List of works - Alan E Bilsland

A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT.

scientific article

A multi-targeted approach to suppress tumor-promoting inflammation

scientific article

A mutation in a functional Sp1 binding site of the telomerase RNA gene (hTERC) promoter in a patient with Paroxysmal Nocturnal Haemoglobinuria

scientific article

Activation of telomerase rna gene promoter activity by NF-Y, Sp1, and the retinoblastoma protein and repression by Sp3.

scientific article

Broad targeting of angiogenesis for cancer prevention and therapy

scientific article

Broad targeting of resistance to apoptosis in cancer.

scientific article

Cancer cell senescence: a new frontier in drug development.

scientific article published on 31 January 2012

Drug insight: Cancer cell immortality-telomerase as a target for novel cancer gene therapies.

scientific article

Dynamic telomerase gene suppression via network effects of GSK3 inhibition

scientific article

Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.

scientific article

Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition.

scientific article

Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms

scientific article published on January 2006

Involvement of NF-Y and Sp1 binding sequences in basal transcription of the human telomerase RNA gene.

scientific article published on February 2003

Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms

scientific article (publication date: February 2014)

MicroRNA and senescence: the senectome, integration and distributed control

scientific article published on January 2013

Modulation of gene expression using zinc finger-based artificial transcription factors

scientific article published on 01 January 2010

Modulation of telomerase promoter tumor selectivity in the context of oncolytic adenoviruses.

scientific article published on February 2007

Plasma N-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome

scientific article published on January 2015

Properties of a telomerase-specific Cre/Lox switch for transcriptionally targeted cancer gene therapy.

scientific article

Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival [...]

scientific article

Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase

scientific article

Synthetic anticancer gene medicine exploits intrinsic antitumor activity of cationic vector to cure established tumors.

scientific article published on September 2005

TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression

scientific article

Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives.

scientific article published on February 2011

Telomerase-directed molecular therapeutics

scientific article published on 22 April 2002

Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954.

scientific article published in November 2001

Therapeutic targeting of replicative immortality

scientific article

Tissue invasion and metastasis: Molecular, biological and clinical perspectives

scientific article published on 09 April 2015

Transcriptional repression of telomerase RNA gene expression by c-Jun-NH2-kinase and Sp1/Sp3.

scientific article published on February 2006

Virotherapy: cancer gene therapy at last?

scientific article

List of works by Alan E Bilsland

A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT.

A multi-targeted approach to suppress tumor-promoting inflammation

A mutation in a functional Sp1 binding site of the telomerase RNA gene (hTERC) promoter in a patient with Paroxysmal Nocturnal Haemoglobinuria

Activation of telomerase rna gene promoter activity by NF-Y, Sp1, and the retinoblastoma protein and repression by Sp3.

Broad targeting of angiogenesis for cancer prevention and therapy

Broad targeting of resistance to apoptosis in cancer.

Cancer cell senescence: a new frontier in drug development.

Drug insight: Cancer cell immortality-telomerase as a target for novel cancer gene therapies.

Dynamic telomerase gene suppression via network effects of GSK3 inhibition

Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.

Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition.

Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms

Involvement of NF-Y and Sp1 binding sequences in basal transcription of the human telomerase RNA gene.

Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms

MicroRNA and senescence: the senectome, integration and distributed control

Modulation of gene expression using zinc finger-based artificial transcription factors

Modulation of telomerase promoter tumor selectivity in the context of oncolytic adenoviruses.

Plasma N-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome

Properties of a telomerase-specific Cre/Lox switch for transcriptionally targeted cancer gene therapy.

Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival [...]

Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase

Synthetic anticancer gene medicine exploits intrinsic antitumor activity of cationic vector to cure established tumors.

TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression

Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives.

Telomerase-directed molecular therapeutics

Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954.

Therapeutic targeting of replicative immortality

Tissue invasion and metastasis: Molecular, biological and clinical perspectives

Transcriptional repression of telomerase RNA gene expression by c-Jun-NH2-kinase and Sp1/Sp3.

Virotherapy: cancer gene therapy at last?