List of works - Jan Nedergaard

Brown adipose tissue: function and physiological significance

scientific article (publication date: 2004)

Unexpected evidence for active brown adipose tissue in adult humans

scientific article (publication date: August 2007)

Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic [...]

scientific article

UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality

scientific journal article

The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue.

scientific article

Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages.

scholarly article

Nonshivering thermogenesis and its adequate measurement in metabolic studies

scientific article published on January 2011

A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans

scientific article

UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic.

scientific article published on 27 November 2013

UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency.

scientific article

Recruited vs. nonrecruited molecular signatures of brown, "brite," and white adipose tissues

scientific article published on 9 August 2011

The changed metabolic world with human brown adipose tissue: therapeutic visions.

scientific article published on April 2010

The Browning of White Adipose Tissue: Some Burning Issues

scientific article published on 07 August 2014

Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation.

scholarly article

Thermogenic responses in brown fat cells are fully UCP1-dependent. UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty scid-induced thermogenesis

scientific article published on August 2000

Genetic and functional characterization of clonally derived adult human brown adipocytes

scientific article

Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation

scientific article published on 01 January 2009

UCP1 mRNA does not produce heat.

scientific article

The 'novel' 'uncoupling' proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions.

scientific article

Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

scientific article published on 17 April 2017

Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans).

scientific article published on October 2010

UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity

scientific article

Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice

scientific article

Three years with adult human brown adipose tissue

scientific article

A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity

scientific article

UCP1 is essential for adaptive adrenergic nonshivering thermogenesis

scientific article published on 04 April 2006

Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes.

scientific article

A stringent validation of mouse adipose tissue identity markers.

scientific article

New powers of brown fat: fighting the metabolic syndrome

scientific article published on 01 March 2011

PPARgamma in the control of brown adipocyte differentiation.

scientific article

Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure

scientific article published on 15 January 2014

Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids.

scientific article

Thermogenically competent nonadrenergic recruitment in brown preadipocytes by a PPARgamma agonist.

scientific article published on 20 May 2008

Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity

scientific article

Depressed thermogenesis but competent brown adipose tissue recruitment in mice devoid of all hormone-binding thyroid hormone receptors.

scientific article published on 20 November 2003

Genome-wide profiling of peroxisome proliferator-activated receptor γ in primary epididymal, inguinal, and brown adipocytes reveals depot-selective binding correlated with gene expression

scientific article published on 25 June 2012

Thermogenesis challenges the adipostat hypothesis for body-weight control.

scientific article

Uncoupling proteins: current status and therapeutic prospects

scientific article

Cig30, a mouse member of a novel membrane protein gene family, is involved in the recruitment of brown adipose tissue.

scientific article published in December 1997

Adipose tissue pathways involved in weight loss of cancer cachexia

scientific article

Overview--preparation and properties of mitochondria from different sources

scientific article published on January 1979

SOD2 overexpression: enhanced mitochondrial tolerance but absence of effect on UCP activity

scientific article published on 10 November 2005

Leptin Raises Defended Body Temperature without Activating Thermogenesis

scientific article

Essential role of UCP1 modulating the central effects of thyroid hormones on energy balance

scientific article published on 10 February 2016

Beta 3- and alpha1-adrenergic Erk1/2 activation is Src- but not Gi-mediated in Brown adipocytes

scientific article

Mitochondrial ('mild') uncoupling and ROS production: physiologically relevant or not?

scientific article published on October 2011

Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects

scientific article

Kinetics of the inhibition of mitochondrial respiration by NO

scientific article published on 01 November 1997

The bioenergetics of brown fat mitochondria from UCP1-ablated mice. Ucp1 is not involved in fatty acid-induced de-energization ("uncoupling")

scientific article published on 01 October 1999

UCP1 in adipose tissues: two steps to full browning.

scientific article published on 18 January 2017

List of works by Jan Nedergaard

Brown adipose tissue: function and physiological significance

Unexpected evidence for active brown adipose tissue in adult humans

Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic [...]

UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality

The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue.

Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages.

Nonshivering thermogenesis and its adequate measurement in metabolic studies

A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans

UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic.

UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency.

Recruited vs. nonrecruited molecular signatures of brown, "brite," and white adipose tissues

The changed metabolic world with human brown adipose tissue: therapeutic visions.

The Browning of White Adipose Tissue: Some Burning Issues

Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation.

Thermogenic responses in brown fat cells are fully UCP1-dependent. UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty scid-induced thermogenesis

Genetic and functional characterization of clonally derived adult human brown adipocytes

Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation

UCP1 mRNA does not produce heat.

The 'novel' 'uncoupling' proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions.

Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans).

UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity

Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice

Three years with adult human brown adipose tissue

A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity

UCP1 is essential for adaptive adrenergic nonshivering thermogenesis

Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes.

A stringent validation of mouse adipose tissue identity markers.

New powers of brown fat: fighting the metabolic syndrome

PPARgamma in the control of brown adipocyte differentiation.

Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure

Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids.

Thermogenically competent nonadrenergic recruitment in brown preadipocytes by a PPARgamma agonist.

Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity

Depressed thermogenesis but competent brown adipose tissue recruitment in mice devoid of all hormone-binding thyroid hormone receptors.

Genome-wide profiling of peroxisome proliferator-activated receptor γ in primary epididymal, inguinal, and brown adipocytes reveals depot-selective binding correlated with gene expression

Thermogenesis challenges the adipostat hypothesis for body-weight control.

Uncoupling proteins: current status and therapeutic prospects

Cig30, a mouse member of a novel membrane protein gene family, is involved in the recruitment of brown adipose tissue.

Adipose tissue pathways involved in weight loss of cancer cachexia

Overview--preparation and properties of mitochondria from different sources

SOD2 overexpression: enhanced mitochondrial tolerance but absence of effect on UCP activity

Leptin Raises Defended Body Temperature without Activating Thermogenesis

Essential role of UCP1 modulating the central effects of thyroid hormones on energy balance

Beta 3- and alpha1-adrenergic Erk1/2 activation is Src- but not Gi-mediated in Brown adipocytes

Mitochondrial ('mild') uncoupling and ROS production: physiologically relevant or not?

Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects

Kinetics of the inhibition of mitochondrial respiration by NO

The bioenergetics of brown fat mitochondria from UCP1-ablated mice. Ucp1 is not involved in fatty acid-induced de-energization ("uncoupling")

UCP1 in adipose tissues: two steps to full browning.