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List of works by José Castillo

A -174G/C polymorphism of the interleukin-6 gene in patients with lacunar infarction

scientific article published in May 2002

A chronic treatment with CDP-choline improves functional recovery and increases neuronal plasticity after experimental stroke.

scientific article

A higher body temperature is associated with haemorrhagic transformation in patients with acute stroke untreated with recombinant tissue-type plasminogen activator (rtPA).

scientific article published in February 2012

Age Determines the Effects of Blood Pressure Lowering During the Acute Phase of Ischemic Stroke

scientific article published on 03 August 2009

Aggravation of acute ischemic stroke by hyperthermia is related to an excitotoxic mechanism

scientific article published in January 1999

Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke

scientific article

Association of growth factors with arterial recanalization and clinical outcome in patients with ischemic stroke treated with tPA

scientific article published on 30 April 2010

Biochemical changes and inflammatory response as markers for brain ischaemia: molecular markers of diagnostic utility and prognosis in human clinical practice.

scientific article published on January 2004

Blood glutamate grabbing does not reduce the hematoma in an intracerebral hemorrhage model but it is a safe excitotoxic treatment modality.

scientific article published on 4 March 2015

Blood levels of glutamate oxaloacetate transaminase are more strongly associated with good outcome in acute ischaemic stroke than glutamate pyruvate transaminase levels

scientific article published on 01 July 2011

Blood pressure decrease during the acute phase of ischemic stroke is associated with brain injury and poor stroke outcome

scientific article published on 15 January 2004

Body temperature and response to thrombolytic therapy in acute ischaemic stroke.

scientific article published on December 2008

Brachial arterial flow mediated dilation in acute ischemic stroke

scientific article published on 19 February 2009

CDP-choline treatment increases circulating endothelial progenitor cells in acute ischemic stroke.

scientific article published in July 2011

Cd34+ progenitor cells likely are involved in the good functional recovery after intracerebral hemorrhage in humans

scientific article published on 12 April 2011

Cerebral hemodynamic reserve and early neurologic deterioration in acute ischemic stroke

scientific article published on 01 November 2004

Cerebrospinal fluid tyrosine and 3,4-dihydroxyphenylacetic acid levels in migraine patients

scientific article published in February 1996

Citicoline in intracerebral haemorrhage: a double-blind, randomized, placebo-controlled, multi-centre pilot study

scientific article published on 15 February 2006

Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial).

scientific article

Clinical management guidelines for subarachnoid haemorrhage. Diagnosis and treatment

scientific article

Clinical practice guidelines in intracerebral haemorrhage

scientific article published on 13 May 2011

Delayed post-ischemic administration of CDP-choline increases EAAT2 association to lipid rafts and affords neuroprotection in experimental stroke.

scientific article published on 21 August 2007

Dengue nonstructural protein-1 status is not associated to circulating levels of interleukin-17, C-reactive protein and complement in children with acute dengue

scientific article published on 30 November 2012

Early biomarkers of clinical-diffusion mismatch in acute ischemic stroke

scientific article published on 11 August 2011

Endothelial dysfunction, vascular disease and stroke: the ARTICO study.

scientific article published on 03 April 2009

Endothelial progenitor cells: a new key for endothelial dysfunction in migraine

scientific article published on 18 July 2012

Endovascular treatment of an acutely ruptured intracranial aneurysm in pregnancy: report of eight cases

scientific article published on 17 November 2009

External validation of the SEDAN score for prediction of intracerebral hemorrhage in stroke thrombolysis.

scientific article published on 30 April 2013

Familial hemiplegic migraine with prolonged global aura: follow-up findings of subtraction ictal SPECT co-registered to MRI (SISCOM)

scientific article

Fingolimod reduces hemorrhagic transformation associated with delayed tissue plasminogen activator treatment in a mouse thromboembolic model

scientific article published on 3 January 2013

Genetic markers: association study in migraine

scientific article published on 01 June 1995

Glutamate excitoxicity is the key molecular mechanism which is influenced by body temperature during the acute phase of brain stroke

scientific article

Glutamate neurotoxicity is involved in the neurological damage in patients undergoing extracorporeal circulation

scientific article published on 15 January 2014

Glutamate oxaloacetate transaminase: a new key in the dysregulation of glutamate in migraine patients

scientific article published on 14 May 2013

Guidelines for the preventive treatment of ischaemic stroke and TIA (I). Update on risk factors and life style

scientific article published on 3 September 2011

Guidelines for the preventive treatment of ischaemic stroke and TIA (II). Recommendations according to aetiological sub-type.

scientific article published on 19 September 2011

Guidelines for the treatment of acute ischaemic stroke

scientific article published on 06 December 2011

Headache as a surrogate marker of the molecular mechanisms implicated in progressing stroke.

scientific article published in May 2002

Headache in cerebral hemorrhage is associated with inflammatory markers and higher residual cavity

scientific article published in October 2005

High blood glutamate oxaloacetate transaminase levels are associated with good functional outcome in acute ischemic stroke.

scientific article

High blood pressure and inflammation are associated with poor prognosis in lacunar infarctions

scientific article

High plasma glutamate concentrations are associated with infarct growth in acute ischemic stroke.

scientific article published on 29 October 2008

High pro-BNP levels predict the occurrence of atrial fibrillation after cryptogenic stroke

scientific article

High serum levels of endothelin-1 predict severe cerebral edema in patients with acute ischemic stroke treated with t-PA

scientific article published on 24 April 2008

High serum levels of growth factors are associated with good outcome in intracerebral hemorrhage.

scientific article published on 16 September 2009

High serum levels of leptin are associated with post-stroke depression.

scientific article published on 9 April 2009

High serum levels of pro-brain natriuretic peptide (pro BNP) identify cardioembolic origin in undetermined stroke.

scientific article published on January 2009

Human recombinant glutamate oxaloacetate transaminase 1 (GOT1) supplemented with oxaloacetate induces a protective effect after cerebral ischemia

scientific article

Hyperthermia in human ischemic and hemorrhagic stroke: similar outcome, different mechanisms

scientific article

Hyperthermia is a surrogate marker of inflammation-mediated cause of brain damage in acute ischaemic stroke.

scientific article

Impaired brachial flow-mediated dilation is a predictor of a new-onset vascular event after stroke

scientific article

Importance of cerebral artery recanalization in patients with stroke with and without neurological improvement after intravenous thrombolysis

scientific article published on 23 July 2013

In vivo theranostics at the peri-infarct region in cerebral ischemia.

scientific article published on 12 December 2013

Incisional hernia in patients at risk: can it be prevented?

scientific article published on 12 February 2011

Increased body iron stores are associated with poor outcome after thrombolytic treatment in acute stroke.

scientific article published on 30 November 2006

Increased expression of Toll-like receptors 2 and 4 is associated with poor outcome in intracerebral hemorrhage

scientific article published on 11 April 2012

Increased levels of circulating endothelial progenitor cells in patients with ischaemic stroke treated with statins during acute phase

scientific article published on 28 May 2012

Increased plasma levels of 15-deoxyDelta prostaglandin J2 are associated with good outcome in acute atherothrombotic ischemic stroke

scientific article published on 5 May 2005

Inflammation markers and prediction of post-stroke vascular disease recurrence: the MITICO study.

scientific article published on 27 February 2009

Inflammation-mediated damage in progressing lacunar infarctions: a potential therapeutic target

scientific article

Inflammatory and neuroimmunomodulatory changes in acute cerebral ischemia.

scientific article published on 03 April 2009

Influence of temperature on ischemic brain: basic and clinical principles

scientific article published on 15 February 2012

Inhibition of iNOS activity by 1400W decreases glutamate release and ameliorates stroke outcome after experimental ischemia

scientific article

Interleukin-10 facilitates the selection of patients for systemic thrombolysis.

scientific article

Iron intake increases infarct volume after permanent middle cerebral artery occlusion in rats

scientific article published in October 2002

Ischemic preconditioning: a novel target for neuroprotective therapy

scientific article published on 2 May 2006

Laboratory studies in the investigation of stroke.

scientific article published on January 2009

Levels of anti-inflammatory cytokines and neurological worsening in acute ischemic stroke

scientific article published on 20 February 2003

Magnetic resonance imaging of muscles in myotonic dystrophy

scientific article published on 01 November 1993

Metabolic syndrome and resistance to IV thrombolysis in middle cerebral artery ischemic stroke

scientific article published in July 2008

Micro- and macroalbuminuria predict hemorrhagic transformation in acute ischemic stroke.

scientific article published in October 2006

Mmp-9 immunoreactivity in acute migraine

scientific article

Molecular signatures of vascular injury are associated with early growth of intracerebral hemorrhage

scientific article

Neuroexcitatory amino acid levels in plasma and cerebrospinal fluid during migraine attacks

scientific article published on 01 April 1993

Neuronal excitotoxicity after carotid angioplasty and stent placement procedures

scientific article published on 22 March 2013

Neuroplasticity and cellular therapy in cerebral infarction.

scientific article published on November 2007

Neuroprotection afforded by antagonists of endothelin-1 receptors in experimental stroke

scientific article published on 4 September 2012

Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport

scientific article

Neuroprotection by glutamate oxaloacetate transaminase in ischemic stroke: an experimental study

scientific article

Neuroprotection or increased brain damage mediated by temperature in stroke is time dependent

scientific article

Neuroprotective effect of aspirin by inhibition of glutamate release after permanent focal cerebral ischaemia in rats

scientific article (publication date: October 2001)

Neuroprotective effect of neuroserpin in rat primary cortical cultures after oxygen and glucose deprivation and tPA.

scientific article published on 14 December 2010

Neuroprotective effects of aspirin in patients with acute cerebral infarction

scientific article (publication date: 27 March 2003)

Neurorepair versus neuroprotection in stroke.

scientific article published on 2 May 2006

New-onset hypertension and inflammatory response/poor outcome in acute ischemic stroke.

scientific article published in December 2006

Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke

scientific article published on 07 October 2020

Oral citicoline in acute ischemic stroke: an individual patient data pooling analysis of clinical trials

scientific article

Oxaloacetate: a novel neuroprotective for acute ischemic stroke

scientific article

Oxidative stress markers are associated to vascular recurrence in non-cardioembolic stroke patients non-treated with statins.

scientific article

Persistent Hyperglycemia >155 mg/dL in Acute Ischemic Stroke Patients: How Well Are We Correcting It? ⬇️

scientific article published on August 19, 2010

Plasma cellular-fibronectin concentration predicts hemorrhagic transformation after thrombolytic therapy in acute ischemic stroke.

scientific article published on 27 May 2004

Plasma monoamines in tension-type headache

scientific article published on 01 October 1994

Platelet derived growth factor-CC isoform is associated with hemorrhagic transformation in ischemic stroke patients treated with tissue plasminogen activator.

scientific article published on 17 November 2012

Platelet-rich plasma serotonin levels in tension-type headache and depression

scientific article published on 01 October 1993

Predictors of deteriorating cerebral infarct: role of inflammatory mechanisms. Would its early treatment be useful?

scientific article

Prevalence of carotid stenosis and silent myocardial ischemia in asymptomatic subjects with a low ankle-brachial index

scientific article published on 01 October 2008

Prior antiplatelet therapy and outcome following intracerebral hemorrhage: a systematic review

scientific article

Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: a systematic review and meta-analysis.

scientific article published on 24 July 2014

Progression of ischaemic stroke and excitotoxic aminoacids

scientific article published on 01 January 1997

Proteomic analysis shows differential protein expression in endothelial progenitor cells between healthy subjects and ischemic stroke patients.

scientific article published in December 2011

Public perception of stroke in Spain

scientific article published on 01 January 2003

Quick adjustment of imaging tracer payload, for in vivo applications of theranostic nanostructures in the brain.

scientific article

Recommendations guide for experimental animal models in stroke research

scientific article published on 20 October 2010

Regulatory T cells modulate inflammation and reduce infarct volume in experimental brain ischaemia

scientific article

Relationship of blood pressure, antihypertensive therapy, and outcome in ischemic stroke treated with intravenous thrombolysis: retrospective analysis from Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SIT

scientific article published on 21 May 2009

Response to Letter by O'Connell et al

Role of inflammatory markers in brain ischemia.

scientific article published on June 2008

Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms.

scientific article published in February 2006

Serial MRI study of the enhanced therapeutic effects of liposome-encapsulated citicoline in cerebral ischemia

scientific article published on 17 December 2010

Serum cellular fibronectin and matrix metalloproteinase-9 as screening biomarkers for the prediction of parenchymal hematoma after thrombolytic therapy in acute ischemic stroke: a multicenter confirmatory study.

scientific article

Statin treatment withdrawal in ischemic stroke: a controlled randomized study

scientific article published in August 2007

Statins and stroke

scientific article published on 01 June 2008

Stroke in 2012: Major advances in the treatment of stroke

scientific article published on 08 January 2013

Stroke on awakening: looking for a more rational management.

scientific article published in January 2003

Stroke with polyvascular atherothrombotic disease

scientific article published on 28 July 2009

TNFR1 upregulation mediates tolerance after brain ischemic preconditioning.

scientific article

Targeting the ischemic penumbra

scientific article published on 16 December 2010

Targets of cytoprotection in acute ischemic stroke: present and future.

scientific article published on 2 May 2006

Temporal profile and clinical significance of serum neuron-specific enolase and S100 in ischemic and hemorrhagic stroke

scientific article published in January 2009

Temporal profile of molecular signatures associated with circulating endothelial progenitor cells in human ischemic stroke

scientific article published on 19 April 2012

The ARTICO study: identification of patients at high risk of vascular recurrence after a first non-cardioembolic stroke

scientific article

The Increase of Circulating Endothelial Progenitor Cells After Acute Ischemic Stroke Is Associated With Good Outcome

scientific article published on 30 August 2007

The costs of stroke in Spain by aetiology: the CONOCES study protocol

scientific article published on 18 September 2012

The differential effects of metformin on markers of endothelial activation and inflammation in subjects with impaired glucose tolerance: a placebo-controlled, randomized clinical trial

scientific article

The effect of simvastatin on the proteome of detergent-resistant membrane domains: decreases of specific proteins previously related to cytoskeleton regulation, calcium homeostasis and cell fate.

scientific article published in May 2010

The human Tp53 Arg72Pro polymorphism explains different functional prognosis in stroke. ⬇️

scientific article

The metabolic syndrome is associated with a higher resistance to intravenous thrombolysis for acute ischemic stroke in women than in men

scientific article published on 24 December 2008

The natural tissue plasminogen activator inhibitor neuroserpin and acute ischaemic stroke outcome

scientific article published on 21 December 2010

The prediction of malignant cerebral infarction by molecular brain barrier disruption markers.

scientific article published on 11 August 2005

The release of tumor necrosis factor-α is associated with ischemic tolerance in human stroke

scientific article published on 01 December 2003

The role of angiogenesis in damage and recovery from ischemic stroke

scientific article published in June 2007

Toll-like receptors 2 and 4 in ischemic stroke: outcome and therapeutic values

scientific article

Toll-like receptors 7 and 8 expression is associated with poor outcome and greater inflammatory response in acute ischemic stroke

scientific article published on 26 February 2011

Unfractionated heparin is associated with a lower rise of serum vascular cell adhesion molecule-1 in acute ischemic stroke patients

scientific article (publication date: 16 August 2002)

Usefulness of haptoglobin and serum amyloid A proteins as biomarkers for atherothrombotic ischemic stroke diagnosis confirmation

scientific article published on 30 December 2008

Usefulness of material recovered from distal embolic protection devices after carotid angioplasty for proteomic studies

scientific article published on 01 June 2012

Value of carotid intima-media thickness and significant carotid stenosis as markers of stroke recurrence

scientific article published on 18 August 2011

Vascular protection in brain ischemia

scientific article published on 2 May 2006

Vascular retinal, neuroimaging and ultrasonographic markers of lacunar infarcts

scientific article published on October 2010

Withdrawal from statins: implications for secondary stroke prevention and acute treatment

scientific article published on 01 May 2008

[Atherothrombosis: an excessively globalizing concept?]

scientific article published on 01 September 2009

[Recommendations guide for the treatment of migraine in the clinical practice]

scientific article published on 01 April 2007

[Stroke health care plan (ICTUS II. 2010)]

scientific article published on 03 November 2010

proMetalloproteinase-10 is associated with brain damage and clinical outcome in acute ischemic stroke.

scientific article published on August 2013

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