List of works - Giulia Casorati

CD1d-mediated recognition of an alpha-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution

scientific article

Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer

scientific article

CD1d-restricted help to B cells by human invariant natural killer T lymphocytes

scientific article published on 14 April 2003

Invariant NKT cells sustain specific B cell responses and memory

scientific article

Immune reconstitution in ADA-SCID after PBL gene therapy and discontinuation of enzyme replacement

scientific article published in May 2002

Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets

scientific article published on 01 September 1998

Dicer-dependent microRNA pathway controls invariant NKT cell development.

scientific article

Activation of invariant NKT cells by alphaGalCer administration protects mice from MOG35-55-induced EAE: critical roles for administration route and IFN-gamma

scientific article published on 01 July 2003

Follicular Helper NKT Cells Induce Limited B Cell Responses and Germinal Center Formation in the Absence of CD4+ T Cell Help

scientific article published on February 29, 2012

Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop.

scientific article published on June 2008

Lipid-protein interactions: biosynthetic assembly of CD1 with lipids in the endoplasmic reticulum is evolutionarily conserved

scientific journal article

NKT-cell help to B lymphocytes can occur independently of cognate interaction.

scientific article

T-cell clonality in immune responses

scientific article

A novel self-lipid antigen targets human T cells against CD1c(+) leukemias

scientific article

Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development

scientific article published on 11 February 2008

Intracellular modulation, extracellular disposal and serum increase of MiR-150 mark lymphocyte activation

scientific article

Co-expression of B7-1 and ICAM-1 on tumors is required for rejection and the establishment of a memory response.

scientific article published in May 1995

Development of lymphocytes in interleukin 7-transgenic mice

article

T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification

scientific article published on 01 July 2002

CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells

scientific article published on 15 March 2007

Invariant NKT Cell Reconstitution in Pediatric Leukemia Patients Given HLA-Haploidentical Stem Cell Transplantation Defines Distinct CD4 + and CD4 − Subset Dynamics and Correlates with Remission State

scientific article published on 25 February 2011

The Wiskott-Aldrich syndrome protein is required for iNKT cell maturation and function.

scientific article published on 23 March 2009

Fine tuning by human CD1e of lipid-specific immune responses

scientific article

Innate immune responses support adaptive immunity: NKT cells induce B cell activation

scientific article

miR-17∼92 family clusters control iNKT cell ontogenesis via modulation of TGF-β signaling

scientific article published on 05 December 2016

CD3+4−8−WT31− (T cell receptor γ+) cells and other unusual phenotypes are frequently detected among spontaneously interleukin 2-responsive T lymphocytes present in the joint fluid in juvenile rheumatoid arthritis. A clonal analysis

article

A comparison of two techniques for the molecular tracking of specific T-cell responses; CD4+ human T-cell clones persist in a stable hierarchy but at a lower frequency than clones in the CD8+ population

scientific article

iNKT cells control mouse spontaneous carcinoma independently of tumor-specific cytotoxic T cells

scientific article

Invariant TCR rather than CD1d shapes the preferential activities of C-glycoside analogues against human versus murine invariant NKT cells

scientific article published on 4 September 2009

An improved PCR-heteroduplex method permits high-sensitivity detection of clonal expansions in complex T cell populations

scientific article published on 01 September 1996

In vitro priming of cytotoxic T lymphocytes against poorly immunogenic epitopes by engineered antigen-presenting cells

scientific article published on November 1994

T cell receptor heterogeneity in gamma delta T cell clones from intestinal biopsies of patients with celiac disease

scientific article published on February 1993

Emergence of antitumor cytolytic T cells is associated with maintenance of hematologic remission in children with acute myeloid leukemia

scientific article published on 25 July 2006

Use of MHC class II tetramers to investigate CD4+ T cell responses: problems and solutions

scientific article

iNKT‐cell help to B cells: A cooperative job between innate and adaptive immune responses

scientific article published on May 30, 2014

Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis

scientific article published on 2 May 2017

Somatically mutated tumor antigens in the quest for a more efficacious patient-oriented immunotherapy of cancer

scientific article

Dual receptor T-cells. Implications for alloreactivity and autoimmunity

scientific article published on July 1995

T cell neoepitope discovery in colorectal cancer by high throughput profiling of somatic mutations in expressed genes

scientific article published on 17 December 2015

On the use of donor-derived iNKT cells for adoptive immunotherapy to prevent leukemia recurrence in pediatric recipients of HLA haploidentical HSCT for hematological malignancies

scientific article published on 24 December 2010

Invariant natural killer T cells reconstitution and the control of leukemia relapse in pediatric haploidentical hematopoietic stem cell transplantation.

scientific article

Generation of functional HLA-DR*1101 tetramers receptive for loading with pathogen- or tumour-derived synthetic peptides

scientific article

Nonrandom TRGγ variable gene rearrangement in normal human T cells and T cell leukemias

article

Restriction of the T-cell receptor V delta gene repertoire is due to preferential rearrangement and is independent of antigen selection.

scientific article published in January 1995

The circulating microRNome demonstrates distinct lymphocyte subset-dependent signatures

scientific article

Group 1 CD1-restricted T cells and the pathophysiological implications of self-lipid antigen recognition

scientific article

Bone marrow-resident memory T cells survive pretransplant chemotherapy and contribute to early immune reconstitution of patients with acute myeloid leukemia given mafosfamide-purged autologous bone marrow transplantation

scientific article

Targeting leukemia by CD1c-restricted T cells specific for a novel lipid antigen

scientific article

Molecular and immunological evidence of B-cell commitment in "null" acute lymphoblastic leukaemia

scientific article published in September 1986

Functional education of invariant NKT cells by dendritic cell tuning of SHP-1.

scientific article published on 20 February 2013

List of works by Giulia Casorati

CD1d-mediated recognition of an alpha-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution

Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer

CD1d-restricted help to B cells by human invariant natural killer T lymphocytes

Invariant NKT cells sustain specific B cell responses and memory

Immune reconstitution in ADA-SCID after PBL gene therapy and discontinuation of enzyme replacement

Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets

Dicer-dependent microRNA pathway controls invariant NKT cell development.

Activation of invariant NKT cells by alphaGalCer administration protects mice from MOG35-55-induced EAE: critical roles for administration route and IFN-gamma

Follicular Helper NKT Cells Induce Limited B Cell Responses and Germinal Center Formation in the Absence of CD4+ T Cell Help

Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop.

Lipid-protein interactions: biosynthetic assembly of CD1 with lipids in the endoplasmic reticulum is evolutionarily conserved

NKT-cell help to B lymphocytes can occur independently of cognate interaction.

T-cell clonality in immune responses

A novel self-lipid antigen targets human T cells against CD1c(+) leukemias

Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development

Intracellular modulation, extracellular disposal and serum increase of MiR-150 mark lymphocyte activation

Co-expression of B7-1 and ICAM-1 on tumors is required for rejection and the establishment of a memory response.

Development of lymphocytes in interleukin 7-transgenic mice

T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification

CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells

Invariant NKT Cell Reconstitution in Pediatric Leukemia Patients Given HLA-Haploidentical Stem Cell Transplantation Defines Distinct CD4 + and CD4 − Subset Dynamics and Correlates with Remission State

The Wiskott-Aldrich syndrome protein is required for iNKT cell maturation and function.

Fine tuning by human CD1e of lipid-specific immune responses

Innate immune responses support adaptive immunity: NKT cells induce B cell activation

miR-17∼92 family clusters control iNKT cell ontogenesis via modulation of TGF-β signaling

CD3+4−8−WT31− (T cell receptor γ+) cells and other unusual phenotypes are frequently detected among spontaneously interleukin 2-responsive T lymphocytes present in the joint fluid in juvenile rheumatoid arthritis. A clonal analysis

A comparison of two techniques for the molecular tracking of specific T-cell responses; CD4+ human T-cell clones persist in a stable hierarchy but at a lower frequency than clones in the CD8+ population

iNKT cells control mouse spontaneous carcinoma independently of tumor-specific cytotoxic T cells

Invariant TCR rather than CD1d shapes the preferential activities of C-glycoside analogues against human versus murine invariant NKT cells

An improved PCR-heteroduplex method permits high-sensitivity detection of clonal expansions in complex T cell populations

In vitro priming of cytotoxic T lymphocytes against poorly immunogenic epitopes by engineered antigen-presenting cells

T cell receptor heterogeneity in gamma delta T cell clones from intestinal biopsies of patients with celiac disease

Emergence of antitumor cytolytic T cells is associated with maintenance of hematologic remission in children with acute myeloid leukemia

Use of MHC class II tetramers to investigate CD4+ T cell responses: problems and solutions

iNKT‐cell help to B cells: A cooperative job between innate and adaptive immune responses

Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis

Somatically mutated tumor antigens in the quest for a more efficacious patient-oriented immunotherapy of cancer

Dual receptor T-cells. Implications for alloreactivity and autoimmunity

T cell neoepitope discovery in colorectal cancer by high throughput profiling of somatic mutations in expressed genes

On the use of donor-derived iNKT cells for adoptive immunotherapy to prevent leukemia recurrence in pediatric recipients of HLA haploidentical HSCT for hematological malignancies

Invariant natural killer T cells reconstitution and the control of leukemia relapse in pediatric haploidentical hematopoietic stem cell transplantation.

Generation of functional HLA-DR*1101 tetramers receptive for loading with pathogen- or tumour-derived synthetic peptides

Nonrandom TRGγ variable gene rearrangement in normal human T cells and T cell leukemias

Restriction of the T-cell receptor V delta gene repertoire is due to preferential rearrangement and is independent of antigen selection.

The circulating microRNome demonstrates distinct lymphocyte subset-dependent signatures

Group 1 CD1-restricted T cells and the pathophysiological implications of self-lipid antigen recognition

Bone marrow-resident memory T cells survive pretransplant chemotherapy and contribute to early immune reconstitution of patients with acute myeloid leukemia given mafosfamide-purged autologous bone marrow transplantation

Targeting leukemia by CD1c-restricted T cells specific for a novel lipid antigen

Molecular and immunological evidence of B-cell commitment in "null" acute lymphoblastic leukaemia

Functional education of invariant NKT cells by dendritic cell tuning of SHP-1.