List of works - Mehdi Mobli

1H chemical shifts in NMR. Part 20--anisotropic and steric effects in halogen substituent chemical shifts (SCS), a modelling and ab initio investigation

scientific article published in May 2004

1H chemical shifts in NMR. Part 21--prediction of the 1H chemical shifts of molecules containing the ester group: a modelling and ab initio investigation

scientific article published in January 2005

1H chemical shifts in NMR: Part 19. Carbonyl anisotropies and steric effects in aromatic aldehydes and ketones

31. Spider-venom Peptides that Target the Human NaV1.7 channel: Potential Analgesics for the Treatment of Chronic Pain

A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain

scientific article

A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a

scientific article

A dynamic pharmacophore drives the interaction between Psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a

scientific article

A non-uniform sampling approach enables studies of dilute and unstable proteins

scientific article

An NMR, IR and theoretical investigation of1H Chemical Shifts and hydrogen bonding in phenols

scientific article published on 01 October 2007

An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria

scientific article published on 23 June 2020

An automated tool for maximum entropy reconstruction of biomolecular NMR spectra

scientific article published on 01 June 2007

Automatic maximum entropy spectral reconstruction in NMR

scientific article published on 15 August 2007

Backbone and side chain NMR assignments of Geobacillus stearothermophilus ZapA allow identification of residues that mediate the interaction of ZapA with FtsZ.

scientific article published on 13 May 2015

Chapter 9. Maximum Entropy Reconstruction

Chemical synthesis and structure of the prokineticin Bv8

scientific article

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

scientific article

Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities

article

Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3

scientific article

Cyclization of peptides by using selenolanthionine bridges.

scientific article

Data sampling in multidimensional NMR: fundamentals and strategies

scientific article

Determination of ligand binding modes in weak protein-ligand complexes using sparse NMR data

scientific article

Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8.

scientific article published on 29 March 2016

Direct visualization of disulfide bonds through diselenide proxies using 77Se NMR spectroscopy

scientific article published in January 2009

Do vicinal disulfide bridges mediate functionally important redox transformations in proteins?

scientific article published on 19 June 2013

Effective protocol for database similarity searching of heteronuclear single quantum coherence spectra.

scientific article published in November 2009

Efficient biosynthesis of heterodimeric C-aryl pyrroloindoline alkaloids

scientific article published in Nature Communications

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

scientific article published on 22 December 2018

Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3.

scientific article

Functional implications of large backbone amplitude motions of the glycoprotein 130-binding epitope of interleukin-6.

scientific article

Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers

scientific article published on 22 February 2016

Insulin-like growth factor binding protein-2: NMR analysis and structural characterization of the N-terminal domain

scientific article published on 22 September 2011

Isolation of an orally active insecticidal toxin from the venom of an Australian tarantula

scientific article

Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels

scientific article published on 19 February 2014

Macromolecular NMR spectroscopy for the non-spectroscopist: beyond macromolecular solution structure determination

scientific article published on 28 January 2011

Macromolecular NMR spectroscopy for the non‐spectroscopist ⬇️

scientific article published on January 28, 2011

Maximum Entropy Spectral Reconstruction of Non-Uniformly Sampled Data

scientific article

Measuring interactions of FERM domain-containing sorting Nexin proteins with endosomal lipids and cargo molecules.

scientific article published on January 2014

Modelling1H NMR Spectra of Organic Compounds

article

Modulation of Ion Channels by Cysteine-Rich Peptides: From Sequence to Structure.

scientific article

Molecular basis of the interaction between gating modifier spider toxins and the voltage sensor of voltage-gated ion channels.

scientific article published on 28 September 2016

Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a.

scientific article

Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide ⬇️

scientific article

N-Acetylated amino sugars: the dependence of NMR 3J(HNH2)-couplings on conformation, dynamics and solvent

scientific article published on 31 May 2007

NUScon: a community-driven platform for quantitative evaluation of nonuniform sampling in NMR

scientific article published in 2021

NaV1.7 as a pain target - From gene to pharmacology.

scientific article published on December 2016

Non-uniform sampling in EPR--optimizing data acquisition for HYSCORE spectroscopy

scientific article

Nonuniform sampling and maximum entropy reconstruction in multidimensional NMR.

scientific article published on 09 January 2014

Nonuniform sampling and non-Fourier signal processing methods in multidimensional NMR.

scientific article published on 13 October 2014

Nonuniform sampling and spectral aliasing.

scientific article

Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases

scientific article

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.

scientific article published on 20 March 2017

Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli.

scientific article

Quantum vs. classical models of the nitro group for proton chemical shift calculations and conformational analysis

RNA polymerase-induced remodelling of NusA produces a pause enhancement complex.

scientific article

Rational Engineering Defines a Molecular Switch That Is Essential for Activity of Spider-Venom Peptides against the Analgesics Target NaV1.7

scientific article

Reducing seed dependent variability of non-uniformly sampled multidimensional NMR data.

scientific article

Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain

scientific article published in Nature Communications

Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach

scientific article published on 4 March 2015

Site-Specific pKa Determination of Selenocysteine Residues in Selenovasopressin by Using 77Se NMR Spectroscopy

scientific article published on 14 October 2011

Solution Structure, Membrane Interactions, and Protein Binding Partners of the Tetraspanin Sm-TSP-2, a Vaccine Antigen from the Human Blood FlukeSchistosoma mansoni

scientific article

Solution structure of the RNA-binding cold-shock domain of the Chlamydomonas reinhardtii NAB1 protein and insights into RNA recognition

scientific article

Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling.

scientific article published on 24 July 2017

Sparse sampling methods in multidimensional NMR. ⬇️

scientific article

Spectral reconstruction methods in fast NMR: Reduced dimensionality, random sampling and maximum entropy

scientific article published on 11 July 2006

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

scientific article

Synthesis of Multivalent [Lys8]-Oxytocin Dendrimers that Inhibit Visceral Nociceptive Responses

article

The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins

scientific article published on 17 October 2016

The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel Deactivation

scientific article

The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels

scientific article

The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop

scientific article

The structural plasticity of heparan sulfate NA-domains and hence their role in mediating multivalent interactions is confirmed by high-accuracy (15)N-NMR relaxation studies.

scientific article published on 13 December 2007

The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.

scientific article

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

scientific article

Three-dimensional 13C-detected CH3-TOCSY using selectively protonated proteins: facile methyl resonance assignment and protein structure determination.

scientific article

Total Synthesis of Human Hepcidin through Regioselective Disulfide-Bond Formation by using the Safety-Catch Cysteine Protecting Group 4,4′-Dimethylsulfinylbenzhydryl

scientific article published on 07 February 2014

Toxin structures as evolutionary tools: Using conserved 3D folds to study the evolution of rapidly evolving peptides

scientific article

Two proteins for the price of one: Structural studies of the dual-destiny protein preproalbumin with sunflower trypsin inhibitor-1.

scientific article published on 23 May 2017

Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with acid-sensing ion channel 3 and hERG channels via overlapping pharmacophores

scientific article

Venomics: a new paradigm for natural products-based drug discovery.

scientific article published on 24 February 2010

Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter

scientific article published on 24 September 2013

Weaponization of a Hormone: Convergent Recruitment of Hyperglycemic Hormone into the Venom of Arthropod Predators

scientific article

α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors.

scientific article

List of works by Mehdi Mobli

1H chemical shifts in NMR. Part 20--anisotropic and steric effects in halogen substituent chemical shifts (SCS), a modelling and ab initio investigation

1H chemical shifts in NMR. Part 21--prediction of the 1H chemical shifts of molecules containing the ester group: a modelling and ab initio investigation

1H chemical shifts in NMR: Part 19. Carbonyl anisotropies and steric effects in aromatic aldehydes and ketones

31. Spider-venom Peptides that Target the Human NaV1.7 channel: Potential Analgesics for the Treatment of Chronic Pain

A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain

A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a

A dynamic pharmacophore drives the interaction between Psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a

A non-uniform sampling approach enables studies of dilute and unstable proteins

An NMR, IR and theoretical investigation of1H Chemical Shifts and hydrogen bonding in phenols

An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria

An automated tool for maximum entropy reconstruction of biomolecular NMR spectra

Automatic maximum entropy spectral reconstruction in NMR

Backbone and side chain NMR assignments of Geobacillus stearothermophilus ZapA allow identification of residues that mediate the interaction of ZapA with FtsZ.

Chapter 9. Maximum Entropy Reconstruction

Chemical synthesis and structure of the prokineticin Bv8

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities

Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3

Cyclization of peptides by using selenolanthionine bridges.

Data sampling in multidimensional NMR: fundamentals and strategies

Determination of ligand binding modes in weak protein-ligand complexes using sparse NMR data

Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8.

Direct visualization of disulfide bonds through diselenide proxies using 77Se NMR spectroscopy

Do vicinal disulfide bridges mediate functionally important redox transformations in proteins?

Effective protocol for database similarity searching of heteronuclear single quantum coherence spectra.

Efficient biosynthesis of heterodimeric C-aryl pyrroloindoline alkaloids

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3.

Functional implications of large backbone amplitude motions of the glycoprotein 130-binding epitope of interleukin-6.

Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers

Insulin-like growth factor binding protein-2: NMR analysis and structural characterization of the N-terminal domain

Isolation of an orally active insecticidal toxin from the venom of an Australian tarantula

Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels

Macromolecular NMR spectroscopy for the non-spectroscopist: beyond macromolecular solution structure determination

Macromolecular NMR spectroscopy for the non‐spectroscopist ⬇️

Maximum Entropy Spectral Reconstruction of Non-Uniformly Sampled Data

Measuring interactions of FERM domain-containing sorting Nexin proteins with endosomal lipids and cargo molecules.

Modelling1H NMR Spectra of Organic Compounds

Modulation of Ion Channels by Cysteine-Rich Peptides: From Sequence to Structure.

Molecular basis of the interaction between gating modifier spider toxins and the voltage sensor of voltage-gated ion channels.

Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a.

Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide ⬇️

N-Acetylated amino sugars: the dependence of NMR 3J(HNH2)-couplings on conformation, dynamics and solvent

NUScon: a community-driven platform for quantitative evaluation of nonuniform sampling in NMR

NaV1.7 as a pain target - From gene to pharmacology.

Non-uniform sampling in EPR--optimizing data acquisition for HYSCORE spectroscopy

Nonuniform sampling and maximum entropy reconstruction in multidimensional NMR.

Nonuniform sampling and non-Fourier signal processing methods in multidimensional NMR.

Nonuniform sampling and spectral aliasing.

Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.

Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli.

Quantum vs. classical models of the nitro group for proton chemical shift calculations and conformational analysis

RNA polymerase-induced remodelling of NusA produces a pause enhancement complex.

Rational Engineering Defines a Molecular Switch That Is Essential for Activity of Spider-Venom Peptides against the Analgesics Target NaV1.7

Reducing seed dependent variability of non-uniformly sampled multidimensional NMR data.

Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain

Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach

Site-Specific pKa Determination of Selenocysteine Residues in Selenovasopressin by Using 77Se NMR Spectroscopy

Solution Structure, Membrane Interactions, and Protein Binding Partners of the Tetraspanin Sm-TSP-2, a Vaccine Antigen from the Human Blood FlukeSchistosoma mansoni

Solution structure of the RNA-binding cold-shock domain of the Chlamydomonas reinhardtii NAB1 protein and insights into RNA recognition

Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling.

Sparse sampling methods in multidimensional NMR. ⬇️

Spectral reconstruction methods in fast NMR: Reduced dimensionality, random sampling and maximum entropy

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

Synthesis of Multivalent [Lys8]-Oxytocin Dendrimers that Inhibit Visceral Nociceptive Responses

The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins

The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel Deactivation

The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels

The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop

The structural plasticity of heparan sulfate NA-domains and hence their role in mediating multivalent interactions is confirmed by high-accuracy (15)N-NMR relaxation studies.

The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Three-dimensional 13C-detected CH3-TOCSY using selectively protonated proteins: facile methyl resonance assignment and protein structure determination.

Total Synthesis of Human Hepcidin through Regioselective Disulfide-Bond Formation by using the Safety-Catch Cysteine Protecting Group 4,4′-Dimethylsulfinylbenzhydryl

Toxin structures as evolutionary tools: Using conserved 3D folds to study the evolution of rapidly evolving peptides

Two proteins for the price of one: Structural studies of the dual-destiny protein preproalbumin with sunflower trypsin inhibitor-1.

Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with acid-sensing ion channel 3 and hERG channels via overlapping pharmacophores

Venomics: a new paradigm for natural products-based drug discovery.