List of works - Nuno Empadinhas

A gene from the mesophilic bacterium Dehalococcoides ethenogenes encodes a novel mannosylglycerate synthase

scientific article

A genuine mycobacterial thermophile: Mycobacterium hassiacum growth, survival and GpgS stability at near-pasteurization temperatures

scientific article published on 25 February 2020

A new bacterial hydrolase specific for the compatible solutes α-d-mannopyranosyl-(1→2)-d-glycerate and α-d-glucopyranosyl-(1→2)-d-glycerate ⬇️

scientific article published on November 16, 2012

A unique combination of genetic systems for the synthesis of trehalose in Rubrobacter xylanophilus: properties of a rare actinobacterial TreT.

scientific article

Albidovulum inexpectatum gen. nov., sp. nov., a nonphotosynthetic and slightly thermophilic bacterium from a marine hot spring that is very closely related to members of the photosynthetic genus Rhodovulum

scientific article

Autophagy in the fight against tuberculosis

scientific article

Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles

scientific article

Biochemical characterization of the maltokinase from Mycobacterium bovis BCG

scientific article

Biosynthesis of mannosylglycerate in the thermophilic bacterium Rhodothermus marinus. Biochemical and genetic characterization of a mannosylglycerate synthase.

scientific article

Biosynthesis of mycobacterial methylglucose lipopolysaccharides ⬇️

scientific article published on 08 June 2012

Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1--methyltransferase specific for 3--methylated mannosides

article published in the Proceedings of the National Academy of Sciences of the United States of America

Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii

scientific article

Crystallization and preliminary crystallographic analysis of mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus

scientific article published on 31 July 2008

Distribution of genes for synthesis of trehalose and Mannosylglycerate in Thermus spp. and direct correlation of these genes with halotolerance

scientific article

Diversity, biological roles and biosynthetic pathways for sugar‐glycerate containing compatible solutes in bacteria and archaea ⬇️

scientific article published on December 22, 2010

Functional and structural characterization of a novel mannosyl‐3‐phosphoglycerate synthase from Rubrobacter xylanophilus reveals its dual substrate specificity ⬇️

scientific article published on November 2, 2010

Gamma-proteobacteria Aquicella lusitana gen. nov., sp. nov., and Aquicella siphonis sp. nov. infect protozoa and require activated charcoal for growth in laboratory media

scientific article

Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of heat-stable mycobacterial proteins.

scientific article published on December 2012

Glucosylglycerate biosynthesis in the deepest lineage of the Bacteria: characterization of the thermophilic proteins GpgS and GpgP from Persephonella marina

scientific article

Glucosylglycerate metabolism, bioversatility and mycobacterial survival.

scientific article

High-Quality Draft Genome Sequences of Rare Nontuberculous Mycobacteria Isolated from Surfaces of a Hospital

scientific article published on 23 May 2019

Hospital microbial surface colonization revealed during monitoring of Klebsiella spp., Pseudomonas aeruginosa, and non-tuberculous mycobacteria

scientific article published on 23 March 2017

Identification of the mycobacterial glucosyl-3-phosphoglycerate synthase

scientific journal article

Mannosylglycerate is essential for osmotic adjustment in Thermus thermophilus strains HB27 and RQ-1.

scientific article published on 29 August 2007

Meiothermus timidus sp. nov., a new slightly thermophilic yellow-pigmented species

scientific article

Microbial BMAA and the Pathway for Parkinson's Disease Neurodegeneration

scientific article published on 07 February 2020

Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment Strategies

scientific article published on 21 September 2017

Molecular Fingerprints for a Novel Enzyme Family in with Glucosamine Kinase Activity

scientific article published on 14 May 2019

Molecular and physiological role of the trehalose-hydrolyzing alpha-glucosidase from Thermus thermophilus HB27.

scientific article

Molecular fingerprints for a novel glucosamine kinase family in Actinobacteria:

Mycobacterium hassiacum recovers from nitrogen starvation with up-regulation of a novel glucosylglycerate hydrolase and depletion of the accumulated glucosylglycerate.

scientific article published on 24 October 2014

Mycobacterium tuberculosis Rv2419c, the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesis ⬇️

scientific article published on November 30, 2011

Mycobacterium tuberculosis glucosyl-3-phosphoglycerate synthase: structure of a key enzyme in methylglucose lipopolysaccharide biosynthesis

scientific article

Octanoylation of early intermediates of mycobacterial methylglucose lipopolysaccharides

scientific journal article

Organic solutes in Rubrobacter xylanophilus: the first example of di-myo-inositol-phosphate in a thermophile

scientific article published on 18 May 2007

Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes

scientific article (publication date: 23 November 2001)

Production, crystallization and structure determination of a mycobacterial glucosylglycerate hydrolase

scientific article

Single-step pathway for synthesis of glucosylglycerate in Persephonella marina

scientific article

Specialized roles of the two pathways for the synthesis of mannosylglycerate in osmoadaptation and thermoadaptation of Rhodothermus marinus.

scientific article

Stabilization of blood for long-term storage can affect antibody-based recognition of cell surface markers

scientific article published on 06 May 2020

Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism

scientific article

Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway

scientific article (publication date: 26 January 2015)

Studies of antimicrobial resistance in rare mycobacteria from a nosocomial environment

scientific article published on 19 March 2019

The Microbiome-Mitochondria Dance in Prodromal Parkinson's Disease.

scientific article published on 9 May 2018

The Mitochondrial Ribosome: A World of Opportunities for Mitochondrial Dysfunction Toward Parkinson's Disease

scientific article published on 31 March 2020

The biosynthesis of trehalose and sugar-glycerate compatible solutes in organisms that live in hot and saline environments

scholarly article published 2013

The looming tide of nontuberculous mycobacterial infections in Portugal and Brazil

scientific article published on 24 October 2015

The molecular biology of mycobacterial trehalose in the quest for advanced tuberculosis therapies

scientific article published on 23 May 2014

The plant Selaginella moellendorffii possesses enzymes for synthesis and hydrolysis of the compatible solutes mannosylglycerate and glucosylglycerate.

scientific article published on 20 November 2012

The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation

scientific article published on 08 May 2019

To be or not to be a compatible solute: bioversatility of mannosylglycerate and glucosylglycerate

scientific article published on 02 July 2008

Two alternative pathways for the synthesis of the rare compatible solute mannosylglucosylglycerate in Petrotoga mobilis ⬇️

scientific article

List of works by Nuno Empadinhas

A gene from the mesophilic bacterium Dehalococcoides ethenogenes encodes a novel mannosylglycerate synthase

A genuine mycobacterial thermophile: Mycobacterium hassiacum growth, survival and GpgS stability at near-pasteurization temperatures

A new bacterial hydrolase specific for the compatible solutes α-d-mannopyranosyl-(1→2)-d-glycerate and α-d-glucopyranosyl-(1→2)-d-glycerate ⬇️

A unique combination of genetic systems for the synthesis of trehalose in Rubrobacter xylanophilus: properties of a rare actinobacterial TreT.

Albidovulum inexpectatum gen. nov., sp. nov., a nonphotosynthetic and slightly thermophilic bacterium from a marine hot spring that is very closely related to members of the photosynthetic genus Rhodovulum

Autophagy in the fight against tuberculosis

Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles

Biochemical characterization of the maltokinase from Mycobacterium bovis BCG

Biosynthesis of mannosylglycerate in the thermophilic bacterium Rhodothermus marinus. Biochemical and genetic characterization of a mannosylglycerate synthase.

Biosynthesis of mycobacterial methylglucose lipopolysaccharides ⬇️

Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1--methyltransferase specific for 3--methylated mannosides

Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii

Crystallization and preliminary crystallographic analysis of mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus

Distribution of genes for synthesis of trehalose and Mannosylglycerate in Thermus spp. and direct correlation of these genes with halotolerance

Diversity, biological roles and biosynthetic pathways for sugar‐glycerate containing compatible solutes in bacteria and archaea ⬇️

Functional and structural characterization of a novel mannosyl‐3‐phosphoglycerate synthase from Rubrobacter xylanophilus reveals its dual substrate specificity ⬇️

Gamma-proteobacteria Aquicella lusitana gen. nov., sp. nov., and Aquicella siphonis sp. nov. infect protozoa and require activated charcoal for growth in laboratory media

Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of heat-stable mycobacterial proteins.

Glucosylglycerate biosynthesis in the deepest lineage of the Bacteria: characterization of the thermophilic proteins GpgS and GpgP from Persephonella marina

Glucosylglycerate metabolism, bioversatility and mycobacterial survival.

High-Quality Draft Genome Sequences of Rare Nontuberculous Mycobacteria Isolated from Surfaces of a Hospital

Hospital microbial surface colonization revealed during monitoring of Klebsiella spp., Pseudomonas aeruginosa, and non-tuberculous mycobacteria

Identification of the mycobacterial glucosyl-3-phosphoglycerate synthase

Mannosylglycerate is essential for osmotic adjustment in Thermus thermophilus strains HB27 and RQ-1.

Meiothermus timidus sp. nov., a new slightly thermophilic yellow-pigmented species

Microbial BMAA and the Pathway for Parkinson's Disease Neurodegeneration

Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment Strategies

Molecular Fingerprints for a Novel Enzyme Family in with Glucosamine Kinase Activity

Molecular and physiological role of the trehalose-hydrolyzing alpha-glucosidase from Thermus thermophilus HB27.

Molecular fingerprints for a novel glucosamine kinase family in Actinobacteria:

Mycobacterium hassiacum recovers from nitrogen starvation with up-regulation of a novel glucosylglycerate hydrolase and depletion of the accumulated glucosylglycerate.

Mycobacterium tuberculosis Rv2419c, the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesis ⬇️

Mycobacterium tuberculosis glucosyl-3-phosphoglycerate synthase: structure of a key enzyme in methylglucose lipopolysaccharide biosynthesis

Octanoylation of early intermediates of mycobacterial methylglucose lipopolysaccharides

Organic solutes in Rubrobacter xylanophilus: the first example of di-myo-inositol-phosphate in a thermophile

Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes

Production, crystallization and structure determination of a mycobacterial glucosylglycerate hydrolase

Single-step pathway for synthesis of glucosylglycerate in Persephonella marina

Specialized roles of the two pathways for the synthesis of mannosylglycerate in osmoadaptation and thermoadaptation of Rhodothermus marinus.

Stabilization of blood for long-term storage can affect antibody-based recognition of cell surface markers

Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism

Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway

Studies of antimicrobial resistance in rare mycobacteria from a nosocomial environment

The Microbiome-Mitochondria Dance in Prodromal Parkinson's Disease.

The Mitochondrial Ribosome: A World of Opportunities for Mitochondrial Dysfunction Toward Parkinson's Disease

The biosynthesis of trehalose and sugar-glycerate compatible solutes in organisms that live in hot and saline environments

The looming tide of nontuberculous mycobacterial infections in Portugal and Brazil

The molecular biology of mycobacterial trehalose in the quest for advanced tuberculosis therapies

The plant Selaginella moellendorffii possesses enzymes for synthesis and hydrolysis of the compatible solutes mannosylglycerate and glucosylglycerate.

The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation

To be or not to be a compatible solute: bioversatility of mannosylglycerate and glucosylglycerate

Two alternative pathways for the synthesis of the rare compatible solute mannosylglucosylglycerate in Petrotoga mobilis ⬇️