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List of works by Jürgen Götz

A decade of tau transgenic animal models and beyond

scientific article published on January 2007

A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions

scientific article published on 31 March 2016

A neuroprotective role for the DNA damage checkpoint in tauopathy.

scientific article published in February 2012

Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction

scientific article

Abeta treatment and P301L tau expression in an Alzheimer's disease tissue culture model act synergistically to promote aberrant cell cycle re-entry

scientific article

Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model

scientific article published on 04 February 2017

Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice

scientific article

Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice

scientific article published on September 2003

Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice

scientific article published on 4 January 2013

Active immunization trial in Abeta42-injected P301L tau transgenic mice

scientific article published on 11 November 2005

Aging in the nervous system of Caenorhabditis elegans.

scientific article published on 18 June 2013

Aging-Related Dysfunction of Striatal Cholinergic Interneurons Produces Conflict in Action Selection.

scientific article published on April 2016

Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation

scientific article published on 11 October 2006

Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation

scientific article published on 5 August 2009

Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice

scientific article published on 20 March 2006

Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome

scientific article

Altered ribosomal function and protein synthesis caused by tau

scientific article published on 19 June 2021

Alzheimer's and Parkinson's disease--overlapping or synergistic pathologies?

scientific article published in January 2002

Alzheimer's disease models and functional genomics-How many needles are there in the haystack?

scientific article

Alzheimer's disease selective vulnerability and modeling in transgenic mice

scientific article published on January 2009

Alzheimer's disease, oestrogen and mitochondria: an ambiguous relationship

scientific article

Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

scientific article

Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models

scientific article published in November 2004

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease ⬇️

scientific article published on December 31, 2010

Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy

scientific article published on 31 May 2010

Animal models for Alzheimer's disease and frontotemporal dementia: a perspective

scientific article (publication date: 9 November 2009)

Animal models of Alzheimer's disease and frontotemporal dementia

scientific article published on July 2008

Animal models reveal role for tau phosphorylation in human disease

scientific article published on 12 September 2009

Antiviral CD8 T cells recognize borna disease virus antigen transgenically expressed in either neurons or astrocytes

scientific article

Are you me? Amyloid-β blocks the conversation between lysosomes and mitochondria

scientific article published on 02 November 2018

Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein

scientific article published on 01 May 2000

Beta-amyloid treatment of two complementary P301L tau-expressing Alzheimer's disease models reveals similar deregulated cellular processes

scientific article published on December 2006

Bio-orthogonal labeling as a tool to visualize and identify newly synthesized proteins in Caenorhabditis elegans

scientific article

Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer's disease

scientific article published on 04 October 2016

Brief update on different roles of tau in neurodegeneration

scientific article published on July 2011

Cell-specific non-canonical amino acid labelling identifies changes in the de novo proteome during memory formation

scientific article published on 6 January 2020

Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease

scientific article published on 9 February 2016

Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model

scientific article

Common features between diabetes mellitus and Alzheimer's disease

scientific article published on April 2009

Compartmentalized tau hyperphosphorylation and increased levels of kinases in transgenic mice

scientific article published in July 2001

Connecting the dots between tau dysfunction and neurodegeneration

scientific article

Convergence of amyloid-beta and tau pathologies on mitochondria in vivo

scientific article

Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons

scientific article

Decoding the non-coding RNAs in Alzheimer's disease

scientific article published on 06 September 2012

Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling

scientific article published on 22 May 2019

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha

scientific journal article

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

scientific journal article

Different tau epitopes define Abeta42-mediated tau insolubility

scientific article published on 5 October 2005

Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils

scientific article

Disease-associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria

scientific article published on 11 December 2018

Dissecting toxicity of tau and beta-amyloid

scientific article

Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development

scientific journal article

Divergent phosphorylation pattern of tau in P301L tau transgenic mice

scientific article published in July 2008

Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A.

scientific article published in December 2002

Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease?

scientific article published on 19 June 2006

ENU mutagenesis screen to establish motor phenotypes in wild-type mice and modifiers of a pre-existing motor phenotype in tau mutant mice

scientific article published on 15 December 2011

Enhanced vascular responses to adrenomedullin in mice overexpressing receptor-activity-modifying protein 2.

scientific article published on 22 December 2005

Erratum: Corrigendum: Bio-orthogonal labeling as a tool to visualize and identify newly synthesized proteins in Caenorhabditis elegans

scholarly article published in Nature Protocols

Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol

scientific article published on 08 January 2021

Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons

scientific article published on 15 February 2018

Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease

scientific article

Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions

scientific article published in April 1998

Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia

scientific article

Extracellular Vesicles Containing P301L Mutant Tau Accelerate Pathological Tau Phosphorylation and Oligomer Formation but Do Not Seed Mature Neurofibrillary Tangles in ALZ17 Mice

scientific article

Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner

scientific article published on 30 March 2016

FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations

scientific article (publication date: 23 September 1994)

FTD and ALS--translating mouse studies into clinical trials

scientific article published on 05 May 2015

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

scientific article published in August 2001

Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines.

scientific article published on 25 June 2019

Functional Genomics meets neurodegenerative disorders Part I: transcriptomic and proteomic technology

scientific article published in June 2005

Functional Genomics meets neurodegenerative disorders. Part II: application and data integration

scientific article

Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response

scientific article published on 06 March 2008

Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins

scientific article

Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice

scientific article published on February 2004

Glial cells under physiologic and pathologic conditions

scientific article

Glutamate Receptors in Alzheimer's Disease: Mechanisms and Therapies

scientific article published on 16 May 2016

Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation

scientific article published on 23 January 2013

Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and Aβ amyloidosis

scientific article published on 27 July 2014

How it all started: tau and protein phosphatase 2A.

scientific article published on January 2013

Human but not rat amylin shares neurotoxic properties with Abeta42 in long-term hippocampal and cortical cultures

scientific article

Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment

scientific article

Immature human NT2 cells grafted into mouse brain differentiate into neuronal and glial cell types.

scientific article

Impact of β-Amyloid on the Tau Pathology in Tau Transgenic Mouse and Tissue Culture Models

article

Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice

article

Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice

scientific article published in July 2006

Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia

scientific article published on 28 January 2016

In vivo analysis of wild-type and FTDP-17 tau transgenic mice.

scientific article

Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol

scientific article

Insights into mitochondrial dysfunction: aging, amyloid-β, and tau-A deleterious trio

scientific article published on 30 January 2012

Lessons from two prevalent amyloidoses-what amylin and Aβ have in common

scientific article published on 08 August 2013

Local Oxidative Damage in the Soma and Dendrites Quarantines Neuronal Mitochondria at the Site of Insult

Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling

scientific article published on 27 May 2021

March separate, strike together--role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease

scientific article

Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta

scientific article

MicroRNA networks surrounding APP and amyloid-β metabolism--implications for Alzheimer's disease

scientific article

Mitochondria modulatory effects of new TSPO ligands in a cellular model of tauopathies

scientific article published on 13 October 2019

Mitochondrial dysfunction - the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-β toxicity ⬇️

scientific article published on May 5, 2011

Mobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant Tau

scientific article published on 05 July 2016

Modeling ultrasound propagation through material of increasing geometrical complexity

Modes of Aβ toxicity in Alzheimer's disease

scientific article

Molecular dissection of the paired helical filament

scientific article

Motor cortical function determines prognosis in sporadic ALS.

scientific article published on 8 July 2016

Mouse models of frontotemporal dementia: A comparison of phenotypes with clinical symptomatology

scientific article published on 11 January 2017

Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation

scientific article published on 05 September 2016

Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta

scientific article

Neuronal protein with tau-like repeats (PTL-1) regulates intestinal SKN-1 nuclear accumulation in response to oxidative stress

scientific article published on 14 November 2014

Neuroproteomics as a promising tool in Parkinson's disease research

scientific article

No full admission for tau to the exclusive prion club yet.

scientific article published on 9 November 2015

Non-tolerance and differential susceptibility to diabetes in transgenic mice expressing major histocompatibility class II genes on pancreatic β cells

article

Oligodendroglial tau filament formation in transgenic mice expressing G272V tau.

scientific article published in June 2001

Oligomeric and fibrillar species of beta-amyloid (A beta 42) both impair mitochondrial function in P301L tau transgenic mice

scientific article published on 16 August 2008

P2-110 Amyloid-induced neurofibrillary tangle formation addressed in vivo and in vitro

P70 S6 kinase mediates tau phosphorylation and synthesis

scientific article published on 6 December 2005

PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathy

scientific article published on 31 March 2020

PTL-1 regulates neuronal integrity and lifespan in C. elegans

scientific article

Parkinson's disease: insights from non-traditional model organisms

scientific article published on 21 September 2010

Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia

scholarly article

Pathogenetic mechanisms in Down Syndrome

Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice

scientific article published on 20 December 2012

Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease

scientific article published on 02 June 2009

Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains

scientific article published on 20 August 2009

Possibilities for the prevention and treatment of cognitive impairment and dementia

scientific article

Posttranslational modifications of tau--role in human tauopathies and modeling in transgenic animals

scientific article published in August 2004

Premature lethality, hyperactivity, and aberrant phosphorylation in transgenic mice expressing a constitutively active form of Fyn.

scientific article

Primary support cultures of hippocampal and substantia nigra neurons

article

Profiling murine tau with 0N, 1N and 2N isoform-specific antibodies in brain and peripheral organs reveals distinct subcellular localization, with the 1N isoform being enriched in the nucleus

scientific article

Pronuclear injection for the production of transgenic mice

scientific article

Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice

scientific article published on 14 April 2005

Pseudophosphorylation of Tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein Tau to dendritic spines

scientific article published on 3 January 2015

Quantitative Imaging of Cholinergic Interneurons Reveals a Distinctive Spatial Organization and a Functional Gradient across the Mouse Striatum.

scientific article published on 17 June 2016

Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice.

scientific article published on 25 July 2001

Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice

Reference genes identified in SH-SY5Y cells using custom-made gene arrays with validation by quantitative polymerase chain reaction

scientific article

Regulation of age-related structural integrity in neurons by protein with tau-like repeats (PTL-1) is cell autonomous.

scientific article

Response to the comment ‘Iron, type 2 diabetes mellitus, and Alzheimer’s disease’ to our Visions and Reflections article ‘Common features between diabetes mellitus and Alzheimer’s disease’

Rodent models for Alzheimer disease

Role for glyoxalase I in Alzheimer's disease.

scholarly article

Role of hippocalcin in mediating Aβ toxicity

scientific article

Role of the protein tau in Alzheimer's disease

scholarly article by Jürgen Götz et al published December 2005 in Drug discovery today. Disease mechanisms

S.03.01 In vivo and in vitro models of AD demonstrate a role of distinct phosphorylation sites of tau in neurofibrillary tangle formation

S.23.02 Transgenic animal models of Alzheimer's disease

scholarly article by Jürgen Götz published January 2006 in European Neuropsychopharmacology

Saitohin gene is not associated with Alzheimer's disease

scientific article

Scanning Ultrasound (SUS) Causes No Changes to Neuronal Excitability and Prevents Age-Related Reductions in Hippocampal CA1 Dendritic Structure in Wild-Type Mice

scientific article

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse model

scientific article

Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-β or hyperphosphorylated tau protein

scientific article

Shedding light on mitophagy in neurons: what is the evidence for PINK1/Parkin mitophagy in vivo?

scientific article published on 30 October 2017

Single nucleotide variants (SNVs) define senescence-accelerated SAMP8 mice, a model of a geriatric condition.

scientific article published in January 2013

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

scientific article

Soluble Beta-Amyloid Leads to Mitochondrial Defects in Amyloid Precursor Protein and Tau Transgenic Mice

article

Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation

scientific article published in September 2017

Special issue on 'Cytoskeletal proteins in health and neurodegenerative disease'.

scientific article published on 5 August 2016

Substrate-specific reduction of PP2A activity exaggerates tau pathology.

scientific article published on 4 January 2009

Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β.

scientific article

Tau aggregation and its interplay with amyloid-β.

scientific article

Tau and transgenic animal models

article

Tau filament formation in transgenic mice expressing P301L tau.

scientific article

Tau physiology and pathomechanisms in frontotemporal lobar degeneration

scientific article

Tau promotes neurodegeneration via DRP1 mislocalization in vivo

scientific journal article

Tau-mediated nuclear depletion and cytoplasmic accumulation of SFPQ in Alzheimer's and Pick's disease

scientific article

Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice

scientific article

Tau-targeted treatment strategies in Alzheimer's disease

scientific article

Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice

scientific article published in August 2014

The Role of Protein Phosphatase 2A Catalytic Subunit Cα in Embryogenesis: Evidence from Sequence Analysis and Localization Studies

article

The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation.

scientific article

The frontotemporal dementia-motor neuron disease continuum

scientific article published on 14 March 2016

The herbal compound geniposide rescues formaldehyde-induced apoptosis in N2a neuroblastoma cells

scientific article published on April 2014

The search for improved animal models of Alzheimer's disease and novel strategies for therapeutic intervention

scientific article published on 01 August 2019

Transgenic and knockout models of PP2A.

scientific article

Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapy.

scientific article published on July 2004

Transgenic mice expressing the nucleoprotein of Borna disease virus in either neurons or astrocytes: decreased susceptibility to homotypic infection and disease

scientific article published on April 2004

Transgenic mice with ocular overexpression of an adrenomedullin receptor reflect human acute angle-closure glaucoma

scientific article published on 01 January 2008

Ultrasound treatment of neurological diseases--current and emerging applications

scientific article published on 19 February 2016

Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody

scientific article published on 25 June 2019

Visualizing the microtubule-associated protein tau in the nucleus

scientific article published on 18 March 2014

What Renders TAU Toxic

scientific article published on 10 June 2013

What we can learn from animal models about cerebral multi-morbidity

scientific article

Why size matters - balancing mitochondrial dynamics in Alzheimer's disease

scientific article published on 11 April 2013

beta-Amyloid induces paired helical filament-like tau filaments in tissue culture

scientific article published on 31 July 2003

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