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List of works by Dennis Christensen

A cationic vaccine adjuvant based on a saturated quaternary ammonium lipid have different in vivo distribution kinetics and display a distinct CD4 T cell-inducing capacity compared to its unsaturated analog

A liposome-based mycobacterial vaccine induces potent adult and neonatal multifunctional T cells through the exquisite targeting of dendritic cells

scientific article

A stable nanoparticulate DDA/MMG formulation acts synergistically with CpG ODN 1826 to enhance the CD4⁺ T-cell response

scientific article published on December 2014

Adjuvants Based on Synthetic Mycobacterial Cord Factor Analogues: Biophysical Properties of Neat Glycolipids and Nanoself-Assemblies with DDA.

scientific article published on 12 May 2017

Alternatives to mineral oil adjuvants in vaccines against Aeromonas salmonicida subsp. salmonicida in rainbow trout offer reductions in adverse effects

scientific article

CAF01 liposomes as a mucosal vaccine adjuvant: In vitro and in vivo investigations

scientific article published on 29 October 2009

CAF01 potentiates immune responses and efficacy of an inactivated influenza vaccine in ferrets

scientific article (publication date: 2011)

Cationic liposomal vaccine adjuvants in animal challenge models: overview and current clinical status

scientific article published on May 2012

Cationic liposomes as vaccine adjuvants

scientific article published on October 2007

Cationic liposomes as vaccine adjuvants

scientific article published on April 2011

Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements

scientific article

Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6'-dibehenate)-a novel adjuvant inducing both strong CMI and antibody responses

scientific article published on 14 November 2005

Characterization of the Antigen-Specific CD4(+) T Cell Response Induced by Prime-Boost Strategies with CAF01 and CpG Adjuvants Administered by the Intranasal and Subcutaneous Routes

scientific article

Comparison of the Depot Effect and Immunogenicity of Liposomes Based on Dimethyldioctadecylammonium (DDA), 3β-[N-(N′,N′-Dimethylaminoethane)carbomyl] Cholesterol (DC-Chol), and 1,2-Dioleoyl-3-trimethylammonium Propane (DOTAP): Prolonged Liposome

Comparison of two different PEGylation strategies for the liposomal adjuvant CAF09: Towards induction of CTL responses upon subcutaneous vaccine administration

article

Comparison of vesicle based antigen delivery systems for delivery of hepatitis B surface antigen

scientific article published on 27 January 2007

Correlating liposomal adjuvant characteristics to in-vivo cell-mediated immunity using a novel Mycobacterium tuberculosis fusion protein: a multivariate analysis study

scientific article published on 12 February 2015

Corrigendum: Site-Specific DC Surface Signatures Influence CD4+ T Cell Co-stimulation and Lung-Homing

scientific article published on 11 November 2019

Cutting Edge: TNF Is Essential for Mycobacteria-Induced MINCLE Expression, Macrophage Activation, and Th17 Adjuvanticity

scientific article published on 15 June 2020

Design of Gadoteridol-Loaded Cationic Liposomal Adjuvant CAF01 for MRI of Lung Deposition of Intrapulmonary Administered Particles

scientific article published on 03 October 2019

Designing CAF-adjuvanted dry powder vaccines: spray drying preserves the adjuvant activity of CAF01.

scientific article published on 8 February 2013

Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization

article

Effect of incorporating cholesterol into DDA:TDB liposomal adjuvants on bilayer properties, biodistribution, and immune responses.

scientific article published on 20 November 2013

Effects of cationic adjuvant formulation particle type, fluidity and immunomodulators on delivery and immunogenicity of saRNA

scientific article published on 06 May 2019

Elucidating the mechanisms of protein antigen adsorption to the CAF/NAF liposomal vaccine adjuvant systems: effect of charge, fluidity and antigen-to-lipid ratio.

scientific article published on 25 April 2014

High-frequency vaccine-induced CD8⁺ T cells specific for an epitope naturally processed during infection with Mycobacterium tuberculosis do not confer protection

scientific article

Immune responses induced by nano-self-assembled lipid adjuvants based on a monomycoloyl glycerol analogue after vaccination with the Chlamydia trachomatis major outer membrane protein

article

Immunity by formulation design: induction of high CD8+ T-cell responses by poly(I:C) incorporated into the CAF01 adjuvant via a double emulsion method

scientific article

Immunological and physical evaluation of the multistage tuberculosis subunit vaccine candidate H56/CAF01 formulated as a spray-dried powder

scientific article published on 24 April 2018

Increased humoral immunity by DNA vaccination using an α-tocopherol-based adjuvant.

scientific article published on 14 June 2017

Increased immunogenicity and protective efficacy of influenza M2e fused to a tetramerizing protein

scientific article

Induction of CD8+ T-cell responses against subunit antigens by the novel cationic liposomal CAF09 adjuvant

scientific article published on 28 May 2014

Induction of Cytotoxic T-Lymphocyte Responses Upon Subcutaneous Administration of a Subunit Vaccine Adjuvanted With an Emulsion Containing the Toll-Like Receptor 3 Ligand Poly(I:C).

scientific article

Influence of trehalose 6,6'-diester (TDX) chain length on the physicochemical and immunopotentiating properties of DDA/TDX liposomes

scientific article published on 11 November 2014

Intranasal vaccination with killed Leishmania amazonensis promastigotes antigen (LaAg) associated with CAF01 adjuvant induces partial protection in BALB/c mice challenged with Leishmania (infantum) chagasi

scientific article published on 23 September 2015

Intranasal vaccination with killed Leishmania amazonensis promastigotes antigen (LaAg) associated with CAF01 adjuvant induces partial protection in BALB/c mice challenged with Leishmania (infantum) chagasi - CORRIGENDUM

scientific article published on 02 November 2015

Investigating Prime-Pull Vaccination through a Combination of Parenteral Vaccination and Intranasal Boosting

scientific article published on 31 December 2019

Lipid conjugation of TLR7 agonist Resiquimod ensures co-delivery with the liposomal Cationic Adjuvant Formulation 01 (CAF01) but does not enhance immunopotentiation compared to non-conjugated Resiquimod+CAF01

scientific article published on 03 October 2018

Liposomal cationic charge and antigen adsorption are important properties for the efficient deposition of antigen at the injection site and ability of the vaccine to induce a CMI response

article

Liposomal vaccine delivery systems

scientific article published on 18 March 2011

Liposome-Based Adjuvants for Subunit Vaccines: Formulation Strategies for Subunit Antigens and Immunostimulators

scientific article

Liposome-based cationic adjuvant formulations (CAF): past, present, and future

scientific article published on January 2009

Liposomes based on dimethyldioctadecylammonium promote a depot effect and enhance immunogenicity of soluble antigen

scientific article published on 26 October 2009

Maternal Antibodies Inhibit Neonatal and Infant Responses to Vaccination by Shaping the Early-Life B Cell Repertoire within Germinal Centers

scientific article published on 01 August 2019

Microscopy imaging of liposomes: from coverslips to environmental SEM.

scientific article published on 21 December 2010

Modulation of immune responses using adjuvants to facilitate therapeutic vaccination

scientific article published on 28 June 2020

Mucosal boosting of H56:CAF01 immunization promotes lung-localized T cells and an accelerated pulmonary response to Mycobacterium tuberculosis infection without enhancing vaccine protection

scientific article published on 13 February 2019

NIR transmission spectroscopy for rapid determination of lipid and lyoprotector content in liposomal vaccine adjuvant system CAF01.

scientific article published on 23 July 2008

Nano-Self-Assemblies Based on Synthetic Analogues of Mycobacterial Monomycoloyl Glycerol and DDA: Supramolecular Structure and Adjuvant Efficacy

scientific article published on 05 July 2016

Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guérin.

scientific article published on 20 July 2009

Parenteral Vaccination With a Tuberculosis Subunit Vaccine in Presence of Retinoic Acid Provides Early but Transient Protection to M. Tuberculosis Infection

scientific article published on 03 May 2019

Peptide-specific T helper cells identified by MHC class II tetramers differentiate into several subtypes upon immunization with CAF01 adjuvanted H56 tuberculosis vaccine formulation

scientific article published on 20 October 2015

Protection against Chlamydia promoted by a subunit vaccine (CTH1) compared with a primary intranasal infection in a mouse genital challenge model

scientific article

Protein Antigen Adsorption to the DDA/TDB Liposomal Adjuvant: Effect on Protein Structure, Stability, and Liposome Physicochemical Characteristics ⬇️

scientific article published on September 6, 2012

Protein adsorption and displacement at lipid layers determined by total internal reflection fluorescence (TIRF).

scientific article

Rational Design and In Vivo Characterization of Vaccine Adjuvants

scientific article published on 01 December 2018

Robust antibody and CD8+ T-cell responses induced by P. falciparum CSP adsorbed to cationic liposomal adjuvant CAF09 confer sterilizing immunity against experimental rodent malaria infection.

scientific article published on 10 April 2017

Scale-Independent Microfluidic Production of Cationic Liposomal Adjuvants and Development of Enhanced Lymphatic Targeting Strategies

scientific article published on 06 September 2019

Site-Specific DC Surface Signatures Influence CD4+ T Cell Co-stimulation and Lung-Homing

scientific article published on 18 July 2019

Synchronization of dendritic cell activation and antigen exposure is required for the induction of Th1/Th17 responses

scientific article

Syringe free vaccination with CAF01 Adjuvated Ag85B-ESAT-6 in Bioneedles provides strong and prolonged protection against tuberculosis

scientific article

Systematic Investigation of the Role of Surfactant Composition and Choice of oil: Design of a Nanoemulsion-Based Adjuvant Inducing Concomitant Humoral and CD4+ T-Cell Responses.

scientific article published on 17 May 2017

Testing the H56 Vaccine Delivered in 4 Different Adjuvants as a BCG-Booster in a Non-Human Primate Model of Tuberculosis

scientific article

Th1 immune responses can be modulated by varying dimethyldioctadecylammonium and distearoyl-sn-glycero-3-phosphocholine content in liposomal adjuvants

scientific article

The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling

scientific article

The adjuvant mechanism of cationic dimethyldioctadecylammonium liposomes

scientific article

The administration route is decisive for the ability of the vaccine adjuvant CAF09 to induce antigen-specific CD8(+) T-cell responses: The immunological consequences of the biodistribution profile

scientific article published on 26 August 2016

The in vivo expressed Mycobacterium tuberculosis (IVE-TB) antigen Rv2034 induces CD4⁺ T-cells that protect against pulmonary infection in HLA-DR transgenic mice and guinea pigs

scientific article published on 14 May 2014

The physical stability of the recombinant tuberculosis fusion antigens h1 and h56.

scientific article published on 19 July 2013

Translating the fabrication of protein-loaded poly(lactic-co-glycolic acid) nanoparticles from bench to scale-independent production using microfluidics

scientific article published on 09 January 2020

Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo

scientific article published on June 2016

Trehalose preserves DDA/TDB liposomes and their adjuvant effect during freeze-drying

scientific article published on 13 May 2007

Vaccine adjuvants: Why and how.

scientific article published on 23 August 2016

Vaccine-induced Th17 cells are established as resident memory cells in the lung and promote local IgA responses

scientific article

alpha,alpha'-trehalose 6,6'-dibehenate in non-phospholipid-based liposomes enables direct interaction with trehalose, offering stability during freeze-drying

scientific article published on 26 January 2008

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