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List of works by Mark S Cragg

A New in Vivo and in Vitro B cell Lymphoma Model, π-BCL1

article

A new anti-idiotype antibody capable of binding rituximab on the surface of lymphoma cells

scientific article published on 22 June 2004

A role for neutrophils in rituximab therapy?

scientific article published on 06 January 2010

Activatory and inhibitory Fcγ receptors augment rituximab-mediated internalization of CD20 independent of signaling via the cytoplasmic domain

scientific article

An unexpected protective role of low affinity allergen-specific IgG via the inhibitory receptor FcγRIIb.

scientific article

Analysis of the interaction of monoclonal antibodies with surface IgM on neoplastic B-cells

scientific article published on February 1999

Antagonistic human FcγRIIB (CD32B) antibodies have anti-tumor activity and overcome resistance to antibody therapy in vivo.

scientific article

Anti-FcγRIIB (CD32) Antibodies Differentially Modulate Murine FVIII-Specific Recall Response in vitro.

scientific article published on 31 May 2017

Anti-mouse FcγRIV antibody 9E9 also blocks FcγRIII in vivo

scientific article

Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function

scientific article published on 13 November 2018

Antibody Distance from the Cell Membrane Regulates Antibody Effector Mechanisms.

scientific article published on 12 April 2017

Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.

scientific article published on 21 November 2017

Antibody modulation: Limiting the efficacy of therapeutic antibodies

scientific article published on 15 July 2015

Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents

scientific article published on 09 October 2003

Antibody-induced intracellular signaling works in combination with radiation to eradicate lymphoma in radioimmunotherapy

scientific article published on 23 October 2003

Antibody-induced nonapoptotic cell death in human lymphoma and leukemia cells is mediated through a novel reactive oxygen species-dependent pathway

scientific article

Antigenic modulation limits the effector cell mechanisms employed by type I anti-CD20 monoclonal antibodies

scientific article published on 28 January 2015

Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection

scientific article published on 11 March 2010

Apparent modulation of CD20 by rituximab: an alternative explanation

scientific article

Augmentation of CD134 (OX40)-dependent NK anti-tumour activity is dependent on antibody cross-linking

scientific article

B cells--masters of the immunoverse

scientific article published on 13 December 2010

BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia

scientific article published on 28 August 2019

BCR-signaling-induced cell death demonstrates dependency on multiple BH3-only proteins in a murine model of B-cell lymphoma.

scientific article

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

scholarly article

CD20 antibodies: doing the time warp ⬇️

scientific article published on July 14, 2011

CD20 as a target for therapeutic type I and II monoclonal antibodies.

scientific article published on April 2010

CD20-induced lymphoma cell death is independent of both caspases and its redistribution into triton X-100 insoluble membrane rafts.

scientific article published in September 2003

CML cells expressing the TEL/MDS1/EVI1 fusion are resistant to imatinib-induced apoptosis through inhibition of BAD, but are resensitized with ABT-737.

scientific article published on 24 May 2012

Cancer: a matter of life cycle?

scientific article published on 02 September 2007

Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons

scientific article published on 13 June 2019

Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas

scientific article published on June 2004

Clinical significance of TP53, BIRC3, ATM and MAPK-ERK genes in chronic lymphocytic leukaemia: data from the randomised UK LRF CLL4 trial

scientific article published on 03 February 2020

Complement mediated cell death is associated with DNA fragmentation

scientific article published on 01 January 2000

Complement-mediated lysis by anti-CD20 mAb correlates with segregation into lipid rafts

scientific article published on 19 September 2002

Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies.

scientific article published on 3 March 2018

Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies.

scientific article

Correction: Evaluation of High-Throughput Genomic Assays for the Fc Gamma Receptor Locus.

scientific article published on 23 March 2016

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

scientific article

Cyclophosphamide Enhances Cancer Antibody Immunotherapy in the Resistant Bone Marrow Niche by Modulating Macrophage FcγR Expression

scientific article published on 26 August 2019

DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells ⬇️

scientific article published on February 1, 2013

Death by a thousand knives: Multiple BH3-only proteins are required for maximal apoptosis triggered through the BCR.

scientific article published on 27 August 2015

Detection of Experimental and Clinical Immune Complexes by Measuring SHIP-1 Recruitment to the Inhibitory FcγRIIB.

scientific article published on 19 January 2018

Detection of candidate biomarkers of prostate cancer progression in serum: a depletion-free 3D LC/MS quantitative proteomics pilot study.

scientific article published on 29 September 2016

Development and Characterization of Monoclonal Antibodies Specific for Mouse and Human Fcγ Receptors

scientific article published on 28 October 2015

Development and characterisation of monoclonal antibodies specific for the murine inhibitory FcγRIIB (CD32B)

article

Development of a T-cell Receptor Mimic Antibody against Wild-Type p53 for Cancer Immunotherapy

scientific article published on 31 March 2017

Development of immunomonitoring of antibody‑dependent cellular cytotoxicity against neuroblastoma cells using whole blood.

scientific article published on June 2014

Effector mechanisms of IgA antibodies against CD20 include recruitment of myeloid cells for antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity.

scientific article published on 27 April 2017

Endopolyploid cells produced after severe genotoxic damage have the potential to repair DNA double strand breaks

scientific article published on 02 September 2003

Evaluating Anti-CD32b F(ab) Conformation Using Molecular Dynamics and Small-Angle X-Ray Scattering

scientific article published on 01 July 2018

Evaluation of High-Throughput Genomic Assays for the Fc Gamma Receptor Locus.

scientific article published on 6 November 2015

Expression of the inhibitory Fc gamma receptor IIB (FCGR2B, CD32B) on follicular lymphoma cells lowers the response rate to rituximab monotherapy (SAKK 35/98)

article

Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy.

scientific article

Fc-Engineering for Modulated Effector Functions-Improving Antibodies for Cancer Treatment

scientific article published on 17 November 2020

Fcγ receptor dependency of agonistic CD40 antibody in lymphoma therapy can be overcome through antibody multimerization

scientific article published on 14 July 2014

Fcγ receptor-mediated inflammation inhibits axon regeneration

scientific article

Fcγ receptors: genetic variation, function, and disease.

scientific article

FcγR requirements leading to successful immunotherapy

scientific article published in November 2015

FcγRIIB as a key determinant of agonistic antibody efficacy

scientific article published on January 2014

FcγRIIB-Independent Mechanisms Controlling Membrane Localization of the Inhibitory Phosphatase SHIP in Human B Cells.

scientific article published on 25 July 2016

FcγRΙΙB controls the potency of agonistic anti-TNFR mAbs.

scientific article published on 31 March 2013

Functional analysis of HIV type 1 Nef reveals a role for PAK2 as a regulator of cell phenotype and function in the murine dendritic cell line, DC2.4.

scientific article published on November 2005

Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics

scientific article

Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia.

scientific article published on 10 June 2016

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HIF activation enhances FcγRIIb expression on mononuclear phagocytes impeding tumor targeting antibody immunotherapy

scientific article published on 07 April 2022

IL-4 enhances expression and function of surface IgM in CLL cells.

scientific article

IgG subclasses determine pathways of anaphylaxis in mice.

scientific article published on 26 April 2016

Immunological Methods to Study Monoclonal Antibody Activity in Chronic Lymphocytic Leukaemia

article

Immunomodulatory monoclonal antibodies combined with peptide vaccination provide potent immunotherapy in an aggressive murine neuroblastoma model

scientific article published on 6 May 2013

Immunotherapy Targeting Inhibitory Fc Receptor IIB (CD32b) in the Mouse Is Limited by Monoclonal Antibody Consumption and Receptor Internalization

article

Impact of Human FcγR Gene Polymorphisms on IgG-Triggered Cytokine Release: Critical Importance of Cell Assay Format

article

Improving Antibody-Based Cancer Therapeutics Through Glycan Engineering.

scientific article published on 2 May 2017

Induction of cytosolic calcium flux by CD20 is dependent upon B Cell antigen receptor signaling.

scientific article published on 21 April 2008

Inhibitory FcγRIIb (CD32b) becomes activated by therapeutic mAb in both cis and trans and drives internalization according to antibody specificity.

scientific article

Integrated Cellular and Plasma Proteomics of Contrasting B-cell Cancers Reveals Common, Unique and Systemic Signatures

scientific article published on 4 January 2017

Interaction with FcγRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody

scientific article published on 8 July 2011

Lamin B1 regulates somatic mutations and progression of B-cell malignancies.

scientific article published on 14 August 2017

MOS, aneuploidy and the ploidy cycle of cancer cells ⬇️

scientific article published on 02 August 2010

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

scientific article

Mechanisms of killing by anti-CD20 monoclonal antibodies.

scientific article published on September 2007

Mitotic catastrophe and endomitosis in tumour cells: an evolutionary key to a molecular solution.

scientific article

New Zealand's revised Ethnicity Data Protocols must not become a shelved document: a challenge from Hei Āhuru Mōwai

scientific article published on 23 February 2018

Novel antibodies targeting immune regulatory checkpoints for cancer therapy.

scientific article published on August 2013

Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies

scientific article

Nuclear envelope-limited chromatin sheets are part of mitotic death

scientific article published on 8 February 2002

OX40: Structure and function - What questions remain?

scientific article published on 13 January 2017

Optimising B-cell depletion in autoimmune disease: is obinutuzumab the answer?

scientific article

PI3Kδ inhibition elicits anti-leukemic effects through Bim-dependent apoptosis

scientific article

Phase 1/2 study of fractionated 131I-rituximab in low-grade B-cell lymphoma: the effect of prior rituximab dosing and tumor burden on subsequent radioimmunotherapy

scientific article published on 12 December 2008

Polyploid giant cells provide a survival mechanism for p53 mutant cells after DNA damage.

scientific article

Polyploid tumour cells elicit paradiploid progeny through depolyploidizing divisions and regulated autophagic degradation

scientific article published on July 2011

Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells

scientific article published on 12 December 2019

Proteomics profiling of CLL versus healthy B-cells identifies putative therapeutic targets and a subtype-independent signature of spliceosome dysregulation

scientific article published on 24 January 2018

Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis

scientific article published on 16 January 2009

Radiation therapy with tositumomab (B1) anti-CD20 monoclonal antibody initiates extracellular signal-regulated kinase/mitogen-activated protein kinase-dependent cell death that overcomes resistance to apoptosis

scientific article

Radioimmunotherapy in the π-BCL1 B cell Lymphoma Model: Efficacy Depends on More Than Targeted Irradiation Alone

article

Regulation of Monoclonal Antibody Immunotherapy by FcγRIIB.

scientific article published on 27 February 2016

Rehabilitation or the death penalty: autoimmune B cells in the dock

scientific article

Release of mitotic descendants by giant cells from irradiated Burkitt's lymphoma cell line..

scientific article published on January 2000

Resistance is futile: Targeting the inhibitory FcγRIIB (CD32B) to maximize immunotherapy

scientific article published on 12 August 2015

Restoration of T-cell Effector Function, Depletion of Tregs, and Direct Killing of Tumor Cells: The Multiple Mechanisms of Action of a-TIGIT Antagonist Antibodies

scientific article published on 04 December 2020

Role of STAT1 in the breast

scientific article published on July 2012

Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide.

scientific article published on 23 June 2015

Role of the pro-survival molecule Bfl-1 in melanoma

scientific article

STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage

scientific article

STING Activation Reverses Lymphoma-Mediated Resistance to Antibody Immunotherapy

scientific article published on 16 May 2017

Segregation of genomes in polyploid tumour cells following mitotic catastrophe.

scientific article

Signaling through the Inhibitory Fc Receptor FcγRIIB Induces CD8+ T Cell Apoptosis to Limit T Cell Immunity

scientific article published on 01 January 2020

Systemic Inflammation Modulates Fc Receptor Expression on Microglia during Chronic Neurodegeneration

scientific article published on 13 May 2011

TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity

scientific article published on 23 June 2021

The "virgin birth", polyploidy, and the origin of cancer

scientific article

The Cancer Aneuploidy Paradox: In the Light of Evolution

article

The European antibody network's practical guide to finding and validating suitable antibodies for research

scientific article published on 29 September 2015

The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the Eµ-TCL1 mouse model

scientific article published on 8 May 2015

The PI3Kδ-Selective Inhibitor Idelalisib Minimally Interferes with Immune Effector Function Mediated by Rituximab or Obinutuzumab and Significantly Augments B Cell Depletion In Vivo.

scientific article published on 16 February 2018

The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1.

scientific article published on 21 October 2015

The alternative transcript of CD79b is overexpressed in B-CLL and inhibits signaling for apoptosis

scientific article published on 01 November 2002

The biology of CD20 and its potential as a target for mAb therapy

scientific article

The development of anti-CD79 monoclonal antibodies for treatment of B-cell neoplastic disease.

scientific article published on August 1995

The importance of antibody-specificity in determining successful radioimmunotherapy of B-cell lymphoma

article

The potential effect of statins on rituximab immunotherapy

scientific article

The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells

scientific article

Therapeutic Antibodies: What Have We Learnt from Targeting CD20 and Where Are We Going?

scientific article published on 4 October 2017

Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal

scientific article

Through the barricades: overcoming the barriers to effective antibody-based cancer therapeutics

scientific article published on 12 June 2018

Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.

scientific article published on 14 December 2012

Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic

scientific article published on 23 October 2008

Tumor cell embryonality and the ploidy number 32n: is it a developmental checkpoint?

scientific article published in June 2011

Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation

scientific article published on 26 June 2008

UC-1V150, a potent TLR7 agonist capable of activating macrophages and potentiating mAb-mediated target cell deletion

scientific article published on 18 April 2018

Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics

scientific article published on 03 April 2009

Up-regulation of the embryonic self-renewal network through reversible polyploidy in irradiated p53-mutant tumour cells

scientific article published on 10 May 2010

Upregulation of FcγRIIb on monocytes is necessary to promote the superagonist activity of TGN1412.

scientific article published on 13 November 2014

Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe

scientific article

Vaccine against peanut allergy based on engineered virus-like particles displaying single major peanut allergens

scientific article published on 19 December 2019

Validation of an ELISA for the determination of rituximab pharmacokinetics in clinical trials subjects

scientific article published on 11 June 2010

When Three Isn't a Crowd: A Digyny Concept for Treatment-Resistant, Near-Triploid Human Cancers

scientific article published on 19 July 2019

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