Search filters

List of works by Toni Cathomen

A functional complex of adenovirus proteins E1B-55kDa and E4orf6 is necessary to modulate the expression level of p53 but not its transcriptional activity.

scientific article published in December 2000

A genetic screen identifies a cellular regulator of adeno-associated virus.

scientific article

A matrix-less measles virus is infectious and elicits extensive cell fusion: consequences for propagation in the brain.

scientific article

A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity.

scientific article

A novel zinc-finger nuclease platform with a sequence-specific cleavage module.

scientific article published on December 2011

A versatile reporter system for multiplexed screening of effective epigenome editors

scientific article published on 04 September 2020

AAV vectors for gene correction

scientific article published in August 2004

Adding fingers to an engineered zinc finger nuclease can reduce activity

scientific article published on 11 May 2011

Adenoviral vector DNA for accurate genome editing with engineered nucleases.

scientific article published on 24 August 2014

An Anti-PSMA Immunotoxin Reduces Mcl-1 and Bcl2A1 and Specifically Induces in Combination with the BAD-Like BH3 Mimetic ABT-737 Apoptosis in Prostate Cancer Cells

scientific article published on 22 June 2020

Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion.

scientific article

Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations

scientific article

Biodegradable Nanocarriers Resembling Extracellular Vesicles Deliver Genetic Material with the Highest Efficiency to Various Cell Types

scientific article published on 16 December 2019

Chimerization Enables Gene Synthesis and Lentiviral Delivery of Customizable TALE-Based Effectors

scientific article published on 25 January 2020

Construction and characterization of adenoviral vectors for the delivery of TALENs into human cells.

scientific article published on 20 February 2014

Correction of IVS I-110(G>A) β-thalassemia by CRISPR/Cas-and TALEN-mediated disruption of aberrant regulatory elements in human hematopoietic stem and progenitor cells

scientific article published on 19 April 2019

Custom zinc-finger nucleases for use in human cells

scientific article published in October 2005

DNA-binding activity of adeno-associated virus Rep is required for inverted terminal repeat-dependent complex formation with herpes simplex virus ICP8.

scientific article published on 28 December 2011

DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases

scientific article published on 20 November 2007

Deciphering the impact of parameters influencing transgene expression kinetics after repeated cell transduction with integration-deficient retroviral vectors

scientific article published on 27 February 2015

Designer epigenome modifiers enable robust and sustained gene silencing in clinically relevant human cells

scientific article published on 10 March 2018

Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells.

scientific article published on 28 December 2012

Editing CCR5: a novel approach to HIV gene therapy.

scientific article

Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition

scientific article

Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition.

scientific article

Efficient ZFN-based gene inactivation in transgenic human iPS cells as a model for gene editing in patient-specific cells

scientific article published on 23 October 2010

Efficient designer nuclease-based homologous recombination enables direct PCR screening for footprintless targeted human pluripotent stem cells

scientific article published on 14 January 2014

Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks

scientific article published on May 2003

Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects

scientific article

Expanding or restricting the target site repertoire of zinc-finger nucleases: the inter-domain linker as a major determinant of target site selectivity

scientific article

Failure to detect DNA-guided genome editing using Natronobacterium gregoryi Argonaute

scientific article published on 28 November 2016

Fate of recombinant adeno-associated viral vector genomes during DNA double-strand break-induced gene targeting in human cells

scientific article

Gene repair: pointing the finger at genetic disease

scientific article published in October 2005

Generation and functional analysis of zinc finger nucleases

scientific article

Generation and genetic modification of induced pluripotent stem cells

scientific article published on July 2010

Generation of a gene-corrected isogenic control iPSC line from cystic fibrosis patient-specific iPSCs homozygous for p.Phe508del mutation mediated by TALENs and ssODN.

scientific article published on 11 July 2017

Genom-Editierung — neue Wege im klinischen Alltag

Genome Editing of the SNAI1 Gene in Rhabdomyosarcoma: A Novel Model for Studies of Its Role

scientific article published on 28 April 2020

Genome and Epigenome Editing to Treat Disorders of the Hematopoietic System

scientific article published on 15 August 2017

Genome editing technologies: defining a path to clinic

scientific article published on May 2015

Genomeditierung in der Zell- und Gentherapie

Genotoxicity in gene therapy: an account of vector integration and designer nucleases.

scientific article published on June 2008

HIV Gene Therapy - An Update

scientific article published on 21 December 2020

Highly efficient zinc-finger nuclease-mediated disruption of an eGFP transgene in keratinocyte stem cells without impairment of stem cell properties.

scientific article published on June 2012

Histone deacetylase inhibition rescues gene knockout levels achieved with integrase-defective lentiviral vectors encoding zinc-finger nucleases.

scientific article published on 29 October 2013

Homologous recombination mediates stable Fah gene integration and phenotypic correction in tyrosinaemia mouse-model.

scientific article

Human Genome Editing in the Clinic: New Challenges in Regulatory Benefit-Risk Assessment.

scientific article published in October 2017

Impaired axonal transport in motor neurons correlates with clinical prion disease

scientific article

Improved bi-allelic modification of a transcriptionally silent locus in patient-derived iPSC by Cas9 nickase

scientific article (publication date: 2 December 2016)

In vitro assessment of zinc finger nuclease activity

scientific article published on 01 January 2010

Inactivation of hepatitis B virus replication in cultured cells and in vivo with engineered transcription activator-like effector nucleases.

scientific article published on 25 July 2013

Influence of N-linked oligosaccharide chains on the processing, cell surface expression and function of the measles virus fusion protein

scientific article published on March 1995

Inhibition of replication of hepatitis B virus using transcriptional repressors that target the viral DNA

scientific article published on 12 September 2019

Integration preferences of wildtype AAV-2 for consensus rep-binding sites at numerous loci in the human genome

scientific article

Matricellular signaling molecule CCN1 attenuates experimental autoimmune myocarditis by acting as a novel immune cell migration modulator.

scientific article published on 6 December 2010

Maßgeschneidertes Genom — Designer-Nukleasen im Einsatz

Measles viruses with altered envelope protein cytoplasmic tails gain cell fusion competence.

scientific article

MicroRNA-221 overexpression accelerates hepatocyte proliferation during liver regeneration

scientific article published in January 2013

MicroRNA-221 regulates FAS-induced fulminant liver failure

scientific article published on 11 March 2011

Non-integrating gamma-retroviral vectors as a versatile tool for transient zinc-finger nuclease delivery

scientific article

Novel lentiviral vectors with mutated reverse transcriptase for mRNA delivery of TALE nucleases

scientific article

On target? Tracing zinc-finger-nuclease specificity

scientific article published on 30 August 2011

PSMA-Directed CAR T Cells Combined with Low-Dose Docetaxel Treatment Induce Tumor Regression in a Prostate Cancer Xenograft Model

scientific article published on 24 June 2020

Preclinical Evaluation of a Novel TALEN Targeting CCR5 Confirms Efficacy and Safety in Conferring Resistance to HIV-1 Infection

scientific article published on 25 October 2020

Prediction and validation of hematopoietic stem and progenitor cell off-target editing in transplanted rhesus macaques

Preferential initiation at the second AUG of the measles virus F mRNA: a role for the long untranslated region

scientific article

Proven and novel strategies for efficient editing of the human genome

scientific article published on 03 September 2015

Quantification of zinc finger nuclease-associated toxicity

scientific article published on January 2010

RNA guides genome engineering

scientific article published in March 2013

Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification

scientific article

Refining strategies to translate genome editing to the clinic

scientific article published on April 2017

Reply to "Genome editing with modularly assembled zinc-finger nucleases"

academic article

Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.

scientific article published on 22 May 2015

Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia.

scientific article

Retargeting sleeping beauty transposon insertions by engineered zinc finger DNA-binding domains

scientific article

Retargeting transposon insertions by the adeno-associated virus Rep protein.

scientific article

Retroviral UNC13D Gene Transfer Restores Cytotoxic Activity of T Cells Derived from Familial Hemophagocytic Lymphohistiocytosis Type 3 Patients In Vitro

scientific article published on 21 May 2019

Selection-independent generation of gene knockout mouse embryonic stem cells using zinc-finger nucleases

scientific article

Selective expression of a subset of measles virus receptor-competent CD46 isoforms in human brain

scientific article published on March 1996

Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome

scientific article published on 14 December 2015

Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases

scientific article

TALE nucleases: tailored genome engineering made easy

scientific article published on 17 February 2012

TALE-PvuII fusion proteins--novel tools for gene targeting.

scientific article

TALEN mediated gene editing in a mouse model of Fanconi anemia

scientific article published on 24 April 2020

TALEN-mediated functional correction of X-linked chronic granulomatous disease in patient-derived induced pluripotent stem cells

scientific article published on 3 August 2015

TALEN-mediated functional correction of human iPSC-derived macrophages in context of hereditary pulmonary alveolar proteinosis.

scientific article published on 9 November 2017

TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity

scientific article

Targeted Integration of Inducible Caspase-9 in Human iPSCs Allows Efficient in vitro Clearance of iPSCs and iPSC-Macrophages

scientific article published on 03 April 2020

Targeted Integration of a Super-Exon into the CFTR Locus Leads to Functional Correction of a Cystic Fibrosis Cell Line Model

scientific article

Targeted chromosomal gene modification in human cells by single-stranded oligodeoxynucleotides in the presence of a DNA double-strand break

scientific article published on 14 August 2006

Targeted genome editing in pluripotent stem cells using zinc-finger nucleases

scientific article published on 23 December 2010

Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model

scientific article published on 29 September 2017

Targeted genome modifications using integrase-deficient lentiviral vectors

scientific article published on 13 November 2007

Targeted integration by adeno-associated virus.

scientific article published on January 2003

The Human Genome Editing Race: Loosening Regulatory Standards for Commercial Advantage?

scientific article published on 13 July 2018

The Scope for Thalassemia Gene Therapy by Disruption of Aberrant Regulatory Elements

scientific article published on 13 November 2019

The nontoxic cell cycle modulator indirubin augments transduction of adeno-associated viral vectors and zinc-finger nuclease-mediated gene targeting.

scientific article

Therapeutic genome editing with engineered nucleases

scientific article published on 10 January 2017

Traceless Targeting and Isolation of Gene-Edited Immortalized Keratinocytes from Epidermolysis Bullosa Simplex Patients.

scientific article published on 5 July 2017

Transfusion-transmitted hepatitis E in Germany, 2013.

scientific article published on 29 May 2014

Translating the genomic revolution - targeted genome editing in primates

scientific article published in June 2014

Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases

scientific article published in February 2013

Ultramicroscopy reveals axonal transport impairments in cortical motor neurons at prion disease

scientific article published on April 2009

Unexpected failure rates for modular assembly of engineered zinc fingers

scientific article

Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors.

scientific article published on 14 December 2011

Zinc-finger Nucleases: The Next Generation Emerges

Zinc-finger nuclease based genome surgery: it's all about specificity

scientific article published on February 2011

Zinc-finger nuclease-induced gene repair with oligodeoxynucleotides: wanted and unwanted target locus modifications

scientific article

Zinc-finger nucleases for somatic gene therapy: the next frontier

scientific article

Zinc-finger nucleases meet iPS cells: Zinc positive: tailored genome engineering meets reprogramming

scientific article published on 12 November 2009

Zinc-finger nucleases-based genome engineering to generate isogenic human cell lines

scientific article published in January 2012

Zinc-finger nucleases: the next generation emerges

scientific article

Paulina is supported by:

About Paulina

Help