List of works - David A. Baker

A cyclic GMP signalling module that regulates gliding motility in a malaria parasite

scientific article

A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes

scientific article (publication date: 14 May 2010)

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.

scientific article published on 5 September 2017

A putative protein serine/threonine phosphatase from Plasmodium falciparum contains a large N-terminal extension and five unique inserts in the catalytic domain ⬇️

scientific article (publication date: 15 September 1998)

A transcriptional switch underlies commitment to sexual development in malaria parasites

scientific article (publication date: 13 March 2014)

A unique phosphatidylinositol 4-phosphate 5-kinase is activated by ADP-ribosylation factor in Plasmodium falciparum.

scientific article published on 10 January 2009

Adenylyl and guanylyl cyclases from the malaria parasite Plasmodium falciparum

scientific article

An analysis of large structural variation in global Plasmodium falciparum isolates identifies a novel duplication of the chloroquine resistance associated gene.

scientific article published on 4 June 2019

Antimalarial activity of primaquine operates via a two-step biochemical relay

scientific article published on 19 July 2019

Ca

scientific article

Crystal structures of the carboxyl cGMP binding domain of the Plasmodium falciparum cGMP-dependent protein kinase reveal a novel capping triad crucial for merozoite egress

scientific article (publication date: February 2015)

Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery

scientific article published on 10 May 2019

Cyclic nucleotide signalling in malaria parasites

scientific article published on 28 December 2010

Cyclic nucleotide signalling in malaria parasites

scientific article published in December 2017

Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites

scientific article published on 14 October 2019

Development of a transgenic Plasmodium berghei line (Pb pfpkg) expressing the P. falciparum cGMP-dependent protein kinase, a novel antimalarial drug target

scientific article (publication date: 2014)

Disruption of a Plasmodium falciparum cyclic nucleotide phosphodiesterase gene causes aberrant gametogenesis

scientific article published on 28 April 2008

Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites

scientific article published in Nature Communications

Evidence on the chromosomal location of centromeric DNA in Plasmodium falciparum from etoposide-mediated topoisomerase-II cleavage

scholarly article

Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase

scientific article

Genomic variation in two gametocyte non-producing Plasmodium falciparum clonal lines

scientific article published on 21 April 2016

Geographical distribution of a variant epitope of Pfs48/45, a Plasmodium falciparum transmission-blocking vaccine candidate

scientific article

Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development

scientific article published in Scientific Reports

High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites

scientific article published on 07 May 2019

Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development

scientific article published on 28 December 2015

Improved synchronous production of Plasmodium falciparum gametocytes in vitro

scientific article published on 20 April 2007

Malaria Parasite Schizont Egress Antigen-1 Plays an Essential Role in Nuclear Segregation during Schizogony.

scientific article published on 9 March 2021

Malaria gametocytogenesis

scientific article

Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress

scientific article (publication date: May 2013)

Malaria parasite epigenetics: when virulence and romance collide.

scientific article published on August 2014

Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum

scientific article published on 31 March 2003

Phosphoantigen Burst upon Plasmodium falciparum Schizont Rupture Can Distantly Activate Vγ9Vδ2 T Cells

scientific article

Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion ⬇️

scientific article

Phosphoinositide metabolism links cGMP-dependent protein kinase G to essential Ca²⁺ signals at key decision points in the life cycle of malaria parasites

scientific article (publication date: March 2014)

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

scientific article

Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony

scientific article (publication date: 17 February 2017)

Plasmodium falciparum Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress.

scientific article published on 26 January 2021

Primary structure and sexual stage-specific expression of a LAMMER protein kinase of Plasmodium falciparum

scientific article (publication date: April 2001)

Probabilistic data integration identifies reliable gametocyte-specific proteins and transcripts in malaria parasites

scientific article published on 11 January 2018

Probabilistic data integration identifies reliable gametocyte-specific proteins and transcripts in malaria parasites

scholarly article published 10 October 2017

Programmed transcription of the var gene family, but not of stevor, in Plasmodium falciparum gametocytes

scientific article

Purine nucleotide cyclases in the malaria parasite

scientific article published on May 2004

Sequence of a giardin subunit cDNA from Giardia lamblia

scientific article published on July 1988

Sexual stage-specific expression of a third calcium-dependent protein kinase from Plasmodium falciparum.

scientific article published on April 2000

Spatiotemporal and functional characterisation of the Plasmodium falciparum cGMP-dependent protein kinase

scientific article (publication date: 2012)

Structure and non-essential function of glycerol kinase in Plasmodium falciparum blood stages

scientific article

Structure, function and evolution of microbial adenylyl and guanylyl cyclases

scientific article published on June 2004

Targeting Plasmodium falciparum protein kinases with adenosine analogue-oligoarginine conjugates

scientific article published on 15 February 2014

The Mu subunit of Plasmodium falciparum clathrin-associated adaptor protein 2 modulates in vitro parasite response to artemisinin and quinine

scientific article (publication date: May 2015)

The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation

scientific article published on 25 February 2020

The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification

scientific article published on September 2005

The gametocyte-activating factor xanthurenic acid stimulates an increase in membrane-associated guanylyl cyclase activity in the human malaria parasite Plasmodium falciparum

scientific article published on October 2001

The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony

scientific article

The role of cGMP signalling in regulating life cycle progression of Plasmodium

scientific article

The role of two novel regulatory sites in the activation of the cGMP-dependent protein kinase from Plasmodium falciparum

scientific article

Trypanosoma cruzi adenylyl cyclase is encoded by a complex multigene family

scientific article published on November 1999

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission

scientific article

List of works by David A. Baker

A cyclic GMP signalling module that regulates gliding motility in a malaria parasite

A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.

A putative protein serine/threonine phosphatase from Plasmodium falciparum contains a large N-terminal extension and five unique inserts in the catalytic domain ⬇️

A transcriptional switch underlies commitment to sexual development in malaria parasites

A unique phosphatidylinositol 4-phosphate 5-kinase is activated by ADP-ribosylation factor in Plasmodium falciparum.

Adenylyl and guanylyl cyclases from the malaria parasite Plasmodium falciparum

An analysis of large structural variation in global Plasmodium falciparum isolates identifies a novel duplication of the chloroquine resistance associated gene.

Antimalarial activity of primaquine operates via a two-step biochemical relay

Ca

Crystal structures of the carboxyl cGMP binding domain of the Plasmodium falciparum cGMP-dependent protein kinase reveal a novel capping triad crucial for merozoite egress

Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery

Cyclic nucleotide signalling in malaria parasites

Cyclic nucleotide signalling in malaria parasites

Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites

Development of a transgenic Plasmodium berghei line (Pb pfpkg) expressing the P. falciparum cGMP-dependent protein kinase, a novel antimalarial drug target

Disruption of a Plasmodium falciparum cyclic nucleotide phosphodiesterase gene causes aberrant gametogenesis

Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites

Evidence on the chromosomal location of centromeric DNA in Plasmodium falciparum from etoposide-mediated topoisomerase-II cleavage

Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase

Genomic variation in two gametocyte non-producing Plasmodium falciparum clonal lines

Geographical distribution of a variant epitope of Pfs48/45, a Plasmodium falciparum transmission-blocking vaccine candidate

Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development

High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites

Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development

Improved synchronous production of Plasmodium falciparum gametocytes in vitro

Malaria Parasite Schizont Egress Antigen-1 Plays an Essential Role in Nuclear Segregation during Schizogony.

Malaria gametocytogenesis

Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress

Malaria parasite epigenetics: when virulence and romance collide.

Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum

Phosphoantigen Burst upon Plasmodium falciparum Schizont Rupture Can Distantly Activate Vγ9Vδ2 T Cells

Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion ⬇️

Phosphoinositide metabolism links cGMP-dependent protein kinase G to essential Ca²⁺ signals at key decision points in the life cycle of malaria parasites

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony

Plasmodium falciparum Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress.

Primary structure and sexual stage-specific expression of a LAMMER protein kinase of Plasmodium falciparum

Probabilistic data integration identifies reliable gametocyte-specific proteins and transcripts in malaria parasites

Probabilistic data integration identifies reliable gametocyte-specific proteins and transcripts in malaria parasites

Programmed transcription of the var gene family, but not of stevor, in Plasmodium falciparum gametocytes

Purine nucleotide cyclases in the malaria parasite

Sequence of a giardin subunit cDNA from Giardia lamblia

Sexual stage-specific expression of a third calcium-dependent protein kinase from Plasmodium falciparum.

Spatiotemporal and functional characterisation of the Plasmodium falciparum cGMP-dependent protein kinase

Structure and non-essential function of glycerol kinase in Plasmodium falciparum blood stages

Structure, function and evolution of microbial adenylyl and guanylyl cyclases

Targeting Plasmodium falciparum protein kinases with adenosine analogue-oligoarginine conjugates

The Mu subunit of Plasmodium falciparum clathrin-associated adaptor protein 2 modulates in vitro parasite response to artemisinin and quinine

The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation

The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification

The gametocyte-activating factor xanthurenic acid stimulates an increase in membrane-associated guanylyl cyclase activity in the human malaria parasite Plasmodium falciparum

The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony

The role of cGMP signalling in regulating life cycle progression of Plasmodium

The role of two novel regulatory sites in the activation of the cGMP-dependent protein kinase from Plasmodium falciparum

Trypanosoma cruzi adenylyl cyclase is encoded by a complex multigene family

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission