List of works - Philippe P. Roux

A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells

scientific article

A comprehensive map of the mTOR signaling network

scientific article published on December 2010

A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling

scientific article published on 18 April 2017

Actin cortex architecture regulates cell surface tension.

scientific article published on 22 May 2017

Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases

scientific article

Activation of transcription factors NF-kappaB and NF-IL-6 by human immunodeficiency virus type 1 protein R (Vpr) induces interleukin-8 expression

scientific article

An ErbB2 splice variant lacking exon 16 drives lung carcinoma

scientific article published on 29 July 2020

Casein kinase 1ε promotes cell proliferation by regulating mRNA translation

scientific article published on 18 November 2013

CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein.

scientific article published on 10 January 2018

Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging.

scientific article published on 17 October 2013

Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression ⬇️

scientific article published on July 15, 2013

Cellular control of cortical actin nucleation

scientific article

Controversies around the function of LARP1

scientific article published on 01 April 2020

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

scientific article published on 24 July 2020

Defining the role of the RSK isoforms in cancer

scientific article published on 2 May 2017

Disruption of TBC1D7, a subunit of the TSC1-TSC2 protein complex, in intellectual disability and megalencephaly

scientific article

EPCR expression marks UM171-expanded CD34+ cord blood stem cells.

scientific article published on 13 April 2017

ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).

scientific article published on 11 November 2010

ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation

scientific article published on 06 February 2019

Effect of the transient pharmacological inhibition of Mapk3/1 pathway on ovulation in mice

scientific article

Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt Signaling

scientific article published on 17 January 2017

F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis

scientific article published on 09 January 2020

F-box proteins elongate translation during stress recovery.

scientific article

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

scientific article published on 13 July 2017

Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1.

scientific article published on 15 April 2013

High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.

scientific article

Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities

scientific article published on 01 November 2019

Identification of RSK substrates using an analog-sensitive kinase approach

scientific article published in 2024

Insulin activates RSK (p90 ribosomal S6 kinase) to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism.

scientific article published on 13 September 2013

K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK.

scientific article published on 17 October 2002

Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling

scientific article published on 09 January 2020

Mechanistic target of rapamycin (MTOR) signaling during ovulation in mice.

scientific article

Mind the GAP: Wnt steps onto the mTORC1 train

scientific article published on September 2006

Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration

scientific article published on 02 September 2019

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia

scientific article published on 01 July 2019

Mutations in DOCK7 in individuals with epileptic encephalopathy and cortical blindness

scientific article

NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis

scientific article (publication date: August 2000)

Paving the way for targeting RSK in cancer.

scientific article

Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.

scientific article

Phosphorylation of the eukaryotic translation initiation factor 4E-transporter (4E-T) by c-Jun N-terminal kinase promotes stress-dependent P-body assembly.

scientific article

Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children

scientific article published on 27 May 2019

Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: A novel mechanism regulating commissural axon extension.

scientific article published in March 2004

Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion

scientific article published on 02 November 2019

Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation

scientific article

Proteomics Screen Identifies Class I Rab11 Family Interacting Proteins as Key Regulators of Cytokinesis

scientific article published on 21 November 2016

Publisher Correction: Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1

scientific article published on 19 February 2020

Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.

scientific article

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

scientific article published on 14 March 2007

RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit

scientific article published on 14 June 2021

RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma.

scientific article published on 12 February 2018

RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation

scientific article

RSK promotes G2 DNA damage checkpoint silencing and participates in melanoma chemoresistance

scientific article

RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth

scientific article published on 16 July 2012

Rapamycin resistance: mTORC1 substrates hold some of the answers

scientific article published in October 2013

Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.

scientific article

Regulation and function of the RSK family of protein kinases

scientific article published on January 2012

Regulation of global and specific mRNA translation by the mTOR signaling pathway

scientific article

Regulation of karyopherin α1 and nuclear import by mammalian target of rapamycin

scientific article published on 6 March 2012

Regulation of mRNA translation by signaling pathways

scientific article

Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1

scientific article published on 26 November 2019

SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization

scientific article published on 22 June 2020

STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity

scientific article published on 01 November 2020

Signaling pathways involved in the regulation of mRNA translation.

scientific article published on 2 April 2018

Targeting copper metabolism to defeat KRAS-driven colorectal cancer

scientific article published on 07 October 2020

The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation.

scientific article

The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression

scientific article published in May 2018

The coming of age of phosphoproteomics--from large data sets to inference of protein functions

scientific article

The expanding role of mTOR in cancer cell growth and proliferation

scientific article

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

scientific article

The p75 neurotrophin receptor (p75NTR) alters tumor necrosis factor-mediated NF-kappaB activity under physiological conditions, but direct p75NTR-mediated NF-kappaB activation requires cell stress

scientific article published in Journal of Biological Chemistry

The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway

scientific article published on 18 April 2001

The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling

scientific article published on October 2005

Translational control by oncogenic signaling pathways.

scientific article

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

scientific article

Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells

scientific article

mTOR, the mammalian target of rapamycin

scientific article published on December 2010

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling

scientific article

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

scientific article

List of works by Philippe P. Roux

A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells

A comprehensive map of the mTOR signaling network

A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling

Actin cortex architecture regulates cell surface tension.

Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases

Activation of transcription factors NF-kappaB and NF-IL-6 by human immunodeficiency virus type 1 protein R (Vpr) induces interleukin-8 expression

An ErbB2 splice variant lacking exon 16 drives lung carcinoma

Casein kinase 1ε promotes cell proliferation by regulating mRNA translation

CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein.

Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging.

Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression ⬇️

Cellular control of cortical actin nucleation

Controversies around the function of LARP1

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

Defining the role of the RSK isoforms in cancer

Disruption of TBC1D7, a subunit of the TSC1-TSC2 protein complex, in intellectual disability and megalencephaly

EPCR expression marks UM171-expanded CD34+ cord blood stem cells.

ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).

ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation

Effect of the transient pharmacological inhibition of Mapk3/1 pathway on ovulation in mice

Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt Signaling

F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis

F-box proteins elongate translation during stress recovery.

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1.

High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.

Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities

Identification of RSK substrates using an analog-sensitive kinase approach

Insulin activates RSK (p90 ribosomal S6 kinase) to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism.

K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK.

Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling

Mechanistic target of rapamycin (MTOR) signaling during ovulation in mice.

Mind the GAP: Wnt steps onto the mTORC1 train

Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia

Mutations in DOCK7 in individuals with epileptic encephalopathy and cortical blindness

NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis

Paving the way for targeting RSK in cancer.

Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.

Phosphorylation of the eukaryotic translation initiation factor 4E-transporter (4E-T) by c-Jun N-terminal kinase promotes stress-dependent P-body assembly.

Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children

Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: A novel mechanism regulating commissural axon extension.

Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion

Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation

Proteomics Screen Identifies Class I Rab11 Family Interacting Proteins as Key Regulators of Cytokinesis

Publisher Correction: Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1

Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit

RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma.

RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation

RSK promotes G2 DNA damage checkpoint silencing and participates in melanoma chemoresistance

RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth

Rapamycin resistance: mTORC1 substrates hold some of the answers

Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.

Regulation and function of the RSK family of protein kinases

Regulation of global and specific mRNA translation by the mTOR signaling pathway

Regulation of karyopherin α1 and nuclear import by mammalian target of rapamycin

Regulation of mRNA translation by signaling pathways

Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1

SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization

STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity

Signaling pathways involved in the regulation of mRNA translation.

Targeting copper metabolism to defeat KRAS-driven colorectal cancer

The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation.

The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression

The coming of age of phosphoproteomics--from large data sets to inference of protein functions

The expanding role of mTOR in cancer cell growth and proliferation

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

The p75 neurotrophin receptor (p75NTR) alters tumor necrosis factor-mediated NF-kappaB activity under physiological conditions, but direct p75NTR-mediated NF-kappaB activation requires cell stress

The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway

The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling

Translational control by oncogenic signaling pathways.

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells

mTOR, the mammalian target of rapamycin

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide