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List of works by Zaklina Kovacevic

A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity

scientific article published on 19 November 2016

Chelators to the Rescue: Different Horses for Different Courses!

scientific article published on 07 January 2011

Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.

scientific article published on 23 June 2016

Expanding horizons in iron chelation and the treatment of cancer: role of iron in the regulation of ER stress and the epithelial-mesenchymal transition.

scientific article published on 25 January 2014

Exploiting Cancer Metal Metabolism using Anti-Cancer Metal-Binding Agents.

scientific article

Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia

scientific article published on June 2016

Identification of differential phosphorylation and sub-cellular localization of the metastasis suppressor, NDRG1.

scientific article published on 18 April 2018

Investigating the anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones

scientific article published on 19 February 2010

Investigating the spectrum of biological activity of ring-substituted salicylanilides and carbamoylphenylcarbamates.

scientific article published on 10 November 2010

Iron chelation: deciphering novel molecular targets for cancer therapy. The tip of the iceberg of a web of iron-regulated molecules

scientific article published on December 2011

Iron chelation: inhibition of key signaling pathways in the induction of the epithelial mesenchymal transition in pancreatic cancer and other tumors

scientific article published on January 2013

Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT).

scientific article published on 18 April 2016

Making a case for albumin – a highly promising drug-delivery system.

scientific article published in January 2015

Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase

scientific article published on 05 April 2016

Metals and metastasis: Exploiting the role of metals in cancer metastasis to develop novel anti-metastatic agents.

scientific article published on 7 December 2016

Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy.

scientific article

N-myc downstream regulated 1 (NDRG1) is regulated by eukaryotic initiation factor 3a (eIF3a) during cellular stress caused by iron depletion.

scientific article

Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization

scientific article published on 8 December 2015

Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial-Mesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1)

scientific article published on 8 March 2017

Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6-induced activation by iron depletion

scientific article

Overcoming tamoxifen resistance in oestrogen receptor-positive breast cancer using the novel thiosemicarbazone anti-cancer agent, DpC

scientific article published on 23 January 2020

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

scientific article published on February 2016

Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1.

scientific article published on 17 February 2017

Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling

scientific article published on February 2016

Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy

scientific article

Synthesis, Characterization, and in Vitro Anticancer Activity of Copper and Zinc Bis(Thiosemicarbazone) Complexes

scientific article published on 24 July 2019

Targeting Iron in Cancer Cells: A New Strategy to Inhibit Metastatic Progression

Targeting autophagy in antitumor agent design: furthering the 'lysosomal love' strategy.

scientific article published on 5 May 2016

Targeting cancer by binding iron: Dissecting cellular signaling pathways

scientific article

The Iron Chelators Dp44mT and DFO Inhibit TGF-β-induced Epithelial-Mesenchymal Transition via Up-Regulation of N-Myc Downstream-regulated Gene 1 (NDRG1) ⬇️

scientific article published on March 27, 2012

The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways

scientific article

The TGF-beta, PI3K/Akt and PTEN pathways: established and proposed biochemical integration in prostate cancer

scientific article published on January 2009

The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action

scientific article

The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and Ras signaling pathways

scientific article

The iron-regulated metastasis suppressor, Ndrg-1: identification of novel molecular targets

scientific article

The medicinal chemistry of novel iron chelators for the treatment of cancer.

scientific article published on January 2011

The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), upregulates p21 via p53-independent mechanisms.

scientific article published on 11 March 2011

The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells.

scientific article published on 15 February 2014

The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms.

scientific article published on 27 September 2016

The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.

scientific article published in April 2015

The redox-active, anti-cancer drug Dp44mT inhibits T-cell activation and CD25 through a copper-dependent mechanism.

scientific article published on 19 February 2013

The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones.

scientific article published on 26 August 2015

The role of NDRG1 in the pathology and potential treatment of human cancers

scientific article published on 08 June 2013

Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.

scientific article published on September 2009

Tuning cell cycle regulation with an iron key.

scientific article

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