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List of works by David R. Spring

(Z)-Selective Takai olefination of salicylaldehydes

scientific article published on 20 February 2017

2-Aminopyridine Analogs Inhibit Both Enzymes of the Glyoxylate Shunt in Pseudomonas aeruginosa

scientific article published on 03 April 2020

2-Heptyl-4-quinolone, a precursor of the Pseudomonas quinolone signal molecule, modulates swarming motility in Pseudomonas aeruginosa

scientific article published on 30 September 2011

2-Methoxycyclopentyl analogues of a Pseudomonas aeruginosa quorum sensing modulator

scientific article published on 18 March 2008

3D small-molecule microarrays

article

A Multidimensional Diversity-Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles

scientific article

A concise total synthesis of deoxyschizandrin and exploration of its antiproliferative effects and those of structurally related derivatives

scientific article published on 3 February 2012

A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds

scientific article published on April 2015

A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.

scientific article published on 30 April 2017

A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates

article

A lysosome-targetable fluorescent probe for imaging hydrogen sulfide in living cells

scientific article published on 24 April 2013

A new Pseudomonas quinolone signal (PQS) binding partner: MexG.

scientific article published on 20 January 2016

A novel complexity-to-diversity strategy for the diversity-oriented synthesis of structurally diverse and complex macrocycles from quinine.

scientific article

A one-bead, one-stock solution approach to chemical genetics: part 2.

scientific article

A quorum-sensing molecule acts as a morphogen controlling gas vesicle organelle biogenesis and adaptive flotation in an enterobacterium

scientific article

A selective and ratiometric Cu2+ fluorescent probe based on naphthalimide excimer–monomer switching

article

A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling

scientific article

A two-component 'double-click' approach to peptide stapling

scientific article published on 12 March 2015

A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds

scientific article

All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading

An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds

scientific article published on 20 May 2020

Anti-MRSA agent discovery using diversity-oriented synthesis

scientific article

Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria

scientific article published on 06 July 2012

Arene C-H functionalisation using a removable/modifiable or a traceless directing group strategy

scientific article published on July 2014

Aryl-Aryl Bond Formation by the Fluoride-Free Cross-Coupling of Aryldisiloxanes with Aryl Bromides

article

Aryl–aryl coupling via directed lithiation and oxidation

article

Assessment of structural diversity in combinatorial synthesis

scientific article

Bioinspired Total Synthesis of Bussealin E.

scientific article published on 2 March 2018

C(sp3)-H arylation to construct all-syn cyclobutane-based heterobicyclic systems: a novel fragment collection

scientific article published on 03 June 2020

C-H activation: Complex peptides made simple

scientific article published in December 2016

Cell-cell communication in Gram-negative bacteria

scientific article published on 25 July 2005

Chemical genetics

scientific article

Chemical genetics to chemical genomics: small molecules offer big insights

scientific article

Cleavable linkers in antibody-drug conjugates

scientific article published on 01 August 2019

Combating multidrug-resistant bacteria: current strategies for the discovery of novel antibacterials

scientific article published on 05 September 2013

Combinatorial Synthesis of Structurally Diverse Triazole-Bridged Flavonoid Dimers and Trimers.

scientific article

Communications blackout? Do N-acylhomoserine-lactone-degrading enzymes have any role in quorum sensing?

scientific article published in July 2004

Complete functionalisation of small and large diameter bromopolystyrene beads; applications for solid-supported reagents, scavengers and diversity-oriented synthesisElectronic supplementary information (ESI) available: experimental techniques, appara

article

Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction

scientific article published on 8 August 2017

Concise copper-catalyzed synthesis of tricyclic biaryl ether-linked aza-heterocyclic ring systems

article

Concise synthesis of rare pyrido[1,2-a]pyrimidin-2-ones and related nitrogen-rich bicyclic scaffolds with a ring-junction nitrogen.

scientific article published on 3 December 2015

Controlling the contents of microdroplets by exploiting the permeability of PDMS.

scientific article published on 7 February 2011

Copper catalyzed oxidation of organozinc halides

article

Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates

article

Coumarin-derived transformable fluorescent sensor for Zn2+

article

Crystal Structure of CK2alpha

Crystal Structure of CK2alpha

Crystal Structure of CK2alpha with 3,4-dichlorophenethylamine bound

article

Crystal Structure of CK2alpha with Compound 10 bound

article

Crystal Structure of CK2alpha with Compound 3 bound

article

Crystal Structure of CK2alpha with Compound 4 bound

article

Crystal Structure of CK2alpha with Compound 5 bound

Crystal Structure of CK2alpha with Compound 5 bound

scholarly article published 27 July 2016

Crystal Structure of CK2alpha with Compound 6 bound

article

Crystal Structure of CK2alpha with a novel closed conformation of the aD loop

article

Crystal Structure of CK2alpha with compound 10 bound

article

Crystal structure of CK2alpha with (methyl 4-((3-(3-chloro-4-(phenyl)benzylamino)propyl)amino)-4-oxobutanoate bound

article

Crystal structure of CK2alpha with 2-hydroxy-5-methylbenzoic acid and (methyl 4-((3-(3-chloro-4-(phenyl)benzylamino)propyl)amino)-4-oxobutanoat bound

article

Crystal structure of CK2alpha with 2-hydroxy-5-methylbenzoic acid and N-(3-(3-chloro-4-(phenyl)benzylamino)propyl)acetamide bound

article

Crystal structure of CK2alpha with 3-(3-chloro-4-(phenyl)benzylamino)propan-1-ol bound

article

Crystal structure of CK2alpha with N-(3-(3-chloro-4-(phenyl)benzylamino)propyl)acetamide bound

article

Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment-Based Drug Discovery

scientific article published on 29 July 2019

Design and Synthesis of a Biotinylated Chemical Probe for Detecting the Molecular Targets of an Inhibitor of the Production of the Pseudomonas aeruginosa Virulence Factor Pyocyanin

article

Design, synthesis and biological evaluation of non-natural modulators of quorum sensing in Pseudomonas aeruginosa

scientific article published on 13 April 2012

Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer

scientific article published on 5 December 2016

Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling

scientific article

Development of off-on fluorescent probes for heavy and transition metal ions

scientific article published on 12 January 2010

Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction

scientific article published on 11 May 2020

Discovery of a highly selective turn-on fluorescent probe for Ag+.

scientific article published on 6 September 2010

Discovery of a quorum sensing modulator pharmacophore by 3D small-molecule microarray screening.

scientific article

Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

scientific article published on 5 April 2016

Discovery of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells

scientific article

Divergent Synthesis of Quinolone Natural Products from Pseudonocardia sp. CL38489.

scientific article published on 15 November 2016

Divergent Total Syntheses of Flavonoid Natural Products Isolated from Rosa rugosa and Citrus unshiu

article

Divergent synthesis of biflavonoids yields novel inhibitors of the aggregation of amyloid β (1-42).

scientific article

Diversity-Oriented Synthesis of Disubstituted Alkenes Using Masked Silanols

article

Diversity-Oriented Synthesis of Macrocycle Libraries for Drug Discovery and Chemical Biology

article

Diversity-oriented synthesis

scientific article

Diversity-oriented synthesis as a tool for identifying new modulators of mitosis

scientific article published in January 2014

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

scientific article

Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform

scientific article

Diversity-oriented synthesis of bicyclic and tricyclic alkaloids

article

Diversity-oriented synthesis of drug-like macrocyclic scaffolds using an orthogonal organo- and metal catalysis strategy

scientific article

Diversity-oriented synthesis of heterocycles and macrocycles by controlled reactions of oxetanes with α-iminocarbenes

scientific article published on 12 June 2017

Diversity-oriented synthesis of macrocyclic peptidomimetics

scientific article

Diversity-oriented synthesis: producing chemical tools for dissecting biology

scientific article

Diversity-oriented synthesis; a challenge for synthetic chemistsElectronic supplementary information (ESI) available: Excel file of all the FDA new molecular entities between the years 1998 and July 2003, and new drug approvals between the years 1990

article

Diversity-oriented synthesis; a spectrum of approaches and results

scientific article

Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides

scientific article

Drug discovery: A question of library design

scientific article published in Nature

Dynamic Combinatorial Chemistry with Novel Dithiol Building Blocks: Towards New Structurally Diverse and Adaptive Screening Collections

article

Editorial: the chemistry–biology interface

article

Efficient Synthesis of Fmoc-Protected Azido Amino Acids

article

Efficient and selective antibody modification with functionalised divinyltriazines

scientific article published on 01 July 2020

Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction.

scientific article published on 12 April 2019

Enantioselective Synthesis of Chromanones via a Peptidic Phosphane Catalyzed Rauhut-Currier Reaction

scientific article published on 27 April 2015

Engineering of new prodigiosin-based biosensors of Serratia for facile detection of short-chain N-acyl homoserine lactone quorum-sensing molecules

scientific article published on 23 February 2010

Exploiting domino enyne metathesis mechanisms for skeletal diversity generation

article

Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips

scientific article

Fluorescent Sensing and Discrimination of ATP and ADP Based on a Unique Sandwich Assembly of Pyrene-Adenine-Pyrene

article

Fluorescent chemosensors for Zn(2+).

scientific article published on 28 April 2010

Fluoride-free cross coupling using vinyldisiloxanes

article

Fluorous tagged small molecule microarrays

scientific article published on 4 September 2007

Fsp3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery

scientific article published on 01 February 2020

Gemmacin B: bringing diversity back into focus

scientific article

General dual functionalisation of biomacromolecules via a cysteine bridging strategy

scientific article published on 20 May 2020

High content screening of diverse compound libraries identifies potent modulators of tubulin dynamics

scientific article

Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design

scientific article published on 02 April 2020

How diverse are diversity assessment methods? A comparative analysis and benchmarking of molecular descriptor space

scientific article

Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells

scientific article published on 27 May 2020

Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis

scientific article

Identification of key residues that confer Rhodobacter sphaeroides LPS activity at horse TLR4/MD-2.

scientific article

Identification of new quorum sensing autoinducer binding partners in Pseudomonas aeruginosa using photoaffinity probes

scientific article

Immunomodulatory effects of Pseudomonas aeruginosa quorum sensing small molecule probes on mammalian macrophages

scientific article published on 6 January 2006

Induction‐Driven Stabilization of the Anion–π Interaction in Electron‐Rich Aromatics as the Key to Fluoride Inclusion in Imidazolium‐Cage Receptors ⬇️

scientific article published on December 13, 2010

Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics

scientific article

Investigating peptide sequence variations for 'double-click' stapled p53 peptides

scientific article

Is synthesis the main hurdle for the generation of diversity in compound libraries for screening?

scientific article

Learning the language of bacteria

scientific article

Ligand binding kinetics of the quorum sensing regulator PqsR.

scientific article published on 13 June 2013

Linear aliphatic dialkynes as alternative linkers for double-click stapling of p53-derived peptides

scientific article

Loving the poison: the methylcitrate cycle and bacterial pathogenesis

scientific article published on 22 January 2018

Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling

scientific article published on 01 August 2019

Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.

scientific article published on 13 January 2017

Mastering the chemical language of bacteria

scientific article

Metabolic and regulatory engineering of Serratia marcescens: mimicking phage-mediated horizontal acquisition of antibiotic biosynthesis and quorum-sensing capacities

scientific article published in July 2006

Microwave and flow syntheses of Pseudomonasquinolone signal (PQS) and analogues

article

Microwave-assisted preparation of the quorum-sensing molecule 2-heptyl-3-hydroxy-4(1H)-quinolone and structurally related analogs

article

Multifunctional supramolecular polymer networks as next-generation consolidants for archaeological wood conservation

scientific article

Multiple-parameter Optimization in Drug Discovery: Example of the 5-HT1B GPCR.

scientific article published on 11 July 2016

Novel Phosphate Derivatives as Scaffolds for the Preparation of Synthetic Phosphoserine-Based Peptides Using the Fmoc/t-Bu Solid-Phase Strategy

article

Novel and efficient copper-catalysed synthesis of nitrogen-linked medium-ring biaryls.

scientific article published on 2 February 2011

Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions

scientific article

PNA to DNA to microarray decoding facilitates ligand discovery

scientific article

Palladium-Catalysed Cross-Coupling of Vinyldisiloxanes with Benzylic and Allylic Halides and Sulfonates

article

Palladium-catalysed cross-coupling of organosilicon reagents

scientific article

Partially Saturated Bicyclic Heteroaromatics as an sp(3) -Enriched Fragment Collection

scientific article

Peptide stapling techniques based on different macrocyclisation chemistries

scientific article published on 08 September 2014

Peptides as a platform for targeted therapeutics for cancer: peptide-drug conjugates (PDCs)

scientific article published on 21 December 2020

Photocatalytic methods for amino acid modification

scientific article published on 11 November 2020

Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst.

scientific article published on 14 March 2017

Quantitatively mapping cellular viscosity with detailed organelle information via a designed PET fluorescent probe

scientific article

Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways

scientific article published on 23 December 2010

Rational methods for the selection of diverse screening compounds

scientific article

Regioselectivity in Thermal Rhodium(II)-Catalysed Büchner-Type Reactions of Substituted Aryl Halides: Studies towards the Synthesis of Halide-Substituted Cycloheptatrienes

article

Second-generation CK2α inhibitors targeting the αD pocket.

scientific article

Semi-syntheses of the 11-hydroxyrotenoids sumatrol and villosinol

article

Site-selective modification strategies in antibody-drug conjugates

scientific article published on 08 December 2020

Skeletal diversity construction via a branching synthetic strategy

article

Small molecules in biology

article

Small-molecule screening: advances in microarraying and cell-imaging technologies

scientific article published on January 2007

Specific inhibition of CK2α from an anchor outside the active site

scientific article published on 12 July 2016

Spirocycles as Rigidified sp3-Rich Scaffolds for a Fragment Collection

scientific article published on 30 May 2019

Stapled peptides as a new technology to investigate protein-protein interactions in human platelets.

scientific article published on 25 April 2018

Stereocontrolled Semisyntheses of Elliptone and 12aβ-Hydroxyelliptone

scientific article

Stereocontrolled semi-syntheses of deguelin and tephrosin

scientific article published on 30 January 2017

Stereoselective Synthesis of Disubstituted Butadienes via Copper-Mediated Coupling of Alkenyl Silanes

article

Strategies for the Diversity-Oriented Synthesis of Macrocycles

scientific article published on 20 June 2019

Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa

scientific article

Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence

scientific article published on 21 June 2016

Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site

scientific article

Structure-activity analysis of the Pseudomonas quinolone signal molecule

scientific article published on 21 May 2010

Structure-activity relationships of Erwinia carotovora quorum sensing signaling molecules

scientific article published in October 2005

Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis.

scientific article published on 24 December 2014

Surface swarming motility by Pectobacterium atrosepticum is a latent phenotype that requires O antigen and is regulated by quorum sensing

scientific article published on 11 September 2013

Synthesis and Reactivity of a Bis-Strained Alkyne Derived from 1,1'-Biphenyl-2,2',6,6'-tetrol

scientific article published on 29 January 2019

Synthesis and biological evaluation of 1,2-disubsubstituted 4-quinolone analogues of sp. natural products

article

Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity

article

Synthesis and stability of small molecule probes for Pseudomonas aeruginosa quorum sensing modulation

scientific article published on 13 October 2004

Synthesis of Biaryl-Containing Medium-Ring Systems by Organocuprate Oxidation: Applications in the Total Synthesis of Ellagitannin Natural Products

article

Synthesis of Highly Substituted Symmetrical 1,3-Dienes via Organocuprate Oxidation

article

Synthesis of Highly Substituted Symmetrical 1,3-Dienes via Tandem Carbocupration and Organocuprate Oxidation

article

Synthesis of Medium-Ring and Iodinated Biaryl Compounds by Organocuprate Oxidation

article

Synthesis of Structurally Diverse N-Substituted Quaternary-Carbon-Containing Small Molecules from α,α-Disubstituted Propargyl Amino Esters

article

Synthesis of a Biotin-Labeled Quorum-Sensing Molecule: Towards a General Method for Target Identification

article

Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck-Suzuki reaction

scientific article published on 9 September 2014

Synthesis of unprecedented scaffold diversity

scientific article

Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides

scientific article published on 21 June 2019

Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design

scientific article published on 17 August 2017

The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein-Protein Interactions.

scientific article

The Pseudomonas Quinolone Signal (PQS)

article

The Serratia LuxR family regulator CarR 39006 activates transcription independently of cognate quorum sensing signals

scientific article published on 28 March 2011

The Synthesis of Quinolone Natural Products from Pseudonocardia sp.

scientific article published on 21 December 2015

The Use of Chlorobenzene as a Probe Molecule in Molecular Dynamics Simulations

article

The discovery of antibacterial agents using diversity-oriented synthesis

scientific article

The molecular basis of the host response to lipopolysaccharide

scientific article published in January 2010

The oxidation of organocuprates--an offbeat strategy for synthesis

scientific article

The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with hydrocinnamoyl-derivatized PLHSpTA peptide

article

Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides

scientific article published on 07 February 2019

Total Synthesis of Sanguiin H-5

article

Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents

scientific article published on 10 January 2020

Towards quorum-quenching catalytic antibodies

scientific article published on 11 December 2008

Toxicity of six plant extracts and two pyridone alkaloids from Ricinus communis against the malaria vector Anopheles gambiae ⬇️

scientific article

Two-directional synthesis as a tool for diversity-oriented synthesis: Synthesis of alkaloid scaffolds

scientific article published on 6 June 2012

Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1

scientific article

Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein–Protein Interactions

article

Using chemical probes to investigate the sub-inhibitory effects of azithromycin

scientific article published on 19 September 2008

Vinyldisiloxanes: their synthesis, cross coupling and applications

article

Virulence in Pectobacterium atrosepticum is regulated by a coincidence circuit involving quorum sensing and the stress alarmone, (p)ppGpp

scientific article published on 30 September 2013

Which microbial factors really are important in Pseudomonas aeruginosa infections?

scientific article

Zn2+-triggered amide tautomerization produces a highly Zn2+-selective, cell-permeable, and ratiometric fluorescent sensor

scientific article published in January 2010

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