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List of works by Charles G. Mullighan

A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor.

scientific article published on 21 August 2017

A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults

scientific article

A genomic random interval model for statistical analysis of genomic lesion data

scientific article

A novel retinoblastoma therapy from genomic and epigenetic analyses

scientific article published on 11 January 2012

A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403

scientific article published on 18 January 2019

A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

scientific article

Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia

scientific article

Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia

scientific article

Acquired isolated factor VII deficiency associated with severe bleeding and successful treatment with recombinant FVIIa (NovoSeven).

scientific article published on June 2004

Acute lymphoblastic leukaemia

scientific article

Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group

scientific article

Adhesion molecule polymorphisms in chronic renal allograft failure

scientific article published in May 1999

Advances in the Genetics of High-Risk Childhood B-Progenitor Acute Lymphoblastic Leukemia and Juvenile Myelomonocytic Leukemia: Implications for Therapy ⬇️

scientific article published on May 15, 2012

Analysis of the Relationship Between Mannose-Binding Lectin (MBL) Genotype, MBL Levels and Function in an Australian Blood Donor Population

article

Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation

scientific article

Analysis of the coding genome of diffuse large B-cell lymphoma

scientific article

Antileukemia Effects of Notch-Mediated Inhibition of Oncogenic PLK1 in B-Cell Acute Lymphoblastic Leukemia

scientific article published on 21 June 2019

Assessment of male CVID patients for mutations in the Btk gene: how many have been misdiagnosed?

article

Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia

scientific article published on 12 March 2019

CONSERTING: integrating copy-number analysis with structural-variation detection

scientific article

CREBBP mutations in relapsed acute lymphoblastic leukaemia

scientific article

CREST maps somatic structural variation in cancer genomes with base-pair resolution.

scientific article

Cell of origin strongly influences genetic selection in a mouse model of T-ALL

scientific article published on 9 August 2011

Characterization of leukemias with ETV6-ABL1 fusion

scientific article published on 26 May 2016

Clinical efficacy of ruxolitinib and chemotherapy in a child with Philadelphia chromosome-like acute lymphoblastic leukemia with GOLGA5-JAK2 fusion and induction failure.

scientific article

Clinical interpretation of whole-genome and whole-transcriptome sequencing for precision oncology

scientific article published on 10 July 2021

Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia

scientific article published on 17 January 2018

Co-occurrence of CRLF2-rearranged and Ph+ acute lymphoblastic leukemia: a report of four patients

scientific article published on 31 August 2017

Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors

scientific article

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

scientific article

Cyclin C is a haploinsufficient tumour suppressor

scientific article

Cytochrome P450 1A2 is a target antigen in hepatitic graft-versus-host disease

article

CytofIn enables integrated analysis of public mass cytometry datasets using generalized anchors

scientific article published on 17 February 2022

Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo

scientific article published on May 2013

Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia

scientific article published on 07 January 2009

Deregulation of DUX4 and ERG in acute lymphoblastic leukemia

scientific article published on 24 October 2016

Dominant-negative Ikaros cooperates with BCR-ABL1 to induce human acute myeloid leukemia in xenografts

scientific article published on 5 May 2014

Donor Mannose‐Binding Lectin Deficiency Increases the Likelihood of Clinically Significant Infection after Liver Transplantation

article

ETV6-NTRK3 induces aggressive acute lymphoblastic leukemia highly sensitive to selective TRK inhibition

scientific article published on 07 June 2018

Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia

scientific article

Emergence of polyclonal FLT3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive acute myeloid leukemia.

scientific article

Enhancer Hijacking Drives Oncogenic <i>BCL11B</i> Expression in Lineage-Ambiguous Stem Cell Leukemia

publication published on 08 June 2021

Evaluation of the in vitro and in vivo efficacy of the JAK inhibitor AZD1480 against JAK-mutated acute lymphoblastic leukemia

scientific article

Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells.

scientific article published in January 2011

Failure of CDKN2A/B (INK4A/B-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL.

scientific article published on June 2008

Fas gene promoter polymorphisms in primary Sjögren's syndrome

scientific article published on January 2004

From trees to the forest: genes to genomics

scientific article published on January 2011

GATA3 rs3824662A allele is associated with CRLF2 rearranged B-cell acute lymphoblastic leukemia in adults and adolescents and young adults (AYAs) and is associated with poor prognosis

scientific article published on 04 December 2020

Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia

scientific article

Genetic Alterations Targeting Lymphoid Development in Acute Lymphoblastic Leukemia

article

Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia

scientific article

Genetic characterization and therapeutic targeting of MYC-rearranged T cell acute lymphoblastic leukaemia

scientific article published on 25 June 2018

Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome

scientific article published on 14 October 2013

Genetic variation and the risk of acute lymphoblastic leukemia

scientific article published on 09 June 2010

Genome-wide analysis links NFATC2 with asparaginase hypersensitivity

scientific article published on 18 May 2015

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

scientific article (publication date: 12 April 2007)

Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma

scientific article published on 07 January 2019

Genome-wide profiling of genetic alterations in acute lymphoblastic leukemia: recent insights and future directions.

scientific article published on 26 February 2009

Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11.

scientific article published on 12 March 2007

Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia

scientific article

Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.

scientific article

Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia

scholarly article

Genomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the Children's Oncology Group

scientific article published on 11 July 2018

Genomic characterization of childhood acute lymphoblastic leukemia

scientific article published on 04 October 2013

Genomic polymorphism and allogeneic hematopoietic transplantation outcome.

scientific article

Genomic profiling of B-progenitor acute lymphoblastic leukemia

scientific article

Genomic profiling of high-risk acute lymphoblastic leukemia.

scientific article published on 26 August 2010

Genomic subtyping and therapeutic targeting of acute erythroleukemia

scientific article published on 29 March 2019

Genomics in acute lymphoblastic leukaemia: insights and treatment implications

scientific article published on 17 March 2015

Germline ETV6 Mutations Confer Susceptibility to Acute Lymphoblastic Leukemia and Thrombocytopenia

scientific article

Germline SAMD9 and SAMD9L mutations are associated with extensive genetic evolution and diverse hematologic outcomes

scientific article published on 26 July 2018

Germline deletion of in familial acute lymphoblastic leukemia

scientific article published on 01 April 2019

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia

scientific article

Global genomic characterization of acute lymphoblastic leukemia

scientific article

High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults

scientific article published on 21 November 2016

Highly sensitive MRD tests for ALL based on the IKZF1 Δ3-6 microdeletion

scientific article published on 9 December 2011

How new advances in genetic analysis are influencing the understanding and treatment of childhood acute leukemia

scientific article published on February 2011

Human cytomegalovirus infection is not increased in common variable immunodeficiency

scientific article published on 01 September 1996

Human gastrointestinal neoplasia-associated myofibroblasts can develop from bone marrow-derived cells following allogeneic stem cell transplantation.

scientific article

Hyper-CVAD regimen in combination with ofatumumab as frontline therapy for adults with Philadelphia chromosome-negative B-cell acute lymphoblastic leukaemia: a single-arm, phase 2 trial

scientific article published on 01 July 2020

IDH1 and IDH2 mutations in pediatric acute leukemia

scientific article published on 07 June 2011

Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk

scientific article published on 25 November 2019

Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome

scientific article published on 10 August 2010

Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors.

scientific article

Improving outcomes for high-risk ALL: translating new discoveries into clinical care

scientific article published on 15 February 2011

Inactivating mutations of acetyltransferase genes in B-cell lymphoma

scientific article (publication date: 10 March 2011)

Increased baseline RASGRP1 signals enhance stem cell fitness during native hematopoiesis

scientific article published on 28 September 2020

Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse

scientific article

Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children

scientific article

Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia

scientific article published on 10 June 2013

Integrative genomic analysis of B-lymphoblastic lymphoma with intrachromosomal amplification of chromosome 21

scientific article published on 29 May 2020

Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential.

scientific article published on 31 March 2014

Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia

scientific article published on 14 December 2021

Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-β, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth

article

JAK mutations in high-risk childhood acute lymphoblastic leukemia

scholarly article

JAK2—a new player in acute lymphoblastic leukaemia

scientific article published in The Lancet

Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group

scientific article

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways

scientific article published on 21 January 2014

LOHAS: loss-of-heterozygosity analysis suite

scientific article published on May 2011

Lack of association between mannose-binding lectin gene polymorphisms and primary Sjögren's syndrome

article

Lin28 promotes transformation and is associated with advanced human malignancies

scientific article published on 31 May 2009

Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia

scientific article published on May 2013

Loss of p19Arf in a Rag1(-/-) B-cell precursor population initiates acute B-lymphoblastic leukemia

scientific article

MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours.

scientific article

Mannose Binding Lectin Polymorphisms are Associated With Early Age of Disease Onset and Autoimmunity in Common Variable Immunodeficiency

scientific article published on 01 February 2000

Mannose-Binding Lectin and Liver Transplantation

scientific article published on 01 November 2005

Mannose-binding lectin and gastric cancer

scientific article published on 01 June 2007

Mannose-binding lectin deficiency does not increase the prevalence of Helicobacter pylori seropositivity

scientific article published on 01 February 2007

Mannose-binding lectin gene polymorphisms are associated with major infection following allogeneic hemopoietic stem cell transplantation.

scientific article

Mannose-binding lectin promoter and structural gene variants in sarcoidosis

scientific article published in June 2000

Mannose-binding lectin status is associated with risk of major infection following myeloablative sibling allogeneic hematopoietic stem cell transplantation

scientific article published on 13 June 2008

Mannose-binding lectin: biology and clinical implications

scientific article

Modeling the evolution of ETV6-RUNX1-induced B-cell precursor acute lymphoblastic leukemia in mice.

scientific article

Mutant PRPS1: a new therapeutic target in relapsed acute lymphoblastic leukemia

scientific article

Mutations of NOTCH1, FBXW7, and prognosis in T-lineage acute lymphoblastic leukemia

scientific article published on October 2009

NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells

scientific article published on 4 May 2015

Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia

scientific article published on 21 January 2021

New Strategies in Acute Lymphoblastic Leukemia: Translating Advances in Genomics into Clinical Practice ⬇️

scientific article published on December 13, 2010

New therapeutic opportunities from dissecting the pre-B leukemia bone marrow microenvironment

scientific article published on 08 May 2018

Non-HLA immunogenetic polymorphisms and the risk of complications after allogeneic hemopoietic stem-cell transplantation.

scientific article

Notch/HES1-mediated PARP1 activation: a cell type-specific mechanism for tumor suppression.

scientific article

Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations

scientific journal article

Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in Hispanics

scientific article published on 03 December 2018

OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL

scientific article published on 23 April 2019

Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study

scientific article published on 24 February 2012

Outcomes of children with BCR-ABL1–like acute lymphoblastic leukemia treated with risk-directed therapy based on the levels of minimal residual disease

scientific article

PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia.

scientific article published on 8 April 2015

PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia

scientific article published on 14 January 2019

PHF6 mutations in T-lineage acute lymphoblastic leukemia

scientific article published on 01 October 2010

Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia

scientific article

Pediatric acute lymphoblastic leukemia: where are we going and how do we get there? ⬇️

scientific article published on June 22, 2012

Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias

article

Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8+ T cell responses

scientific article published on 01 June 2019

Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults

scientific article published on 5 December 2016

Polymorphisms in immunoregulatory genes and the risk of histologic chorioamnionitis in Caucasoid women: a case control study

scientific article

Rare allelic forms of PRDM9 associated with childhood leukemogenesis.

scientific article

Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia

scientific article published on 18 October 2009

Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia

scientific article

Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors.

scientific article published on February 2015

Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine

scientific article

Reference alignment of SNP microarray signals for copy number analysis of tumors

scientific article (publication date: February 2009)

Relapse of BCR-ABL1-like ALL mediated by the ABL1 kinase domain mutation T315I following initial response to dasatinib treatment.

scientific article published on 2 September 2014

Relapse-Fated Latent Diagnosis Subclones in Acute B Lineage Leukemia Are Drug Tolerant and Possess Distinct Metabolic Programs

scientific article published on 21 February 2020

Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia.

scientific article

Shared acquired genomic changes in zebrafish and human T-ALL.

scientific article published on 9 May 2011

Single Nucleotide Polymorphism Microarray Analysis of Genetic Alterations in Cancer ⬇️

scientific article published on January 1, 2011

Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia

scientific article published on 3 June 2013

Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells

scientific article

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

scientific article

St. Jude Cloud-a Pediatric Cancer Genomic Data Sharing Ecosystem

scientific article published on 06 January 2021

Subclonal evolution in disease progression from MGUS/SMM to multiple myeloma is characterised by clonal stability

scientific article published on 25 July 2018

T-Lineage Lymphoblastic Lymphoma and Leukemia—a MASSive Problem

scientific article published on 01 October 2010

TET2 mutations in myelodysplasia and myeloid malignancies

Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group

scientific article published on 13 April 2017

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia

scientific article

Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia

scientific article

The ASH Agenda for Hematology Research: a roadmap for advancing scientific discovery and cures for hematologic diseases

scientific article published on 01 October 2018

The Biology of B-Progenitor Acute Lymphoblastic Leukemia

scientific article published on 25 October 2019

The Heme-regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics

scientific article published on 07 December 2020

The Role of TET2 in Hematologic Neoplasms

scientific article published on 01 July 2011

The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy.

scientific article published on 25 October 2012

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

scientific article

The genomic landscape of acute lymphoblastic leukemia in children and young adults

scientific article

The genomic landscape of core-binding factor acute myeloid leukemias

scientific article

The genomic landscape of hypodiploid acute lymphoblastic leukemia

scientific article published on 20 January 2013

The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia.

scientific article published on 3 July 2017

The genomic landscape of pediatric myelodysplastic syndromes.

scientific article published on 16 November 2017

The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias

scientific article

Therapy of pediatric ALL: from Bowie to Obama

scientific article published on 01 October 2013

Tissue plasminogen activator -7351C/T enhancer polymorphism is a risk factor for lacunar stroke.

scientific article published on 18 March 2004

Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia

scientific article published on February 2016

Tyrosine kinase inhibitor therapy induces remission in a patient with refractory EBF1-PDGFRB-positive acute lymphoblastic leukemia.

scientific article

Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project

scientific article published on 4 December 2012

VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia.

scientific article

Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer

scientific article

Variation in immune response genes and chronic Q fever. Concepts: preliminary test with post-Q fever fatigue syndrome.

scientific article published on January 2003

Vitamin D receptor gene polymorphism: association with Crohn's disease susceptibility.

scientific article published in August 2000

Welcoming a new age for gene therapy in hematology

scientific article

Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

scientific article published on 14 April 2013

YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway

scientific article published on 22 April 2015

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