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List of works by Elisa Giovannetti

"One marker does not fit all": additional translational and validation studies are needed to identify faithful predictors of pemetrexed activity in mesothelioma

scientific article

"The only thing I know is that I know nothing": 5-fluorouracil in human milk

scientific article published on 01 February 2012

2,6-Disubstituted imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent staphylococcal biofilm inhibitors

scientific article published on 10 February 2019

5'-nucleotidase cN-II emerges as a new predictive biomarker of response to gemcitabine/platinum combination chemotherapy in non-small cell lung cancer

scientific article published on 16 February 2018

A bug in the resistance to EGFR inhibitors: is there a role for Mycoplasma and cytidine deaminase in reducing the activity of osimertinib in lung cancer patients?

scientific article published in 2021

A mechanopharmacology approach to overcome chemoresistance in pancreatic cancer.

scientific article published in March 2017

A microRNA meta-signature for pancreatic ductal adenocarcinoma.

scientific article published on 28 February 2014

A multicenter phase II study of erlotinib and sorafenib in chemotherapy-naive patients with advanced non-small cell lung cancer

scientific article published on 15 April 2010

A polymorphism in the promoter is associated with EZH2 expression but not with outcome in advanced pancreatic cancer patients

scientific article

A single nucleotide polymorphism in EZH2 predicts overall survival rate in patients with cholangiocarcinoma

scientific article

A specific inhibitor of lactate dehydrogenase overcame the resistance toward gemcitabine in hypoxic mesothelioma cells, and modulated the expression of the human equilibrative transporter-1.

scientific article published on December 2016

A synthetic lethal bullet

scientific article published on 4 December 2017

AKT1 and SELP polymorphisms predict the risk of developing cachexia in pancreatic cancer patients

scientific article

Aminopeptidase antibodies in mesothelioma: new wine deserves new sacks

scientific article published on 24 May 2018

An analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: impli

scientific article

Analysis of Drug Interactions

scientific article published on 01 January 2011

Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits

scientific article published on 11 January 2022

Anaplastic lymphoma kinase inhibition in metastatic non-small cell lung cancer: clinical impact of alectinib

scientific article

Antibiotics and Adverse Events in Pancreatic Cancer Patients Treated with Gemcitabine: Looking for Novel Clinical and Preclinical Insights

scientific article published on 23 November 2020

Are erlotinib and gefitinib interchangeable, opposite or complementary for non-small cell lung cancer treatment? Biological, pharmacological and clinical aspects.

scientific article

Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy.

scientific article published on 25 October 2011

Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib.

scientific article published on 16 February 2010

Author Correction: TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression

scientific article published on 14 August 2019

Better to be alone than in bad company: The antagonistic effect of cisplatin and crizotinib combination therapy in non-small cell lung cancer.

scientific article published on December 2016

Bioinformatic analysis reveals pancreatic cancer molecular subtypes specific to the tumor and the microenvironment.

scientific article

Biological Evaluation of the Antiproliferative and Anti-migratory Activity of a Series of 3-(6-Phenylimidazo[2,1-b][1,3,4]thiadiazol-2-yl)-1H-indole Derivatives Against Pancreatic Cancer Cells

scientific article published on 01 July 2019

Bortezomib induces schedule-dependent modulation of gemcitabine pharmacokinetics and pharmacodynamics in non-small cell lung cancer and blood mononuclear cells

scientific article published on 21 April 2009

Breastfeeding during R-CHOP chemotherapy: please abstain!

scientific article published on 19 August 2019

CX-5461 Inhibits Pancreatic Ductal Adenocarcinoma Cell Growth, Migration and Induces DNA Damage

scientific article published on 04 December 2019

CYB5A and autophagy-mediated cell death in pancreatic cancer

scientific article published on 17 January 2014

Calcium/Magnesium Infusion for Oxaliplatin-Induced Neuropathy: Protective or Not?

scientific article published on 18 August 2014

Can circulating tumor and exosomal nucleic acids act as biomarkers for pancreatic ductal adenocarcinoma?

scientific article published on 10 June 2019

Can cytidine deaminase be used as predictive biomarker for gemcitabine toxicity and response?

article

Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines.

scientific article

Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells

scientific article

Cellular folate status modulates the expression of BCRP and MRP multidrug transporters in cancer cell lines from different origins

scientific article

Ceramide analogues in apoptosis: a new strategy for anticancer drug development.

scientific article

Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels

scientific article published on March 2007

Characterization of and protection from neurotoxicity induced by oxaliplatin, bortezomib and epothilone-B.

scientific article

Chemotherapy, targeted agents, antiemetics and growth-factors in human milk: how should we counsel cancer patients about breastfeeding?

scientific article

Circulating microRNAs as diagnostic biomarkers for pancreatic cancer

scientific article published on 15 November 2015

Co-expression analysis of pancreatic cancer proteome reveals biology and prognostic biomarkers

scientific article published on 29 August 2020

Combined exosomal RNA and circulating tumor DNA for epidermal growth factor mutation detection in non-small cell lung cancer

scientific article published on 01 November 2018

Comment on: Targeting the HGF/c-MET pathway in advanced pancreatic cancer: a key element of treatment that limits primary tumour growth and eliminates metastasis

scientific article published on 28 July 2020

Conformationally restrained ceramide analogues: effects of lipophilic modifications on the antiproliferative activity.

scientific article published in January 2003

Correlation between cytidine deaminase genotype and gemcitabine deamination in blood samples

scientific article published in June 2008

Correlation of CDA, ERCC1, and XPD polymorphisms with response and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients.

scientific article

Correlation of basal EGFR expression with pancreatic cancer grading but not with clinical outcome after gemcitabine-based treatment

scientific article published on 31 December 2010

Correlation of cytidine deaminase polymorphisms and activity with clinical outcome in gemcitabine-/platinum-treated advanced non-small-cell lung cancer patients

scientific article published on 7 June 2011

Critical role of laser microdissection for genetic, epigenetic and proteomic analyses in pancreatic cancer

scientific article

Crizotinib inhibits metabolic inactivation of gemcitabine in c-Met-driven pancreatic carcinoma

scientific article

Crizotinib sensitizes the erlotinib resistant HCC827GR5 cell line by influencing lysosomal function

scientific article published on 20 January 2020

Crossing borders: A systematic review with quantitative analysis of genetic mutations of carcinomas of the biliary tract

scientific article published on 24 May 2019

Cytidine deaminase enzymatic activity is a prognostic biomarker in gemcitabine/platinum-treated advanced non-small-cell lung cancer: a prospective validation study

scientific article published on 08 November 2018

Cytochrome 450 1B1 (CYP1B1) polymorphisms associated with response to docetaxel in Castration-Resistant Prostate Cancer (CRPC) patients.

scientific article

Cytochrome P450 1B1 (CYP1B1) polymorphisms are associated with clinical outcome of docetaxel in non-small cell lung cancer (NSCLC) patients

scientific article published on 14 December 2014

Cytotoxic activity of gemcitabine and correlation with expression profile of drug-related genes in human lymphoid cells

article

DNA copy number profiles correlate with outcome in colorectal cancer patients treated with fluoropyrimidine/antifolate-based regimens

scientific article published on December 2011

Decrease in phospho-PRAS40 plays a role in the synergy between erlotinib and crizotinib in an EGFR and cMET wild-type squamous non-small cell lung cancer cell line

scientific article published on 10 May 2019

Defining a prognostic molecular profile for ductal adenocarcinoma of the pancreas highlights known key signaling pathways.

scientific article

Design, synthesis, and characterization of the antitumor activity of novel ceramide analogues

scientific article published in November 2001

Determination of the phosphorylated metabolites of gemcitabine and of difluorodeoxyuridine by LCMSMS.

scientific article

Development of bioluminescent chick chorioallantoic membrane (CAM) models for primary pancreatic cancer cells: a platform for drug testing.

scientific article published on 17 March 2017

Diagnosing pancreatic ductal adenocarcinoma using plasma extracellular vesicle RNA profiles

scientific article published on 04 December 2019

Differences of Gene Expression in Non-small Cell Lung Cancer: Are Histology, Tumor Site, and Methodology Relevant?

article

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

scientific article published on 18 February 2011

Distinct miRNA profiles are associated with malignant transformation of pancreatic cystic tumors revealing potential biomarkers for clinical use.

scientific article

Drug resistance in pancreatic cancer: Impact of altered energy metabolism

scientific article published on 23 March 2017

EGF receptor-targeted therapy in non-small-cell lung cancer: role of germline polymorphisms in outcome and toxicity

scientific article published on August 2012

Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN

scientific article published on 23 May 2017

Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer

scientific article published on January 2013

Entrectinib: a potent new TRK, ROS1, and ALK inhibitor

scientific article published on 12 October 2015

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and Chemotherapy: A Glimmer of Hope?

scientific article

Epidermal growth factor receptor tyrosine kinase inhibitors: current status and future perspectives in the development of novel irreversible inhibitors for the treatment of mutant non-small cell lung cancer

scientific article published on January 2013

Epigenetic mechanisms of irinotecan sensitivity in colorectal cancer cell lines.

scientific article

Erratum to: miRNAs: micro-managers of anticancer combination therapies.

scientific article published on 19 July 2017

Expression of gemcitabine- and cisplatin-related genes in non-small-cell lung cancer.

scientific article

FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer

scientific article

Feasibility of cell-free circulating tumor DNA testing for lung cancer

scientific article published in 2016

Focal adhesion kinase inhibition synergizes with nab-paclitaxel to target pancreatic ductal adenocarcinoma

scientific article published on 09 March 2021

Folate deprivation induces BCRP (ABCG2) expression and mitoxantrone resistance in Caco-2 cells.

scientific article

Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells

scientific article

Gefitinib inhibits invasive phenotype and epithelial-mesenchymal transition in drug-resistant NSCLC cells with MET amplification

scientific article (publication date: 2013)

Gender, Cytidine Deaminase, and 5-Aza/Decitabine--Letter

scientific article published on 08 May 2013

Genetic variation: effect on prostate cancer.

scientific article

Glucocorticoid Resistant Pediatric Acute Lymphoblastic Leukemia Samples Display Altered Splicing Profile and Vulnerability to Spliceosome Modulation

scientific article published on 19 March 2020

Glypican-1 is enriched in circulating-exosomes in pancreatic cancer and correlates with tumor burden.

scientific article published on 10 April 2018

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HGF/MET pathway aberrations as diagnostic, prognostic, and predictive biomarkers in human cancers

scientific article published on 12 September 2019

High-throughput microRNA (miRNAs) arrays unravel the prognostic role of MiR-211 in pancreatic cancer

scientific article

Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer

scientific article published on 14 May 2010

Immunocytochemical detection of hENT1 and hCNT1 in normal tissues, lung cancer cell lines, and NSCLC patient samples

scientific article

Immunotherapy in NSCLC: A Promising and Revolutionary Weapon.

scientific article published in January 2017

Impact of cellular folate status and epidermal growth factor receptor expression on BCRP/ABCG2-mediated resistance to gefitinib and erlotinib.

scientific article published on 10 March 2009

Impact of cytidine deaminase polymorphisms on toxicity after gemcitabine: the question is still ongoing.

scientific article published on 29 March 2010

Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds

scientific article published on 04 June 2020

Impact of microRNAs in resistance to chemotherapy and novel targeted agents in non-small cell lung cancer.

scientific article published on January 2014

Impact ofABCG2polymorphisms on the clinical outcome and toxicity of gefitinib in non-small-cell lung cancer patients

article

In vitro studies on gemcitabine combinations with other antiblastics.

scientific article published on May 2006

In vitro synergistic cytotoxicity of gemcitabine and pemetrexed and pharmacogenetic evaluation of response to gemcitabine in bladder cancer patients.

scientific article published on 25 July 2006

Influence of polymorphisms on EGFR targeted therapy in non-small-cell lung cancer

scientific article published on January 2011

Inherited germline T790M mutation and somatic epidermal growth factor receptor mutations in non-small cell lung cancer patients.

scientific article

Interaction between gemcitabine and topotecan in human non-small-cell lung cancer cells: effects on cell survival, cell cycle and pharmacogenetic profile.

scientific article published on February 2005

Interrelationship between miRNA and splicing factors in pancreatic ductal adenocarcinoma

publication published on 30 May 2021

Investigating miRNA-mRNA regulatory networks using crosslinking immunoprecipitation methods for biomarker and target discovery in cancer

scientific article published on 27 October 2016

Key biological processes driving metastatic spread of pancreatic cancer as identified by multi-omics studies.

scientific article published on 30 March 2017

Laser microdissection and primary cell cultures improve pharmacogenetic analysis in pancreatic adenocarcinoma.

scientific article

Light and shadow on innovative clinical trial designs: reflections from the EORTC-PAMM course on 'preclinical and early-phase clinical pharmacology'

scientific article published on 30 October 2019

Liquid biopsies to optimize therapeutic efficacy in unresponsive lung cancer patients

scientific article published on 04 July 2018

Loss of 18q22.3 involving the carboxypeptidase of glutamate-like gene is associated with poor prognosis in resected pancreatic cancer

scientific article published on 29 November 2011

Loss of heterozygosity status of D9S105 marker is associated with downregulation of Krüppel-like factor 4 expression in pancreatic ductal adenocarcinoma and pancreatic intraepithelial lesions

scientific article

MAPK p38 and JNK have opposing activities on TRAIL-induced apoptosis activation in NSCLC H460 cells that involves RIP1 and caspase-8 and is mediated by Mcl-1.

scientific article published on July 2013

MET as a potential target for the treatment of upper gastrointestinal cancers: characterization of novel c-Met inhibitors from bench to bedside

scientific article published on January 2014

Methylation specific PCR to characterize methylation of the promoter of deoxycytidine kinase

scientific article published on June 2010

Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia

scientific article

MicroRNA profiling of primary pulmonary enteric adenocarcinoma in members from the same family reveals some similarities to pancreatic adenocarcinoma-a step towards personalized therapy

scientific article

MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity.

scientific article

MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients

scientific article published on 7 October 2015

MicroRNAs as a drug resistance mechanism to targeted therapies in EGFR-mutated NSCLC: Current implications and future directions

scientific article published on 28 November 2018

MicroRNAs cooperatively inhibit a network of tumor suppressor genes to promote pancreatic tumor growth and progression

scientific article published on 9 October 2013

MicroRNAs in Cancer Management: Big Challenges for Small Molecules.

scientific article

Molecular basis and rationale for combining immune checkpoint inhibitors with chemotherapy in non-small cell lung cancer

scientific article published on 17 September 2019

Molecular mechanisms and modulation of key pathways underlying the synergistic interaction of sorafenib with erlotinib in non-small-cell-lung cancer (NSCLC) cells.

scientific article published on January 2013

Molecular mechanisms underlying the antitumor activity of 3-aminopropanamide irreversible inhibitors of the epidermal growth factor receptor in non-small cell lung cancer.

scientific article published on January 2013

Molecular mechanisms underlying the role of microRNAs (miRNAs) in anticancer drug resistance and implications for clinical practice.

scientific article published on 05 May 2011

Molecular mechanisms underlying the role of microRNAs in resistance to epidermal growth factor receptor-targeted agents and novel therapeutic strategies for treatment of non-small-cell lung cancer

scientific article published on January 2013

Molecular mechanisms underlying the role of microRNAs in the chemoresistance of pancreatic cancer

scientific article

Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells.

scientific article published on 10 January 2008

Molecular pathways involved in the synergistic interaction of the PKC beta inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells

scientific article

Multidrug-resistant transporter expression does not always result in drug resistance

scientific article published on 08 September 2018

Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR.

scientific article published on 19 October 2015

N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation

scientific article published on 8 September 2011

NF-κB drives acquired resistance to a novel mutant-selective EGFR inhibitor

scientific article published on 29 April 2015

NUC-1031 in biliary tract cancer: from bench to bedside and back?

scientific article published on 31 May 2020

Never let it go: Stopping key mechanisms underlying metastasis to fight pancreatic cancer.

scientific article

New avenues in pancreatic cancer: exploiting microRNAs as predictive biomarkers and new approaches to target aberrant metabolism

scientific article published on 24 November 2019

New developments in the management of non-small-cell lung cancer, focus on rociletinib: what went wrong?

scientific article

New tricks for old biomarkers: thymidylate synthase expression as a predictor of pemetrexed activity in malignant mesothelioma

scientific article published on 5 May 2010

Noncoding Rnas Emerging as Novel Biomarkers in Pancreatic Cancer

scientific article published on 01 January 2018

Notch pathway in small-cell lung cancer: from preclinical evidence to therapeutic challenges

scientific article published on 09 April 2019

Novel targeted strategies to overcome resistance in small-cell lung cancer: focus on PARP inhibitors and rovalpituzumab tesirine

scientific article published on 31 May 2019

Novel therapeutic strategies for patients with NSCLC that do not respond to treatment with EGFR inhibitors.

scientific article

Omics Analysis of Educated Platelets in Cancer and Benign Disease of the Pancreas

scientific article published on 29 December 2020

On the pharmacogenetics of non-small cell lung cancer treatment

scientific article

On the use of pharmacogenetics in cancer treatment and clinical trials

scientific article published on 04 August 2014

Optimizing pemetrexed-gemcitabine combination in patients with advanced non-small cell lung cancer: a pharmacogenetic approach.

scientific article published in April 2011

Overcoming crizotinib resistance in ALK-rearranged NSCLC with the second-generation ALK-inhibitor ceritinib.

scientific article

PTEN Alterations as a Potential Mechanism for Tumor Cell Escape from PD-1/PD-L1 Inhibition

scientific article published on 06 September 2019

Pemetrexed induced thymidylate synthase inhibition in non-small cell lung cancer patients: a pilot study with 3'-deoxy-3'-[¹⁸F]fluorothymidine positron emission tomography

scientific article

Pharmacogenetic study of patients with advanced non-small cell lung cancer (NSCLC) treated with second-line pemetrexed or pemetrexed-carboplatin.

scientific article published on 11 August 2012

Pharmacogenetics of conventional chemotherapy in non-small-cell lung cancer: a changing landscape?

scientific article published on July 2012

Pharmacogenetics of non-small cell lung cancer (NSCLC): time to "work it out"?

scientific article published on January 2014

Pharmacogenetics of treatments for pancreatic cancer

scientific article published on 24 May 2019

Pharmacokinetics and pharmacogenetics of Gemcitabine as a mainstay in adult and pediatric oncology: an EORTC-PAMM perspective

scientific article

Pharmacologic rationale for early G-CSF prophylaxis in cancer patients and role of pharmacogenetics in treatment optimization.

scientific article published on 25 December 2008

Pharmacological aspects of the enzastaurin-pemetrexed combination in non-small cell lung cancer (NSCLC).

scientific article published on January 2010

Phase I Clinical Trial to Determine the Feasibility and Maximum Tolerated Dose of Panitumumab to Standard Gemcitabine-Based Chemoradiation in Locally Advanced Pancreatic Cancer.

scientific article

Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer

scientific article published on 06 January 2017

Platinum-induced neurotoxicity and preventive strategies: past, present, and future

scientific article

Polymorphisms in the enhancer region of the thymidylate synthase gene are associated with thymidylate synthase levels in normal tissues but not in malignant tissues of patients with colorectal cancer.

scientific article published in July 2009

Polymorphisms to predict outcome to the tyrosine kinase inhibitors gefitinib, erlotinib, sorafenib and sunitinib

scientific article published on January 2012

Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: molecular mechanisms underlying its synergistic interaction with pemetrexed and carboplatin

scientific article published on 4 October 2011

Predictive role of repair enzymes in the efficacy of Cisplatin combinations in pancreatic and lung cancer

scientific article published on January 2014

Primary and metastatic brain cancer genomics and emerging biomarkers for immunomodulatory cancer treatment.

scientific article published on 30 January 2018

Profiling of different pancreatic cancer cells used as models for metastatic behaviour shows large variation in their N-glycosylation

scientific article published on 30 November 2017

Prognostic and Predictive Roles of Thymidylate Synthase Expression in Lung Cancer: The Debate Is Still Open

scientific article published on 28 December 2015

Prognostic factors in gemcitabine-cisplatin polychemotherapy regimens in pancreatic cancer: XPD-Lys751Gln polymorphism strikes back

scientific article published on 04 March 2013

Prolonged fixed dose rate infusion of gemcitabine with autologous haemopoietic support in advanced pancreatic adenocarcinoma.

scientific article published on July 2005

Prospective validation of microRNA signatures for detecting pancreatic malignant transformation in endoscopic-ultrasound guided fine-needle aspiration biopsies.

scientific article published on 12 April 2016

Proteomic analysis of gemcitabine-resistant pancreatic cancer cells reveals that microtubule-associated protein 2 upregulation associates with taxane treatment

scientific article published on 10 May 2019

Proton-coupled folate transporter as a biomarker of outcome to treatment for pleural mesothelioma

scientific article published on 19 June 2018

RX-3117 (fluorocyclopentenyl cytosine): a novel specific antimetabolite for selective cancer treatment

scientific article published on 16 March 2019

Randomized phase 2 study of gemcitabine and cisplatin with or without vitamin supplementation in patients with advanced esophagogastric cancer.

scientific article published on 25 April 2018

Regulation of deoxycytidine kinase expression and sensitivity to gemcitabine by micro-RNA 330 and promoter methylation in cancer cells.

scientific article

Research Highlights: Highlights from the Latest Articles in Pharmacogenomics of Irinotecan/Cisplatin Toxicity ⬇️

scientific article published on October 1, 2012

Resistance Mechanisms to AZD9291 and Rociletinib-Letter

scientific article published in July 2017

Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer

scientific article published on 30 September 2019

Role of Akt signaling in resistance to DNA-targeted therapy

scientific article

Role of CYB5A in pancreatic cancer prognosis and autophagy modulation

scientific article published on 03 December 2013

Role of c-MET Inhibitors in Overcoming Drug Resistance in Spheroid Models of Primary Human Pancreatic Cancer and Stellate Cells.

scientific article

Role of cMET expression in non-small-cell lung cancer patients treated with EGFR tyrosine kinase inhibitors

scientific article published on 7 May 2008

Role of miRNAs in the response to anticancer therapy

scientific article published on 01 November 2012

Role of proton-coupled folate transporter in pemetrexed resistance of mesothelioma: clinical evidence and new pharmacological tools ⬇️

scientific article

SNPs in PI3K-PTEN-mTOR and brain metastases in NSCLC--letter

scientific article

Selection of the best blood compartment to measure cytidine deaminase activity to stratify for optimal gemcitabine or cytarabine treatment.

scientific article published in January 2014

Serum miR-1290 as a Marker of Pancreatic Cancer--Letter

scientific article published on 25 July 2013

Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9

scientific article published on 24 February 2021

Simple and selective method for the determination of various tyrosine kinase inhibitors used in the clinical setting by liquid chromatography tandem mass spectrometry

scientific article published on 15 March 2010

Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma

scientific article published on 20 December 2018

Study of apoptosis induction and deoxycytidine kinase/cytidine deaminase modulation in the synergistic interaction of a novel ceramide analog and gemcitabine in pancreatic cancer cells.

scientific article published on June 2010

Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets.

scientific article published in August 2017

Synergistic activity of the c-Met and tubulin inhibitor tivantinib (ARQ197) with pemetrexed in mesothelioma cells

scientific article

Synergistic antitumor activity of ZD6474, an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, with gemcitabine and ionizing radiation against pancreatic cancer.

scientific article published on December 2006

Synergistic cytotoxicity and pharmacogenetics of gemcitabine and pemetrexed combination in pancreatic cancer cell lines.

scientific article published on May 2004

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

scientific article published on 31 October 2013

Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance

scientific article published on 17 October 2018

TFAP2E-DKK4and Chemoresistance in Colorectal Cancer ⬇️

scientific article published on 01 March 2012

TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression.

scientific article

Targeting the Ribosome Biogenesis Key Molecule Fibrillarin to Avoid Chemoresistance

scientific article published on 01 January 2019

The EGFR pathway regulates BCRP expression in NSCLC cells: role of erlotinib

scientific article

The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy-Letter.

scientific article

The Role of MicroRNAs in Resistance to Current Pancreatic Cancer Treatment: Translational Studies and Basic Protocols for Extraction and PCR Analysis

scientific article published on January 2016

The Role of c-Met as a Biomarker and Player in Innate and Acquired Resistance in Non-Small-Cell Lung Cancer: Two New Mutations Warrant Further Studies

scientific article published on 04 December 2019

The dichotomous role of the glycolytic metabolism pathway in cancer metastasis: Interplay with the complex tumor microenvironment and novel therapeutic strategies

scientific article published on 21 August 2019

The good, the bad and the ugly: a tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasms

scientific article

The microbiome of pancreatic cancer: from molecular diagnostics to new therapeutic approaches to overcome chemoresistance caused by metabolic inactivation of gemcitabine

scientific article published on 09 November 2018

The potential of neurotrophic tyrosine kinase (NTRK) inhibitors for treating lung cancer.

scientific article published on 16 February 2016

The role of pharmacogenetics in adjuvant treatment of non-small cell lung cancer.

scientific article

Thymidylate Synthase and Excision Repair Cross-Complementing Group-1 as Predictors of Responsiveness in Mesothelioma Patients Treated with Pemetrexed/Carboplatin

Thymidylate synthase inhibitors for non-small cell lung cancer

scientific article published on 09 September 2011

To Combine or Not Combine: Drug Interactions and Tools for Their Analysis. Reflections from the EORTC-PAMM Course on Preclinical and Early-phase Clinical Pharmacology

scientific article published on 01 July 2019

Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine.

scientific article

Tumor microbiome: Pancreatic cancer and duodenal fluids contain multitudes, …but do they contradict themselves?

scientific article published on 02 November 2019

USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy ⬇️

scientific article published on August 10, 2013

Unraveling the complexity of autophagy: Potential therapeutic applications in Pancreatic Ductal Adenocarcinoma

scientific article published on 23 September 2015

Unravelling the Diagnostic Dilemma: A MicroRNA Panel of Circulating MiR-16 and MiR-877 as A Diagnostic Classifier for Distal Bile Duct Tumors

scientific article published on 15 August 2019

Uridine Cytidine Kinase 2 as a Potential Biomarker for Treatment with RX-3117 in Pancreatic Cancer

scientific article published on 01 July 2019

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models.

scientific article published on 9 December 2016

cMET Exon 14 Skipping: From the Structure to the Clinic.

scientific article published on 17 May 2016

hENT-1 Expression and Localization Predict Outcome After Adjuvant Gemcitabine in Resected Cholangiocarcinoma Patients

scientific article published on 2 November 2016

miR-211 modulates gemcitabine activity through downregulation of ribonucleotide reductase and inhibits the invasive behavior of pancreatic cancer cells

scientific article

miRNA profiling for diagnosis, prognosis and stratification of cancer treatment in cholangiocarcinoma

scientific article published on 23 August 2017

miRNAs: micro-managers of anticancer combination therapies.

scientific article published on 4 May 2017

microRNAs with prognostic significance in pancreatic ductal adenocarcinoma: A meta-analysis

scientific article published on 19 May 2015

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