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List of works by Massimo Libra

'Genetic profiling' and ovarian cancer therapy (review).

scientific article published on 17 June 2011

A spindle cell variant of diffuse large B-cell lymphoma possesses genotypic and phenotypic markers characteristic of a germinal center B-cell origin

scientific article published in February 2006

Absence of human parvovirus B19 DNA in myoepithelial sialadenitis of primary Sjögren's syndrome

scientific article published in September 2002

Activation of the osteopontin/matrix metalloproteinase-9 pathway correlates with prostate cancer progression.

scientific article

Adherence to the Mediterranean Diet in Maltese Adults

scientific article published on 22 December 2020

Adherence to the Mediterranean diet and nasopharyngeal cancer risk in Italy

scientific article published on 2 February 2017

Advances in targeting signal transduction pathways

scientific article

Akt as a therapeutic target in cancer

scientific article published on 01 September 2008

Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy

scientific article published on 21 February 2008

Analysis of TIMP-1 gene polymorphisms in Italian sclerodermic patients.

scientific article published in January 2006

Analysis of aberrant somatic hypermutation (SHM) in non-Hodgkin's lymphomas of patients with chronic HCV infection

scientific article published on May 2005

Analysis of the B-RafV600E mutation in cutaneous melanoma patients with occupational sun exposure

scientific article published on 14 January 2014

Anticancer properties of the novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide in vitro and in vivo.

scientific article

Association between Nutrient-Based Dietary Patterns and Bladder Cancer in Italy

scientific article published on 28 May 2020

Association between dietary inflammatory index and Hodgkin's lymphoma in an Italian case-control study

scientific article published on 12 February 2018

Association of t(14;18) translocation with HCV infection in gastrointestinal MALT lymphomas.

scientific article published on 16 May 2008

Associations of dietary carbohydrates, glycaemic index and glycaemic load with risk of bladder cancer: a case-control study.

scientific article

BRAF mutations in papillary thyroid carcinoma and emerging targeted therapies (review).

scientific article published on 02 August 2012

Breast cancer risk in women treated with augmentation mammoplasty (review).

scientific article published on 18 April 2012

Cancer Management during COVID-19 Pandemic: Is Immune Checkpoint Inhibitors-Based Immunotherapy Harmful or Beneficial?

scientific article published on 10 August 2020

Characterization of human melanoma cell lines and melanocytes by proteome analysis

scientific article

Coffee, Tea, Cola, and Bladder Cancer Risk: Dose and Time Relationships.

scientific article

Combining chemo-, hormonal and targeted therapies to treat breast cancer (Review).

scientific article published on March 2008

Comparative study of rapamycin and temsirolimus demonstrates superimposable anti-tumour potency on prostate cancer cells.

scientific article

Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.

scientific article published on 13 March 2008

Correction: Genetic Diversity of the KIR/HLA System and Susceptibility to Hepatitis C Virus-Related Diseases

scientific article published on 15 May 2015

Correlation of the risk of breast cancer and disruption of the circadian rhythm (Review).

scientific article published on 29 May 2012

Critical Roles of EGFR Family Members in Breast Cancer and Breast Cancer Stem Cells: Targets for Therapy

scientific article published on 4 March 2016

D1S80 VNTR locus genotypes in a population of Southeastern Sicily: Distribution and genetic disequilibrium

scientific article published on 01 January 2004

Dehydroxymethylepoxyquinomicin inhibits expression and production of inflammatory mediators in interleukin-1beta-induced human chondrocytes

scientific article published on 23 March 2010

Dehydroxymethylepoxyquinomicin, a novel nuclear factor-kappaB inhibitor, prevents inflammatory injury induced by interferon-gamma and histamine in NCTC 2544 keratinocytes

scientific article published on 12 March 2010

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention

scientific article

Diabetes mellitus and the risk of bladder cancer: an Italian case–control study

scientific article

Dietary Inflammatory Index and Risk of Bladder Cancer in a Large Italian Case-control Study

scientific article published on 29 September 2016

Dietary inflammatory index and cancer risk in the elderly: A pooled-analysis of Italian case-control studies

scientific article published on 19 February 2019

Dietary inflammatory index and non-Hodgkin lymphoma risk in an Italian case-control study.

scientific article published on 13 May 2017

Dietary intakes of carotenoids and other nutrients in the risk of nasopharyngeal carcinoma: a case-control study in Italy

scientific article

Dietary water intake and bladder cancer risk: An Italian case–control study

article

Different pediatric brain tumors are associated with different gene expression profiling.

scientific article published on 16 March 2015

Differentiation between non-Hodgkin's lymphoma recurrence and second primary lymphoma by VDJ rearrangement analysis

article

Diverse roles of GSK-3: tumor promoter-tumor suppressor, target in cancer therapy

scientific article published on 08 October 2013

Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs

scientific article published on 15 April 2010

Droplet Digital PCR Analysis of Liquid Biopsy Samples Unveils the Diagnostic Role of hsa-miR-133a-3p and hsa-miR-375-3p in Oral Cancer

scientific article published on 06 November 2020

Duration and intensity of tobacco smoking and the risk of papillary and non-papillary transitional cell carcinoma of the bladder

scientific article published on 26 June 2014

Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine

scientific article published on 16 November 2012

Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity ⬇️

scientific article published on October 1, 2012

Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity-Diverse effects on cell growth, metabolism and cancer

scientific article published on 06 September 2016

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

scientific article published on 12 June 2017

Emerging MEK inhibitors.

scientific article published on June 2010

Emerging Raf inhibitors.

scientific article published on December 2009

Emerging targeted therapies for melanoma treatment (review)

scientific article

Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapy

scientific article published on 15 May 2010

Expression of cyclin-dependent kinase inhibitor p27(Kip1) in AIDS-related diffuse large-cell lymphomas is associated with Epstein-Barr virus-encoded latent membrane protein 1.

scientific article published on July 2002

Family history of cancer and the risk of bladder cancer: A case–control study from Italy

article

Functional Roles of Matrix Metalloproteinases and Their Inhibitors in Melanoma

scientific article published on 07 May 2020

GSK-3 as potential target for therapeutic intervention in cancer

scientific article

Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance (review).

scientific article published on 20 December 2011

Genetic diversity of the KIR/HLA system and susceptibility to hepatitis C virus-related diseases.

scientific article

Genetic insights into the disease mechanisms of type II mixed cryoglobulinemia induced by hepatitis C virus.

scientific article published on September 2007

HCV-associated B cell clonalities in the liver do not carry the t(14;18) chromosomal translocation.

scientific article published in November 2005

HLA DR-DQ combination associated with the increased risk of developing human HCV positive non-Hodgkin's lymphoma is related to the type II mixed cryoglobulinemia

scientific article published on 9 December 2009

Hepatitis B and C viruses and risk of non-Hodgkin lymphoma: a case-control study in Italy

scientific article published on 23 June 2016

IL-6-174 G > C and MMP-9-1562 C > T polymorphisms are associated with increased risk of deep vein thrombosis in cancer patients.

scientific article published on 11 March 2013

Identification of Modulated MicroRNAs Associated with Breast Cancer, Diet, and Physical Activity

scientific article published on 08 September 2020

Improved outcome with multimodal treatment and imatinib rechallenge in advanced GIST

scientific article published on 15 February 2014

In vitro inhibition of enterobacteria-reactive CD4+CD25- T cells and suppression of immunoinflammatory colitis in mice by the novel immunomodulatory agent VGX-1027.

scientific article published on 17 February 2008

Increased Levels of NF-kB-Dependent Markers in Cancer-Associated Deep Venous Thrombosis.

scientific article published on 20 July 2015

Increased Risk of Nasopharyngeal Carcinoma with Increasing Levels of Diet-Associated Inflammation in an Italian Case-Control Study

scientific article

Induction of caspase-independent apoptotic-like cell death of mouse mammary tumor TA3Ha cells in vitro and reduction of their lethality in vivo by the novel chemotherapeutic agent GIT-27NO.

scientific article

Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells

scientific article published on September 2011

Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy

scientific article published on July 2011

Involvement of p53 and Raf/MEK/ERK pathways in hematopoietic drug resistance

scientific article published on 7 August 2008

Low frequency of bcl-2 rearrangement in HCV-associated non-Hodgkin's lymphoma tissue

scientific article published on 01 July 2003

Malignant melanoma in elderly patients: biological, surgical and medical issues.

scientific article published on 24 September 2014

Mediterranean Diet and Bladder Cancer Risk in Italy

article

Metabolic disorders and the risk of nasopharyngeal carcinoma: a case-control study in Italy.

scientific article published on 29 July 2016

Metabolic syndrome and the risk of urothelial carcinoma of the bladder: a case-control study

scientific article published on 16 October 2015

Modulation of YY1 and p53 expression by transforming growth factor-β3 in prostate cell lines

scientific article

Molecular analysis of the APC gene in Sicilian patients with familial adenomatous polyposis (F.A.P.).

scientific article

Molecular screening in Sicilian families with hereditary non-poliposis colorectal cancer (H.N.P.C.C.) syndrome: identification of a novel mutation in MSH2 gene.

scientific article

Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.

scientific article published on 19 June 2013

Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response

scientific article published on September 2012

New perspectives in HCV therapy: entry inhibitors.

scientific article

Novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide (GIT-27NO) induces p53 mediated apoptosis in human A375 melanoma cells.

scientific article

PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches

scientific article published on 23 May 2009

Patient-Derived Tumor Organoids for Drug Repositioning in Cancer Care: A Promising Approach in the Era of Tailored Treatment

scientific article published on 04 December 2020

Patients with unrecognized peripheral arterial disease (PAD) assessed by ankle-brachial index (ABI) present a defined profile of proinflammatory markers compared to healthy subjects.

scientific article published on 15 May 2012

Phase II study of the antiretroviral activity and safety of the glucocorticoid receptor antagonist mifepristone in HIV-1-infected patients

article

Plasma levels and zymographic activities of matrix metalloproteinases 2 and 9 in type II diabetics with peripheral arterial disease

scientific article published on 01 February 2005

Polyphenol-Rich and Alcoholic Beverages and Metabolic Status in Adults Living in Sicily, Southern Italy

scientific article published on 9 February 2021

Processed Meat and Risk of Renal Cell and Bladder Cancers

scientific article published on 23 March 2018

Prognostic factors in soft tissue sarcomas: a study of 395 patients

scientific article published on 01 March 2002

Raf kinase inhibitor protein (RKIP) and phospho-RKIP expression in melanomas ⬇️

scientific article published on April 17, 2013

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance

scientific article

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health

scientific article published on March 2011

Red meat and cancer risk in a network of case-control studies focusing on cooking practices

scientific article published on 11 October 2013

Regular aspirin use and nasopharyngeal cancer risk: A case-control study in Italy

article

Role of genetic polymorphisms and mutations in colorectal cancer therapy (Review).

scientific article published on 16 December 2010

Role of the HLA class II: HCV-related disorders.

scientific article published in June 2007

Role of the Transcription Factor Yin Yang 1 and Its Selectively Identified Target Survivin in High-Grade B-Cells Non-Hodgkin Lymphomas: Potential Diagnostic and Therapeutic Targets

scientific article published on 03 September 2020

Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells

scientific article published on 17 July 2015

Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells

scientific article

Roles of NGAL and MMP-9 in the tumor microenvironment and sensitivity to targeted therapy

scientific article published on 13 August 2015

Roles of signaling pathways in drug resistance, cancer initiating cells and cancer progression and metastasis

scientific article

Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance

scientific article published on 18 July 2006

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

scientific article

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

scientific article

Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.

scientific article published on 15 April 2011

Second primary lymphoma or recurrence: a dilemma solved by VDJ rearrangement analysis.

scientific article published in August 2004

Solid pseudopapillary tumour of the pancreas

scientific article published on 01 April 2003

Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer.

scientific article published on 22 April 2013

Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.

scientific article published on 10 March 2008

Targeting GSK3 and Associated Signaling Pathways Involved in Cancer

scientific article published on 30 April 2020

Targeting breast cancer initiating cells: advances in breast cancer research and therapy

scientific article

Targeting prostate cancer based on signal transduction and cell cycle pathways.

scientific article published on 16 June 2008

Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy.

scientific article published on 13 March 2008

Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance.

scientific article published on 26 March 2007

Targeting the cancer initiating cell: the ultimate target for cancer therapy.

scientific article published on January 2012

Targeting the leukemic stem cell: the Holy Grail of leukemia therapy

scientific article published on 18 September 2008

Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway

scientific article

The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation

The Effect of Dietary Polyphenols on Vascular Health and Hypertension: Current Evidence and Mechanisms of Action

scientific article published on 27 January 2022

The NO-modified HIV protease inhibitor as a valuable drug for hematological malignancies: Role of p70S6K.

scientific article published on 28 June 2015

The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy

scientific article published on 10 May 2010

The antitumor properties of a nontoxic, nitric oxide-modified version of saquinavir are independent of Akt.

scientific article

The therapeutic potential of mTOR inhibitors in breast cancer

scientific article published on 5 April 2016

The tumor microenvironment in hepatocellular carcinoma (review).

scientific article published on 22 March 2012

Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways.

scientific article

Tobacco smoking, alcohol drinking, and the risk of different histological types of nasopharyngeal cancer in a low-risk population

article published in 2011

Total Nut, Tree Nut, and Peanut Consumption and Metabolic Status in Southern Italian Adults

scientific article published on 14 February 2021

Tumor microenvironment in diffuse large B-cell lymphoma: Matrixmetalloproteinases activation is mediated by osteopontin overexpression

scientific article published on 14 September 2015

Understanding rituximab function and resistance: implications for tailored therapy.

scientific article published on January 2011

Unique Pattern of Overexpression of Raf-1 Kinase Inhibitory Protein in Its Inactivated Phosphorylated Form in Human Multiple Myeloma

scientific article published on April 2011

Uterine cervical carcinoma: role of matrix metalloproteinases (review).

scientific article published on April 2009

microRNAs and thyroid cancer: biological and clinical significance (Review).

scientific article published on 08 August 2012

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