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List of works by Geoffrey Brown

1 alpha,25-Dihydroxyvitamin D3 promotes monocytopoiesis and suppresses granulocytopoiesis in cultures of normal human myeloid blast cells

scientific article published on 01 August 1994

1Alpha,25-dihydroxyvitamin D3-mediated stimulation of steroid sulphatase activity in myeloid leukaemic cell lines requires VDRnuc-mediated activation of the RAS/RAF/ERK-MAP kinase signalling pathway

scientific article published on June 2006

1alpha,25-dihydroxyvitamin D3 stimulates steroid sulphatase activity in HL60 and NB4 acute myeloid leukaemia cell lines by different receptor-mediated mechanisms.

scientific article published on April 2005

A monoclonal antibody recognizes a human nuclear protein resembling Xenopus oocyte nucleoplasmin.

scientific article published on June 1987

A retinoid-related molecule that does not bind to classical retinoid receptors potently induces apoptosis in human prostate cancer cells through rapid caspase activation.

scientific article published on May 2004

All-trans retinoic acid and 1 alpha,25-dihydroxyvitamin D3 co-operate to promote differentiation of the human promyeloid leukemia cell line HL60 to monocytes

scientific article published on May 1994

An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium.

scientific article published on August 2004

Antagonizing Retinoic Acid Receptors Increases Myeloid Cell Production by Cultured Human Hematopoietic Stem Cells

scientific article published on 13 July 2016

Antiproliferative Activity of Double Point Modified Analogs of 1,25-Dihydroxyvitamin D₂ Against Human Malignant Melanoma Cell Lines.

scientific article published on 8 January 2016

Biological Evaluation of Double Point Modified Analogues of 1,25-Dihydroxyvitamin D₂ as Potential Anti-Leukemic Agents.

scientific article published on February 2016

Biological evaluation of new vitamin D2 analogues

scientific article

Cell differentiation and proliferation--simultaneous but independent?

scientific article published on December 2003

Cell proliferation and CD11b expression are controlled independently during HL60 cell differentiation initiated by 1,25 alpha-dihydroxyvitamin D(3) or all-trans-retinoic acid.

scientific article

Changes in inositol transport during DMSO-induced differentiation of HL60 cells towards neutrophils

scientific article published on January 1991

Changes in insulin receptor expression in HL60 cells induced to differentiate towards neutrophils or monocytes

scientific article published on 01 November 1988

Changes in phosphoproteins during commitment of HL60 cells to monocyte differentiation: evidence for multiple protein kinase involvement

scientific article published in August 1988

Changes in the kinetics of inositol transport during TPA-induced differentiation of HL60 cells towards monocytes

scientific article published on July 1991

Changes in the levels of inositol lipids and phosphates during the differentiation of HL60 promyelocytic cells towards neutrophils or monocytes

scientific article published on 01 September 1991

Changes in the phosphorylation status of a 19 kD cytosolic protein are linked to the growth arrest of HL-60 cells

scientific article published on January 1992

Clofibric acid: a potential therapeutic agent in AML and MDS

scientific article published on 01 May 1999

Comparison of the levels of inositol metabolites in transformed haemopoietic cells and their normal counterparts.

scientific article published on February 1993

Convergent synthesis of double point modified analogs of 1α,25-dihydroxyvitamin D2 for biological evaluation

scientific article published on 24 August 2015

Defective erythropoiesis in myelodysplastic syndromes.

scientific article

Defective erythropoiesis in primary myelofibrosis associated with a chromosome 11 abnormality

scientific article published on July 1991

Differentiation and cell survival of myeloid leukemia cells

scientific article published on 31 July 2012

Down-regulation but not phosphorylation of stathmin is associated with induction of HL60 cell growth arrest and differentiation by physiological agents

scientific article published on 01 May 1995

Effect of Mg2+ on Na(+)-dependent inositol transport. Role for Mg2+ in etiology of diabetic complications.

scientific article published on January 1992

Estrone potentiates myeloid cell differentiation

scientific article published in March 1999

Evidence that precursor cells of monocytes and B-lymphocytes are closely related

scientific article published on 01 October 1989

Expression of WASP and Scar1/WAVE1 actin-associated proteins is differentially modulated during differentiation of HL-60 cells

scientific article published on April 2003

Expression of a nuclear envelope protein recognized by the monoclonal antibody BU31 in lung tumours: relationship to Ki-67 antigen expression

scientific article published on 01 June 1994

Expression of epithelial membrane and 3-fucosyl-N-acetyllactosamine antigens in cervix uteri with particular reference to adenocarcinoma in situ

scientific article

Growth of single HL60 cells in liquid culture: analysis of the influences of differentiative agents

scientific article published on 01 October 1996

HL60 cells halted in G1 or S phase differentiate normally

scientific article published in November 2002

Hematopoietic Stem Cells: Nature and Niche Nurture

scientific article published on 17 May 2021

Indomethacin potentiates the induction of HL60 differentiation to neutrophils, by retinoic acid and granulocyte colony-stimulating factor, and to monocytes, by vitamin D3.

scientific article published in April 1994

Inositol lipids and phosphates in erythrocytes and HL60 cells

scientific article published on January 1988

Inositol lipids and phosphates in the differentiation of blood cells

scientific article published on 01 January 1990

Inositol lipids and phosphates in the proliferation and differentiation of lymphocytes and myeloid cells

scientific article published on January 1, 1992

Intracellular concentrations of inositol, glycerophosphoinositol and inositol pentakisphosphate increase during haemopoietic cell differentiation

scientific article published on May 1994

Is lineage decision-making restricted during tumoral reprograming of haematopoietic stem cells?

scientific article

Levels of inositol metabolites within normal myeloid blast cells and changes during their differentiation towards monocytes

scientific article published on 01 January 1992

Metabolism of 1alpha,25(OH)2D3 and its 20-epi analog integrates clonal expansion, maturation and apoptosis during HL-60 cell differentiation

scientific article published on 01 March 1999

Models of haemopoiesis

scientific article published on January 1990

Monocytically Differentiating HL60 Cells Proliferate Rapidly before They Mature

scientific article published on 01 December 1999

Near neighbour analysis of variant cell lines derived from the promyeloid cell line HL60

scientific article published on June 1988

Particular combinations of signals, by retinoic acid and 1 alpha, 25 dihydroxyvitamin D3, promote apoptosis of HL60 cells.

scientific article

Persistent growth of BALB/C mouse plasmacytoma and human myeloma cell lines in the presence of phorbol myristate acetate is associated with continued expression of Lap18 (stathmin).

scientific article published on January 1995

Phorbol myristate acetate treatment of normal human myeloid blast cells promotes monopoiesis and inhibits granulopoiesis

scientific article published on 01 January 1990

Potentiation of myeloid differentiation by anti-inflammatory agents, by steroids and by retinoic acid involves a single intracellular target, probably an enzyme of the aldoketoreductase family

article

Presence of 3-fucosyl-N-acetyllactosamine shown by monoclonal antibody AGF 4.48 in Reed-Sternberg cells

scientific article published on May 1986

Regulation of vitamin D receptor expression by retinoic acid receptor alpha in acute myeloid leukemia cells.

scientific article published on 8 March 2016

Retinoid differentiation therapy for common types of acute myeloid leukemia

scientific article published on 12 June 2012

Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

scientific article published in February 2006

Selective Expression of Flt3 within the Mouse Hematopoietic Stem Cell Compartment.

scientific article published on 12 May 2017

Sequential determination of lineage potentials during haemopoiesis

scientific article published on November 1985

Sodium dependent inositol transport in HL60 cells is not related to Na+/K+ ATPase activity

scientific article published on April 1991

Stathmin expression is a feature of proliferating cells of most, if not all, cell lineages

scientific article published on 01 January 1995

Stathmin is expressed by the proliferating hepatocytes during liver regeneration

scientific article

Stochastic or ordered lineage commitment during hemopoiesis?

scientific article published on February 1987

Synergistic growth inhibition of prostate cancer cells by 1 alpha,25 Dihydroxyvitamin D(3) and its 19-nor-hexafluoride analogs in combination with either sodium butyrate or trichostatin A.

scientific article published in April 2001

Synthesis and evaluation of geometric analogs of 1α,25-dihydroxyvitamin D2 as potential therapeutics

scientific article published on 27 August 2015

The Cytokine Flt3-Ligand in Normal and Malignant Hematopoiesis

scientific article

The Use of 1α,25-Dihydroxyvitamin D₃ as an Anticancer Agent

scientific article

The development and growth of tissues derived from cranial neural crest and primitive mesoderm is dependent on the ligation status of retinoic acid receptor γ: evidence that retinoic acid receptor γ functions to maintain stem/progenitor cells in the

scientific article

The development of cell lineages: a sequential model.

scientific article published on December 1988

The proliferation-associated cytosolic protein Lap18 (stathmin) is expressed at atypically low levels in BALB/c plasmacytoma cells

scientific article published on 01 January 1995

The prospects of retinoids in the treatment of prostate cancer.

scientific article

The role of inositol transport in cellular differentiation

scientific article published on April 1991

The role of protein phosphorylation in the control of cell growth and differentiation

scientific article published on November 1988

The sequential determination model of hematopoiesis

scientific article published on 7 September 2007

The versatile landscape of haematopoiesis: are leukaemia stem cells as versatile?

scientific article published on September 2012

The versatility of haematopoietic stem cells: implications for leukaemia

scientific article published on August 2010

The vitamin D receptor-mediated activation of phosphatidylinositol 3-kinase (PI3Kalpha) plays a role in the 1alpha,25-dihydroxyvitamin D3-stimulated increase in steroid sulphatase activity in myeloid leukaemic cell lines

scientific article published on 01 April 2008

Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review.

scientific article published on 23 June 2016

Transferrin receptors in human tissues: their distribution and possible clinical relevance

scientific article published on May 1983

Treatment of HL60 cells with various combinations of retinoids and 1 alpha,25 dihydroxyvitamin D3 results in differentiation towards neutrophils or monocytes or a failure to differentiate and apoptosis

scientific article published on 01 March 1995

Triiodothyronine blocks potentiation of HL60 monocyte differentiation by anti-inflammatory agents and by steroids and induces apoptosis of all-trans retinoic acid "primed" cells

scientific article published on July 1997

Up-regulation of steroid sulphatase activity in HL60 promyelocytic cells by retinoids and 1alpha,25-dihydroxyvitamin D3

scientific article

Versatility and nuances of the architecture of haematopoiesis - Implications for the nature of leukaemia

scientific article

Versatility of stem and progenitor cells and the instructive actions of cytokines on hematopoiesis.

scientific article published on 27 July 2015

Vitamin D and hematopoiesis.

scientific article published on August 1997

Vitamin D3-driven signals for myeloid cell differentiation--implications for differentiation therapy

scientific article

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