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List of works by Ian D. Kerr

A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma

scientific article published on 16 July 2019

ABC proteins and antibiotic drug resistance: is it all about transport?

scientific article published on November 2005

ABC transporter research: going strong 40 years on

scientific article

ABCB1 in children's brain tumours.

scientific article

ABCG2: does resolving its structure elucidate the mechanism?

scientific article published on 21 November 2018

Alamethicin Pyromellitate: An Ion-Activated Channel-Forming Peptide

scientific article published on 01 June 1994

Alamethicin channels - modelling via restrained molecular dynamics simulations

scientific article published on April 1997

An atomic detail model for the human ATP binding cassette transporter P‐glycoprotein derived from disulphide cross‐ linking and homology modeling ⬇️

scientific article published on October 16, 2003

Analysis of the Sam50 translocase of excavate organisms supports evolution of divergent organelles from a common endosymbiotic event

scientific article

Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy

scientific article

Cation selectivity in ion channels

scientific article published in Nature

Cellular Patterning of Arabidopsis Roots Under Low Phosphate Conditions.

scientific article

Communication between the nucleotide binding domains of P-glycoprotein occurs via conformational changes that involve residue 508.

scientific article published on July 2003

Cytosolic region of TM6 in P-glycoprotein: topographical analysis and functional perturbation by site directed labeling

scientific article

Definition of the domain boundaries is critical to the expression of the nucleotide-binding domains of P-glycoprotein

scientific article published on 26 June 2003

Detergent-free purification of ABC (ATP-binding-cassette) transporters.

scientific article published on July 2014

Dimerization of ABCG2 analysed by bimolecular fluorescence complementation

scientific article

Ferrocenoyl Derivatives of Alamethicin: Redox-Sensitive Ion Channels†

scientific article published on 01 February 1997

Heterologous expression of a membrane-spanning auxin importer: implications for functional analyses of auxin transporters

scientific article

Hydrophilic surface maps of channel-forming peptides: analysis of amphipathic helices

scientific article published on 01 January 1993

Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences.

scientific article published on 17 July 2015

Improving the stability and function of purified ABCB1 and ABCA4: the influence of membrane lipids.

scientific article

Induction of a stress response in Lactococcus lactis is associated with a resistance to ribosomally active antibiotics

article

Influenza virus M2 protein: a molecular modelling study of the ion channel.

scientific article

Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids ⬇️

scientific article published on 3 January 2013

Ion channel formation by synthetic analogues of staphylococcal δ-toxin

scientific article published on 01 June 1995

Ion channel stability and hydrogen bonding. Molecular modelling of channels formed by synthetic alamethicin analogues.

scientific article published on December 1997

Ion channels formed by HIV-1 Vpu: a modelling and simulation study

scientific article

Ion channels formed by amphipathic helical peptides

scientific article published on 01 January 1991

Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?

scientific article

Localisation of a family of complex-forming β-barrels in the T. vaginalis hydrogenosomal membrane

scientific article

Location of contact residues in pharmacologically distinct drug binding sites on P-glycoprotein

scientific article

Long-term exposure to irinotecan reduces cell migration in glioma cells.

scientific article published on 30 January 2016

Mechanistic insight into the role of AUXIN RESISTANCE4 in trafficking of AUXIN1 and LIKE AUX1-2

Modelling membrane proteins using structural restraints

scientific article published on 01 August 1995

Modelling the packing of transmembrane helices: application to aquaporin-1

scientific article published on 01 August 1998

Modelling the restoration of wild-type dynamic behaviour in ΔF508-CFTR NBD1 by 8-cyclopentyl-1,3-dipropylxanthine

scientific article published on 24 April 2007

Molecular dynamics of ion/channel interactions [1]

article

Multidrug efflux pumps: the structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues.

scientific article published on 03 December 2009

Multiple drugbinding sites on the R482G isoform of the ABCG2 transporter.

scientific article published on 18 September 2006

New insight into the biochemical mechanisms regulating auxin transport in plants

scientific article published on February 2007

Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors

scientific article published on 9 September 2015

Overcoming multiple drug resistance mechanisms in medulloblastoma.

scientific article

Packing interactions of aib-containing helices: Molecular modeling of parallel dimers of simple hydrophobic helices and of alamethicin

article

Pediatric brain tumor cancer stem cells: cell cycle dynamics, DNA repair, and etoposide extrusion ⬇️

scientific article published on 25 October 2010

Picky ABCG5/G8 and promiscuous ABCG2 - a tale of fatty diets and drug toxicity

scientific article published on 26 September 2020

Plasma membrane dynamics and tetrameric organisation of ABCG2 transporters in mammalian cells revealed by single particle imaging techniques

scientific article published on 7 October 2015

Polymorphisms of the multidrug pump ABCG2: a systematic review of their effect on protein expression, function and drug pharmacokinetics

scholarly article by Niall Heyes et al published 28 September 2018 in Drug Metabolism and Disposition

Protein-water-ion interactions in a model of the pore domain of a potassium channel: a simulation study.

scientific article

Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2.

scientific article published on November 2006

Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

scientific article

Residue G346 in transmembrane segment six is involved in inter-domain communication in P-glycoprotein

scientific article published on 14 August 2007

Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets

scientific article published on 4 May 2018

Secondary structure of an isolated P-region from the voltage-gated sodium channel: a molecular modelling/dynamics study

scientific article published on 01 December 1997

Sequence analysis of twin ATP binding cassette proteins involved in translational control, antibiotic resistance, and ribonuclease L inhibition

scientific article published on February 2004

Seven-helix bundles: molecular modeling via restrained molecular dynamics.

scientific article published on April 1995

Simulation studies on bacteriorhodopsin bundle of transmembrane α segments

scientific article published on 01 January 2000

Structure and association of ATP-binding cassette transporter nucleotide-binding domains

scientific article (publication date: 19 March 2002)

Structure-based interpretation of the mutagenesis database for the nucleotide binding domains of P-glycoprotein.

scientific article

Structure-function analysis of the presumptive Arabidopsis auxin permease AUX1

article

Studies of the pore-forming domain of a voltage-gated potassium channel protein.

scientific article

The ABCG family of membrane-associated transporters: you don't have to be big to be mighty

scientific article published on December 2011

The ATP-binding cassette proteins of the deep-branching protozoan parasite Trichomonas vaginalis

scientific article

The auxin influx carrier LAX3 promotes lateral root emergence

article

The binding of auxin to the Arabidopsis auxin influx transporter AUX1.

scientific article

The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis

scientific article published on April 2014

The coupling mechanism of P-glycoprotein involves residue L339 in the sixth membrane spanning segment.

scientific article published on July 2005

The influenza A virus M2 channel: a molecular modeling and simulation study.

scientific article published in June 1997

The multidrug transporter ABCG2: still more questions than answers

scientific article

The nucleotide-binding domains of P-glycoprotein. Functional symmetry in the isolated domain demonstrated by N-ethylmaleimide labelling

scientific article published in April 2003

The pore-lining region of shaker voltage-gated potassium channels: comparison of beta-barrel and alpha-helix bundle models ⬇️

scientific article published on August 1, 1997

The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein.

scientific article published on 10 June 2004

The translocation mechanism of P-glycoprotein.

scientific article

Towards understanding promiscuity in multidrug efflux pumps

scientific article published on 06 December 2013

Transmembrane helix 12 modulates progression of the ATP catalytic cycle in ABCB1.

scientific article

Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1.

scientific article published on 20 August 2010

Unraveling the evolution of auxin signaling

scientific article

Water in channel-like cavities: structure and dynamics.

scientific article published on February 1996

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