List of works - Jan Nedergaard

'Neuropeptide tyrosine' (NPY) is co-stored with noradrenaline in vascular but not in parenchymal sympathetic nerves of brown adipose tissue

scientific article published on 01 June 1986

A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans

scientific article

A dual component analysis explains the distinctive kinetics of cAMP accumulation in brown adipocytes

scientific article published on 01 December 1999

A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity

scientific article

A sequence predicted to form a stem-loop is proposed to be required for formation of an RNA-protein complex involving the 3'UTR of beta-subunit F0F1-ATPase mRNA

scientific article published on 04 June 2008

A stringent validation of mouse adipose tissue identity markers.

scientific article

Adaptive facultative diet-induced thermogenesis in wild-type but not in UCP1-ablated mice.

scientific article published on 5 July 2017

Adenosine 5'-monophosphate is a selective inhibitor of the brown adipocyte nonselective cation channel

scientific article published in August 2002

Adipose tissue pathways involved in weight loss of cancer cachexia

scientific article

Adrenergic receptor density in brown adipose tissue of active and hibernating hamsters and ground squirrels.

scientific article published on 28 November 2006

Adrenergically stimulated blood flow in brown adipose tissue is not dependent on thermogenesis

scientific article published on 3 March 2015

Alpha 1- and beta-adrenergic regulation of intracellular Ca2+ levels in brown adipocytes

scientific article published on 01 August 1989

Alpha 1-adrenergic inositol trisphosphate production in brown adipocytes is Na+ dependent

scientific article published in October 1987

Alpha 1-adrenergic stimulation of Cl- efflux in isolated brown adipocytes

scientific article published on 01 March 1990

Alpha-adrenergic effects on 86Rb+ (K+) potentials and fluxes in brown fat cells

scientific article published on 01 July 1984

Alpha1- and beta1-adrenoceptor signaling fully compensates for beta3-adrenoceptor deficiency in brown adipocyte norepinephrine-stimulated glucose uptake

scientific article published on 21 January 2005

Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

scientific article published on 17 April 2017

An essential role for Tbx15 in the differentiation of brown and "brite" but not white adipocytes.

scientific article

An siRNA-based method for efficient silencing of gene expression in mature brown adipocytes

scientific article published on 20 November 2015

Analysis of inhibition by H89 of UCP1 gene expression and thermogenesis indicates protein kinase A mediation of beta(3)-adrenergic signalling rather than beta(3)-adrenoceptor antagonism by H89.

scientific article

As the proliferation promoter noradrenaline induces expression of ICER (induced cAMP early repressor) in proliferative brown adipocytes, ICER may not be a universal tumour suppressor

scientific article

Beta 3- and alpha1-adrenergic Erk1/2 activation is Src- but not Gi-mediated in Brown adipocytes

scientific article

Beta-adrenergic stimulation of fatty acid release from brown fat cells differentiated in monolayer culture

scientific article published on 01 February 1986

Brown adipocytes differentiated in vitro can express the gene for the uncoupling protein thermogenin: effects of hypothyroidism and norepinephrine

scientific article published on 01 May 1989

Brown adipose tissue as an anti-obesity tissue in humans

scientific article published on 25 October 2013

Brown adipose tissue: function and physiological significance

scientific article (publication date: 2004)

Ca(2+) -independent effects of BAPTA and EGTA on single-channel Cl(-) currents in brown adipocytes

scientific article published on 17 July 2007

Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 may be responsible for basal and fatty-acid-induced uncoupling respectively.

scientific article published on November 2006

Carteolol is a weak partial agonist on beta 3-adrenergic receptors in brown adipocytes.

scientific article published in April 1998

Caveolin-1-ablated mice survive in cold by nonshivering thermogenesis despite desensitized adrenergic responsiveness.

scientific article published on 8 June 2010

Chloride channels in brown adipocyte plasma membranes: candidates for mediation of alpha 1-adrenergic depolarization?

scientific article

Choline+ is a low-affinity ligand for alpha 1-adrenoceptors

scientific article published on 01 October 1994

Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic [...]

scientific article

Cidea improves the metabolic profile through expansion of adipose tissue

scientific article

Cig30 and Pitx3 genes are arranged in a partially overlapping tail-to-tail array resulting in complementary transcripts

scientific article published in September 1999

Cig30, a mouse member of a novel membrane protein gene family, is involved in the recruitment of brown adipose tissue.

scientific article published in December 1997

Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects

scientific article

Cold-induced alterations of phospholipid fatty acyl composition in brown adipose tissue mitochondria are independent of uncoupling protein-1

article

Cold-induced expression of the VEGF gene in brown adipose tissue is independent of thermogenic oxygen consumption

scientific article

Comparison of the pharmacological profiles of adrenergic drugs (including BRL-agonists) at [3H]prazosin and [3H]CGP-12177 binding sites in brown adipose tissue

scientific article published on 01 January 1989

Contrasting adrenergic effects on lipoprotein lipase gene expression in the brown adipose tissue of intact mice and in cultured brown adipocytes from mice

article

Contrasting effects of cold acclimation versus obesogenic diets on chemerin gene expression in brown and brite adipose tissues

scientific article published on 01 December 2014

Corrigendum: Cidea improves the metabolic profile through expansion of adipose tissue

scientific article published on 4 August 2016

DNA synthesis in mouse brown adipose tissue is under beta-adrenergic control

scientific article published on 01 February 1989

Depressed thermogenesis but competent brown adipose tissue recruitment in mice devoid of all hormone-binding thyroid hormone receptors.

scientific article published on 20 November 2003

Development of brown fat cells in monolayer culture. I. Morphological and biochemical distinction from white fat cells in culture

scientific article published on 01 November 1983

Developmental biology: Neither fat nor flesh.

scientific article published in August 2008

Differential adrenergic regulation of the gene expression of the beta-adrenoceptor subtypes beta1, beta2 and beta3 in brown adipocytes.

scientific article published on May 2000

Differential involvement of caveolin-1 in brown adipocyte signaling: impaired beta3-adrenergic, but unaffected LPA, PDGF and EGF receptor signaling.

scientific article published on 8 April 2010

Differential role of Presenilin-1 and -2 on mitochondrial membrane potential and oxygen consumption in mouse embryonic fibroblasts

scientific article

Differential signalling pathways for EGF versus PDGF activation of Erk1/2 MAP kinase and cell proliferation in brown pre-adipocytes

scientific article published on 24 September 2008

Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes.

scientific article

Down-regulation of beta3 adrenoreceptor gene expression in brown fat cells is transient and recovery is dependent upon a short-lived protein factor

scientific article published on 01 December 1996

ERRγ enhances UCP1 expression and fatty acid oxidation in brown adipocytes.

scientific article published in March 2013

Effect of transforming growth factor-beta on calcium homeostasis in prostate carcinoma cells.

scientific article published on May 2003

Effects of guanine nucleotides and cations on agonist affinity of alpha 1-adrenoceptors in brown adipose tissue

scientific article published on 01 September 1985

Enzyme-linked immunosorbent assay (ELISA) studies of the interaction between mammalian and avian anti-thermogenin antibodies and brown-adipose-tissue mitochondria from different species

scientific article published on 01 January 1984

Essential role of UCP1 modulating the central effects of thyroid hormones on energy balance

scientific article published on 10 February 2016

Euthyroid status is essential for the perinatal increase in thermogenin mRNA in brown adipose tissue of rat pups

scientific article published on 01 October 1987

Exclusive occurrence of thermogenin antigen in brown adipose tissue

scientific article published on 01 December 1982

Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity

scientific article

Genetic and functional characterization of clonally derived adult human brown adipocytes

scientific article

Genome-wide profiling of peroxisome proliferator-activated receptor γ in primary epididymal, inguinal, and brown adipocytes reveals depot-selective binding correlated with gene expression

scientific article published on 25 June 2012

Halothane selectively inhibits nonshivering thermogenesis. Possible implications for thermoregulation during anesthesia of infants.

scientific article published in February 1995

Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure

scientific article published on 15 January 2014

How brown is brown fat? It depends where you look.

scientific article published in May 2013

Human mediastinal adipose tissue displays certain characteristics of brown fat.

scientific article published on 13 May 2013

Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation

scientific article published on 01 January 2009

Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1.

scientific article published on 15 February 2017

In brown adipocytes, adrenergically induced β₁-/β₃-(Gs)-, α₂-(Gi)- and α₁-(Gq)-signalling to Erk1/2 activation is not mediated via EGF receptor transactivation

scientific article published on 13 August 2013

Increased alpha 1-adrenergic receptor density in brown adipose tissue of cafeteria-fed rats

scientific article published on 01 October 1984

Increased alpha 1-adrenergic receptor density in brown adipose tissue of cold-acclimated rats and hamsters

scientific article published on 01 November 1984

Increased fatigue resistance linked to Ca2+-stimulated mitochondrial biogenesis in muscle fibres of cold-acclimated mice

scientific article published on November 2010

Increased respiration in skeletal muscle mitochondria from cold-acclimated ducklings: uncoupling effects of free fatty acids.

scientific article

Induction of uncoupling protein in brown adipose tissue. Synergy between norepinephrine and pioglitazone, an insulin-sensitizing agent

scientific article published on 01 September 1996

Inhibition of acetyl-carnitine oxidation in rat brown-adipose-tissue mitochondria by erucoyl-carnitine is due to sequestration of CoA.

scientific article published on April 1985

Inhibitory effects of halothane on the thermogenic pathway in brown adipocytes: localization to adenylyl cyclase and mitochondrial fatty acid oxidation.

scientific article published in August 2004

Kinetics of the inhibition of mitochondrial respiration by NO

scientific article published on 01 November 1997

Leptin Raises Defended Body Temperature without Activating Thermogenesis

scientific article

Leptin-deficient mice are not hypothermic, they are anapyrexic

scientific article published on 9 November 2016

Leptin: Is It Thermogenic?

scientific article published on 01 April 2020

Leydig cell steroidogenesis unexpectedly escapes mitochondrial dysfunction in prematurely aging mice.

scientific article published on 21 April 2015

Life without UCP1: mitochondrial, cellular and organismal characteristics of the UCP1-ablated mice.

scientific article

Metabolic consequences of limited substrate anion permeability in brown fat mitochondria from a hibernator, the golden hamster

scientific article published on 01 August 1984

Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans).

scientific article published on October 2010

Metabolically inert perfluorinated fatty acids directly activate uncoupling protein 1 in brown-fat mitochondria

scientific article published on 4 June 2015

Mitochondrial ('mild') uncoupling and ROS production: physiologically relevant or not?

scientific article published on October 2011

Mitochondrial ATP synthase levels in brown adipose tissue are governed by the c-Fo subunit P1 isoform

scientific article published on 31 July 2007

Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages.

scholarly article

Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids.

scientific article

Neither brown nor white

scientific article published in Nature

New powers of brown fat: fighting the metabolic syndrome

scientific article published on 01 March 2011

No insulating effect of obesity.

scientific article

Non-transactivational, dual pathways for LPA-induced Erk1/2 activation in primary cultures of brown pre-adipocytes

scientific article published on June 2010

Nonshivering thermogenesis and its adequate measurement in metabolic studies

scientific article published on January 2011

Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) gamma2 gene expression in brown adipocytes: intracellular signalling and effects on PPARgamma2 and PPARgamma1 protein levels

scientific article published on September 2004

Norepinephrine but not hypoxia stimulates HIF-1alpha gene expression in brown adipocytes

scientific article published in November 2005

Norepinephrine specifically stimulates ribonucleotide reductase subunit R2 gene expression in proliferating brown adipocytes: mediation via a cAMP/PKA pathway involving Src and Erk1/2 kinases

scientific article

Norepinephrine-induced synthesis of the uncoupling protein thermogenin (UCP) and its mitochondrial targeting in brown adipocytes differentiated in culture

scientific article published on 01 July 1990

Optimal housing temperatures for mice to mimic the thermal environment of humans: An experimental study.

scientific article published on 31 October 2017

Overview--preparation and properties of mitochondria from different sources

scientific article published on January 1979

PPARalpha does not suppress muscle-associated gene expression in brown adipocytes but does influence expression of factors that fingerprint the brown adipocyte

scientific article published on 23 May 2010

PPARgamma in the control of brown adipocyte differentiation.

scientific article

Parallel increases in amount of (3H)GDP binding and thermogenin antigen in brown-adipose-tissue mitochondria of cafeteria-fed rats

scientific article published on 01 August 1984

Partial protection against erucoyl-carnitine inhibition in hamster brown-adipose-tissue mitochondria is due to high CoA levels: a comparison with rat brown-adipose-tissue mitochondria.

scientific article published on January 1986

Physiological activation of brown adipose tissue destabilizes thermogenin mRNA

scientific article published on 01 November 1987

Presence of a Ca2+-dependent K+ channel in brown adipocytes. Possible role in maintenance of alpha 1-adrenergic stimulation

scientific article published on 01 January 1985

Promotion of lipid storage rather than of thermogenic competence by fetal versus newborn calf serum in primary cultures of brown adipocytes

scientific article published on 16 July 2018

Protein kinase a-mediated cell proliferation in brown preadipocytes is independent of Erk1/2, PI3K and mTOR.

scientific article published on 4 August 2014

Pyruvate kinase M2 represses thermogenic gene expression in brown adipocytes

scientific article published on 10 December 2019

Quantitative differentiation of alpha- and beta-adrenergic respiratory responses in isolated hamster brown fat cells: evidence for the presence of an alpha 1-adrenergic component

scientific article published on 01 September 1983

ROS production in brown adipose tissue mitochondria: the question of UCP1-dependence.

scientific article published on 24 April 2014

Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.

scientific article

Recruited vs. nonrecruited molecular signatures of brown, "brite," and white adipose tissues

scientific article published on 9 August 2011

Reply to letter to the editor: at thermoneutrality, neither the lean nor the obese freeze

scientific article published on 01 September 2016

Requirement of gene transcription and protein synthesis for cold- and norepinephrine-induced stimulation of thyroxine deiodinase in rat brown adipose tissue

scientific article published on 01 December 1986

Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation.

scholarly article

Reversible blockade of the calcium-activated nonselective cation channel in brown fat cells by the sulfhydryl reagents mercury and thimerosal

scientific article published on 01 December 1993

S10.25 Effect of targeted quinones on ROS production and lipid peroxidation in mitochondria: Mitochondrial DNA polymerase mutant mice exibit high sensitivity

S14.4 Random mtDNA mutations cause respiratory dysfunction through failure in complex assembly

S14.6 Impaired thermogenesis in PolgA mtDNA polymerase mutant mice

SOD2 overexpression: enhanced mitochondrial tolerance but absence of effect on UCP activity

scientific article published on 10 November 2005

Single Case Method in Psychology: How to Improve as a Possible Methodology in Quantitative Research.

scientific article published on September 2015

Studies of thermogenesis and mitochondrial function in adipose tissues

scientific article published on 01 January 2008

Sulfonates are low-affinity ligands for the GDP-binding site of brown-fat mitochondria

scientific article published on 01 May 1994

The 'novel' 'uncoupling' proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions.

scientific article

The Environmental Pollutants Perfluorooctane Sulfonate and Perfluorooctanoic Acid Upregulate Uncoupling Protein 1 (UCP1) in Brown-Fat Mitochondria Through a UCP1-Dependent Reduction in Food Intake.

scientific article published on 21 May 2015

The bioenergetics of brown fat mitochondria from UCP1-ablated mice. Ucp1 is not involved in fatty acid-induced de-energization ("uncoupling")

scientific article published on 01 October 1999

The browning of white adipose tissue: some burning issues

scientific article published on 07 August 2014

The changed metabolic world with human brown adipose tissue: therapeutic visions.

scientific article published on April 2010

The effect of intermittent cold treatment on the adipose tissue of the cat. Apparent transformation from white to brown adipose tissue.

scientific article published in October 1986

The expression of subunit c correlates with and thus may limit the biosynthesis of the mitochondrial F0F1-ATPase in brown adipose tissue.

scientific article

The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue.

scientific article

The β3-adrenergic receptor is dispensable for browning of adipose tissues.

scientific article published on 21 February 2017

Thermogenesis challenges the adipostat hypothesis for body-weight control.

scientific article

Thermogenesis inhibition in brown adipocytes is a specific property of volatile anesthetics.

scientific article published on February 2003

Thermogenic responses in brown fat cells are fully UCP1-dependent. UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty scid-induced thermogenesis

scientific article published on August 2000

Thermogenically competent nonadrenergic recruitment in brown preadipocytes by a PPARgamma agonist.

scientific article published on 20 May 2008

Three years with adult human brown adipose tissue

scientific article

Thyroid hormones: igniting brown fat via the brain

scientific article published on 01 September 2010

UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality

scientific journal article

UCP1 and defense against oxidative stress. 4-Hydroxy-2-nonenal effects on brown fat mitochondria are uncoupling protein 1-independent.

scientific article

UCP1 in adipose tissues: two steps to full browning.

scientific article published on 18 January 2017

UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic.

scientific article published on 27 November 2013

UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity

scientific article

UCP1 inhibition in Cidea-overexpressing mice is physiologically counteracted by brown adipose tissue hyperrecruitment.

scientific article published on 6 December 2016

UCP1 is essential for adaptive adrenergic nonshivering thermogenesis

scientific article published on 04 April 2006

UCP1 mRNA does not produce heat.

scientific article

UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency.

scientific article

UCP1: the original uncoupling protein--and perhaps the only one? New perspectives on UCP1, UCP2, and UCP3 in the light of the bioenergetics of the UCP1-ablated mice.

scientific article

Ultraendurance exercise increases the production of reactive oxygen species in isolated mitochondria from human skeletal muscle.

scientific article

Uncoupled respiration, ROS production, acute lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice

scientific article published on May 2011

Uncoupling protein-1 is not leaky

scientific article published on 14 April 2010

Uncoupling proteins: current status and therapeutic prospects

scientific article

Unexpected evidence for active brown adipose tissue in adult humans

scientific article (publication date: August 2007)

What Ignites UCP1?

scientific article published in November 2017

Within brown-fat cells, UCP1-mediated fatty acid-induced uncoupling is independent of fatty acid metabolism

scientific article published in May 2008

Yes, even human brown fat is on fire!

scientific article published on 24 January 2012

alpha- and beta-adrenergic control of thermogenin mRNA expression in brown adipose tissue

scientific article published on 01 July 1986

alpha1-Adrenergic stimulation potentiates the thermogenic action of beta3-adrenoreceptor-generated cAMP in brown fat cells

scientific article published on 01 December 1997

β3-Adrenergically induced glucose uptake in brown adipose tissue is independent of UCP1 presence or activity: Mediation through the mTOR pathway

scientific article

List of works by Jan Nedergaard

'Neuropeptide tyrosine' (NPY) is co-stored with noradrenaline in vascular but not in parenchymal sympathetic nerves of brown adipose tissue

A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans

A dual component analysis explains the distinctive kinetics of cAMP accumulation in brown adipocytes

A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity

A sequence predicted to form a stem-loop is proposed to be required for formation of an RNA-protein complex involving the 3'UTR of beta-subunit F0F1-ATPase mRNA

A stringent validation of mouse adipose tissue identity markers.

Adaptive facultative diet-induced thermogenesis in wild-type but not in UCP1-ablated mice.

Adenosine 5'-monophosphate is a selective inhibitor of the brown adipocyte nonselective cation channel

Adipose tissue pathways involved in weight loss of cancer cachexia

Adrenergic receptor density in brown adipose tissue of active and hibernating hamsters and ground squirrels.

Adrenergically stimulated blood flow in brown adipose tissue is not dependent on thermogenesis

Alpha 1- and beta-adrenergic regulation of intracellular Ca2+ levels in brown adipocytes

Alpha 1-adrenergic inositol trisphosphate production in brown adipocytes is Na+ dependent

Alpha 1-adrenergic stimulation of Cl- efflux in isolated brown adipocytes

Alpha-adrenergic effects on 86Rb+ (K+) potentials and fluxes in brown fat cells

Alpha1- and beta1-adrenoceptor signaling fully compensates for beta3-adrenoceptor deficiency in brown adipocyte norepinephrine-stimulated glucose uptake

Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

An essential role for Tbx15 in the differentiation of brown and "brite" but not white adipocytes.

An siRNA-based method for efficient silencing of gene expression in mature brown adipocytes

Analysis of inhibition by H89 of UCP1 gene expression and thermogenesis indicates protein kinase A mediation of beta(3)-adrenergic signalling rather than beta(3)-adrenoceptor antagonism by H89.

As the proliferation promoter noradrenaline induces expression of ICER (induced cAMP early repressor) in proliferative brown adipocytes, ICER may not be a universal tumour suppressor

Beta 3- and alpha1-adrenergic Erk1/2 activation is Src- but not Gi-mediated in Brown adipocytes

Beta-adrenergic stimulation of fatty acid release from brown fat cells differentiated in monolayer culture

Brown adipocytes differentiated in vitro can express the gene for the uncoupling protein thermogenin: effects of hypothyroidism and norepinephrine

Brown adipose tissue as an anti-obesity tissue in humans

Brown adipose tissue: function and physiological significance

Ca(2+) -independent effects of BAPTA and EGTA on single-channel Cl(-) currents in brown adipocytes

Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 may be responsible for basal and fatty-acid-induced uncoupling respectively.

Carteolol is a weak partial agonist on beta 3-adrenergic receptors in brown adipocytes.

Caveolin-1-ablated mice survive in cold by nonshivering thermogenesis despite desensitized adrenergic responsiveness.

Chloride channels in brown adipocyte plasma membranes: candidates for mediation of alpha 1-adrenergic depolarization?

Choline+ is a low-affinity ligand for alpha 1-adrenoceptors

Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic [...]

Cidea improves the metabolic profile through expansion of adipose tissue

Cig30 and Pitx3 genes are arranged in a partially overlapping tail-to-tail array resulting in complementary transcripts

Cig30, a mouse member of a novel membrane protein gene family, is involved in the recruitment of brown adipose tissue.

Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects

Cold-induced alterations of phospholipid fatty acyl composition in brown adipose tissue mitochondria are independent of uncoupling protein-1

Cold-induced expression of the VEGF gene in brown adipose tissue is independent of thermogenic oxygen consumption

Comparison of the pharmacological profiles of adrenergic drugs (including BRL-agonists) at [3H]prazosin and [3H]CGP-12177 binding sites in brown adipose tissue

Contrasting adrenergic effects on lipoprotein lipase gene expression in the brown adipose tissue of intact mice and in cultured brown adipocytes from mice

Contrasting effects of cold acclimation versus obesogenic diets on chemerin gene expression in brown and brite adipose tissues

Corrigendum: Cidea improves the metabolic profile through expansion of adipose tissue

DNA synthesis in mouse brown adipose tissue is under beta-adrenergic control

Depressed thermogenesis but competent brown adipose tissue recruitment in mice devoid of all hormone-binding thyroid hormone receptors.

Development of brown fat cells in monolayer culture. I. Morphological and biochemical distinction from white fat cells in culture

Developmental biology: Neither fat nor flesh.

Differential adrenergic regulation of the gene expression of the beta-adrenoceptor subtypes beta1, beta2 and beta3 in brown adipocytes.

Differential involvement of caveolin-1 in brown adipocyte signaling: impaired beta3-adrenergic, but unaffected LPA, PDGF and EGF receptor signaling.

Differential role of Presenilin-1 and -2 on mitochondrial membrane potential and oxygen consumption in mouse embryonic fibroblasts

Differential signalling pathways for EGF versus PDGF activation of Erk1/2 MAP kinase and cell proliferation in brown pre-adipocytes

Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes.

Down-regulation of beta3 adrenoreceptor gene expression in brown fat cells is transient and recovery is dependent upon a short-lived protein factor

ERRγ enhances UCP1 expression and fatty acid oxidation in brown adipocytes.

Effect of transforming growth factor-beta on calcium homeostasis in prostate carcinoma cells.

Effects of guanine nucleotides and cations on agonist affinity of alpha 1-adrenoceptors in brown adipose tissue

Enzyme-linked immunosorbent assay (ELISA) studies of the interaction between mammalian and avian anti-thermogenin antibodies and brown-adipose-tissue mitochondria from different species

Essential role of UCP1 modulating the central effects of thyroid hormones on energy balance

Euthyroid status is essential for the perinatal increase in thermogenin mRNA in brown adipose tissue of rat pups

Exclusive occurrence of thermogenin antigen in brown adipose tissue

Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity

Genetic and functional characterization of clonally derived adult human brown adipocytes

Genome-wide profiling of peroxisome proliferator-activated receptor γ in primary epididymal, inguinal, and brown adipocytes reveals depot-selective binding correlated with gene expression

Halothane selectively inhibits nonshivering thermogenesis. Possible implications for thermoregulation during anesthesia of infants.

Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure

How brown is brown fat? It depends where you look.

Human mediastinal adipose tissue displays certain characteristics of brown fat.

Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation

Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1.

In brown adipocytes, adrenergically induced β₁-/β₃-(Gs)-, α₂-(Gi)- and α₁-(Gq)-signalling to Erk1/2 activation is not mediated via EGF receptor transactivation

Increased alpha 1-adrenergic receptor density in brown adipose tissue of cafeteria-fed rats

Increased alpha 1-adrenergic receptor density in brown adipose tissue of cold-acclimated rats and hamsters

Increased fatigue resistance linked to Ca2+-stimulated mitochondrial biogenesis in muscle fibres of cold-acclimated mice

Increased respiration in skeletal muscle mitochondria from cold-acclimated ducklings: uncoupling effects of free fatty acids.

Induction of uncoupling protein in brown adipose tissue. Synergy between norepinephrine and pioglitazone, an insulin-sensitizing agent

Inhibition of acetyl-carnitine oxidation in rat brown-adipose-tissue mitochondria by erucoyl-carnitine is due to sequestration of CoA.

Inhibitory effects of halothane on the thermogenic pathway in brown adipocytes: localization to adenylyl cyclase and mitochondrial fatty acid oxidation.

Kinetics of the inhibition of mitochondrial respiration by NO

Leptin Raises Defended Body Temperature without Activating Thermogenesis