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List of works by Graham R. Leggatt

A combination of local inflammation and central memory T cells potentiates immunotherapy in the skin

scientific article published on 9 November 2012

Antigen-specific CD4 cells assist CD8 T-effector cells in eliminating keratinocytes

scientific article published on 11 February 2010

Changes to peptide structure, not concentration, contribute to expansion of the lowest avidity cytotoxic T lymphocytes

scientific article published on 7 July 2004

Chimeric human papilloma virus-simian/human immunodeficiency virus virus-like-particle vaccines: immunogenicity and protective efficacy in macaques

scientific article published in September 2002

Cytotoxic T lymphocyte (CTL) adherence assay (CAA): a non-radioactive assay for murine CTL recognition of peptide-MHC class I complexes

scientific article published in February 1997

Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients

scientific article

Enhanced tumor growth in the NaS1 sulfate transporter null mouse

scientific article

Epithelial expression of human papillomavirus type 16 E7 protein results in peripheral CD8 T-cell suppression mediated by CD4+CD25+ T cells

scientific article published on 01 February 2009

Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytes

scientific article

Expression of the HPV16E7 oncoprotein by thymic epithelium is accompanied by disrupted T cell maturation and a failure of the thymus to involute with age

scientific article published on June 2003

Functional memory CD8+ T cells can be generated in vivo without evident T help

scientific article published on 01 December 2004

Further characterization of the 38 kDa antigen from Echinococcus granulosus (hydatid disease) cyst fluid: evidence for antigenic heterogeneity and reactivity with anti-P1 antibodies

scientific article published on 01 June 1995

HPV vaccines: the beginning of the end for cervical cancer.

scientific article published on 12 February 2007

HPV16 E7-Driven Epithelial Hyperplasia Promotes Impaired Antigen Presentation and Regulatory T-Cell Development

scientific article published on 15 June 2019

HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells

scientific article

Histone deacetylase inhibitors in the generation of the anti-tumour immune response

scientific article

Human growth hormone presented by K14hGH-transgenic skin grafts induces a strong immune response but no graft rejection

scientific article published on 01 December 2004

Human papillomavirus 16 E7 protein inhibits interferon-γ-mediated enhancement of keratinocyte antigen processing and T-cell lysis

scientific article published on 05 February 2011

Hydatid immunoblot test and cross-reactivity with sera from patients with cysticercosis

scientific article published on 01 May 1993

IFN-gamma promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host

scientific article published on 17 June 2009

IL-1 signalling determines the fate of skin grafts expressing non-self protein in keratinocytes

scientific article

Immunosuppressive roles of natural killer T (NKT) cells in the skin

scientific article published on 05 May 2014

Impact of sex steroid ablation on viral, tumour and vaccine responses in aged mice.

scientific article

Impaired Antigen Presentation and Effectiveness of Combined Active/Passive Immunotherapy for Epithelial Tumors

scientific article published on 01 November 2004

Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein e7.

scientific article published on 07 May 2013

Inhibition of cervical cancer cell growth in vitro and in vivo with lentiviral-vector delivered short hairpin RNA targeting human papillomavirus E6 and E7 oncogenes.

scientific article

Interferon-gamma enhances cytotoxic T lymphocyte recognition of endogenous peptide in keratinocytes without lowering the requirement for surface peptide

scientific article published on 01 October 2002

Invariant NKT Cells in Hyperplastic Skin Induce a Local Immune Suppressive Environment by IFN- Production

scientific article published on 18 December 2009

Keratinocytes efficiently process endogenous antigens for cytotoxic T-cell mediated lysis.

scientific article

Modulation of antigen presenting cell functions during chronic HPV infection.

scientific article published on 18 August 2017

NKT Cell-Driven Enhancement of Antitumor Immunity Induced by Clec9a-Targeted Tailorable Nanoemulsion

scientific article published on 03 May 2019

NKT cells inhibit antigen-specific effector CD8 T cell induction to skin viral proteins.

scientific article

Nonspecific down-regulation of CD8+ T-cell responses in mice expressing human papillomavirus type 16 E7 oncoprotein from the keratin-14 promoter.

scientific article published in July 2001

Papillomavirus virus-like particles for the delivery of multiple cytotoxic T cell epitopes

scientific article published on August 2000

Paucity of functional CTL epitopes in the E7 oncoprotein of cervical cancer associated human papillomavirus type 16

scientific article published on 01 February 2003

Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell Responses

scientific article published on 02 July 2014

Polynucleotide viral vaccines: codon optimisation and ubiquitin conjugation enhances prophylactic and therapeutic efficacy.

scientific article

Prevention and Treatment of Papillomavirus-Related Cancers Through Immunization ⬇️

scientific article published on January 1, 2011

RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin.

scientific article published on 24 August 2005

Recent progress in vaccination against human papillomavirus-mediated cervical cancer

scientific article

Regulation of immune responses to HPV infection and during HPV-directed immunotherapy

scientific article published on January 2011

Role of intratumoural heterogeneity in cancer drug resistance: molecular and clinical perspectives

scientific article

Route of administration of chimeric BPV1 VLP determines the character of the induced immune responses

article

Secondary immunisation with high-dose heterologous peptide leads to CD8 T cell populations with reduced functional avidity

scientific article published on 01 February 2007

Secretion of IFN-gamma but not IL-17 by CD1d-restricted NKT cells enhances rejection of skin grafts expressing epithelial cell-derived antigen

scientific article

Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy.

scientific article published on April 1996

Sequence homology between two immunodiagnostic fusion proteins from Echinococcus multilocularis

scientific article published on September 1992

Serological evaluation of the 12 kDa subunit of antigen B in Echinococcus granulosus cyst fluid by immunoblot analysis

scientific article published on March 1992

Split tolerance to a viral antigen expressed in thymic epithelium and keratinocytes

article

TLR7 stimulation augments T effector-mediated rejection of skin expressing neo-self antigen in keratinocytes

scientific article published on 01 January 2008

The kinematics of cytotoxic lymphocytes influence their ability to kill target cells

scientific article

The number of long-lasting functional memory CD8+ T cells generated depends on the nature of the initial nonspecific stimulation

scientific article published in June 2002

Tumour susceptibility to innate and adaptive immunotherapy changes during tumour maturation.

scientific article

γδ T cells augment rejection of skin grafts by enhancing cross-priming of CD8 T cells to skin-derived antigen

scientific article

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