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List of works by Mathieu Lupien

A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies

scientific article published on 17 January 2018

A chemical toolbox for the study of bromodomains and epigenetic signaling

scientific article published on 23 April 2019

A comprehensive view of nuclear receptor cancer cistromes

scientific article published on 22 September 2011

A global assessment of cancer genomic alterations in epigenetic mechanisms

scientific article published on 04 December 2014

ABC: a tool to identify SNVs causing allele-specific transcription factor binding from ChIP-Seq experiments

scientific article

Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer

scientific article published on July 2009

Antibodies against the PER protein of Drosophila label neurons in the optic lobe, central brain, and thoracic ganglia of the crickets Teleogryllus commodus and Teleogryllus oceanicus

scientific article

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors

scientific article

Biological and therapeutic implications of a unique subtype of NPM1 mutated AML

scientific article published on 16 February 2021

Blockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance.

scientific article published on 10 March 2016

Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression

scientific article

C3D: a tool to predict 3D genomic interactions between cis-regulatory elements

scientific article published on 01 March 2019

CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1.

scientific article published in January 2008

Cancer heterogeneity: origins and implications for genetic association studies

scientific article published on 31 July 2012

Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers

scientific article

Chromatin and epigenetic determinants of estrogen receptor alpha (ESR1) signaling.

scientific article published on 16 May 2013

Chromatin landscape and endocrine response in breast cancer.

scientific article published on December 2012

Chromatin profiling reveals regulatory network shifts and a protective role for hepatocyte nuclear factor 4α during colitis.

scientific article

Cistromics of hormone-dependent cancer

scientific article (publication date: June 2009)

Coactivator function defines the active estrogen receptor alpha cistrome

scientific article published on 13 April 2009

Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits

scientific article published on 6 November 2013

Combining chromatin immunoprecipitation and oligonucleotide tiling arrays (ChIP-Chip) for functional genomic studies

scientific article published in January 2009

Dual suppression of the cyclin-dependent kinase inhibitors CDKN2C and CDKN1A in human melanoma.

scientific article

Early-life antibiotic treatment enhances the pathogenicity of CD4+ T cells during intestinal inflammation.

scientific article

Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery

scientific article

Emergence of the Noncoding Cancer Genome: A Target of Genetic and Epigenetic Alterations

scientific article published on 19 October 2016

Enhancer alterations in cancer: a source for a cell identity crisis

scientific article

Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers

scientific article

Epigenetic switch-induced viral mimicry evasion in chemotherapy resistant breast cancer

scientific article published on 16 June 2020

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

scientific article

Epigenomic enhancer profiling defines a signature of colon cancer

scientific article

Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway

scientific article published on 24 February 2014

Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer

scientific article

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

scientific article

Exploiting tumor epigenetics to improve oncolytic virotherapy

scientific article published in 2013

Expression of constitutively active Notch1 in male genital tracts results in ectopic growth and blockage of efferent ducts, epididymal hyperplasia and sterility.

scientific article published on 14 September 2006

FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription

scientific article

GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer

scientific article published on 21 August 2020

Genomic collaboration of estrogen receptor alpha and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs

scientific article

Genomic hallmarks of localized, non-indolent prostate cancer.

scientific article published on 9 January 2017

Growth factor stimulation induces a distinct ER(alpha) cistrome underlying breast cancer endocrine resistance

scientific article

Human somatic cell mutagenesis creates genetically tractable sarcomas

scientific article published on 17 August 2014

Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation

scientific article

Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites

scientific article

Identifying clusters of cis-regulatory elements underpinning TAD structures and lineage-specific regulatory networks

scientific article published on 18 September 2019

Inferring Human Phenotype Networks from Genome-Wide Genetic Associations

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

scientific article

Integrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q24.3 prostate cancer risk locus

scientific article published on 4 June 2012

Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer.

scientific article published on 24 July 2014

Layers of epistasis: genome-wide regulatory networks and network approaches to genome-wide association studies

scientific article published on 31 December 2010

Laying a solid foundation for Manhattan--'setting the functional basis for the post-GWAS era'.

scientific article

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin

scientific article published on 25 November 2015

Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation

scientific article published on 25 March 2014

Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer.

scientific article published on 15 August 2016

Molecular Insights of Pathways Resulting from Two Common PIK3CA Mutations in Breast Cancer

scientific article published on 25 April 2016

Multimodal regulation of E2F1 gene expression by progestins

scientific article

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.

scientific article published on 9 July 2016

Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer

scientific article published on 23 January 2020

Noncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer.

scientific article published on 29 August 2016

Nucleosome dynamics define transcriptional enhancers

scientific article

PBX1 genomic pioneer function drives ERα signaling underlying progression in breast cancer.

scientific article

PRMT5 inhibition disrupts splicing and stemness in glioblastoma

scientific article published on 12 February 2021

PRMT5 regulates ATF4 transcript splicing and oxidative stress response

scientific article published on 11 March 2022

PRMT5 regulates ATF4 transcript splicing and oxidative stress response

preprint

Personalized diagnosis of medulloblastoma subtypes across patients and model systems

scientific article published on 12 May 2015

PharmacoGx: an R package for analysis of large pharmacogenomic datasets.

scientific article published on 9 December 2015

Pioneer factors: directing transcriptional regulators within the chromatin environment ⬇️

scientific article published on August 30, 2011

Pioneer of prostate cancer: past, present and the future of FOXA1

scientific article published on 18 September 2020

Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer

scientific article

Pre-neoplastic epigenetic disruption of transcriptional enhancers in chronic inflammation.

scientific article published on 19 February 2016

Raloxifene and ICI182,780 increase estrogen receptor-alpha association with a nuclear compartment via overlapping sets of hydrophobic amino acids in activation function 2 helix 12.

scientific article published on 13 February 2007

SMuRF: a novel tool to identify regulatory elements enriched for somatic point mutations

scholarly article by Paul Guilhamon published in November 2018

Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival

scientific article published in 2021

TMPRSS2-ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer.

scientific article published on 07 August 2017

Tamoxifen and raloxifene differ in their functional interactions with aspartate 351 of estrogen receptor alpha

scientific article published on 5 May 2006

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

scientific article published on 29 March 2019

Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment

scientific article published on 16 April 2020

The Transcriptional Repressor Polycomb Group Factor 6, PCGF6, Negatively Regulates Dendritic Cell Activation and Promotes Quiescence.

scientific article published on 3 August 2016

The histone variant H2A.Z is an important regulator of enhancer activity

scientific article

Transcriptome-wide characterization of the endogenous miR-34A-p53 tumor suppressor network

scientific article published on 6 July 2016

Unique ERalpha cistromes control cell type-specific gene regulation

scientific article published on 25 September 2008

Variant Set Enrichment: an R package to identify disease-associated functional genomic regions.

scientific article published on 22 February 2017

ZNF143 provides sequence specificity to secure chromatin interactions at gene promoters

scientific article published on 3 February 2015

[Colorectal cancer is typified by enhancer specific epigenetic mutations]

scientific article published on 12 November 2012

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