precursors Acquire Interleukin-15 Responsiveness at the CD1a- CD95+ CD28- CCR7- Developmental Stage

Human fetal liver cells differentiate into thymocytes in chimeric mouse fetal thymus organ culture.

Human hematopoietic cells and thymic epithelial cells induce tolerance via different mechanisms in the SCID-hu mouse thymus

Human intrathymic development: a selective approach.

Human thymocytes become lineage committed at an early postselection CD69+ stage, before the onset of functional maturation

Humanized Mice to Study Human T Cell Development.

IL-2 reverses human T cell unresponsiveness induced by thymic epithelium in SCID-hu mice

Immunological unresponsiveness induced by ultraviolet-B-irradiated and nonirradiated skin grafts.

In vitro expanded cells contributing to rapid severe combined immunodeficient repopulation activity are CD34+38-33+90+45RA-.

In vitro generation of immune cells from pluripotent stem cells

In vitro generation of mature, naive antigen-specific CD8(+) T cells with a single T-cell receptor by agonist selection

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis

In vitro intrathymic differentiation kinetics of human fetal liver CD34+CD38- progenitors reveals a phenotypically defined dendritic/T-NK precursor split

In vivo cytokine expression in the thymus. CD3high human thymocytes are activated and already functionally differentiated in helper and cytotoxic cells

Increase of donor-specific cytotoxic T lymphocyte precursors after transfusion

Induction of isotype switching and Ig production by CD5+ and CD10+ human fetal B cells

Influence of TGF-beta on murine thymocyte development in fetal thymus organ culture.

Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes

Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes

Interleukin-7 is a critical growth factor in early human T-cell development.

Intracoronary delivery of hematopoietic bone marrow stem cells and luminal loss of the infarct-related artery in patients with recent myocardial infarction

Intracoronary injection of CD133-positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction: feasibility and safety

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions

Langerhans cells are not required for epidermal Vgamma3 T cell homeostasis and function

Ly49E expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases

Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator.

MHC class II molecules are required for initiation of positive selection but not during terminal differentiation of human CD4 single positive thymocytes.

Nanobody Based Dual Specific CARs

Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway.

Notch signaling is required for proliferation but not for differentiation at a well-defined beta-selection checkpoint during human T-cell development

Notch3 activation is sufficient but not required for inducing human T-lineage specification

Phenotypic and functional maturation of TCR gammadelta cells in the human thymus

Pluripotent stem cell based gene therapy for hematological diseases.

RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia

Radiation Sensitivity of Human CD34(+) Cells Versus Peripheral Blood T Lymphocytes of Newborns and Adults: DNA Repair and Mutagenic Effects.

Rapid and Effective Generation of Nanobody Based CARs using PCR and Gibson Assembly

Recommendations in the event of a suspected transfusion-related acute lung injury (TRALI)

SCID-hu mice as a model to study tolerance after fetal stem cell transplantation

Safe eradication of large established tumors using neovasculature-targeted tumor necrosis factor-based therapies

Selecting cord blood units for storage by CD34+ cell counts

Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.