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List of works by Chris R Triggle

2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist

scientific article published on 19 February 2004

A comparative study of endothelin and sarafotoxin action in vascular and non-vascular smooth muscle

scientific article published on 01 January 1991

A comparison of the effects of acute versus chronic administration of phenoxybenzamine on pressor responses elicited by the selective alpha 1-adrenoceptor agonist cirazoline in the pithed rat preparation

scientific article published in June 1992

A nonthiazolidinedione peroxisome proliferator-activated receptor gamma agonist reverses endothelial dysfunction in diabetic (db/db-/-) mice

scientific article

A photosensitive vascular smooth muscle store of nitric oxide in mouse aorta: no dependence on expression of endothelial nitric oxide synthase

scientific article published on March 2003

A review of changes in vascular smooth muscle functions in hypertension: isolated tissue versus in vivo studies.

scientific article

A review of endothelial dysfunction in diabetes: a focus on the contribution of a dysfunctional eNOS.

scientific article published on May 2010

A role for nitroxyl (HNO) as an endothelium-derived relaxing and hyperpolarizing factor in resistance arteries.

scientific article published on 26 March 2009

Acetylcholine relaxes the human umbilical artery by an endothelium-independent but ouabain and tetraethylammonium-sensitive process

scientific article published on 01 January 1994

Acetylcholine-induced relaxation of peripheral arteries isolated from mice lacking endothelial nitric oxide synthase

scientific article published on October 1999

Actions of L- and D-arginine and NG-monomethyl-L-arginine on the blood pressure of pithed normotensive and spontaneously hypertensive rats

scientific article published on 01 January 1992

Alpha adrenoceptor sites in vascular smooth muscle. Differentiation by selective antagonist binding

scientific article published on 01 November 1988

Alpha-adrenoceptor activation of polyphosphoinositide hydrolysis in the rat tail artery

scientific article published in December 1990

Alpha-mediated vasoconstriction: transmembrane signalling and receptor reclassification

scientific article published on 01 January 1992

An analysis of the action of lanthanum on aortic tissue from normotensive and spontaneously hypertensive rats

scientific article published on October 1977

Antihypertensive properties of a nitric oxide-releasing naproxen derivative in two-kidney, one-clip rats

scientific article published on 01 August 2000

Are we over oxidized? Oxidative stress, cardiovascular disease, and the future of intervention studies with antioxidants

scientific article

Benextramine and nifedipine distinguish between sub-classes of alpha 1-adrenoceptors

scientific article published on 01 January 1989

Blood pressure, lanthanum-, and norepinephrine-induced mechanical response in thoracic aortic tissue.

scientific article

Calcium antagonizes the magnesium-induced high affinity state of the hepatic vasopressin receptor for the agonist interaction

scientific article published on May 1990

Calcium-activated potassium channel and connexin expression in small mesenteric arteries from eNOS-deficient (eNOS-/-) and eNOS-expressing (eNOS+/+) mice

scientific article published on 19 January 2007

Can dihydropyridines enhance photorelaxation of smooth muscle by calcium-independent mechanisms?

scientific article published on 01 January 1990

Cardiac hypertrophy in experimental hypertension: interaction of the sodium ion, blood pressure and lisinopril.

scientific article

Cardiac regression and blood pressure control in the Dahl rat treated with either enalapril maleate (MK 421, an angiotensin converting enzyme inhibitor) or hydrochlorothiazide.

scientific article

Cardiovascular effects of CPU-23, a novel L-type calcium channel blocker with a unique molecular structure.

scientific article published in December 1997

Catalase has negligible inhibitory effects on endothelium-dependent relaxations in mouse isolated aorta and small mesenteric artery

scientific article published on 3 November 2003

Challenges in the Biomedical Research Enterprise in the 21st century: Antecedents in the writings of David Triggle

scientific article published on 13 August 2015

Changes in vascular smooth muscle function in hypertension

scientific article published on 01 April 1993

Characterization of a specific, high affinity [3H]arginine8 vasopressin-binding site on liver microsomes from different strains of rat and the role of magnesium

scientific article published on 01 March 1986

Chloride removal and excitation-contraction coupling in guinea pig ileal smooth muscle

scientific article (publication date: December 1986)

Chloride removal selectively inhibits phasic contractions of guinea pig ileal longitudinal smooth muscle.

scientific article published on December 1982

Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice

scientific article published on October 2003

Cocaine-induced supersensitivity in the human umbilical artery

scientific article

Comparative behavioral, neurochemical and pharmacological activities of dihydropyridine calcium channel activating drugs.

scientific article published on June 1990

Comparative effects of the K+ channel openers, pinacidil and cromakalim on vascular tone: sensitivity to glyburide and calcium

scientific article published on 01 January 1992

Comparative studies with enantiomers of dihydropyridine ligands suggests that there are multiple binding sites associated with the calcium channel

scientific article published in January 1990

Comparison between the vasoactive actions of endothelin and arginine vasopressin in pithed rats after pretreatment with BAY K 8644, nifedipine or pertussis toxin

scientific article published in April 1990

Comparison of the pharmacological properties of EDHF-mediated vasorelaxation in guinea-pig cerebral and mesenteric resistance vessels

scientific article published in August 2000

Competitive binding experiments reveal differential interactions for dihydropyridine calcium channel activators and antagonists at dihydropyridine receptors on mouse brain membranes

scientific article

Cyclic GMP-dependent and cyclic GMP-independent actions of nitric oxide on the renal afferent arteriole

scientific article published on October 1998

Cytochrome P450 products and arachidonic acid-induced, non-store-operated, Ca2+ entry in cultured bovine endothelial cells

scientific article

Defying the economists: a decrease in heart rate improves not only cardiac but also endothelial function

scientific article published on 28 April 2008

Differential sensitivity of Dahl salt-sensitive and Dahl salt-resistant rats to the hypotensive action of acute nifedipine administration

scientific article published on 01 February 1984

Dual endothelium-dependent vascular activities of proteinase-activated receptor-2-activating peptides: evidence for receptor heterogeneity.

scientific article

Effects of Staurosporine on the Pressor Responses to Alpha-Adrenoceptor Agonists in Pithed Rats: A Comparison with Nifedipine ⬇️

scientific article published on January 1, 1991

Effects of a Western diet versus high glucose on endothelium-dependent relaxation in murine micro- and macro-vasculature

scientific article

Effects of cold storage on relaxation responses in the rat oesophageal tunica muscularis mucosae

scientific article

Effects of nifedipine, BAY K 8644, and pertussis toxin on pressor response to sarafotoxin-b in pithed rats

scientific article published in September 1990

Effects of noradrenaline, serotonin, and selected antagonists on the vascular smooth muscle of normal and dystrophic chickens

scientific article published on May 1986

Effects of oxidative and thermal stresses on stress granule formation in human induced pluripotent stem cells.

scientific article

Effects of pertussis and cholera toxins on alpha-adrenoceptor function in rat tail artery: differences in hypertension.

scientific article

Effects of some inorganic divalent cations and protein kinase C inhibitors on endothelium-dependent relaxation in rat isolated aorta and mesenteric arteries

scientific article published on 01 October 1991

Elevated vascular reactivity in the timolol-treated spontaneously hypertensive rat.

scientific article

Endothelial cell dysfunction and the vascular complications associated with type 2 diabetes: assessing the health of the endothelium

scientific article (publication date: 2005)

Endothelial dysfunction in Type 2 diabetes correlates with deregulated expression of the tail-anchored membrane protein SLMAP.

scientific article

Endothelial dysfunction in the streptozotocin-induced diabetic apoE-deficient mouse

scientific article published on December 2005

Endothelin blockade potentiates endothelial protective effects of ACE inhibitors in saphenous veins

scientific article

Endothelin receptor blockade improves endothelial function in human internal mammary arteries

scientific article published in January 2001

Endothelium-dependent contractile actions of proteinase-activated receptor-2-activating peptides in human umbilical vein: release of a contracting factor via a novel receptor

scientific article published on December 1998

Endothelium-dependent contractile effect of trypsin-activated receptor (PAR2) stimulation in rat vascular tissue

scientific article published on 01 January 1997

Endothelium-dependent hyperpolarization of vascular smooth muscle: role for a non-nitric oxide synthase product.

scientific article

Endothelium-dependent vasodilation in myogenically active mouse skeletal muscle arterioles: role of EDH and K(+) channels.

scientific article published on 7 May 2009

Endothelium-derived hyperpolarizing factor(s): species and tissue heterogeneity

scientific article published in February 1999

Endothelium-derived hyperpolarizing factor: is there a novel chemical mediator?

scientific article

Endothelium-derived reactive oxygen species: their relationship to endothelium-dependent hyperpolarization and vascular tone.

scientific article published on November 2003

Endothelium-independent relaxations to acetylcholine and A23187 in the human umbilical artery

scientific article published in March 1994

Enhanced vascular reactivity of small mesenteric arteries from diabetic mice is associated with enhanced oxidative stress and cyclooxygenase products

scientific article published on April 2005

Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues

scientific article published on 01 March 2019

FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting

scientific article published on 14 July 2014

Functional characterization and m-RNA expression of 5-HT receptors mediating contraction in human umbilical artery

scientific article

Fura-2 used as a probe to show elevated intracellular free calcium in platelets of Dahl-sensitive rats fed a high salt diet.

scientific article

Hepatic vasopressin receptor: differential effects of divalent cations, guanine nucleotides, and N-ethylmaleimide on agonist and antagonist interactions with the V1 subtype receptor

scientific article published on 01 August 1988

Hyperglycaemia disrupts conducted vasodilation in the resistance vasculature of db/db mice.

scientific article published on 12 January 2018

Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress

scientific article published on 13 June 2018

Hyperpolarization of murine small caliber mesenteric arteries by activation of endothelial proteinase-activated receptor 2.

scientific article published in December 2004

Hypertensive mechanisms: the role of altered smooth muscle and membrane function in the etiology of hypertension

Impact of currently used anti-diabetic drugs on myoendothelial communication

scientific article published on 28 November 2018

Increased oxidative stress in the streptozotocin-induced diabetic apoE-deficient mouse: changes in expression of NADPH oxidase subunits and eNOS

scientific article published on 20 January 2007

Influence of N omega-nitro-L-arginine methyl on pressor responses elicited by sympathetic nerve stimulation in pithed normotensive and hypertensive rats

scientific article published on 01 January 1991

Inhibition of field stimulation-evoked relaxations in rat oesophageal smooth muscle by the calcium antagonist PN 200-110

scientific article

Interactions of nitric oxide synthase inhibitors and dexamethasone with alpha-adrenoceptor-mediated responses in rat aorta

scientific article published on June 1993

Interleukin-1beta, tumor necrosis factor-alpha, and LPS enhance calcium channel current in isolated vascular smooth muscle cells of rat tail artery

scientific article published on 01 May 1996

Involvement of nitrosothiols, nitric oxide and voltage-gated K+ channels in photorelaxation of vascular smooth muscle

scientific article published in April 1998

Lack of involvement of endothelin-1 in angiotensin II-induced contraction of the isolated rat tail artery

scientific article published in November 2000

Lipids as endogenous Na,K-ATPase inhibitors in plasma of healthy individuals and in dialysis dependent patients

scientific article published on 01 August 1989

Mechanism of bile salt vasoactivity: dependence on calcium channels in vascular smooth muscle

scientific article published on August 1994

Mechanism of vascular smooth muscle contraction by sodium fluoride in the isolated aorta of rat and rabbit

scientific article published on 01 July 1991

Membrane fractionation of canine aortic smooth muscle: Subcellular distribution of calcium transport activity ⬇️

scientific article published on August 1, 1984

Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1.

scientific article published on January 2014

Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death.

scientific article published on 5 March 2017

Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium

scientific article

Metformin: The Answer to Cancer in a Flower? Current Knowledge and Future Prospects of Metformin as an Anti-Cancer Agent in Breast Cancer

scientific article published on 09 December 2019

Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes

scientific article published on 23 January 2019

Modulation of right and left ventricular wall thicknesses in experimental hypertension.

scientific article

Molecular Interplay between microRNA-34a and Sirtuin1 in Hyperglycemia-Mediated Impaired Angiogenesis in Endothelial Cells: Effects of Metformin

scientific article published on 18 November 2015

Morphometric study of mesenteric arteries from genetically hypertensive Dahl strain rats

scientific article published in January 1986

Multiple mechanisms of vascular smooth muscle relaxation by the activation of proteinase-activated receptor 2 in mouse mesenteric arterioles

scientific article

NO and the vasculature: where does it come from and what does it do?

scientific article

NO/PGI2-independent vasorelaxation and the cytochrome P450 pathway in rabbit carotid artery.

scientific article

Nature of norepinephrine-sensitive Ca-pool in rabbit aortic smooth muscle: effect of pH.

scientific article published on April 1983

Nitric oxide and sodium nitroprusside-induced relaxation of the human umbilical artery

scientific article published in October 2000

Nitric oxide, a possible mediator of 1,4-dihydropyridine-induced photorelaxation of vascular smooth muscle

scientific article published on June 1996

Nitrosothiol stores in vascular tissue: modulation by ultraviolet light, acetylcholine and ionomycin

scientific article

Novel endothelium-derived relaxing factors. Identification of factors and cellular targets.

scientific article

Novel role for K+-dependent Na+/Ca2+ exchangers in regulation of cytoplasmic free Ca2+ and contractility in arterial smooth muscle

scientific journal article

On the oxalate stimulation of ATP-dependent calcium accumulation by smooth muscle subcellular membranes.

scientific article published on June 1983

Oxidative stress and increased eNOS and NADPH oxidase expression in mouse microvessel endothelial cells

scientific article published on 01 September 2007

Perivascular adipose tissue-derived relaxing factors: release by peptide agonists via proteinase-activated receptor-2 (PAR2) and non-PAR2 mechanisms.

scientific article published on December 2011

Pharmacological characteristics of endothelium-derived hyperpolarizing factor-mediated relaxation of small mesenteric arteries from db/db mice

scientific article published on 12 September 2006

Pharmacological characterization of the postsynaptic alpha adrenoceptors in vascular smooth muscle from canine and rat mesenteric vascular beds.

scientific article published on June 1984

Pharmacological profile of the 5-hydroxytryptamine receptor that mediates relaxation of rat oesophageal smooth muscle

scientific article published on 01 July 1992

Pharmacological properties of acetylcholine mediated relaxation of the human umbilical artery

scientific article published on 01 January 1992

Pharmacological properties of mechanical responses of the rat oesophageal muscularis mucosae to vagal and field stimulation

scientific article published on January 1985

Pharmacological studies of smooth muscle from Dahl salt-sensitive and salt-resistant rats

scientific article published in January 1984

Photosensitization of oesophageal smooth muscle by 3-NO2-1, 4-dihydropyridines: evidence for two cyclic GMP-dependent effector pathways

scientific article

Potassium- and acetylcholine-induced vasorelaxation in mice lacking endothelial nitric oxide synthase

scientific article published on March 2000

Potent and PPARα-independent anti-proliferative action of the hypolipidemic drug fenofibrate in VEGF-dependent angiosarcomas in vitro

scientific article published on 19 April 2019

Pressor actions of arginine vasopressin in pithed Sprague-Dawley, Wistar-Kyoto and spontaneously hypertensive rats before and after treatment with nifedipine or pertussis toxin

scientific article (publication date: September 1991)

Pressor responses to the alpha 1-adrenoceptor agonist cirazoline: effects of captopril, phenoxybenzamine and nifedipine

scientific article published on 01 January 1994

Prevention of hypertension and vascular changes by captopril treatment

scientific article published in February 1991

Proteinase-activated receptor-2 (PAR2): vascular effects of a PAR2-derived activating peptide via a receptor different than PAR2.

scientific article published in December 2002

Proteinase-activated receptors 1 and 2 and the regulation of porcine coronary artery contractility: a role for distinct tyrosine kinase pathways

scientific article published on May 2014

Quantitation of nitric oxide by a computerized chemiluminescence detector measurement of photolytic degradation of streptozotocin and sodium nitroprusside to release nitric oxide

scientific article published on 01 January 1993

Reduced EDHF responses and connexin activity in mesenteric arteries from the insulin-resistant obese Zucker rat.

scientific article published on 7 March 2008

Regression of left ventricular hypertrophy and control of hypertension in the spontaneously hypertensive rat (SHR): oxprenolol versus hydrochlorothiazide

scientific article published on 01 January 1983

Role of NO in vascular smooth muscle and cardiac muscle function

scientific article published on 01 July 1994

Role of guanylate cyclase activation in the smooth muscle actions of dihydropyridines

scientific article published on 01 January 1992

Roles of calcium-activated and voltage-gated delayed rectifier potassium channels in endothelium-dependent vasorelaxation of the rabbit middle cerebral artery

scientific article published in March 1998

Similarity of relaxations evoked by BRL 34915, pinacidil and field-stimulation in rat oesophageal tunica muscularis mucosae

scientific article published on October 1988

Some properties of noradrenaline uptake in non-innervated vascular smooth muscle

scientific article published in June 1974

Specific high affinity binding of the calcium channel antagonist, [3H]nitrendipine, to rat liver microsomes

scientific article published on 01 September 1984

State-dependent block of rabbit vascular smooth muscle delayed rectifier and Kv1.5 channels by inhibitors of cytochrome P450-dependent enzymes

scientific article published in August 2001

Structural and functional consequence of neonatal sympathectomy on the blood vessels of spontaneously hypertensive rats.

scientific article

Studies of the desensitization of atrial natriuretic factor and nitroglycerin in rat aortic rings

scientific article published on 01 January 1990

Synthesis and calcium channel antagonist activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-(pyridinyl)-3,5-pyridinedicarboxylates.

scientific article

Synthesis and calcium channel antagonist activity of dialkyl 4- (dihydropyridinyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylates

scientific article

Synthesis and calcium channel antagonist activity of nifedipine analogues containing 1,2-dihydropyridyl in place of the 1,4-dihydropyridyl moiety

scientific article published on 01 February 1988

Systolic blood pressure responses to enalapril maleate (MK 421, an angiotensin converting enzyme inhibitor) and hydrochlorothiazide in conscious Dahl salt-sensitive and salt-resistant rats

scientific article published on 01 July 1984

Tetrahydrobiopterin improves endothelial function in human saphenous veins

scientific article published on 01 October 2000

Tetrodotoxin-sensitive and -insensitive relaxations in the rat oesophageal tunica muscularis mucosae

scientific article published in December 1986

The contribution of d-tubocurarine-sensitive and apamin-sensitive K-channels to EDHF-mediated relaxation of mesenteric arteries from eNOS-/- mice

scientific article published on 01 May 2012

The early effects of elevated glucose on endothelial function as a target in the treatment of type 2 diabetes

scientific article published on 04 February 2008

The early effects of elevated glucose on endothelial function as a target in the treatment of type 2 diabetes.

scientific article

The effect of indomethacin on the duration of the hypotensive action of bradykinin in Dahl salt-resistant rats: role of cyclooxygenase inhibition

scientific article published on 01 April 1984

The effect of the calcium channel agonist, Bay K-8644 on human vascular smooth muscle

scientific article published on 01 July 1985

The effects of alpha-adrenoceptor agonists on intracellular Ca2+ levels in freshly dispersed single smooth muscle cells from rat tail artery

scientific article published on August 1993

The effects of changes in pO2 on endothelium-dependent and -independent relaxations of the human umbilical artery and rat aorta

scientific article published on 01 January 1992

The effects of perfusion rate and NG-nitro-L-arginine methyl ester on cirazoline- and KCl-induced responses in the perfused mesenteric arterial bed of rats

scientific article published on January 1994

The endothelium contributes to the contractile responses of the human umbilical artery to 5-hydroxytryptamine and endothelin-1 under low but not high PO2 conditions

scientific article published on 01 October 1994

The endothelium in compliance and resistance vessels

scientific article published on January 2011

The endothelium in health and disease: a discussion of the contribution of non-nitric oxide endothelium-derived vasoactive mediators to vascular homeostasis in normal vessels and in type II diabetes.

scientific article

The endothelium: influencing vascular smooth muscle in many ways.

scientific article

The future of pharmacology in Canada

scientific article

The interrelationship between the effects of captopril and nifedipine on pressor responses elicited by selective alpha-adrenoceptor agonists in the pithed rat preparation

scientific article published on 01 April 1992

The relationship between the elevated blood pressure of the spontaneously hypertensive rat and the chemical sensitivity of smooth muscle to adrenergic agents

scientific article published in January 1984

The reversal of left ventricular hypertrophy with control of blood pressure in experimental hypertension

scientific article published on 01 December 1984

Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy

scientific article published on 06 November 2019

Twenty-five years since the discovery of endothelium-derived relaxing factor (EDRF): does a dysfunctional endothelium contribute to the development of type 2 diabetes?

scientific article

Varying extracellular [K+]: a functional approach to separating EDHF- and EDNO-related mechanisms in perfused rat mesenteric arterial bed.

scientific article

Vascular alpha-adrenoceptors: from the gene to the human

scientific article

Vascular dysfunction in type 2 diabetic TallyHo mice: role for an increase in the contribution of PGH2/TxA2 receptor activation and cytochrome p450 products

scientific article published on 01 March 2007

Vasopressin (V1) receptor characteristics in rat aortic smooth muscle cells

scientific article published on 01 December 1991

Widespread vascular production of C-reactive protein (CRP) and a relationship between serum CRP, plaque CRP and intimal hypertrophy

scientific article published on 09 June 2006

h1- and h2-calponins are not essential for norepinephrine- or sodium fluoride-induced contraction of rat aortic smooth muscle.

scientific article published in August 1998

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