List of works by Susanne Mandrup

A Genome-Wide Perspective on Metabolism

scientific article published on 23 April 2015

A novel intronic peroxisome proliferator-activated receptor gamma enhancer in the uncoupling protein (UCP) 3 gene as a regulator of both UCP2 and -3 expression in adipocytes

scientific article published on April 2010

A novel role for central ACBP/DBI as a regulator of long-chain fatty acid metabolism in astrocytes

scientific article published on 6 February 2015

ACBP--a PPAR and SREBP modulated housekeeping gene

scientific article published on 13 January 2006

Activation of peroxisome proliferator-activated receptor gamma by human cytomegalovirus for de novo replication impairs migration and invasiveness of cytotrophoblasts from early placentas

scientific article

Acute TNF-induced repression of cell identity genes is mediated by NFκB-directed redistribution of cofactors from super-enhancers

scientific article

Acute genome-wide effects of rosiglitazone on PPARγ transcriptional networks in adipocytes

scientific article

Acyl-CoA binding protein and epidermal barrier function

scientific article published on 29 September 2013

Acyl-CoA esters antagonize the effects of ligands on peroxisome proliferator-activated receptor alpha conformation, DNA binding, and interaction with Co-factors

scientific article published on 20 February 2001

Acyl-CoA-binding protein/diazepam-binding inhibitor gene and pseudogenes

scientific article (publication date: December 1992)

Adipocyte differentiation and leptin expression

scientific article published on January 1997

Adipogenesis: forces that tip the scales.

scientific article

Antiobesity mechanisms of action of conjugated linoleic acid

scientific article

Archived neonatal dried blood spot samples can be used for accurate whole genome and exome-targeted next-generation sequencing

scientific article published on 13 June 2013

Author Correction: Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis

scientific article published on 01 April 2019

Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers

scientific article

CD1d-mediated presentation of endogenous lipid antigens by adipocytes requires microsomal triglyceride transfer protein

scientific article published on 25 June 2014

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

scholarly article by Elahu G. Sustarsic published in July 2018

ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells

scientific article

Chromatin Immunoprecipitation for Identification of Protein-DNA Interactions in Human Cells

scientific article published on 01 January 2018

Co-Administration of Propionate or Protocatechuic Acid Does Not Affect DHA-Specific Transcriptional Effects on Lipid Metabolism in Cultured Hepatic Cells

scientific article published on 26 September 2020

Cofactor squelching: Artifact or fact?

scientific article

Compromised epidermal barrier stimulates Harderian gland activity and hypertrophy in ACBP-/- mice

scientific article

Conjugated linoleic acid induces human adipocyte delipidation: autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines

scientific article

Conjugated linoleic acids reduce body fat in healthy postmenopausal women

scientific article

Cross species comparison of C/EBPα and PPARγ profiles in mouse and human adipocytes reveals interdependent retention of binding sites

scientific article

Cross-species ChIP-seq studies provide insights into regulatory strategies of PPARγ in adipocytes

scientific article published on January 2012

DBI/ACBP loss-of-function does not affect anxiety-like behaviour but reduces anxiolytic responses to diazepam in mice

scientific article published on 27 June 2016

Delayed hepatic adaptation to weaning in ACBP-/- mice is caused by disruption of the epidermal barrier.

scientific article published on 5 December 2013

Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.

scientific article published on 17 November 2008

Differential effects of environmental chemicals and food contaminants on adipogenesis, biomarker release and PPARγ activation

scientific article published on 14 April 2012

Disruption of the acyl-CoA-binding protein gene delays hepatic adaptation to metabolic changes at weaning

scientific article

Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo

scientific journal article

Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation

scientific article published on May 2017

ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination

scientific article published on 01 November 2019

Effect of heterologous expression of acyl-CoA-binding protein on acyl-CoA level and composition in yeast

scientific article

Effects of selected bioactive food compounds on human white adipocyte function

scientific article

Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men

scientific article published on 08 September 2012

Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesis.

scientific article

Gene program-specific regulation of PGC-1{alpha} activity

scientific article published on July 2011

Genome organization and expression of the rat ACBP gene family

article

Genome-Wide Insights into the Development and Function of Thermogenic Adipocytes

scientific article published on 12 December 2016

Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis

scientific article published on November 2008

Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites

scientific article published on 12 December 2011

Genome-wide profiling of peroxisome proliferator-activated receptor γ in primary epididymal, inguinal, and brown adipocytes reveals depot-selective binding correlated with gene expression

scientific article published on 25 June 2012

Genome-wide profiling of transcription factor binding and epigenetic marks in adipocytes by ChIP-seq.

scientific article published in January 2014

Genomic organization of the mouse peroxisome proliferator-activated receptor beta/delta gene: alternative promoter usage and splicing yield transcripts exhibiting differential translational efficiency

scientific article published on September 2002

Glucose-induced lipogenesis in pancreatic beta-cells is dependent on SREBP-1.

scientific article published on August 2005

Glucose-induced repression of PPAR gene expression in pancreatic -cells involves PP2A activation and AMPK inactivation

article

HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation

scientific article published on 16 July 2010

Hierarchical role for transcription factors and chromatin structure in genome organization along adipogenesis.

scientific article

High fat diet-induced changes of mouse hepatic transcription and enhancer activity can be reversed by subsequent weight loss

scientific article published on 10 January 2017

Highly interconnected enhancer communities control lineage-determining genes in human mesenchymal stem cells

scientific article published on 05 October 2020

Hypoxia-inducible lipid droplet-associated (HILPDA) is not a direct physiological regulator of lipolysis in adipose tissue.

scientific article

In memoriam: M. Daniel Lane, 1930-2014.

scientific article

Inflammation and insulin resistance induced by trans-10, cis-12 conjugated linoleic acid depend on intracellular calcium levels in primary cultures of human adipocytes

scientific article

Inhibition of 3T3-L1 adipocyte differentiation by expression of acyl-CoA-binding protein antisense RNA.

scientific article published on September 1998

Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver

article

Insulin-like growth factor-1/insulin bypasses Pref-1/FA1-mediated inhibition of adipocyte differentiation

scientific article published on 21 March 2003

Integrated analysis of motif activity and gene expression changes of transcription factors.

scientific article published on 12 December 2017

Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells

scientific article published on 17 August 2016

Interplay between regulatory elements and chromatin topology in cellular lineage determination

scientific article published in 2022

Isolation of nuclei from mouse white adipose tissues for single-nucleus genomics

scientific article published on 17 June 2021

Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes

scientific article

Lessons Learned from Systems Approaches to Metabolism

scholarly article by Susanne Mandrup published December 2015 in Trends in Endocrinology and Metabolism

Lighting the fat furnace without SFRP5

scientific article

Lipid-binding proteins modulate ligand-dependent trans-activation by peroxisome proliferator-activated receptors and localize to the nucleus as well as the cytoplasm.

scientific article

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

scientific article published in 2021

Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity

scientific article

Loss of TLE3 Promotes Mitochondrial Program in Beige Adipocytes and Improves Glucose Metabolism

Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism

scientific article published on 23 May 2019

Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection

article published in the Proceedings of the National Academy of Sciences of the United States of America

MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3

scientific article published on 30 June 2016

MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis

scientific article

Meeting report: nuclear receptors: transcription factors and drug targets connecting basic research with translational medicine

scientific article

Mice with targeted disruption of the acyl-CoA binding protein display attenuated urine concentrating ability and diminished renal aquaporin-3 abundance

scientific article published on 11 January 2012

Microaffinity Columns for Analysis of Protein–Protein Interactions

scientific article published in 1999

Modulating the Genomic Programming of Adipocytes.

scientific article published on 02 October 2015

Modulation of chromatin access during adipocyte differentiation

scientific article published in January 2012

Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation

scientific article published on 31 August 2010

Molecular architecture of transcription factor hotspots in early adipogenesis.

scientific article

Molecular basis for gene-specific transactivation by nuclear receptors

scientific article published on 28 December 2010

Multi-omics Analyses of Starvation Responses Reveal a Central Role for Lipoprotein Metabolism in Acute Starvation Survival in C. elegans

scientific article published on 12 July 2017

Neuroprotective effects of the gliopeptide ODN in an in vivo model of Parkinson's disease

scientific article published on 20 December 2017

Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) gamma2 gene expression in brown adipocytes: intracellular signalling and effects on PPARgamma2 and PPARgamma1 protein levels

scientific article published on September 2004

Nuclear phosphoproteome analysis of 3T3-L1 preadipocyte differentiation reveals system-wide phosphorylation of transcriptional regulators

scientific article published on 26 September 2016

Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation

scientific article published on April 2002

Obese gene expression at in vivo levels by fat pads derived from s.c. implanted 3T3-F442A preadipocytes

scientific article

Opposing effects of fatty acids and acyl-CoA esters on conformation and cofactor recruitment of peroxisome proliferator-activated receptors

scientific article

Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis.

scientific article

PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction

scientific journal article

PPARgamma in adipocyte differentiation and metabolism--novel insights from genome-wide studies

scientific article published on 11 June 2010

PPARs: fatty acid sensors controlling metabolism

scientific article published on 18 January 2012

PPARγ and the global map of adipogenesis and beyond

scientific article

Pancreatic beta-cell lipotoxicity induced by overexpression of hormone-sensitive lipase

scientific article published in August 2003

Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells

scientific article

Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells

scientific article

Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism

scientific article published on 12 November 2009

Peroxisome proliferator-activated receptor gamma regulates expression of the anti-lipolytic G-protein-coupled receptor 81 (GPR81/Gpr81).

scientific article

Peroxisome proliferator-activated receptor subtype- and cell-type-specific activation of genomic target genes upon adenoviral transgene delivery

scientific article published on August 2006

Peroxisome proliferator-activated receptor γ and C/EBPα synergistically activate key metabolic adipocyte genes by assisted loading

scientific article

Peroxisome proliferator-activated receptor-alpha is a functional target of p63 in adult human keratinocytes

scientific article

Polymorphisms in the tumor necrosis factor alpha and interleukin 1-beta promoters with possible gene regulatory functions increase the risk of preterm birth

article

RNA-Seq and Mass-Spectrometry-Based Lipidomics Reveal Extensive Changes of Glycerolipid Pathways in Brown Adipose Tissue in Response to Cold.

scientific article published on 24 November 2015

RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs

scientific article published on 13 February 2017

Regulating adipogenesis

scientific article published on February 1997

Regulatory elements in the promoter region of the rat gene encoding the acyl-CoA-binding protein

scientific article published on September 1996

Rexinoid bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR/LXR heterodimer in the liver

scientific article

Role of adipocyte lipid-binding protein (ALBP) and acyl-coA binding protein (ACBP) in PPAR-mediated transactivation

scientific article published on October 2002

SREBP-1 dimerization specificity maps to both the helix-loop-helix and leucine zipper domains: use of a dominant negative

scientific article published on 31 December 2003

Selection of LNA-containing DNA aptamers against recombinant human CD73.

scientific article published on May 2015

Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor γ

scientific article

SnapShot: Niche Determines Adipocyte Character I.

scientific article published in January 2018

SnapShot: Niche Determines Adipocyte Character II.

scientific article published in January 2018

Structure of the rat gene encoding the multifunctional acyl-CoA-binding protein: conservation of intron 1 sequences in rodents and man. Addendum

scientific article

Surfactant protein d deficiency in mice is associated with hyperphagia, altered fat deposition, insulin resistance, and increased basal endotoxemia

scientific article

TLE3 is a dual-function transcriptional coregulator of adipogenesis

scientific article published on April 2011

Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance.

scientific article

The Gliopeptide ODN, a Ligand for the Benzodiazepine Site of GABA<sub>A</sub> Receptors, Boosts Functional Recovery after Stroke

scientific article published on 01 July 2021

The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation

scientific article

The PPARgamma2 A/B-domain plays a gene-specific role in transactivation and cofactor recruitment

scientific article published on 12 March 2009

The acyl-CoA binding protein is required for normal epidermal barrier function in mice

scientific article

The adipogenic acetyltransferase Tip60 targets activation function 1 of peroxisome proliferator-activated receptor gamma

scientific article published on 20 December 2007

The gene encoding acyl-CoA-binding protein is subject to metabolic regulation by both sterol regulatory element-binding protein and peroxisome proliferator-activated receptor alpha in hepatocytes

scientific article published on 15 December 2004

The gene encoding the Acyl-CoA-binding protein is activated by peroxisome proliferator-activated receptor gamma through an intronic response element functionally conserved between humans and rodents

scientific journal article

The orphan nuclear receptor Rev-Erbalpha is a peroxisome proliferator-activated receptor (PPAR) gamma target gene and promotes PPARgamma-induced adipocyte differentiation

scientific article

The transcription factor encyclopedia

scientific article (publication date: 2012)

Time-Resolved Systems Medicine Reveals Viral Infection-Modulating Host Targets

scientific article published on 28 March 2019

Trans-10, cis-12 conjugated linoleic acid decreases de novo lipid synthesis in human adipocytes

scientific article

Transcription factor cooperativity in early adipogenic hotspots and super-enhancers.

scientific article

Transcriptional and epigenetic mechanisms underlying enhanced in vitro adipocyte differentiation by the brominated flame retardant BDE-47.

scientific article published on 11 March 2014

Transcriptional dynamics of hepatic sinusoid-associated cells after liver injury

scientific article published on 07 March 2020

Transcriptional networks and chromatin remodeling controlling adipogenesis

scientific article

Transcriptional networks controlling adipocyte differentiation

scientific article published on 06 September 2011

Transcriptional regulation of Hepatic Stellate Cell activation in NASH

scientific article published on 20 February 2019

iRNA-seq: computational method for genome-wide assessment of acute transcriptional regulation from total RNA-seq data

scientific article