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List of works by Leo Koenderman

1,2-Diacylglycerol accumulation in human neutrophils does not correlate with respiratory burst activation

scientific article published in January 1989

A 2D-DIGE approach to identify proteins involved in inside-out control of integrins.

scientific article

A comprehensive three-dimensional assay to assess neutrophil defense against bacteria

scientific article published on 08 September 2018

A novel data fusion method for the effective analysis of multiple panels of flow cytometry data

scientific article published on 01 May 2019

A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1.

scientific article published on 12 December 2011

A systemic neutrophil response precedes robust CD8(+) T-cell activation during natural respiratory syncytial virus infection in infants.

scientific article

A unique protein profile of peripheral neutrophils from COPD patients does not reflect cytokine-induced protein profiles of neutrophils in vitro

scientific article

Aberrant regulation of polymorphonuclear phagocyte responsiveness in multitrauma patients

scientific article published on 01 December 2006

Abrogation of NF-κB signaling in human neutrophils induces neutrophil survival through sustained p38-MAPK activation.

scientific article published on 23 June 2010

Activation of 12-O-tetradecanoylphorbol-13-acetate response element- and dyad symmetry element-dependent transcription by interleukin-5 is mediated by Jun N-terminal kinase/stress-activated protein kinase kinases

scientific article published on 01 January 1997

Activation of the STAT3/acute phase response factor transcription factor by interleukin-5.

scientific article published on October 1995

Acute and chronic inflammatory responses induced by smoking in individuals susceptible and non-susceptible to development of COPD: from specific disease phenotyping towards novel therapy. Protocol of a cross-sectional study

scientific article published on February 2013

Acute-phase concentrations of soluble fibrinogen inhibit neutrophil adhesion under flow conditions in vitro through interactions with ICAM-1 and MAC-1 (CD11b/CD18).

scientific article published in June 2013

Adalimumab-induced bronchospasm: not a class effect

scientific article published on 01 May 2008

Adherence of human neutrophils changes Ca2+ signaling during activation with opsonized particles

scientific article published in September 1990

Advanced glycation end products in the skin are enhanced in COPD.

scientific article published on 13 June 2014

An AP-1 site in the promoter of the human IL-5R alpha gene is necessary for promoter activity in eosinophilic HL60 cells

scientific article

Analysis of human neutrophil phenotypes as biomarker to monitor exercise-induced immune changes

scientific article published on 06 September 2020

Arachidonic acid can induce leukotriene C4 formation by purified human eosinophils in the absence of other stimuli

scientific article published on 01 June 1988

Arg16 ADRB2 genotype increases the risk of asthma exacerbation in children with a reported use of long-acting β2-agonists: results of the PACMAN cohort.

scientific article published in December 2013

Association of RACK1 and PKCbeta with the common beta-chain of the IL-5/IL-3/GM-CSF receptor.

scientific article

Asthma therapy modulates priming-associated blood eosinophil responsiveness in allergic asthmatics

scientific article

Asthmatic children that are uncontrolled despite inhaled corticosteroids have a distinct breathprint (the pacman2 study).

scientific article published on 23 March 2015

Automated flow cytometric identification of disease-specific cells by the ECLIPSE algorithm

scientific article published on 19 July 2018

Biomarkers of therapy responsiveness in asthma: pitfalls and promises

scientific article published on May 2011

Bronchial and cutaneous responses in atopic dermatitis patients after allergen inhalation challenge

scientific article published on 01 September 1997

Cerebral ischemia initiates an immediate innate immune response in neonates during cardiac surgery ⬇️

scientific article published on February 7, 2013

Characteristics of CR3-mediated aggregation in human eosinophils: effect of priming by platelet-activating factor

scientific article published on 01 May 1991

Characteristics of hexokinase, pyruvate kinase, and glucose-6-phosphate dehydrogenase during adult and neonatal reticulocyte maturation.

scientific article published in November 1985

Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function

scientific article

Cigarette smoke attenuates the production of cytokines by human plasmacytoid dendritic cells and enhances the release of IL-8 in response to TLR-9 stimulation

scientific article published on 10 June 2009

Cigarette smoke-induced collagen destruction; key to chronic neutrophilic airway inflammation?

scientific article

Circulatory and maturation kinetics of human monocyte subsets in vivo.

scientific article published on 25 July 2017

Clinical utility of asthma biomarkers: from bench to bedside

scientific article published on 29 August 2013

Correction: Cigarette Smoke-Induced Collagen Destruction; Key to Chronic Neutrophilic Airway Inflammation?

Cytokine mediated suppression of TF-1 apoptosis requires PI3K activation and inhibition of Bim expression.

scientific article

Cytokine-induced inside-out activation of FcalphaR (CD89) is mediated by a single serine residue (S263) in the intracellular domain of the receptor

scientific article published in June 2001

Cytokine-induced protein tyrosine phosphorylation is essential for cytokine priming of human eosinophils

scientific article published on 01 January 1998

Cytokine-mediated cPLA(2) phosphorylation is regulated by multiple MAPK family members

scientific article

Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein

scientific article

Differential antibacterial control by neutrophil subsets

scientific article published on 01 June 2018

Differential fMet-Leu-Phe- and platelet-activating factor-induced signaling toward Ral activation in primary human neutrophils

scientific article published on 01 July 1999

Differential mechanisms in the stimulus-secretion coupling in human basophils: evidence for a protein-kinase-C-dependent and a protein-kinase-C-independent route

scientific article

Differential regulation of TNFalpha and GM-CSF induced activation of P38 MAPK in neutrophils and eosinophils

scientific article published on 28 November 2006

Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2

scientific article published on 08 February 2005

Differentiation and activation of eosinophils in the human bone marrow during experimental human endotoxemia

scientific article published on 10 January 2020

Effects of nedocromil sodium on in vitro induced migration, activation, and mediator release from human granulocytes

scientific article published on 01 July 1993

Elevated mean neutrophil volume represents altered neutrophil composition and reflects damage after myocardial infarction

scientific article

Eosinophil chemotactic activity in bronchoalveolar lavage from idiopathic pulmonary fibrosis is dependent on cytokine priming of eosinophils

scientific article published in May 1998

Exhaled NO is a poor marker of asthma control in children with a reported use of asthma medication: a pharmacy-based study

scientific article published on 25 May 2012

Expression of activated Fc gamma RII discriminates between multiple granulocyte-priming phenotypes in peripheral blood of allergic asthmatic subjects

scientific article

Expression of priming-associated cellular markers on neutrophils during an exacerbation of COPD

scientific article published on 13 March 2006

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

scientific article (publication date: 5 October 2000)

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity

scientific article

FOXO3a induces differentiation of Bcr-Abl-transformed cells through transcriptional down-regulation of Id1.

scientific article published on 27 November 2006

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

scientific article

Functional analysis of the interleukin-5 receptor antagonist peptide, AF18748.

scientific article published on June 2004

Functional antagonism by GM-CSF on TNF-α-induced CD83 expression in human neutrophils

scientific article published on 27 August 2008

Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia

scientific article published on 16 April 2010

Future treatment in patients with chronic obstructive pulmonary disease: to reverse or not to reverse steroid resistance-that is the question

scientific article

GM-CSF and TNFα modulate protein expression of human neutrophils visualized by fluorescence two-dimensional difference gel electrophoresis

scientific article published on 27 August 2011

Gelsolin expression increases β1 -integrin affinity and L1210 cell adhesion

scientific article published on 10 May 2013

Genetic variation in uncontrolled childhood asthma despite ICS treatment

scientific article published on 12 May 2015

Gradual increase in priming of human eosinophils during extravasation from peripheral blood to the airways in response to allergen challenge

scientific article

Granulocyte signal transduction and priming: cause without effect?

scientific article published on June 1997

Homology in systemic neutrophil response induced by human experimental endotoxemia and by trauma

scientific article published on 01 February 2012

How Neutrophils Shape Adaptive Immune Responses

scientific article

Human CD62Ldim neutrophils identified as a separate subset by proteome profiling and in vivo pulse-chase labeling.

scientific article published on 17 May 2017

Human neutrophils switch to an activated phenotype after homing to the lung irrespective of inflammatory disease.

scientific article

Human suppressive neutrophils CD16bright/CD62Ldim exhibit decreased adhesion.

scientific article published on 27 August 2012

IFN-γ-stimulated neutrophils suppress lymphocyte proliferation through expression of PD-L1.

scientific article

IL-5-mediated eosinophil survival requires inhibition of GSK-3 and correlates with beta-catenin relocalization

scientific article published on 9 May 2006

IL-5-mediated eosinophil survival requires inhibition of GSK-3 and correlates with β-catenin relocalization

scientific article published in July 2006

Immature Neutrophils Released in Acute Inflammation Exhibit Efficient Migration despite Incomplete Segmentation of the Nucleus

scientific article published on 30 November 2018

Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differences

scientific article

Immunological and hematological effects of IL-5(Rα)-targeted therapy: An overview

scientific article published on 08 October 2018

Immunophenotyping of posttraumatic neutrophils on a routine haematology analyser

scientific article

Immunotherapy after trauma: timing is essential.

scientific article published on April 2011

Increased activation of blood neutrophils after cigarette smoking in young individuals susceptible to COPD

scientific article

Inhibition of cytokine-primed eosinophil chemotaxis by nedocromil sodium

scientific article published on 01 March 1993

Integrins on neutrophils are dispensable for migration into three-dimensional fibrin gels

scientific article published on 29 June 2010

Intracellular Penetration and Effects of Antibiotics on Staphylococcus aureus Inside Human Neutrophils: A Comprehensive Review

scientific article published on 04 May 2019

Intramedullary nailing of the femur and the systemic activation of monocytes and neutrophils

scientific article published on 31 October 2011

Invasive surgery reduces infarct size and preserves cardiac function in a porcine model of myocardial infarction

scientific article

Isolated blunt chest injury leads to transient activation of circulating neutrophils ⬇️

scientific article published on July 27, 2010

Kinetics of the innate immune response after trauma: implications for the development of late onset sepsis.

scientific article published in July 2013

Leukotriene C4 formation by purified human eosinophils can be induced by arachidonic acid in the absence of calcium-ionophore A23187

scientific article published on 01 January 1989

Limited agreement between current and long-term asthma control in children: the PACMAN cohort study

scientific article published on 13 July 2011

Lipopolysaccharide and hemorrhagic shock cause systemic inflammation by different mechanisms

scientific article published in January 2013

Lower corticosteroid skin blanching response is associated with severe COPD.

scientific article published on 12 March 2014

Mechanical ventilation increases the inflammatory response induced by lung contusion

scientific article published on 22 January 2013

Mechanical ventilation is the determining factor in inducing an inflammatory response in a hemorrhagic shock model

scientific article published on 30 October 2012

Modulation of granulocyte kinetics by GM-CSF/IFN-γ in a human LPS rechallenge model

scientific article published on 21 June 2013

Modulation of the innate immune response after trauma visualised by a change in functional PMN phenotype

scientific article published on 31 March 2009

Monitoring eosinophils to guide therapy with Biologics in Asthma: does the compartment matter?

scientific article published on 10 December 2020

Multi-dimensional flow cytometry analysis reveals increasing changes in the systemic neutrophil compartment during seven consecutive days of endurance exercise

scientific article published in PLoS ONE

Multi-set Pre-processing of Multicolor Flow Cytometry Data

scientific article published on 16 June 2020

Multiple tyrosine residues in the intracellular domain of the common beta subunit of the interleukin 5 receptor are involved in activation of STAT5.

scientific article published on July 1997

NADPH:O2 oxidoreductase of human eosinophils in the cell-free system

scientific article published on 01 July 1990

Neutrophil Mediated Suppression of Influenza-induced Pathology Requires CD11b/CD18 (MAC-1).

scientific article published on 15 November 2017

Neutrophil phenotypes in health and disease.

scientific article published on 23 April 2018

On the origin of low-density neutrophils

scientific article published on 14 March 2020

Penetrating thorax injury leads to mild systemic activation of neutrophils without inflammatory complications

scientific article published on 27 September 2013

Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS) after Polytrauma: A Rare Syndrome with Major Consequences

scientific article published on 10 January 2020

Pharmacogenetic analysis of GLCCI1 in three north European pediatric asthma populations with a reported use of inhaled corticosteroids

scientific article published in April 2014

Pharmacogenetics of anti-inflammatory treatment in children with asthma: rationale and design of the PACMAN cohort

scientific article published on 01 August 2009

Phenotyping asthma using an unsupervised prediction model based on blood granulocyte responsiveness

Physiological concentrations of leptin do not affect human neutrophils

scientific article

Platelet-activating factor (PAF) acts as an intercellular messenger in the changes of cytosolic free Ca2+ in human neutrophils induced by opsonized particles

scientific article published on 01 December 1989

Platelet-activating factor (PAF-acether) induced leukotriene C4 formation and luminol dependent chemiluminescence by human eosinophils

scientific article published on 01 August 1986

Platelet-monocyte complexes support monocyte adhesion to endothelium by enhancing secondary tethering and cluster formation

scientific article published on 13 November 2003

Platelets promote eosinophil adhesion of patients with asthma to endothelium under flow conditions

scientific article published on 01 April 2003

Postinjury immune monitoring: can multiple organ failure be predicted?

scientific article published on December 2008

Preoperative cerebrospinal fluid cytokine levels and the risk of postoperative delirium in elderly hip fracture patients

scientific article published on 07 October 2013

Priming of circulating human eosinophils following late response to allergen challenge

scientific article published on 01 January 1997

Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis

scientific article published on 21 September 2007

Proteomic profiling of peripheral blood neutrophils identifies two inflammatory phenotypes in stable COPD patients

scientific article

Recognizing the mobilization of neutrophils with banded nuclei early after trauma

scientific article published on 06 July 2020

Regulation and function of protein kinase B and MAP kinase activation by the IL-5/GM-CSF/IL-3 receptor

scientific article published on June 1999

Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family

scientific article published on 01 October 1998

Role of Ca2+/calmodulin regulated signaling pathways in chemoattractant induced neutrophil effector functions. Comparison with the role of phosphotidylinositol-3 kinase

scientific article published in September 2002

ST13 polymorphisms and their effect on exacerbations in steroid-treated asthmatic children and young adults.

scientific article published on June 2015

STAT5-Dependent CyclinD1 and Bcl-xL expression in Bcr-Abl-transformed cells

scientific article published on May 2000

Signal transducer and activator of transcription 5 (STAT5).

scientific article

Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood-derived CD34+ cells

scientific article published on 15 August 2002

Similar activation of sputum granulocytes in eosinophilic and non-eosinophilic asthma

scientific article

Similar activation state of neutrophils in sputum of asthma patients irrespective of sputum eosinophilia

scientific article

Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family.

scientific article

Squamous tissue lymphocytes in the esophagus of controls and patients with reflux esophagitis and Barrett's esophagus are characterized by a non-inflammatory phenotype

scientific article

Steroids induce a disequilibrium of secreted interleukin-1 receptor antagonist and interleukin-1 synthesis by human neutrophils

scientific article published on 22 July 2010

Systemic eosinophil response induced by respiratory syncytial virus

scientific article

Systemic inflammation and fracture healing

scientific article published on 04 January 2011

Systemic inflammation in COPD visualised by gene profiling in peripheral blood neutrophils

scientific article published on July 2005

Targeting neutrophilic inflammation in severe neutrophilic asthma: can we target the disease-relevant neutrophil phenotype?

scientific article

The Impact of Intramedullary Nailing of Tibia Fractures on the Innate Immune System.

scientific article published on 22 May 2015

The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection.

scientific article

The effect of C1-esterase inhibitor on systemic inflammation in trauma patients with a femur fracture - The CAESAR study: study protocol for a randomized controlled trial

scientific article published on 11 October 2011

The eosinophil, a Trojan Horse?

scientific article

The immune cell composition in Barrett's metaplastic tissue resembles that in normal duodenal tissue

scientific article

The innate immune response

scientific article published on 19 October 2014

The systemic immune response to trauma: an overview of pathophysiology and treatment

scientific article published on 17 October 2014

The systemic inflammatory response induced by trauma is reflected by multiple phenotypes of blood neutrophils.

scientific article published on 03 December 2007

Transcriptional machinery in asthma: closing the gap with clinical phenotypes

scientific article published on 01 August 2002

Transduction of a dominant-negative H-Ras into human eosinophils attenuates extracellular signal-regulated kinase activation and interleukin-5-mediated cell viability

scientific article published in October 2001

Upregulation of formyl-peptide and interleukin-8-induced eosinophil chemotaxis in patients with allergic asthma

scientific article published on 01 June 1993

What's your age again? Determination of human neutrophil half-lives revisited

scientific article

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