List of works - Sabrina Castellano

5-aryl-imidazo[2,1-c][1,4]benzodiazepine derivatives as tricyclic constrained analogues of diazepam and Ro5-4864. Synthesis and binding properties at peripheral and central benzodiazepine receptors.

scientific article published in June 2006

6-alkylthio-4-[1-(2,6-difluorophenyl)alkyl]-1H-[1,3,5]triazin-2-ones (ADATs): novel regulators of cell differentiation and proliferation

scientific article published on October 2006

A chemoenzymatic approach to the synthesis of the stereoisomers of a β-adrenergic receptor antagonist

A new class of antifungal agents. Synthesis and antimycotic activity of disubstituted N-azolylamines

scientific article published in September 2000

A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach.

scientific article

A practical, green, and selective approach toward the synthesis of pharmacologically important quinone-containing heterocyclic systems using alumina-catalyzed Michael addition reaction

article

A regioselective approach toward the synthesis of pharmacologically important quinone-containing heterocyclic systems

scholarly article by Sabrina Castellano et al published December 2009 in Tetrahedron Letters

Antifungal activity of azole compounds CPA18 and CPA109 against azole-susceptible and -resistant strains of Candida albicans

scientific article published on 04 January 2013

Antimycobacterial activity of ionic fullerene derivatives

scientific article published in May 2000

Azole antifungal agents related to naftifine and butenafine.

scientific article published in June 2000

CARM1 modulators affect epigenome of stem cells and change morphology of nucleoli.

scientific article published on 5 June 2015

CYP19 (aromatase): Exploring the scaffold flexibility for novel selective inhibitors

scientific article published in September 2008

Chemical biology of histone acetyltransferase natural compounds modulators

scientific article published on January 2011

Constrained analogues of procaine as novel small molecule inhibitors of DNA methyltransferase-1.

scientific article

Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1).

scientific article published in March 2010

Diversity through a branched reaction pathway: generation of multicyclic scaffolds and identification of antimigratory agents.

scientific article

Effects of azole treatments on the physical properties of Candida albicans plasma membrane: a spin probe EPR study

scientific article published on 31 October 2013

Enhancement of lysine acetylation accelerates wound repair

scientific article published on 02 July 2013

Highly efficient synthesis and chemical separation of 5-amino- and 7-amino-4-hydroxy-2-naphthoic acids

Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees.

scientific article

Identification of 4-hydroxyquinolines inhibitors of p300/CBP histone acetyltransferases

scientific article published on 30 December 2008

Identification of Limonol Derivatives as Heat Shock Protein 90 (Hsp90) Inhibitors through a Multidisciplinary Approach

scientific article

Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells

scientific article

Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases.

scientific article published on 11 April 2008

Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1.

scientific article

Identification of structural features of 2-alkylidene-1,3-dicarbonyl derivatives that induce inhibition and/or activation of histone acetyltransferases KAT3B/p300 and KAT2B/PCAF.

scientific article

Interaction of azole compounds with DOPC and DOPC/ergosterol bilayers by spin probe EPR spectroscopy: implications for antifungal activity

scientific article

Luminometric sub-nanoliter droplet-to-droplet array (LUMDA) and its application to drug screening by phase I metabolism enzymes.

scientific article published on 6 November 2012

Modulation of cell differentiation, proliferation, and tumor growth by dihydrobenzyloxopyrimidine non-nucleoside reverse transcriptase inhibitors

scientific article published on 22 July 2011

Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs).

scientific article published on 14 January 2011

New structural analogues of Tubulozole induce apoptosis, [Ca2+]i modifications and cytoskeletal disorganization in glial (GL15) and neuronal-like (PC12) cell lines

scientific article

Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies

scientific article published on 01 December 2019

Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity

scientific article published on 13 June 2011

Nε-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart

scientific article

P300/CBP associated factor regulates nitroglycerin-dependent arterial relaxation by N(ε)-lysine acetylation of contractile proteins

scientific journal article

Progress in the Development of Lysine Methyltransferase SETD8 Inhibitors.

scientific article

Quinoline-Based p300 Histone Acetyltransferase Inhibitors with Pro-apoptotic Activity in Human Leukemia U937 Cells

scientific article published on 06 February 2014

Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations

scientific article

Small-molecule inhibitors of protein geranylgeranyltransferase type I.

scientific article published on 17 April 2007

Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors

scientific article published on 17 March 2014

Synthesis and antifungal properties of N-[(1,1'-biphenyl)-4-ylmethyl]-1H-imidazol-1-amine derivatives

scientific article published on December 2002

Synthesis and antimicrobial properties of 3-aryl-1-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-yl)propanes as 'carba-analogues' of the N-arylmethyl-N-[(1,1'-biphenyl)-4-ylmethyl])-1H-imidazol-1-amines, a new class of antifungal agents

scientific article published in August 2003

Synthesis and biochemical evaluation of δ(2)-isoxazoline derivatives as DNA methyltransferase 1 inhibitors

scientific article published on 7 October 2011

Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein

scientific article

Synthesis and evaluation of translocator 18 kDa protein (TSPO) positron emission tomography (PET) radioligands with low binding sensitivity to human single nucleotide polymorphism rs6971.

scientific article

Synthesis of 11-aryl-5H-imidazo[2,1-c][1,4]benzodiazepines and their benzodiazepine and A1 adenosine binding activity

scientific article published in October 2001

Synthesis of 3-aryl/benzyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole derivatives: a comparison between conventional, microwave-assisted and flow-based methodologies

scientific article published on November 2010

The Histone Acetylase Activator Pentadecylidenemalonate 1b Rescues Proliferation and Differentiation in the Human Cardiac Mesenchymal Cells of Type 2 Diabetic Patients

scientific article published on 23 January 2014

Unprecedented synthesis of a novel amino quinone ring system via oxidative decarboxylation of quinone-based alpha,alpha-amino esters

scientific article published on 8 December 2009

p300/CBP-associated factor selectively regulates the extinction of conditioned fear

scientific article

List of works by Sabrina Castellano

5-aryl-imidazo[2,1-c][1,4]benzodiazepine derivatives as tricyclic constrained analogues of diazepam and Ro5-4864. Synthesis and binding properties at peripheral and central benzodiazepine receptors.

6-alkylthio-4-[1-(2,6-difluorophenyl)alkyl]-1H-[1,3,5]triazin-2-ones (ADATs): novel regulators of cell differentiation and proliferation

A chemoenzymatic approach to the synthesis of the stereoisomers of a β-adrenergic receptor antagonist

A new class of antifungal agents. Synthesis and antimycotic activity of disubstituted N-azolylamines

A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach.

A practical, green, and selective approach toward the synthesis of pharmacologically important quinone-containing heterocyclic systems using alumina-catalyzed Michael addition reaction

A regioselective approach toward the synthesis of pharmacologically important quinone-containing heterocyclic systems

Antifungal activity of azole compounds CPA18 and CPA109 against azole-susceptible and -resistant strains of Candida albicans

Antimycobacterial activity of ionic fullerene derivatives

Azole antifungal agents related to naftifine and butenafine.

CARM1 modulators affect epigenome of stem cells and change morphology of nucleoli.

CYP19 (aromatase): Exploring the scaffold flexibility for novel selective inhibitors

Chemical biology of histone acetyltransferase natural compounds modulators

Constrained analogues of procaine as novel small molecule inhibitors of DNA methyltransferase-1.

Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1).

Diversity through a branched reaction pathway: generation of multicyclic scaffolds and identification of antimigratory agents.

Effects of azole treatments on the physical properties of Candida albicans plasma membrane: a spin probe EPR study

Enhancement of lysine acetylation accelerates wound repair

Highly efficient synthesis and chemical separation of 5-amino- and 7-amino-4-hydroxy-2-naphthoic acids

Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees.

Identification of 4-hydroxyquinolines inhibitors of p300/CBP histone acetyltransferases

Identification of Limonol Derivatives as Heat Shock Protein 90 (Hsp90) Inhibitors through a Multidisciplinary Approach

Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells

Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases.

Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1.

Identification of structural features of 2-alkylidene-1,3-dicarbonyl derivatives that induce inhibition and/or activation of histone acetyltransferases KAT3B/p300 and KAT2B/PCAF.

Interaction of azole compounds with DOPC and DOPC/ergosterol bilayers by spin probe EPR spectroscopy: implications for antifungal activity

Luminometric sub-nanoliter droplet-to-droplet array (LUMDA) and its application to drug screening by phase I metabolism enzymes.

Modulation of cell differentiation, proliferation, and tumor growth by dihydrobenzyloxopyrimidine non-nucleoside reverse transcriptase inhibitors

Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs).

New structural analogues of Tubulozole induce apoptosis, [Ca2+]i modifications and cytoskeletal disorganization in glial (GL15) and neuronal-like (PC12) cell lines

Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies

Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity

Nε-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart

P300/CBP associated factor regulates nitroglycerin-dependent arterial relaxation by N(ε)-lysine acetylation of contractile proteins

Progress in the Development of Lysine Methyltransferase SETD8 Inhibitors.

Quinoline-Based p300 Histone Acetyltransferase Inhibitors with Pro-apoptotic Activity in Human Leukemia U937 Cells

Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations

Small-molecule inhibitors of protein geranylgeranyltransferase type I.

Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors

Synthesis and antifungal properties of N-[(1,1'-biphenyl)-4-ylmethyl]-1H-imidazol-1-amine derivatives

Synthesis and antimicrobial properties of 3-aryl-1-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-yl)propanes as 'carba-analogues' of the N-arylmethyl-N-[(1,1'-biphenyl)-4-ylmethyl])-1H-imidazol-1-amines, a new class of antifungal agents

Synthesis and biochemical evaluation of δ(2)-isoxazoline derivatives as DNA methyltransferase 1 inhibitors

Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein

Synthesis and evaluation of translocator 18 kDa protein (TSPO) positron emission tomography (PET) radioligands with low binding sensitivity to human single nucleotide polymorphism rs6971.

Synthesis of 11-aryl-5H-imidazo[2,1-c][1,4]benzodiazepines and their benzodiazepine and A1 adenosine binding activity

Synthesis of 3-aryl/benzyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole derivatives: a comparison between conventional, microwave-assisted and flow-based methodologies

The Histone Acetylase Activator Pentadecylidenemalonate 1b Rescues Proliferation and Differentiation in the Human Cardiac Mesenchymal Cells of Type 2 Diabetic Patients

Unprecedented synthesis of a novel amino quinone ring system via oxidative decarboxylation of quinone-based alpha,alpha-amino esters

p300/CBP-associated factor selectively regulates the extinction of conditioned fear