List of works - Bruno Ragazzon

8Cl-cAMP modifies the balance between PKAR1 and PKAR2 and modulates the cell cycle, growth and apoptosis in human adrenocortical H295R cells.

scientific article published on 17 March 2010

A concomitant false-negative ¹⁸F-FDG PET imaging in an adrenocortical carcinoma and a high uptake in a corresponding liver metastasis

scientific article published on 8 February 2012

A transgenic mouse line with specific Cre recombinase expression in the adrenal cortex

scientific article published on 08 November 2008

ACTH and PRL sensitivity of highly differentiated cell lines obtained by adrenocortical targeted oncogenesis.

scientific article published on November 2004

ARMC5 Mutations in a Large Cohort of Primary Macronodular Adrenal Hyperplasia: Clinical and Functional Consequences

scientific article

ARMC5 mutations in macronodular adrenal hyperplasia with Cushing's syndrome

scientific article

AXIN genetic analysis in adrenocortical carcinomas updated

scientific article published on July 2013

Adrenocortical growth and cancer

scientific article

Adrenocorticotropin-dependent changes in SF-1/DAX-1 ratio influence steroidogenic genes expression in a novel model of glucocorticoid-producing adrenocortical cell lines derived from targeted tumorigenesis

scientific article published on 26 January 2006

Adrenocorticotropin/3',5'-cyclic AMP-mediated transcription of the scavenger akr1-b7 gene in adrenocortical cells is dependent on three functionally distinct steroidogenic factor-1-responsive elements

scientific article published on 6 November 2003

Aldo keto reductase 1B7 and prostaglandin F2alpha are regulators of adrenal endocrine functions

scientific article published on 7 October 2009

Analysis of the role of Igf2 in adrenal tumour development in transgenic mouse models

scientific article (publication date: 2012)

Assessment of VAV2 Expression Refines Prognostic Prediction in Adrenocortical Carcinoma.

scientific article

Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of β-catenin in adrenocortical carcinoma

scientific article published on 27 July 2015

Comparison of the effects of PRKAR1A and PRKAR2B depletion on signaling pathways, cell growth, and cell cycle control of adrenocortical cells

scientific article published on 30 September 2014

Cushing's syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice

scientific article

Dosage-dependent regulation of VAV2 expression by steroidogenic factor-1 drives adrenocortical carcinoma cell invasion.

scientific article

EZH2 is overexpressed in adrenocortical carcinoma and is associated with disease progression

scientific article published on 5 May 2016

Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype

scientific article

Growth factor receptor binding protein 14 inhibition triggers insulin-induced mouse hepatocyte proliferation and is associated with hepatocellular carcinoma

scientific article published on 16 December 2016

High Diagnostic and Prognostic Value of Steroidogenic Factor-1 Expression in Adrenal Tumors

scientific article published on 21 July 2010

IGF2 promotes growth of adrenocortical carcinoma cells, but its overexpression does not modify phenotypic and molecular features of adrenocortical carcinoma.

scientific article

Identification of a CpG island methylator phenotype in adrenocortical carcinomas

scientific article published on 23 October 2012

Identification of gene expression profiles associated with cortisol secretion in adrenocortical adenomas.

scientific article published on 28 March 2013

Inactivation of the APC gene is constant in adrenocortical tumors from patients with familial adenomatous polyposis but not frequent in sporadic adrenocortical cancers.

scientific article published on 26 October 2010

Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells.

scientific article

Integrated genomic characterization of adrenocortical carcinoma

scientific article published on 20 April 2014

Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signalling pathway.

scientific article published on 02 December 2013

Macronodular adrenal hyperplasia due to mutations in an armadillo repeat containing 5 (ARMC5) gene: a clinical and genetic investigation

scientific article

Mass-array screening of frequent mutations in cancers reveals RB1 alterations in aggressive adrenocortical carcinomas.

scientific article

Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2 Pathways Regulates Liver Lipogenesis and Selective Insulin Resistance

scientific article published on 23 May 2016

Novel Insights into the Genetics and Pathophysiology of Adrenocortical Tumors

scientific article published on 09 June 2015

PKA regulatory subunit 1A inactivating mutation induces serotonin signaling in primary pigmented nodular adrenal disease.

scientific article published on 22 September 2016

Pancreatic ductal and acinar cell neoplasms in Carney complex: a possible new association

scientific article (publication date: November 2011)

Phosphodiesterase 11A (PDE11A) and genetic predisposition to adrenocortical tumors

scientific article

Phosphodiesterase 11A (PDE11A) gene defects in patients with acth-independent macronodular adrenal hyperplasia (AIMAH): functional variants may contribute to genetic susceptibility of bilateral adrenal tumors

scientific article

Primary Aldosteronism and ARMC5 Variants

scientific article published on 30 March 2015

Protein kinase A alterations in adrenocortical tumors

scientific article

Protein kinase A alterations in endocrine tumors.

scientific article published on 29 June 2012

Silencing mutated β-catenin inhibits cell proliferation and stimulates apoptosis in the adrenocortical cancer cell line H295R.

scientific article

TNF alpha signaling is associated with therapeutic responsiveness to vascular disrupting agents in endocrine tumors

scientific article published on 5 January 2016

Transcriptome analysis of adrenocortical cancers: from molecular classification to the identification of new treatments.

scientific article published on 23 February 2011

Transcriptome analysis reveals that p53 and {beta}-catenin alterations occur in a group of aggressive adrenocortical cancers.

scientific article

WNT/β-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production

scientific article published on October 2013

Wnt/beta-catenin and 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors

scientific article published on 22 July 2008

Wnt/β-catenin pathway activation in adrenocortical adenomas is frequently due to somatic CTNNB1-activating mutations, which are associated with larger and nonsecreting tumors: a study in cortisol-secreting and -nonsecreting tumors

scientific article published on 17 November 2010

β-catenin activation is associated with specific clinical and pathologic characteristics and a poor outcome in adrenocortical carcinoma

scientific article published on 18 November 2010

List of works by Bruno Ragazzon

8Cl-cAMP modifies the balance between PKAR1 and PKAR2 and modulates the cell cycle, growth and apoptosis in human adrenocortical H295R cells.

A concomitant false-negative ¹⁸F-FDG PET imaging in an adrenocortical carcinoma and a high uptake in a corresponding liver metastasis

A transgenic mouse line with specific Cre recombinase expression in the adrenal cortex

ACTH and PRL sensitivity of highly differentiated cell lines obtained by adrenocortical targeted oncogenesis.

ARMC5 Mutations in a Large Cohort of Primary Macronodular Adrenal Hyperplasia: Clinical and Functional Consequences

ARMC5 mutations in macronodular adrenal hyperplasia with Cushing's syndrome

AXIN genetic analysis in adrenocortical carcinomas updated

Adrenocortical growth and cancer

Adrenocorticotropin-dependent changes in SF-1/DAX-1 ratio influence steroidogenic genes expression in a novel model of glucocorticoid-producing adrenocortical cell lines derived from targeted tumorigenesis

Adrenocorticotropin/3',5'-cyclic AMP-mediated transcription of the scavenger akr1-b7 gene in adrenocortical cells is dependent on three functionally distinct steroidogenic factor-1-responsive elements

Aldo keto reductase 1B7 and prostaglandin F2alpha are regulators of adrenal endocrine functions

Analysis of the role of Igf2 in adrenal tumour development in transgenic mouse models

Assessment of VAV2 Expression Refines Prognostic Prediction in Adrenocortical Carcinoma.

Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of β-catenin in adrenocortical carcinoma

Comparison of the effects of PRKAR1A and PRKAR2B depletion on signaling pathways, cell growth, and cell cycle control of adrenocortical cells

Cushing's syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice

Dosage-dependent regulation of VAV2 expression by steroidogenic factor-1 drives adrenocortical carcinoma cell invasion.

EZH2 is overexpressed in adrenocortical carcinoma and is associated with disease progression

Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype

Growth factor receptor binding protein 14 inhibition triggers insulin-induced mouse hepatocyte proliferation and is associated with hepatocellular carcinoma

High Diagnostic and Prognostic Value of Steroidogenic Factor-1 Expression in Adrenal Tumors

IGF2 promotes growth of adrenocortical carcinoma cells, but its overexpression does not modify phenotypic and molecular features of adrenocortical carcinoma.

Identification of a CpG island methylator phenotype in adrenocortical carcinomas

Identification of gene expression profiles associated with cortisol secretion in adrenocortical adenomas.

Inactivation of the APC gene is constant in adrenocortical tumors from patients with familial adenomatous polyposis but not frequent in sporadic adrenocortical cancers.

Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells.

Integrated genomic characterization of adrenocortical carcinoma

Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signalling pathway.

Macronodular adrenal hyperplasia due to mutations in an armadillo repeat containing 5 (ARMC5) gene: a clinical and genetic investigation

Mass-array screening of frequent mutations in cancers reveals RB1 alterations in aggressive adrenocortical carcinomas.

Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2 Pathways Regulates Liver Lipogenesis and Selective Insulin Resistance

Novel Insights into the Genetics and Pathophysiology of Adrenocortical Tumors

PKA regulatory subunit 1A inactivating mutation induces serotonin signaling in primary pigmented nodular adrenal disease.

Pancreatic ductal and acinar cell neoplasms in Carney complex: a possible new association

Phosphodiesterase 11A (PDE11A) and genetic predisposition to adrenocortical tumors

Phosphodiesterase 11A (PDE11A) gene defects in patients with acth-independent macronodular adrenal hyperplasia (AIMAH): functional variants may contribute to genetic susceptibility of bilateral adrenal tumors

Primary Aldosteronism and ARMC5 Variants

Protein kinase A alterations in adrenocortical tumors

Protein kinase A alterations in endocrine tumors.

Silencing mutated β-catenin inhibits cell proliferation and stimulates apoptosis in the adrenocortical cancer cell line H295R.

TNF alpha signaling is associated with therapeutic responsiveness to vascular disrupting agents in endocrine tumors

Transcriptome analysis of adrenocortical cancers: from molecular classification to the identification of new treatments.

Transcriptome analysis reveals that p53 and {beta}-catenin alterations occur in a group of aggressive adrenocortical cancers.

WNT/β-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production

Wnt/beta-catenin and 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors

Wnt/β-catenin pathway activation in adrenocortical adenomas is frequently due to somatic CTNNB1-activating mutations, which are associated with larger and nonsecreting tumors: a study in cortisol-secreting and -nonsecreting tumors

β-catenin activation is associated with specific clinical and pathologic characteristics and a poor outcome in adrenocortical carcinoma