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List of works by Wenjun Ouyang

A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator

scientific article

A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes

scientific journal article

A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis

scientific article

A novel IL-25 signaling pathway through STAT5

scientific article

A reversed sulfonamide series of selective RORc inverse agonists

scientific article

Activation of epithelial STAT3 regulates intestinal homeostasis

scientific article

An instructive component in T helper cell type 2 (Th2) development mediated by GATA-3.

scientific article

An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy

scientific article published on 4 August 2013

Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to Induce Type 2 Inflammation from Human Lymphocytes

scientific article published on 15 February 2019

Deciphering the crosstalk among IL-1 and IL-10 family cytokines in intestinal immunity

scientific article published on 13 July 2015

Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus.

scientific article published on 28 October 2011

Discovery of 1-{4-[3-fluoro-4-((3s,6r)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C (RORc or RORγ) i

scientific article published on 23 June 2015

Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists

scientific article published on 28 May 2015

Distinct roles of IL-22 in human psoriasis and inflammatory bowel disease.

scientific article

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

scientific article

ERM is required for transcriptional control of the spermatogonial stem cell niche

scientific article

Friend of GATA-1 represses GATA-3-dependent activity in CD4+ T cells.

scientific article

GATA-3-dependent enhancer activity in IL-4 gene regulation

article

Guidelines for the use of flow cytometry and cell sorting in immunological studies

scientific article published on October 2017

Homeostatic IL-23 receptor signaling limits Th17 response through IL-22-mediated containment of commensal microbiota.

scientific article

IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation

scientific article published on 01 April 2019

IL-17-induced Act1-mediated signaling is critical for cuprizone-induced demyelination

scientific article

IL-17RC is required for IL-17A- and IL-17F-dependent signaling and the pathogenesis of experimental autoimmune encephalomyelitis.

scientific article published on 15 March 2010

IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail

scientific journal article

IL-18-stimulated GADD45 beta required in cytokine-induced, but not TCR-induced, IFN-gamma production.

scientific article

IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium

scientific article published on 28 August 2011

IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection

scientific article published on 27 June 2012

IL-22 in mucosal immunity.

scientific article

IL-22, not simply a Th17 cytokine

scientific article published on March 2013

IL-22-induced antimicrobial peptides are key determinants of mucosal vaccine-induced protection against H. pylori in mice.

scientific article published on 4 May 2016

IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis.

scientific article published on 18 June 2013

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

scientific journal article

IL-4 Derived from Non-T Cells Induces Basophil- and IL-3-independent Th2 Immune Responses

scientific article published on 20 December 2013

Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data.

scientific article

Induction of interferon-γ production in Th1 CD4+ T cells: evidence for two distinct pathways for promoter activation

article

Inflammatory Bowel Disease Susceptibility Gene C1ORF106 Regulates Intestinal Epithelial Permeability

scientific article published on 30 May 2018

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

article

Innate-like function of memory Th17 cells for enhancing endotoxin-induced acute lung inflammation through IL-22

scientific article

Integrative biology approach identifies cytokine targeting strategies for psoriasis

scientific article

Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17.

scientific article

Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

scientific article

Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection

scientific article published on 10 February 2015

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

scientific article (publication date: March 2008)

Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

scientific article (publication date: 8 February 2007)

LILRB1 Blockade Enhances Bispecific T Cell Engager Antibody-Induced Tumor Cell Killing by Effector CD8+ T Cells

scientific article published on 28 June 2019

Mice deficient in NRROS show abnormal microglial development and neurological disorders.

scientific article published in May 2017

Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action.

scientific article published on 4 December 2014

Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1 ⬇️

scientific article

Nonclinical safety assessment of a human interleukin-22FC IG fusion protein demonstrates in vitro to in vivo and cross-species translatability

scientific article published on 15 November 2018

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

scientific journal article

Novel therapeutic targets along the Th17 pathway

scientific article published in March 2009

Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice.

scientific article published on 16 November 2011

PILRα negatively regulates mouse inflammatory arthritis

scientific article

Phosphatidylserine receptor Tim-4 is essential for the maintenance of the homeostatic state of resident peritoneal macrophages

scientific article

Proteomic profiling of surface proteins on Th1 and Th2 cells

scientific article published in March 2005

Psoriasis-like skin lesions are dependent on IL-23 but develop in the absence of IL-22 in a model mouse

scientific article published on 19 November 2013

Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome

scientific article published on 23 May 2016

Regulation and functions of the IL-10 family of cytokines in inflammation and disease

scientific article published on January 2011

Regulation of epithelial immunity by IL-17 family cytokines

scientific article published on 02 April 2012

Regulation of interleukin-10 and interleukin-22 expression in T helper cells

scientific article published on 20 August 2011

Role of IL-22 in microbial host defense

scientific article published on January 2014

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

scientific article published on 29 June 2009

Signaling via the IL-20 receptor inhibits cutaneous production of IL-1β and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus

scientific article published on 23 June 2013

Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment

scientific article published in January 2000

TRAF4-SMURF2-mediated DAZAP2 degradation is critical for IL-25 signaling and allergic airway inflammation.

scientific article

TRIMming TGF-β signals in Th17 cells

scientific article published on 26 June 2018

Targeting IL-10 Family Cytokines for the Treatment of Human Diseases.

scientific article published on 16 October 2017

Targeting interferon-alpha: a promising approach for systemic lupus erythematosus therapy.

scientific article published in January 2004

Targeting the development and effector functions of TH17 cells.

scientific article published on December 2007

Th17 Cells at the Crossroads of Autoimmunity, Inflammation, and Atherosclerosis

scientific article published on 01 January 2014

Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria

scientific article published on 29 November 2012

The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis

scientific article published on 01 February 2007

The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway.

scientific article

The IL-17 family cytokines in immunity and disease.

scientific article published on 23 February 2010

The IL-17 pathway as a major therapeutic target in autoimmune diseases

scientific article published in January 2011

The IL-20 subfamily of cytokines--from host defence to tissue homeostasis

scientific article

The Itch to degrade ROR-γt

scientific article published in July 2016

The biological functions of T helper 17 cell effector cytokines in inflammation

scientific article

The cytokine IL-22 promotes pathogen colonization by suppressing related commensal bacteria.

scientific article published on 06 February 2014

The function role of GATA-3 in Th1 and Th2 differentiation.

scientific article

The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90.

scientific article published on 2 December 2012

The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds

scientific article published on 23 October 2008

Therapeutic opportunities of the IL-22-IL-22R1 system

scientific article published on January 2014

Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in T(H)17 cells.

scientific article

Unexpected characteristics of the IFN-gamma reporters in nontransformed T cells

scientific article

Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18

scientific article

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