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List of works by Hiroyuki Nakamura

1,2-Bis(diphenylphosphino)carborane As a Dual Mode Ligand for Both the Sonogashira Coupling and Hydride-Transfer Steps in Palladium-Catalyzed One-Pot Synthesis of Allenes from Aryl Iodides

scientific article published on 01 May 2006

1-Carboranyl-3-(2-methylaziridino)-2-propanol. Synthesis, selective uptake by B-16 melanoma, and selective cytotoxicity toward cancer cells

scientific article published on 01 July 1993

1-Methyl-4-aryl-urazole (MAUra) labels tyrosine in proximity to ruthenium photocatalysts

scientific article published on 01 June 2018

1-[4-(N-Benzylamino)phenyl]-3-phenylurea derivatives as a new class of hypoxia-inducible factor-1alpha inhibitors

scientific article published on 3 May 2009

A Concise Synthesis of Enantiomerically Purel-(4-Boronophenyl)alanine froml-Tyrosine

scientific article published on 01 October 1998

A Novel[3+2] Annelation betweenortho-Carboranyltrimethylsilane and Conjugated Carbonyl Compounds

scholarly article by Hiroyuki Nakamura et al published 3 March 1997 in Angewandte Chemie International Edition

A laccase-catalysed tyrosine click reaction

scientific article published on 01 May 2020

A novel photodynamic therapy for drug-resistant prostate cancer cells using porphyrus envelope as a novel photosensitizer

scientific article published on 19 October 2013

A rapid and clean synthetic approach to cyclic peptides via micro-flow peptide chain elongation and photochemical cyclization: synthesis of a cyclic RGD peptide.

scientific article published on 16 November 2016

Allene as an alternative functional group for drug design: effect of C--C multiple bonds conjugated with quinazolines on the inhibition of EGFR tyrosine kinase.

scientific article

Amphiphilic COSAN and I2-COSAN crossing synthetic lipid membranes: planar bilayers and liposomes

scientific article published on 01 June 2014

Amphiphilic allylation of arylidene-1,3-oxazol-5(4H)-one using bis-π-allylpalladium complexes: an approach to synthesis of cyclohexyl and cyclohexenyl α-amino acids

scientific article published on 22 August 2011

Antitumor effect of boron nitride nanotubes in combination with thermal neutron irradiation on BNCT

scientific article published on 08 December 2014

Benzamides and benzamidines as specific inhibitors of epidermal growth factor receptor and v-Src protein tyrosine kinases

scientific article published on July 2004

Biological evaluation of dopamine analogues containing phenylboronic acid group as new boron carriers.

scientific article published on 19 April 2011

Boron lipid-based liposomal boron delivery system for neutron capture therapy: recent development and future perspective

scientific article published on April 2013

Boron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1α inhibitors

scientific article published on 06 January 2010

Boron-containing protoporphyrin IX derivatives and their modification for boron neutron capture therapy: synthesis, characterization, and comparative in vitro toxicity evaluation

scientific article

Carboranyl bisglycosides for the treatment of cancer by boron neutron capture therapy

scientific article published in May 2001

Carrier proteins-based boron delivery to tumor

scientific article published on 30 November 2019

Catalyst-proximity protein chemical labelling on affinity beads targeting endogenous lectins

scientific article published on 01 October 2019

Copper(I)-Catalyzed Deacetylenative Coupling of Propargylic Amines: An Efficient Synthesis of Symmetric 1,4-Diamino-2-butynes

scientific article published on 29 September 2011

Copper(I)-Catalyzed Substitution Reactions of Propargylic Amines: Importance of C(sp)−C(sp3) Bond Cleavage in Generation of Iminium Intermediates

scientific article published on 01 April 2010

Design and synthesis of fluorescence-labeled closo-dodecaborate lipid: its liposome formation and in vivo imaging targeting of tumors for boronneutron capture therapy

scientific article published on 23 December 2011

Design of S-S bond containing maleimide-conjugated closo-dodecaborate (SSMID): identification of unique modification sites on albumin and investigation of intracellular uptake

scientific article published on 01 June 2019

Design, synthesis, and biological evaluation of aminoboronic acids as growth-factor receptor inhibitors of EGFR and VEGFR-1 tyrosine kinases

scientific article published on April 2004

Design, synthesis, and evaluation of azo D-π-A dyes as photothermal agents

scientific article published on 01 December 2019

Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity

scientific article published on 09 November 2019

Development of 1-aryl-3-furanyl/thienyl-imidazopyridine templates for inhibitors against hypoxia inducible factor (HIF)-1 transcriptional activity.

scientific article published on 5 November 2016

Development of High Boron Content Liposomes and Their Promising Antitumor Effect for Neutron Capture Therapy of Cancers

article

Development of boron nanocapsules for neutron capture therapy.

scientific article published on 28 March 2009

Development of curcumin-based amyloid β aggregation inhibitors for Alzheimer's disease using the SAR matrix approach

scientific article published in 2021

Development of hypoxia-inducible factor (HIF)-1α inhibitors: effect of ortho-carborane substituents on HIF transcriptional activity under hypoxia.

scientific article published on 8 December 2012

Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors.

scientific article published on April 2014

Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors

scientific article published on 03 July 2012

Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors

scientific article published on 27 January 2013

Discovery of boron-conjugated 4-anilinoquinazoline as a prolonged inhibitor of EGFR tyrosine kinase.

scientific article published on 20 August 2009

Discovery of carboranes as inducers of 20S proteasome activity.

scientific article published on August 2010

Discovery of indenopyrazoles as EGFR and VEGFR-2 tyrosine kinase inhibitors by in silico high-throughput screening.

scientific article published on 30 October 2007

Dodecaborate lipid liposomes as new vehicles for boron delivery system of neutron capture therapy.

scientific article published on 27 March 2010

Effective photodynamic therapy in drug-resistant prostate cancer cells utilizing a non-viral antitumor vector (a secondary publication)

scientific article

Elucidating the mode of action for thiophene-based organic D-π-A sensitizers for use in photodynamic therapy

scientific article published on 06 December 2018

Enhancement of EGFR tyrosine kinase inhibition by C-C multiple bonds-containing anilinoquinazolines

scientific article

Facile allylative dearomatization catalyzed by palladium

scientific article published in January 2001

Fluorous Solvent as a New Phase-Screen Medium between Reagents and Reactants in the Bromination and Chlorination of Alcohols

scientific article published on 01 April 2003

Fluorous triphasic reactions: transportative deprotection of fluorous silyl ethers with concomitant purification

scientific article

Folate receptor-targeted novel boron compound for boron neutron capture therapy on F98 glioma-bearing rats

scientific article published on 24 November 2018

Formation of cyclic ethers via the palladium-catalyzed cycloaddition of activated olefins with allylic carbonates having a hydroxy group at the terminus of the carbon chain

scientific article

Functional analysis of the single nucleotide polymorphism (787T>C) in the tissue-nonspecific alkaline phosphatase gene associated with BMD.

scientific article

Generation of an 4-Isoxazolyl Anion Species: Facile Access to Multifunctionalized Isoxazoles

scientific article published on 26 September 2016

Gold(I)-Catalyzed Intramolecular SEAr Reaction: Efficient Synthesis of Isoxazole-Containing Fused Heterocycles.

scientific article published on 5 January 2018

Horseradish-Peroxidase-Catalyzed Tyrosine Click Reaction.

scientific article published on 23 December 2016

Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).

scientific article published on 16 February 2016

Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004 - 2010).

scientific article published on 06 January 2011

Identification of HSP60 as a Primary Target ofo-Carboranylphenoxyacetanilide, an HIF-1α Inhibitor

scientific article published on 01 September 2010

In vitroinvestigation of efficient photodynamic therapy using a nonviral vector; hemagglutinating virus of Japan envelope

scientific article published on 01 July 2012

Ligand-directed selective protein modification based on local single-electron-transfer catalysis

scientific article

Liposomal boron delivery system for neutron capture therapy

scientific article published in February 2008

Localization-dependent cell-killing effects of protoporphyrin (PPIX)-lipid micelles and liposomes in photodynamic therapy

scientific article published on 2 November 2015

Maleimide-functionalized closo-dodecaborate albumin conjugates (MID-AC): Unique ligation at cysteine and lysine residues enables efficient boron delivery to tumor for neutron capture therapy.

scientific article published on 12 July 2016

Metallacarboranes on the Road to Anticancer Therapies: Cellular Uptake, DNA Interaction, and Biological Evaluation of Cobaltabisdicarbollide [COSAN]

scientific article published on 09 November 2018

Micro-flow synthesis of β-amino acid derivatives via a rapid dual activation approach

scientific article published on 03 April 2020

Molecular effects of the tissue-nonspecific alkaline phosphatase gene polymorphism (787T > C) associated with bone mineral density

scientific article

N'-acyl-N-methylphenylenediamine as a novel proximity labeling agent for signal amplification in immunohistochemistry

scientific article published on 31 January 2019

New strategy for synthesis of mercaptoundecahydrododecaborate derivatives via click chemistry: possible boron carriers and visualization in cells for neutron capture therapy

scientific article published in December 2009

Novel Addition and [3+2] Cycloaddition Reactions of Stannyl- and Silyl-ortho-carboranes to Carbonyl Compounds

article

Novel carboranes with a DNA binding unit for the treatment of cancer by boron neutron capture therapy

scientific article published in March 2002

Ortho-carboranyl glycosides for the treatment of cancer by boron neutron capture therapy

scientific article published in July 2001

Palladium-catalyzed aminoallylation of activated olefins with allylic halides and phthalimide

scientific article published in August 2002

Peptide Synthesis Utilizing Micro-flow Technology

article

Peptide-Chain Elongation Using Unprotected Amino Acids in a Micro-Flow Reactor

scientific article published on 24 October 2019

Phase-vanishing reactions that use fluorous media as a phase screen. Facile, controlled bromination of alkenes by dibromine and dealkylation of aromatic ethers by boron tribromide

scientific article published in November 2002

Photochemical Conversion of Isoxazoles to 5-Hydroxyimidazolines

scientific article published on 14 April 2020

Protein Chemical Labeling Using Biomimetic Radical Chemistry

scientific article published on 03 November 2019

Rapid and Mild Synthesis of Amino Acid N -Carboxy Anhydrides: Basic-to-Acidic Flash Switching in a Microflow Reactor

scientific article published on 24 July 2018

Recent progresses in the synthesis of functionalized isoxazoles

Rhodium(III)-catalysed decarboxylative C-H functionalization of isoxazoles with alkenes and sulfoxonium ylides

scientific article published on 21 October 2020

Rhodium(iii)-catalysed carboxylate-directed C-H functionalizations of isoxazoles with alkynes

scientific article published on 20 June 2019

Salicylate restores transport function and anion exchanger activity of missense pendrin mutations

scientific article published on 6 September 2010

Selective purification and chemical labeling of a target protein on ruthenium photocatalyst-functionalized affinity beads

scientific article published on 18 April 2017

Single-Step, Rapid, and Mild Synthesis of β-Amino Acid N-Carboxy Anhydrides Using Micro-Flow Technology

scientific article published on 28 November 2019

Site-Selective Protein Chemical Modification of Exposed Tyrosine Residues Using Tyrosine Click Reaction

scientific article published on 13 April 2020

Spermidinium closo-dodecaborate-encapsulating liposomes as efficient boron delivery vehicles for neutron capture therapy

scientific article published on October 2014

Strategic design to create HER2-targeting proteins with target-binding peptides immobilized on a fibronectin type III domain scaffold

scientific article published on 17 April 2020

Structural Basis of Beneficial Design for Effective Nicotinamide Phosphoribosyltransferase Inhibitors

scientific article published on 10 August 2020

Structure-based drug design of novel carborane-containing nicotinamide phosphoribosyltransferase inhibitors

scientific article published on 10 May 2019

Suppression of hypoxia-induced HIF-1alpha accumulation by VEGFR inhibitors: Different profiles of AAL993 versus SU5416 and KRN633.

scientific article published on 7 April 2010

Synthesis and biological evaluation of benzamides and benzamidines as selective inhibitors of VEGFR tyrosine kinases

scientific article published on 08 August 2006

Synthesis and biological evaluation of benzamides and benzamidines: structural requirement of a pyrimidine ring for inhibition of EGFR tyrosine kinase

scientific article published on May 2004

Synthesis and biological evaluation of boron peptide analogues of Belactosin C as proteasome inhibitors.

scientific article published on 3 May 2009

Synthesis and biological evaluation of boronic acid containing cis-stilbenes as apoptotic tubulin polymerization inhibitors

scientific article published on July 2006

Synthesis and biological evaluation of diaryl-substituted carboranes as inhibitors of hypoxia inducible factor (HIF)-1 transcriptional activity

scientific article

Synthesis and in vivo biodistribution of BPA-Gd-DTPA complex as a potential MRI contrast carrier for neutron capture therapy

scientific article published in February 2005

Synthesis and vesicle formation of a nido-carborane cluster lipid for boron neutron capture therapy.

scientific article

Synthesis of 2-Indolyltetrahydroquinolines by Zinc(II)-Catalyzed Intramolecular Hydroarylation-Redox Cross-Dehydrogenative Coupling of N -Propargylanilines with Indoles

scientific article published on 21 April 2016

Synthesis of 3-Hydroxy-4-Substituted Picolinonitriles from 4-Propargylaminoisoxazoles via Stepwise and One-Pot Isoxazolopyridine Formation/N-O Bond Cleavage Sequence

scientific article published on 03 December 2018

Synthesis of Boron Cluster Lipids: closo-Dodecaborate as an Alternative Hydrophilic Function of Boronated Liposomes for Neutron Capture Therapy

scientific article published on 01 January 2007

Synthesis of Carboranes Containing an Azulene Framework andin VitroEvaluation as Boron Carriers

scientific article published on 01 August 1997

Synthesis of allenes via palladium-catalyzed hydrogen-transfer reactions: propargylic amines as an allenyl anion equivalent

scientific article

Synthesis of carboranes containing nucleoside bases

scientific article

Synthesis of heterocyclic allenes via palladium-catalyzed hydride-transfer reaction of propargylic amines

scientific article

Synthesis of mono- and 1,3-disubstituted allenes from propargylic amines via palladium-catalysed hydride-transfer reaction

scientific article published on 6 March 2008

Synthesis of protoporphyrin-lipids and biological evaluation of micelles and liposomes

scientific article published on 9 July 2014

Target-protein-selective inactivation and labelling using an oxidative catalyst

scientific article published on 01 August 2018

The Fate of Bis(η3-allyl)palladium Complexes in the Presence of Aldehydes (or Imines) and Allylic Chlorides: Stille Coupling versus Allylation of Aldehydes (or Imines)

scientific article published on 01 September 2001

The Life of Pi Star: Exploring the Exciting and Forbidden Worlds of the Benzophenone Photophore

scientific article published on 16 December 2016

The design, synthesis, and evaluation of organic dithienopyrrole-based D-π-A dyes for use as sensitizers in photodynamic therapy

scientific article published on 17 July 2018

Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation.

scientific article published on 28 November 2016

Towards new boron carriers for boron neutron capture therapy: metallacarboranes bearing cobalt, iron and chromium and their cholesterol conjugates

scientific article published on 5 January 2013

Transferrin-Loadednido-Carborane Liposomes: Tumor-Targeting Boron Delivery System for Neutron Capture Therapy

scientific article published on 01 September 2006

Undecahydro-closo-dodecaborates as good leaving groups in organic synthesis: generation of substituted styrenes via elimination of arylethyl dodecaborates

scientific article published on 13 August 2010

V843I, a lung cancer predisposing EGFR mutation, is responsible for resistance to EGFR tyrosine kinase inhibitors

scientific article

Water-Soluble closo-Docecaborate-Containing Pteroyl Derivatives Targeting Folate Receptor-Positive Tumors for Boron Neutron Capture Therapy

scientific article published on 03 July 2020

Zinc(II)-Catalyzed Redox Cross-Dehydrogenative Coupling of Propargylic Amines and Terminal Alkynes for Synthesis of N-Tethered 1,6-Enynes

scientific article published on 30 January 2012

Zinc(ii)-catalyzed intramolecular hydroarylation-redox cross-dehydrogenative coupling of N-propargylanilines with diverse carbon pronucleophiles: facile access to functionalized tetrahydroquinolines

scientific article published on 02 June 2020

de novo design and synthesis of N-benzylanilines as new candidates for VEGFR tyrosine kinase inhibitors

scientific article

m-Carborane-Based Chiral NBN Pincer-Metal Complexes: Synthesis, Structure, and Application in Asymmetric Catalysis

scientific article published on 25 March 2011

o-Carboranyl derivatives of 1,3,5-s-triazines: structures, properties andin vitro activities

o-Carboranylalkoxy-1,3,5-Triazine Derivatives: Synthesis, Characterization, X-ray Structural Studies, and Biological Activity

scientific article published on 30 August 2018

ortho-Carboranylphenoxyacetanilides as inhibitors of hypoxia-inducible factor (HIF)-1 transcriptional activity and heat shock protein (HSP) 60 chaperon activity

scientific article published on 02 May 2015

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