List of works - Ruth Kluck

A Role for the Mitochondrial Protein Mrpl44 in Maintaining OXPHOS Capacity

scientific article published on 29 July 2015

A cytochrome c mutant with high electron transfer and antioxidant activities but devoid of apoptogenic effect

scientific article published on March 2002

A lively meeting on a deathly topic

scientific article published on 01 January 1997

A single cell analysis of apoptosis. Ordering the apoptotic phenotype

scientific article

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

scientific article

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

scientific article

Assaying cytochrome C translocation during apoptosis

scientific article

Assembly of the Bak apoptotic pore: a critical role for the Bak protein α6 helix in the multimerization of homodimers during apoptosis

scientific article published on 26 July 2013

Avoiding adsorption of Bcl-2 proteins to plasticware is important for accurate quantitation

scientific article published on 13 February 2019

BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove

scientific article published on 3 July 2017

Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices

scientific article published in November 2009

Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains

scientific article published on 6 March 2015

Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers

scientific article

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

scientific article

Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function

scientific article

Bcl-xL does not inhibit the function of Apaf-1.

scientific article published in April 2000

Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax.

scientific article

Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis

scientific article

Calcium chelators induce apoptosis--evidence that raised intracellular ionised calcium is not essential for apoptosis

scientific article published on September 1994

Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system.

scientific article

DISPOSITION OF PHENYTOIN AND PHENOBARBITONE IN THE ISOLATED PERFUSED HUMAN PLACENTA

scientific article published on 01 November 1988

Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation

scientific article published on May 2000

Disordered clusters of Bak dimers rupture mitochondria during apoptosis.

scientific article

Disposition of beta-glucuronidase-resistant "glucuronides" of valproic acid after intrabiliary administration in the rat: intact absorption, fecal excretion and intestinal hydrolysis.

scientific article

Dissociation of Bak α1 helix from the core and latch domains is required for apoptosis

scientific article

Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization

scientific article

Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737

scientific article

Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

scientific article published on 24 May 2016

Impaired biliary elimination of beta-glucuronidase-resistant "glucuronides" of valproic acid after intravenous administration in the rat. Evidence for oxidative metabolism of the resistant isomers

scientific article published on 01 March 1986

Induction of cell surface peptidase activity: a global response to cell stress correlated with apoptosis

scientific article published in March 1994

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor

scientific article

MARKERS OF PHYSICAL INTEGRITY AND METABOLIC VIABILITY OF THE PERFUSED HUMAN PLACENTAL LOBULE

scientific article published on 01 November 1988

MCMV-mediated inhibition of the pro-apoptotic Bak protein is required for optimal in vivo replication

scientific article

Maternofetal transfer of phenytoin, p-hydroxy-phenytoin and p-hydroxy-phenytoin-glucuronide in the perfused human placenta

scientific article

Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins.

scientific article published on 19 February 2018

Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis

scientific article published on August 2009

Mitochondrial Release of Pro-apoptotic Proteins

scientific article published on 9 November 2004

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.

scientific article

Molecular biology of Bax and Bak activation and action

scientific article published on 30 December 2010

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

scientific article

Physiological restraint of Bak by Bcl-xL is essential for cell survival

scientific article published on 19 May 2016

Pore formation by dimeric Bak and Bax: an unusual pore?

scientific article published in August 2017

Probing BAK and BAX Activation and Pore Assembly with Cytochrome c Release, Limited Proteolysis, and Oxidant-Induced Linkage

scientific article published on 01 January 2019

Rearrangement of valproate glucuronide in a patient with drug-associated hepatobiliary and renal dysfunction

scientific article published on November 1985

Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target

scientific article published on 23 April 2020

Spontaneous apoptosis in NS-1 myeloma cultures: effects of cell density, conditioned medium and acid pH.

scientific article

The (Holey) study of mitochondria in apoptosis

scientific article published in January 2001

The mitochondrial gateway to cell death

scientific article published on June 2008

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

scientific article published in May 2008

Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function

scientific article published on 19 March 2012

VDAC2 enables BAX to mediate apoptosis and limit tumor development

scientific article published in Nature Communications

List of works by Ruth Kluck

A Role for the Mitochondrial Protein Mrpl44 in Maintaining OXPHOS Capacity

A cytochrome c mutant with high electron transfer and antioxidant activities but devoid of apoptogenic effect

A lively meeting on a deathly topic

A single cell analysis of apoptosis. Ordering the apoptotic phenotype

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

Assaying cytochrome C translocation during apoptosis

Assembly of the Bak apoptotic pore: a critical role for the Bak protein α6 helix in the multimerization of homodimers during apoptosis

Avoiding adsorption of Bcl-2 proteins to plasticware is important for accurate quantitation

BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove

Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices

Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains

Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function

Bcl-xL does not inhibit the function of Apaf-1.

Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax.

Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis

Calcium chelators induce apoptosis--evidence that raised intracellular ionised calcium is not essential for apoptosis

Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system.

DISPOSITION OF PHENYTOIN AND PHENOBARBITONE IN THE ISOLATED PERFUSED HUMAN PLACENTA

Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation

Disordered clusters of Bak dimers rupture mitochondria during apoptosis.

Disposition of beta-glucuronidase-resistant "glucuronides" of valproic acid after intrabiliary administration in the rat: intact absorption, fecal excretion and intestinal hydrolysis.

Dissociation of Bak α1 helix from the core and latch domains is required for apoptosis

Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization

Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737

Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

Impaired biliary elimination of beta-glucuronidase-resistant "glucuronides" of valproic acid after intravenous administration in the rat. Evidence for oxidative metabolism of the resistant isomers

Induction of cell surface peptidase activity: a global response to cell stress correlated with apoptosis

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor

MARKERS OF PHYSICAL INTEGRITY AND METABOLIC VIABILITY OF THE PERFUSED HUMAN PLACENTAL LOBULE

MCMV-mediated inhibition of the pro-apoptotic Bak protein is required for optimal in vivo replication

Maternofetal transfer of phenytoin, p-hydroxy-phenytoin and p-hydroxy-phenytoin-glucuronide in the perfused human placenta

Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins.

Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis

Mitochondrial Release of Pro-apoptotic Proteins

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.

Molecular biology of Bax and Bak activation and action

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

Physiological restraint of Bak by Bcl-xL is essential for cell survival

Pore formation by dimeric Bak and Bax: an unusual pore?

Probing BAK and BAX Activation and Pore Assembly with Cytochrome c Release, Limited Proteolysis, and Oxidant-Induced Linkage

Rearrangement of valproate glucuronide in a patient with drug-associated hepatobiliary and renal dysfunction

Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target

Spontaneous apoptosis in NS-1 myeloma cultures: effects of cell density, conditioned medium and acid pH.

The (Holey) study of mitochondria in apoptosis

The mitochondrial gateway to cell death

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function

VDAC2 enables BAX to mediate apoptosis and limit tumor development