List of works - Philip C. Sharpe

2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity.

scientific article

Amyloid Formation from an α‐Helix Peptide Bundle Is Seeded by 310‐Helix Aggregates ⬇️

scientific article published on December 15, 2010

C-substituted macrocycles as candidates for radioimmunotherapy

scientific article published on 01 September 2000

Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: structure-activity relationships of novel thiohydrazone analogues.

scientific article published on 27 October 2007

Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.

scientific article

Dipyridyl Thiosemicarbazone Chelators with Potent and Selective Antitumor Activity Form Iron Complexes with Redox Activity

scientific article published on 01 November 2006

Electrochemically mediated enantioselective reduction of chiral sulfoxides.

scientific article published on 20 November 2014

Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity

scientific article

Hydrazone chelators for the treatment of iron overload disorders: iron coordination chemistry and biological activity

scientific article published on 08 June 2007

Iron chelators of the dipyridylketone thiosemicarbazone class: precomplexation and transmetalation effects on anticancer activity.

scientific article

Methemoglobin formation by triapine, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and other anticancer thiosemicarbazones: identification of novel thiosemicarbazones and therapeutics that prevent this effect

scientific article published on 16 April 2012

Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization

scientific article published on 8 December 2015

Novel diaroylhydrazine ligands as iron chelators: coordination chemistry and biological activity.

scientific article published on 8 November 2005

Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.

scientific article

Novel thiosemicarbazones of the ApT and DpT series and their copper complexes: identification of pronounced redox activity and characterization of their antitumor activity.

scientific article published on August 2010

Structurally reinforced tetraazamacrocyclic complexes

scientific article published on 01 May 2000

Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: the methyl pyrazinylketone isonicotinoyl hydrazone series.

scientific article published on 27 December 2007

Synthetic and natural products as iron chelators

scientific article published on January 2011

Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.

scientific article published on September 2009

Transition metal complexes as mediator-titrants in protein redox potentiometry

scientific article published on 26 July 2006

Tuning the antiproliferative activity of biologically active iron chelators: characterization of the coordination chemistry and biological efficacy of 2-acetylpyridine and 2-benzoylpyridine hydrazone ligands

scientific article

List of works by Philip C. Sharpe

2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity.

Amyloid Formation from an α‐Helix Peptide Bundle Is Seeded by 310‐Helix Aggregates ⬇️

C-substituted macrocycles as candidates for radioimmunotherapy

Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: structure-activity relationships of novel thiohydrazone analogues.

Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.

Dipyridyl Thiosemicarbazone Chelators with Potent and Selective Antitumor Activity Form Iron Complexes with Redox Activity

Electrochemically mediated enantioselective reduction of chiral sulfoxides.

Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity

Hydrazone chelators for the treatment of iron overload disorders: iron coordination chemistry and biological activity

Iron chelators of the dipyridylketone thiosemicarbazone class: precomplexation and transmetalation effects on anticancer activity.

Methemoglobin formation by triapine, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and other anticancer thiosemicarbazones: identification of novel thiosemicarbazones and therapeutics that prevent this effect

Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization

Novel diaroylhydrazine ligands as iron chelators: coordination chemistry and biological activity.

Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.

Novel thiosemicarbazones of the ApT and DpT series and their copper complexes: identification of pronounced redox activity and characterization of their antitumor activity.

Structurally reinforced tetraazamacrocyclic complexes

Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: the methyl pyrazinylketone isonicotinoyl hydrazone series.

Synthetic and natural products as iron chelators

Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.

Transition metal complexes as mediator-titrants in protein redox potentiometry

Tuning the antiproliferative activity of biologically active iron chelators: characterization of the coordination chemistry and biological efficacy of 2-acetylpyridine and 2-benzoylpyridine hydrazone ligands