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List of works by Philip Newsholme

Activation of survival and apoptotic signaling pathways in lymphocytes exposed to palmitic acid.

scientific article published on January 2012

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

scientific article

Adrenaline induced inhibition of neutrophil PLA2 activity

scientific article published on 01 August 1998

Amino acid supplementation and impact on immune function in the context of exercise

scientific article

Amino acids and diabetes: implications for endocrine, metabolic and immune function

scientific article published on January 2011

Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line

scientific article published on March 2011

Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity

scientific article published on February 2004

Are Heat Shock Proteins an Important Link between Type 2 Diabetes and Alzheimer Disease?

scientific article published on 02 November 2020

Attenuation of obesity and insulin resistance by fish oil supplementation is associated with improved skeletal muscle mitochondrial function in mice fed a high-fat diet

scientific article published on 11 December 2017

Comparative toxicity of oleic and linoleic acid on human lymphocytes.

scientific article published on 19 October 2005

Complement activation of electrogenic ion transport in isolated rat colon

scientific article published on 01 November 1997

Complement is involved in the mechanism of IDDM serum induced pancreatic beta-cell cytotoxicity

scientific article published on 01 May 1997

Cystine accumulation attenuates insulin release from the pancreatic β-cell due to elevated oxidative stress and decreased ATP levels

scientific article

Cystine dimethylester loading promotes oxidative stress and a reduction in ATP independent of lysosomal cystine accumulation in a human proximal tubular epithelial cell line.

scientific article published on 28 June 2013

Differential nitric oxide levels in the blood and skeletal muscle of type 2 diabetic subjects may be consequence of adiposity: a preliminary study

scientific article published on 07 June 2012

Divergence of intracellular and extracellular HSP72 in type 2 diabetes: does fat matter? ⬇️

scientific article published on January 4, 2012

Editorial: genes and cell metabolism

scientific article published in July 2013

Effect of docosahexaenoic acid-rich fish oil supplementation on human leukocyte function.

scientific article

Effects of EPA and DHA on proliferation, cytokine production, and gene expression in Raji cells.

scientific article published on September 2004

Effects of adrenaline on glucose and glutamine metabolism and superoxide production by rat neutrophils

scientific article published on 01 June 1999

Effects of high EPA and high DHA fish oils on changes in signaling associated with protein metabolism induced by hindlimb suspension in rats.

scientific article published on September 2016

Effects of pharmacological inhibition of NADPH oxidase or iNOS on pro-inflammatory cytokine, palmitic acid or H2O2-induced mouse islet or clonal pancreatic β-cell dysfunction

scientific article

Effects of short chain fatty acids on effector mechanisms of neutrophils

scientific article

Elevated levels of branched-chain amino acids have little effect on pancreatic islet cells, but L-arginine impairs function through activation of the endoplasmic reticulum stress response

scientific article published on 13 December 2013

Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro

scientific article published on May 2014

Evidence for murine macrophage nitric oxide synthesis in the absence of exogenous L-arginine

scientific article published on 01 August 1996

Evidence for the involvement of glutamine in nitric oxide (NO) production by immunostimulated neutrophils

scientific article published on 01 August 1997

Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide

scientific article published on 23 November 2009

Fatty acid oxidation by lymphocytes

scientific article published on 01 May 1994

Genes regulated by arachidonic and oleic acids in Raji cells.

scientific article

Glucose metabolism in lymphoid and inflammatory cells and tissues.

scientific article published on July 2007

Glucose, but not glutamine, protects against spontaneous and anti-Fas antibody-induced apoptosis in human neutrophils

scientific article published in August 2002

Glutamine and glutamate--their central role in cell metabolism and function.

scientific article

Glutamine as a possible precursor of L-arginine and thus nitric oxide synthesis in murine macrophages

scientific article published on 01 August 1997

Glutamine delays spontaneous apoptosis in neutrophils

scientific article published on 15 January 2003

Glutamine, gene expression, and cell function

scientific article published on January 2007

Housekeeping proteins: How useful are they in skeletal muscle diabetes studies and muscle hypertrophy models?

scientific article published on 06 April 2016

Identification of a novel complement-dependent serum-elicited inward current in the Xenopus oocyte provoking Ca2+ influx and subsequent activation of Cl- channels.

scientific article published in March 1999

Importance of glutamine metabolism in murine macrophages and human monocytes to L-arginine biosynthesis and rates of nitrite or urea production

scientific article published on October 1998

In vivo and in vitro studies of GAD-antibody positive subjects with Type 2 diabetes: A distinct sub-phenotype

scientific article

Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease

scientific article

Inhibition of formyl-methionyl-leucyl-phenylalanine-stimulated respiratory burst in human neutrophils by adrenaline: inhibition of Phospholipase A2 activity but not p47phox phosphorylation and translocation

scientific article

Inhibition of nitric oxide induced cytotoxicity in pancreatic b-cells

scientific article published on 01 February 1996

Investigation into the effects of adrenaline and/or lipopolysaccaride on nitrite production by murine macrophages

scientific article published on 01 February 1996

Investigation into the mechanisms of complement mediated cytotoxicity in pancreatic beta cells

scientific article published on February 1996

Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism

scientific article published on 20 October 2006

Investigation of the inhibition of complement mediated cell death

scientific article published on February 1996

Investigation of the mechanisms of complement mediated cell death in lymphocytes

scientific article published on 01 May 1997

Ion-transfer electrochemistry of rat amylin at the water-organogel microinterface array and its selective detection in a protein mixture

scientific article published on 7 June 2013

L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic beta-cell line and protects from pro-inflammatory cytokine-induced apoptosis

scientific article

Life and death decisions of the pancreatic beta-cell: the role of fatty acids

scientific article published on January 2007

Lysosomal cystine accumulation promotes mitochondrial depolarization and induction of redox-sensitive genes in human kidney proximal tubular cells

scientific article published on 24 February 2016

Macrophage-mediated lysis of a beta-cell line, tumour necrosis factor-alpha release from bacillus Calmette-Guérin (BCG)-activated murine macrophages and interleukin-8 release from human monocytes are dependent on extracellular glutamine concentratio

scientific article published on January 1999

Mathematical model of metabolism and electrophysiology of amino acid and glucose stimulated insulin secretion: in vitro validation using a β-cell line

scientific article

Metabolic regulation of insulin secretion.

scientific article published on January 2014

Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines

scientific article published on April 2011

Mitochondria and diabetes. An intriguing pathogenetic role

scientific article published on January 2012

Mitochondria-derived glutamate at the interplay between branched-chain amino acid and glucose-induced insulin secretion

scientific article

Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β-Cell Dysfunction

scientific article (publication date: 2015)

Multi-lineage differentiation of mesenchymal stem cells - To Wnt, or not Wnt.

scientific article published on 24 September 2015

New insights into amino acid metabolism, beta-cell function and diabetes

scientific article

Novel dehydroepiandrosterone troche supplementation improves the serum androgen profile of women undergoing in vitro fertilization

scientific article

Oleic, linoleic and linolenic acids increase ros production by fibroblasts via NADPH oxidase activation.

scientific article

Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism.

scientific article published on September 2009

Persistence of inflammatory response to intense exercise in diabetic rats.

scientific article

Phagocyte-like NADPH oxidase (Nox2) promotes activation of p38MAPK in pancreatic β-cells under glucotoxic conditions: Evidence for a requisite role of Ras-related C3 botulinum toxin substrate 1 (Rac1).

scientific article

Pigment epithelium-derived factor (PEDF) regulates metabolism and insulin secretion from a clonal rat pancreatic beta cell line BRIN-BD11 and mouse islets.

scientific article published on 8 February 2016

Polyunsaturated and monounsaturated fatty acids increase neutral lipid accumulation, caspase activation and apoptosis in a neutrophil-like, differentiated HL-60 cell line

scientific article published on February 2003

Prolonged L-alanine exposure induces changes in metabolism, Ca(2+) handling and desensitization of insulin secretion in clonal pancreatic beta-cells.

scientific article published on February 2009

Regulation of superoxide production in human polymorphonuclear leukocytes (PMNs)

scientific article published on 01 May 1997

Regulatory principles in metabolism-then and now.

scientific article published on July 2016

The Critical Role of Cell Metabolism for Essential Neutrophil Functions

scientific article published on 01 June 2020

The Impact of Vitamin D Levels on Inflammatory Status: A Systematic Review of Immune Cell Studies

scientific article

The chaperone balance hypothesis: the importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes, the effect of exercise, and the implications for clinical management

scientific article

The effect of cigarette smoking, alcohol consumption and fruit and vegetable consumption on IVF outcomes: a review and presentation of original data

scientific article

The effects of aerobic exercise training at two different intensities in obesity and type 2 diabetes: implications for oxidative stress, low-grade inflammation and nitric oxide production

scientific article published on 01 February 2014

The enemy within. The role played by immunostimulated macrophages in the pathogenesis of insulin dependent diabetes mellitus

scientific article published on 01 May 1997

The fat cell senescence hypothesis: a mechanism responsible for abrogating the resolution of inflammation in chronic disease

scientific article published on July 2014

The impact of cryopreservation on human peripheral blood leucocyte bioenergetics

scientific article published on May 2015

The proposed role of glutamine in some cells of the immune system and speculative consequences for the whole animal

scientific article published on July 1997

The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes.

scientific article published on June 2015

Therapeutic approach to target mesothelioma cancer cells using the Wnt antagonist, secreted frizzled-related protein 4: Metabolic state of cancer cells.

scientific article published on 8 February 2016

Wnt antagonist secreted frizzled-related protein 4 upregulates adipogenic differentiation in human adipose tissue-derived mesenchymal stem cells

scientific article published on 25 February 2015

You, your children, your grandchildren, and their inflammatory responses are what you eat

scientific article published on 01 July 2015

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