List of works - Giulia Casorati

A Subset of CD8αβ+ Invariant NKT Cells in a Humanized Mouse Model

scientific article

A comparison of two techniques for the molecular tracking of specific T-cell responses; CD4+ human T-cell clones persist in a stable hierarchy but at a lower frequency than clones in the CD8+ population

scientific article

A novel self-lipid antigen targets human T cells against CD1c(+) leukemias

scientific article

Activation of invariant NKT cells by alphaGalCer administration protects mice from MOG35-55-induced EAE: critical roles for administration route and IFN-gamma

scientific article published on 01 July 2003

Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets

scientific article published on 01 September 1998

An efficient strategy to induce and maintain in vitro human T cells specific for autologous non-small cell lung carcinoma

scientific article (publication date: 9 August 2010)

An improved PCR-heteroduplex method permits high-sensitivity detection of clonal expansions in complex T cell populations

scientific article published on 01 September 1996

An unexpected requirement for CD4+ T cells in anti‐glycolipid antibody responses ⬇️

scientific article published on April 12, 2011

Bimodal CD40/Fas-Dependent Crosstalk between iNKT Cells and Tumor-Associated Macrophages Impairs Prostate Cancer Progression.

scientific article published in March 2018

Bone marrow-resident memory T cells survive pretransplant chemotherapy and contribute to early immune reconstitution of patients with acute myeloid leukemia given mafosfamide-purged autologous bone marrow transplantation

scientific article

CD1d-mediated recognition of an alpha-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution

scientific article

CD1d-restricted help to B cells by human invariant natural killer T lymphocytes

scientific article published on 14 April 2003

CD3+4−8−WT31− (T cell receptor γ+) cells and other unusual phenotypes are frequently detected among spontaneously interleukin 2-responsive T lymphocytes present in the joint fluid in juvenile rheumatoid arthritis. A clonal analysis

article

CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells

scientific article published on 15 March 2007

CD4+ T cell immunity against the human papillomavirus-18 E6 transforming protein in healthy donors: identification of promiscuous naturally processed epitopes

scientific article published on 01 March 2005

Casting a wider net: Immunosurveillance by nonclassical MHC molecules ⬇️

scientific article published on 21 February 2019

Clonally expanded CD3+, CD4−, CD8− cells bearing the or the T-cell receptor in patients with the lymphoproliferative disease of granular lymphocytes

scientific article published on 01 September 1991

Co-expression of B7-1 and ICAM-1 on tumors is required for rejection and the establishment of a memory response.

scientific article published in May 1995

Development of lymphocytes in interleukin 7-transgenic mice

article

Dicer-dependent microRNA pathway controls invariant NKT cell development.

scientific article

Dual receptor T-cells. Implications for alloreactivity and autoimmunity.

scientific article published on July 1995

Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer

scientific article

Emergence of antitumor cytolytic T cells is associated with maintenance of hematologic remission in children with acute myeloid leukemia

scientific article published on 25 July 2006

Fine tuning by human CD1e of lipid-specific immune responses

scientific article

Follicular Helper NKT Cells Induce Limited B Cell Responses and Germinal Center Formation in the Absence of CD4+ T Cell Help ⬇️

scientific article published on February 29, 2012

Functional education of invariant NKT cells by dendritic cell tuning of SHP-1.

scientific article published on 20 February 2013

Generation of functional HLA-DR*1101 tetramers receptive for loading with pathogen- or tumour-derived synthetic peptides

scientific article

Group 1 CD1-restricted T cells and the pathophysiological implications of self-lipid antigen recognition

scientific article

Harnessing the CD1 restricted T cell response for leukemia adoptive immunotherapy.

scientific article

Heterogeneity of large granular lymphocyte proliferations: morphological, immunological and molecular analysis in seven patients

scientific article published on 01 June 1987

Immune reconstitution in ADA-SCID after PBL gene therapy and discontinuation of enzyme replacement

scientific article published in May 2002

In vitro priming of cytotoxic T lymphocytes against poorly immunogenic epitopes by engineered antigen-presenting cells

scientific article published on November 1994

Innate immune responses support adaptive immunity: NKT cells induce B cell activation

scientific article

Intracellular modulation, extracellular disposal and serum increase of MiR-150 mark lymphocyte activation

scientific article

Invariant NKT Cell Reconstitution in Pediatric Leukemia Patients Given HLA-Haploidentical Stem Cell Transplantation Defines Distinct CD4 + and CD4 − Subset Dynamics and Correlates with Remission State

scientific article published on 25 February 2011

Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis

scientific article published on 2 May 2017

Invariant NKT cells sustain specific B cell responses and memory

scientific article

Invariant TCR rather than CD1d shapes the preferential activities of C-glycoside analogues against human versus murine invariant NKT cells

scientific article published on 4 September 2009

Invariant natural killer T cells reconstitution and the control of leukemia relapse in pediatric haploidentical hematopoietic stem cell transplantation.

scientific article

Lipid-protein interactions: biosynthetic assembly of CD1 with lipids in the endoplasmic reticulum is evolutionarily conserved

scientific journal article

MAGE-A3161–175 contains an HLA-DRβ4 restricted natural epitope poorly formed through indirect presentation by dendritic cells

scientific article published on 13 July 2007

Molecular and immunological evidence of B-cell commitment in "null" acute lymphoblastic leukaemia

scientific article published in September 1986

NKT-cell help to B lymphocytes can occur independently of cognate interaction.

scientific article

Nonrandom TRGγ variable gene rearrangement in normal human T cells and T cell leukemias

article

Of self-lipids, CD1-restricted T cells, and contact sensitization.

scientific article published on July 2017

On the use of donor-derived iNKT cells for adoptive immunotherapy to prevent leukemia recurrence in pediatric recipients of HLA haploidentical HSCT for hematological malignancies

scientific article published on 24 December 2010

Peptidome from renal cell carcinoma contains antigens recognized by CD4+ T cells and shared among tumors of different histology

scientific article published on August 2006

Phage display-derived recombinant antibodies with TCR-like specificity against alpha-galactosylceramide and its analogues in complex with human CD1d molecules

scientific article

Restriction of the T-cell receptor V delta gene repertoire is due to preferential rearrangement and is independent of antigen selection.

scientific article published in January 1995

Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop.

scientific article published on June 2008

Somatically mutated tumor antigens in the quest for a more efficacious patient-oriented immunotherapy of cancer

scientific article

T cell neoepitope discovery in colorectal cancer by high throughput profiling of somatic mutations in expressed genes

scientific article published on 17 December 2015

T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification

scientific article published on 01 July 2002

T cell receptor heterogeneity in gamma delta T cell clones from intestinal biopsies of patients with celiac disease

scientific article published on February 1993

T-cell clonality in immune responses

scientific article

Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development

scientific article published on 11 February 2008

Targeting leukemia by CD1c-restricted T cells specific for a novel lipid antigen

scientific article

The CD4+ T-cell epitope-binding register is a critical parameter when generating functional HLA-DR tetramers with promiscuous peptides

scientific article published on June 2010

The T cell receptor alpha beta V-J shuffling shows lack of autonomy between the combining site and the constant domain of the receptor chains

scientific article

The TCR Vδ repertoire and the restricted TCR V gene expression and pairing

article

The Wiskott-Aldrich syndrome protein is required for iNKT cell maturation and function.

scientific article published on 23 March 2009

The circulating microRNome demonstrates distinct lymphocyte subset-dependent signatures.

scientific article

Use of MHC class II tetramers to investigate CD4+ T cell responses: problems and solutions

scientific article

Vascular attack and immunotherapy: a 'two hits' approach to improve biological treatment of cancer

scientific article published in February 1999

iNKT cells control mouse spontaneous carcinoma independently of tumor-specific cytotoxic T cells

scientific article

iNKT-cell help to B cells: a cooperative job between innate and adaptive immune responses

scientific article published on 30 May 2014

miR-17∼92 family clusters control iNKT cell ontogenesis via modulation of TGF-β signaling

scientific article published on 05 December 2016

List of works by Giulia Casorati

A Subset of CD8αβ+ Invariant NKT Cells in a Humanized Mouse Model

A comparison of two techniques for the molecular tracking of specific T-cell responses; CD4+ human T-cell clones persist in a stable hierarchy but at a lower frequency than clones in the CD8+ population

A novel self-lipid antigen targets human T cells against CD1c(+) leukemias

Activation of invariant NKT cells by alphaGalCer administration protects mice from MOG35-55-induced EAE: critical roles for administration route and IFN-gamma

Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets

An efficient strategy to induce and maintain in vitro human T cells specific for autologous non-small cell lung carcinoma

An improved PCR-heteroduplex method permits high-sensitivity detection of clonal expansions in complex T cell populations

An unexpected requirement for CD4+ T cells in anti‐glycolipid antibody responses ⬇️

Bimodal CD40/Fas-Dependent Crosstalk between iNKT Cells and Tumor-Associated Macrophages Impairs Prostate Cancer Progression.

Bone marrow-resident memory T cells survive pretransplant chemotherapy and contribute to early immune reconstitution of patients with acute myeloid leukemia given mafosfamide-purged autologous bone marrow transplantation

CD1d-mediated recognition of an alpha-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution

CD1d-restricted help to B cells by human invariant natural killer T lymphocytes

CD3+4−8−WT31− (T cell receptor γ+) cells and other unusual phenotypes are frequently detected among spontaneously interleukin 2-responsive T lymphocytes present in the joint fluid in juvenile rheumatoid arthritis. A clonal analysis

CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells

CD4+ T cell immunity against the human papillomavirus-18 E6 transforming protein in healthy donors: identification of promiscuous naturally processed epitopes

Casting a wider net: Immunosurveillance by nonclassical MHC molecules ⬇️

Clonally expanded CD3+, CD4−, CD8− cells bearing the or the T-cell receptor in patients with the lymphoproliferative disease of granular lymphocytes

Co-expression of B7-1 and ICAM-1 on tumors is required for rejection and the establishment of a memory response.

Development of lymphocytes in interleukin 7-transgenic mice

Dicer-dependent microRNA pathway controls invariant NKT cell development.

Dual receptor T-cells. Implications for alloreactivity and autoimmunity.

Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer

Emergence of antitumor cytolytic T cells is associated with maintenance of hematologic remission in children with acute myeloid leukemia

Fine tuning by human CD1e of lipid-specific immune responses

Follicular Helper NKT Cells Induce Limited B Cell Responses and Germinal Center Formation in the Absence of CD4+ T Cell Help ⬇️

Functional education of invariant NKT cells by dendritic cell tuning of SHP-1.

Generation of functional HLA-DR*1101 tetramers receptive for loading with pathogen- or tumour-derived synthetic peptides

Group 1 CD1-restricted T cells and the pathophysiological implications of self-lipid antigen recognition

Harnessing the CD1 restricted T cell response for leukemia adoptive immunotherapy.

Heterogeneity of large granular lymphocyte proliferations: morphological, immunological and molecular analysis in seven patients

Immune reconstitution in ADA-SCID after PBL gene therapy and discontinuation of enzyme replacement

In vitro priming of cytotoxic T lymphocytes against poorly immunogenic epitopes by engineered antigen-presenting cells

Innate immune responses support adaptive immunity: NKT cells induce B cell activation

Intracellular modulation, extracellular disposal and serum increase of MiR-150 mark lymphocyte activation

Invariant NKT Cell Reconstitution in Pediatric Leukemia Patients Given HLA-Haploidentical Stem Cell Transplantation Defines Distinct CD4 + and CD4 − Subset Dynamics and Correlates with Remission State

Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis

Invariant NKT cells sustain specific B cell responses and memory

Invariant TCR rather than CD1d shapes the preferential activities of C-glycoside analogues against human versus murine invariant NKT cells

Invariant natural killer T cells reconstitution and the control of leukemia relapse in pediatric haploidentical hematopoietic stem cell transplantation.

Lipid-protein interactions: biosynthetic assembly of CD1 with lipids in the endoplasmic reticulum is evolutionarily conserved

MAGE-A3161–175 contains an HLA-DRβ4 restricted natural epitope poorly formed through indirect presentation by dendritic cells

Molecular and immunological evidence of B-cell commitment in "null" acute lymphoblastic leukaemia

NKT-cell help to B lymphocytes can occur independently of cognate interaction.

Nonrandom TRGγ variable gene rearrangement in normal human T cells and T cell leukemias

Of self-lipids, CD1-restricted T cells, and contact sensitization.

On the use of donor-derived iNKT cells for adoptive immunotherapy to prevent leukemia recurrence in pediatric recipients of HLA haploidentical HSCT for hematological malignancies

Peptidome from renal cell carcinoma contains antigens recognized by CD4+ T cells and shared among tumors of different histology

Phage display-derived recombinant antibodies with TCR-like specificity against alpha-galactosylceramide and its analogues in complex with human CD1d molecules

Restriction of the T-cell receptor V delta gene repertoire is due to preferential rearrangement and is independent of antigen selection.

Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop.

Somatically mutated tumor antigens in the quest for a more efficacious patient-oriented immunotherapy of cancer

T cell neoepitope discovery in colorectal cancer by high throughput profiling of somatic mutations in expressed genes

T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification

T cell receptor heterogeneity in gamma delta T cell clones from intestinal biopsies of patients with celiac disease

T-cell clonality in immune responses

Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development

Targeting leukemia by CD1c-restricted T cells specific for a novel lipid antigen

The CD4+ T-cell epitope-binding register is a critical parameter when generating functional HLA-DR tetramers with promiscuous peptides

The T cell receptor alpha beta V-J shuffling shows lack of autonomy between the combining site and the constant domain of the receptor chains

The TCR Vδ repertoire and the restricted TCR V gene expression and pairing

The Wiskott-Aldrich syndrome protein is required for iNKT cell maturation and function.

The circulating microRNome demonstrates distinct lymphocyte subset-dependent signatures.

Use of MHC class II tetramers to investigate CD4+ T cell responses: problems and solutions

Vascular attack and immunotherapy: a 'two hits' approach to improve biological treatment of cancer

iNKT cells control mouse spontaneous carcinoma independently of tumor-specific cytotoxic T cells

iNKT-cell help to B cells: a cooperative job between innate and adaptive immune responses

miR-17∼92 family clusters control iNKT cell ontogenesis via modulation of TGF-β signaling