List of works by Lars Frelin

A bi-functional hepatitis B virus core antigen (HBcAg) chimera activates HBcAg-specific T cells and preS1-specific antibodies

scientific article published on 21 September 2011

A heterologous prime/boost vaccination strategy enhances the immunogenicity of therapeutic vaccines for hepatitis C virus.

scientific article published on 17 June 2013

A small step closer to the Holy Grail of DNA vaccines: undisputed clinical benefit in humans

scientific article published on 23 January 2009

A synthetic codon-optimized hepatitis C virus nonstructural 5A DNA vaccine primes polyfunctional CD8+ T cell responses in wild-type and NS5A-transgenic mice

scientific article published on 2 January 2013

A targeted controlled force injection of genetic material in vivo

scientific article published on 30 March 2016

Anti-tumor necrosis factor α treatment promotes apoptosis and prevents liver regeneration in a transgenic mouse model of chronic hepatitis C.

scientific article published on November 2010

Cleavage of the IPS-1/Cardif/MAVS/VISA does not inhibit T cell-mediated elimination of hepatitis C virus non-structural 3/4A-expressing hepatocytes

scientific article (publication date: April 2009)

Codon optimization and mRNA amplification effectively enhances the immunogenicity of the hepatitis C virus nonstructural 3/4A gene

scientific article published on March 2004

Containing "The Great Houdini" of viruses: combining direct acting antivirals with the host immune response for the treatment of chronic hepatitis C.

scientific article published on July 2013

DNA vaccine therapy for chronic hepatitis C virus (HCV) infection: immune control of a moving target.

scientific article published on July 2009

Electroporation for therapeutic DNA vaccination in patients

scientific article published on 23 December 2014

Electroporation: a promising method for the nonviral delivery of DNA vaccines in humans?

scientific article published on December 2010

Functional aspects of intrahepatic hepatitis B virus-specific T cells induced by therapeutic DNA vaccination

scientific article published on 10 December 2014

Functional differences in hepatitis C virus nonstructural (NS) 3/4A- and 5A-specific T cell responses

scientific article published on 4 May 2016

Generation of T-cell receptors targeting a genetically stable and immunodominant cytotoxic T-lymphocyte epitope within hepatitis C virus non-structural protein 3.

scientific article

Hepatitis C Virus Nonstructural 3/4A Protein Dampens Inflammation and Contributes to Slow Fibrosis Progression during Chronic Fibrosis In Vivo

scientific article published on June 2015

Hepatitis C Virus-Specific T Cell Receptor mRNA-Engineered Human T Cells: Impact of Antigen Specificity on Functional Properties.

scientific article published on 22 February 2017

Hepatitis C virus non-structural 3/4A protein interferes with intrahepatic interferon-γ production.

scientific article published on 3 August 2011

Heterologous T cells can help restore function in dysfunctional hepatitis C virus nonstructural 3/4A-specific T cells during therapeutic vaccination

scientific article published on 23 March 2011

Humoral and CD4(+) T helper (Th) cell responses to the hepatitis C virus non-structural 3 (NS3) protein: NS3 primes Th1-like responses more effectively as a DNA-based immunogen than as a recombinant protein

scientific article published in June 2001

Identification of a unique double-negative regulatory T-cell population

scientific article published on 01 December 2011

Immune-mediated effects targeting hepatitis C virus in a syngeneic replicon cell transplantation mouse model.

scientific article published on 23 June 2017

Improving on the ability of endogenous hepatitis B core antigen to prime cytotoxic T lymphocytes

scientific article published in June 2010

In vivo clearance of hepatitis C virus nonstructural 3/4A-expressing hepatocytes by DNA vaccine-primed cytotoxic T lymphocytes

scientific article published on 4 November 2005

In vivo electroporation enhances the immunogenicity of hepatitis C virus nonstructural 3/4A DNA by increased local DNA uptake, protein expression, inflammation, and infiltration of CD3+ T cells

scientific article published in October 2007

Lack of association between interleukin 28B polymorphism and vertical transmission of hepatitis C.

scientific article

Limited effect on NS3-NS4A protein cleavage after alanine substitutions within the immunodominant HLA-A2-restricted epitope of the hepatitis C virus genotype 3a non-structural 3/4A protease

scientific article published on 16 May 2012

Long-term functional duration of immune responses to HCV NS3/4A induced by DNA vaccination

scientific article

Low dose and gene gun immunization with a hepatitis C virus nonstructural (NS) 3 DNA-based vaccine containing NS4A inhibit NS3/4A-expressing tumors in vivo.

scientific article published in April 2003

Methods for monitoring gene gun-induced HBV- and HCV-specific immune responses in mouse models

scientific article published on January 2013

Methods to Evaluate Novel Hepatitis C Virus Vaccines

scientific article published on January 2016

Microvesicular fat, inter cellular adhesion molecule-1 and regulatory T-lymphocytes are of importance for the inflammatory process in livers with non-alcoholic steatohepatitis

scientific article published on 25 April 2011

Neonatal Exposure to Hepatitis C Virus Antigens in Uninfected Children Born to Infected Mothers

scientific article published on 26 September 2017

Non-structural 3 protein expression is associated with T cell protein tyrosine phosphatase and viral RNA levels in chronic hepatitis C patients.

scientific article published on 27 February 2013

Nonstructural 3/4A protease of hepatitis C virus activates epithelial growth factor-induced signal transduction by cleavage of the T-cell protein tyrosine phosphatase

scientific article published on June 2009

Prospects and progress of DNA vaccines for treating hepatitis B.

scientific article

Relation between viral fitness and immune escape within the hepatitis C virus protease

scientific article

TCR-redirected human T cells inhibit hepatitis C virus replication: hepatotoxic potential is linked to antigen specificity and functional avidity

scientific article

The hepatitis C virus and immune evasion: non-structural 3/4A transgenic mice are resistant to lethal tumour necrosis factor mediated liver disease

scientific article (publication date: October 2006)

The hepatitis C virus non-structural NS5A protein impairs both the innate and adaptive hepatic immune response in vivo

scientific article

Paulina is supported by:

About Paulina

Help