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List of works by Giampaolo Merlini

4 ′‐iodo‐4′‐Deoxydoxorubicin and tetracyclines disrupt transthyretin amyloid fibrils in vitro producing noncytotoxic species: screening for TTR fibril disrupters ⬇️

scientific article published on May 1, 2003

A Caenorhabditis elegans-based assay recognizes immunoglobulin light chains causing heart amyloidosis

scientific article

A European collaborative study of cyclophosphamide, bortezomib, and dexamethasone in upfront treatment of systemic AL amyloidosis

scientific article published on 18 May 2015

A European collaborative study of treatment outcomes in 346 patients with cardiac stage III AL amyloidosis.

scientific article

A focus on recent advances in proteomics – one step closer to entrance into the clinical arena

scientific article published on 01 January 2009

A human myeloma immunoglobulin G binding four moles of calcium associated with asymptomatic hypercalcemia

scientific article published on 01 May 1984

A modified high-dose dexamethasone regimen for primary systemic (AL) amyloidosis

scientific article published on 01 June 2001

A multicenter phase II trial of 4'-iodo-4'deoxydoxorubicin (IDOX) in primary amyloidosis (AL).

scientific article

A new genetic variant of hereditary apolipoprotein A-I amyloidosis: a case-report followed by discussion of diagnostic challenges and therapeutic options

scientific article published on 21 January 2019

A novel AbetaPP mutation exclusively associated with cerebral amyloid angiopathy

scientific article published in October 2005

A novel approach for the purification and proteomic analysis of pathogenic immunoglobulin free light chains from serum.

scientific article published on 4 January 2011

A partially structured species of beta 2-microglobulin is significantly populated under physiological conditions and involved in fibrillogenesis

scientific article

A patient with AL amyloidosis with negative free light chain results.

scientific article published in June 2016

A phase 1/2 study of the oral proteasome inhibitor ixazomib in relapsed or refractory AL amyloidosis.

scientific article published on 26 May 2017

A phase 2 trial of pomalidomide and dexamethasone rescue treatment in patients with AL amyloidosis.

scientific article published on 27 January 2017

A phase II trial of cyclophosphamide, lenalidomide and dexamethasone in previously treated patients with AL amyloidosis.

scientific article published on 14 September 2012

A powerful oral triplet for AL amyloidosis

scientific article published on 03 February 2020

A practical approach to the diagnosis of systemic amyloidoses.

scientific article published on 30 January 2015

A primer of amyloid nomenclature

scientific article (publication date: September 2007)

A prospective phase II of daratumumab in previously treated systemic light chain amyloidosis (AL) patients

scientific article published on 27 February 2020

A prospective, controlled, nonrandomized study on prophylactic parenteral dichloromethylene bisphosphonate (clodronate) in multiple-myeloma ⬇️

scientific article published on 01 October 1994

A revised international prognostic score system for Waldenström's macroglobulinemia

scientific article published on 22 May 2019

A staging system for renal outcome and early markers of renal response to chemotherapy in AL amyloidosis

article

A strategy for synthesis of pathogenic human immunoglobulin free light chains in E. coli

scientific article

A validated composite organ and hematologic response model for early assessment of treatment outcomes in light chain amyloidosis

scientific article published on 14 April 2020

AA amyloidosis: basic knowledge, unmet needs and future treatments ⬇️

scientific article published on May 31, 2012

AL amyloidosis associated with IgM monoclonal protein: a distinct clinical entity

scientific article published in March 2009

AMICA: an electronic patient record specifically designed for an amyloidosis network ⬇️

scientific article published on June 1, 2011

ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI Expert Consensus Recommendations for Multimodality Imaging in Cardiac Amyloidosis: Part 1 of 2-Evidence Base and Standardized Methods of Imaging

scientific article published on 29 August 2019

ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI Expert Consensus Recommendations for Multimodality Imaging in Cardiac Amyloidosis: Part 2 of 2-Diagnostic Criteria and Appropriate Utilization

scientific article published on 29 August 2019

ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: Part 1 of 2-evidence base and standardized methods of imaging

scientific article published on 01 December 2019

ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: Part 2 of 2-Diagnostic criteria and appropriate utilization

scientific article published on 29 August 2019

ATR-FTIR Spectroscopy Supported by Multivariate Analysis for the Characterization of Adipose Tissue Aspirates from Patients Affected by Systemic Amyloidosis

scientific article published on 04 February 2019

ATTRv amyloidosis Italian Registry: clinical and epidemiological data

scientific article published on 22 July 2020

Acute phase proteins and prognosis in multiple myeloma ⬇️

scientific article published on 01 April 1993

Advances in proteomic study of cardiac amyloidosis: progress and potential.

scientific article published on 28 September 2016

Advantages of the lognormal approach to determining reference change values for N-terminal propeptide B-type natriuretic peptide

scientific article published on 3 December 2011

Amino acid sequence of k Sci, the Bence Jones protein isolated from a patient with light chain deposition disease

scientific article published on 01 October 1991

Amyloid fibril protein nomenclature: 2010 recommendations from the nomenclature committee of the International Society of Amyloidosis

scientific article

Amyloid fibril protein nomenclature: 2012 recommendations from the Nomenclature Committee of the International Society of Amyloidosis

scientific article published in November 2012

Amyloid fibrils containing fragmented ATTR may be the standard fibril composition in ATTR amyloidosis.

scientific article

Amyloid fibrils derived from the apolipoprotein A1 Leu174Ser variant contain elements of ordered helical structure

scientific article

Amyloid nomenclature 2020: update and recommendations by the International Society of Amyloidosis (ISA) nomenclature committee

scientific article published on 26 October 2020

Amyloid: toward terminology clarification. Report from the Nomenclature Committee of the International Society of Amyloidosis.

scientific article

Amyloidogenic and associated proteins in systemic amyloidosis proteome of adipose tissue.

scientific article

Amyloidosis and Waldenström's macroglobulinemia

scientific article

Amyloidosis in autoinflammatory syndromes

scientific article published on 02 August 2012

Amyloidosis: 2008 BMT Tandem Meetings (February 13-17, San Diego).

scientific article published on January 2008

Amyloidosis: is a cure possible?

scientific article published on June 2008

Amyloidosis: pathogenesis and new therapeutic options.

scientific article

An overview of drugs currently under investigation for the treatment of transthyretin-related hereditary amyloidosis

scientific article

Analysis of Hepatitis C Virus Hypervariable Region 1 Sequence from Cryoglobulinemic Patients and Associated Controls

scientific article

Analysis of V(lambda)-J(lambda) expression in plasma cells from primary (AL) amyloidosis and normal bone marrow identifies 3r (lambdaIII) as a new amyloid-associated germline gene segment

scientific article

Anatomic and Clinical Clues to In Vivo Mechanisms of Amyloidogenesis

Application of Monoclonal Anti-idiotypes in the Study of AL Amyloidosis: Therapeutic Implications

scientific article published on 01 January 1993

Assay to rapidly screen for immunoglobulin light chain glycosylation: a potential path to earlier AL diagnosis for a subset of patients

scientific article published on 06 July 2018

Assessing mNIS+7Ionis and international neurologists' proficiency in a familial amyloidotic polyneuropathy trial

scientific article published on 7 January 2017

Association of Patisiran, an RNA Interference Therapeutic, With Regional Left Ventricular Myocardial Strain in Hereditary Transthyretin Amyloidosis: The APOLLO Study

scientific article published on 01 May 2019

Association of melphalan and high-dose dexamethasone is effective and well tolerated in patients with AL (primary) amyloidosis who are ineligible for stem cell transplantation.

scientific article

Attitudes about when and how to treat patients with AL amyloidosis: an international survey.

scientific article published on 31 August 2017

Autologous Stem Cell and Kidney Transplantation for Primary Amyloidosis Associated with ESRD: Which Should Come First?

Avoiding misdiagnosis: expert consensus recommendations for the suspicion and diagnosis of transthyretin amyloidosis for the general practitioner

scientific article published on 23 September 2020

BDR in newly diagnosed patients with WM: final analysis of a phase 2 study after a minimum follow-up of 6 years

scientific article published on 21 November 2016

Benefit of doxycycline treatment on articular disability caused by dialysis related amyloidosis.

scientific article published on 4 June 2013

Best use of cardiac biomarkers in patients with AL amyloidosis and renal failure

scientific article published on 3 March 2012

Beta2-microglobulin causes abnormal phosphatidylserine exposure in human red blood cells

scientific article published on 25 November 2010

Beta2-microglobulin isoforms display an heterogeneous affinity for type I collagen

scientific article published on 2 February 2005

Bevacizumab treatment followed by maintenance in life-threatening POEMS syndrome

scientific article published on 19 January 2013

Biochemical markers in early diagnosis and management of systemic amyloidoses.

scientific article

Bioelectrical impedance vector analysis-derived phase angle predicts survival in patients with systemic immunoglobulin light-chain amyloidosis

scientific article published on 26 March 2020

Biological variation of N-terminal pro-brain natriuretic peptide in healthy individuals

scientific article published in September 2003

Biology and therapy of immunoglobulin deposition diseases

scientific article published on February 1997

Bone marrow amyloidosis

scientific article published on 01 May 2006

Bortezomib in a phase 1 trial for patients with relapsed AL amyloidosis: cardiac responses and overall effects

article

Bortezomib in the treatment of AL amyloidosis: targeted therapy?

scientific article published in October 2007

Bortezomib with or without dexamethasone in primary systemic (light chain) amyloidosis

scientific article published on 19 January 2010

Bortezomib, Melphalan, and Dexamethasone for Light-Chain Amyloidosis

scientific article published on 30 July 2020

Can ISSWM be used for making treatment decisions?

scientific article published on February 2011

Cardiac Light Chain Amyloidosis: The Role of Metal Ions in Oxidative Stress and Mitochondrial Damage.

scientific article published on 28 January 2017

Cardiac and pleuropulmonary AL amyloid imaging with technetium-99m labelled aprotinin

article

Cardiac immunocyte-derived (AL) amyloidosis: an endomyocardial biopsy study in 11 patients.

scientific article

Challenges in the Management of patients with systemic light chain (AL) amyloidosis during the COVID-19 pandemic

scientific article published on 01 June 2020

Changes in tissue proteome associated with ATTR amyloidosis: insights into pathogenesis.

scientific article published on 2 May 2012

Characterization for anti-cytoplasmic antibodies specificity by morphological and molecular techniques

scientific article

Characterization of immunoglobulin variable regions of two human pathogenic monoclonal cryocrystalglobulins

scientific article published on 18 October 2007

Characterization of the New Serum Protein Reference Material ERM-DA470k/IFCC: Value Assignment by Immunoassay

scientific article published on 05 October 2010

Characterization of the two unique human anti-flavin monoclonal immunoglobulins

scientific journal article

Circulating amyloidogenic free light chains and serum N-terminal natriuretic peptide type B decrease simultaneously in association with improvement of survival in AL.

scientific article published on 24 January 2006

Circulating free light chain measurement in the diagnosis, prognostic assessment and evaluation of response of AL amyloidosis: comparison of Freelite and N latex FLC assays

scientific article published on 27 March 2017

Clinical Features at Onset and Genetic Characterization of Pediatric and Adult Patients with TNF-α Receptor-Associated Periodic Syndrome (TRAPS): A Series of 80 Cases from the AIDA Network

scientific article published on 07 August 2020

Clinical Pregenetic Screening for Stroke Monogenic Diseases: Results From Lombardia GENS Registry

scientific article published on 31 May 2016

Clinical aspects of systemic amyloid diseases.

scientific article

Clinical indications for plasma protein assays: transthyretin (prealbumin) in inflammation and malnutrition

scientific article published in January 2007

Clinical proteomics for diagnosis and typing of systemic amyloidoses.

scientific article published on January 2013

Clinical, radiological, and biochemical features of a bilateral buttock amyloidoma emerging after 27 years of hemodialysis

scientific article published on January 2009

Clonality and specificity of cryoglobulins associated with HCV: pathophysiological implications

scientific article published on 01 December 1998

Comparison of three strategies for myocardial protection during coronary artery bypass graft surgery based on markers of cardiac damage.

scientific article published in June 2005

Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity

scientific article published in December 2017

Conformational switching and fibrillogenesis in the amyloidogenic fragment of apolipoprotein a-I.

scientific article published on 5 November 2002

Consensus guidelines for the conduct and reporting of clinical trials in systemic light-chain amyloidosis

scientific article published on 05 April 2012

Correction: Assay to rapidly screen for immunoglobulin light chain glycosylation: a potential path to earlier AL diagnosis for a subset of patients

scientific article published on 01 April 2019

Correction: First Report of Circulating MicroRNAs in Tumour Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS).

scientific article published on 10 October 2013

Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient

scientific article published on 20 March 2019

Current treatment of AL amyloidosis

scientific article published on August 2009

CyBorD: stellar response rates in AL amyloidosis

article

Dangerous small B-cell clones.

scientific article published on 22 June 2006

Daratumumab Plus CyBorD for Patients With Newly Diagnosed AL Amyloidosis: Safety Run-in Results of ANDROMEDA

scientific article published on 03 April 2020

Daratumumab in light chain deposition disease: rapid and profound hematologic response preserves kidney function

scientific article published on 01 April 2020

Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): a consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis, Tours, France, 18-22 April 2004.

scientific article

Design and Rationale of the Phase 3 ATTR-ACT Clinical Trial (Tafamidis in Transthyretin Cardiomyopathy Clinical Trial).

scientific article published on June 2017

Determining the significance of MGUS

scientific article published on 01 January 2014

Development and preparation of a new serum protein reference material: feasibility studies and processing

article

Diagnosis of monoclonal gammopathy of renal significance

scientific article

Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis

scientific article

Diagnostic Challenges of Amyloidosis in Waldenström Macroglobulinemia ⬇️

scientific article published on 07 March 2013

Diagnostic and prognostic value of low QRS voltages in cardiac AL amyloidosis.

scientific article published on 20 January 2013

Diagnostic performance of amyloid A protein quantification in fat tissue of patients with clinical AA amyloidosis.

scientific article

Diagnostic performance of triggering receptor expressed on myeloid cells-1 and CD64 index as markers of sepsis in preterm newborns.

scientific article

Differential diagnosis of monoclonal gammopathy of undetermined significance

scientific article published on January 2012

Differential expression of Cathepsin E in transthyretin amyloidosis: from neuropathology to the immune system

scientific article

Differential impact of high and low penetrance TNFRSF1A gene mutations on conventional and regulatory CD4+ T cell functions in TNFR1-associated periodic syndrome.

scientific article published on 23 November 2015

Differential serum levels of interleukin-37 in patients with tumour necrosis factor receptor-associated periodic syndrome (TRAPS)

scientific article published on 30 May 2019

Diflunisal in late-onset FAP patients with moderate to severe neuropathy.

scientific article published on 2 November 2015

Disease profile and differential diagnosis of hereditary transthyretin-related amyloidosis with exclusively cardiac phenotype: an Italian perspective.

scientific article

Doxycycline plus tauroursodeoxycholic acid for transthyretin amyloidosis: a phase II study

scientific article

Early Data on Long-Term Efficacy and Safety of Inotersen in Patients With Hereditary Transthyretin Amyloidosis: A 2-Year Update From the Open-Label Extension of the NEURO-TTR Trial

scientific article published on 28 April 2020

Early Identification of Transthyretin-Related Hereditary Cardiac Amyloidosis∗

article published in 2014

Effect of the amyloidogenic L75P apolipoprotein A-I variant on HDL subpopulations

scientific article

Effects of Patisiran, an RNA Interference Therapeutic, on Cardiac Parameters in Patients With Hereditary Transthyretin-Mediated Amyloidosis

scientific article published on 01 January 2019

Effects of tafamidis on transthyretin stabilization and clinical outcomes in patients with non-Val30Met transthyretin amyloidosis

scientific article published on 08 October 2013

Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I

article

Efficacy and safety of once-weekly and twice-weekly bortezomib in patients with relapsed systemic AL amyloidosis: results of a phase 1/2 study

scientific article published on 11 May 2011

Efficacy and safety of tafamidis doses in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT) and long-term extension study

scientific article published on 18 October 2020

Efficacy of peptide bound m-l-sarcolysin (peptichemio) on melphalan resistant human myeloma cellsIn vitro ⬇️

scientific article published on January 1, 1991

Eight novel loci implicate shared genetic etiology in multiple myeloma, AL amyloidosis, and monoclonal gammopathy of unknown significance

scientific article published on 06 November 2019

Embryonic stem and haematopoietic progenitor cells resist to Aβ oligomer toxicity and maintain the differentiation potency in culture

scientific article published on September 2010

Enlightening light chain deposition disease

scientific article published in December 2015

Eprodisate for the treatment of renal disease in AA amyloidosis.

scientific article

Erratum: International uniform response criteria for multiple myeloma

scholarly article published in Leukemia

Erratum: International uniform response criteria for multiple myeloma

article

Etiology of amyloidosis determines myocardial 99mTc-DPD uptake in amyloidotic cardiomyopathy

scientific article published on 01 May 2015

European Collaborative Study Defining Clinical Profile Outcomes and Novel Prognostic Criteria in Monoclonal Immunoglobulin M-Related Light Chain Amyloidosis

scientific article

European myeloma network recommendations on diagnosis and management of patients with rare plasma cell dyscrasias

scientific article published on 23 July 2018

Evaluation of Mortality During Long-Term Treatment with Tafamidis for Transthyretin Amyloidosis with Polyneuropathy: Clinical Trial Results up to 8.5 Years

scientific article published on 27 February 2020

Expanding the spectrum of systemic amyloid diseases: a new hint from the kidney

scientific article published in September 2016

Expert Consensus Recommendations for the Suspicion and Diagnosis of Transthyretin Cardiac Amyloidosis

scientific article published on 04 September 2019

Expert consensus recommendations to improve diagnosis of ATTR amyloidosis with polyneuropathy

scientific article published on 06 January 2020

Favourable and sustained response to anakinra in tumour necrosis factor receptor-associated periodic syndrome (TRAPS) with or without AA amyloidosis

article

First report of circulating microRNAs in tumour necrosis factor receptor-associated periodic syndrome (TRAPS). ⬇️

scientific article

First report of systemic reactive (AA) amyloidosis in a patient with the hyperimmunoglobulinemia D with periodic fever syndrome

scientific article published on September 2004

First-in-Human Phase I/II Study of NEOD001 in Patients With Light Chain Amyloidosis and Persistent Organ Dysfunction

scientific article

Gender-related risk of myocardial involvement in systemic amyloidosis.

scientific article published in March 2008

Genetic microheterogeneity of human transthyretin detected by IEF

article

Genome-wide association study of clinical parameters in immunoglobulin light chain amyloidosis in three patient cohorts.

scientific article published on 4 July 2017

Growth Differentiation Factor 15 Is a New Biomarker for Survival and Renal Outcomes in Light Chain (AL) Amyloidosis

scientific article published on 31 January 2018

Guidelines for the Analysis of Bence Jones Protein

article

Heavy Chain Disease Can Be Detected by Capillary Zone Electrophoresis

scientific article published on 01 January 2005

Helical superstructures between amyloid and collagen in cardiac fibrils from a patient with AL amyloidosis

scientific article published in 2024

Hereditary apolipoprotein A1 amyloidosis with cutaneous and cardiac involvement: a long familial history

scientific article published on 01 March 2014

High 99mTc-DPD myocardial uptake in a patient with apolipoprotein AI-related amyloidotic cardiomyopathy

scientific article published on 12 December 2012

High rate of profound clonal and renal responses with Daratumumab treatment in heavily pre-treated patients with AL amyloidosis and high bone marrow plasma cell infiltrate

scientific article published on 13 April 2020

High sensitivity M-protein detection in a case of light-chain cardiac amyloidosis without evidence of plasma cell dyscrasia

scientific article published on 08 January 2019

How do we improve treatments for patients with amyloidosis using proteomics?

scientific article published on 23 May 2017

How we treat Waldenström's macroglobulinemia

scientific article

Human amyloidogenic light chain proteins result in cardiac dysfunction, cell death, and early mortality in zebrafish

scientific article published on 26 April 2013

IX International Symposium on Amyloidosis July 15–21, 2001 Budapest, Hungary

scientific article published on 01 March 2002

Identification and quantification of urinary monoclonal proteins by capillary electrophoresis in AL amyloidosis.

scientific article published in March 2017

Identification of Amyloidogenic Light Chains Requires the Combination of Serum-Free Light Chain Assay with Immunofixation of Serum and Urine

scientific article published on 08 January 2009

Immune mechanisms of AL amyloidosis

Immunoglobulin Light Chain Systemic Amyloidosis

scientific article

Immunoglobulin M monoclonal gammopathies of undetermined significance and indolent Waldenstrom's macroglobulinemia recognize the same determinants of evolution into symptomatic lymphoid disorders: proposal for a common prognostic scoring system.

scientific article

Immunoglobulin light chain amyloidosis

scientific article published on 18 December 2013

Impaired osteoblastogenesis in a murine model of dominant osteogenesis imperfecta: a new target for osteogenesis imperfecta pharmacological therapy. ⬇️

scientific article

Importance of the echocardiographic evaluation of right ventricular function in patients with AL amyloidosis

scientific article published on 22 June 2007

Improved outcomes for kidney transplantation in AL amyloidosis: impact on practice

scientific article published on 01 February 2019

In situ characterization of protein aggregates in human tissues affected by light chain amyloidosis: a FTIR microspectroscopy study.

scientific article published on 04 July 2016

Independent Prognostic Value of Stroke Volume Index in Patients With Immunoglobulin Light Chain Amyloidosis

scientific article published on 01 May 2018

Indicators of profound hematologic response in AL amyloidosis: complete response remains the goal of therapy

scientific article published on 01 September 2020

Infertility and Hypergonadotropic Hypogonadism as First Evidence of Hereditary Apolipoprotein A-I Amyloidosis

article

Inherent Biophysical Properties Modulate the Toxicity of Soluble Amyloidogenic Light Chains

scientific article published on 24 December 2019

Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis

scientific article published on 01 July 2018

Inotersen preserves or improves quality of life in hereditary transthyretin amyloidosis

scientific article published on 18 December 2019

Insights into the regulation of immunoglobulin light chain gene rearrangements via analysis of the kappa light chain locus in lambda myeloma

scientific article published in July 2004

International Myeloma Working Group Recommendations for the Diagnosis and Management of Myeloma-Related Renal Impairment

scientific article

International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders

scientific article

International Myeloma Working Group recommendations for the treatment of multiple myeloma-related bone disease

scientific article published on 20 May 2013

International Myeloma Working Group risk stratification model for smoldering multiple myeloma (SMM)

scientific article published on 16 October 2020

International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma

scientific article

International myeloma working group (IMWG) consensus statement and guidelines regarding the current status of stem cell collection and high-dose therapy for multiple myeloma and the role of plerixafor (AMD 3100).

scientific article published on 25 June 2009

International prognostic scoring system for Waldenstrom macroglobulinemia

scientific article published on 5 February 2009

International uniform response criteria for multiple myeloma.

scientific article

Introducing the new editor of amyloid: the journal of protein folding disorders, Per Westermark, M.D., Ph.D.

scientific article published in September 2010

Inverse polymerase chain reaction for cloning complete human immunoglobulin variable regions and leaders conserving the original sequence

scientific article published in July 1996

Investigating heart-specific toxicity of amyloidogenic immunoglobulin light chains: A lesson from C. elegans

scientific article published on July 2014

Investigation and management of IgM and Waldenström-associated peripheral neuropathies: recommendations from the IWWM-8 consensus panel

scientific article published on 15 February 2017

Late-Onset Familial Mediterranean Fever: An Atypical Presentation of Dermatologic Interest

scientific article published on 01 August 2007

Light Chain Amyloidosis.

scientific article published in March 2018

Light Chain Amyloidosis: Patient Experience Survey from the Amyloidosis Research Consortium

scientific article

Light and electron microscopy immunohistochemical characterization of amyloid deposits

article by Eloisa Arbustini et al published January 1997 in Amyloid

Light chain amyloidosis: the heart of the problem

scientific article published on October 2013

Liver biopsy discloses a new apolipoprotein A-I hereditary amyloidosis in several unrelated Italian families

scientific article

Long-term follow-up from a phase 1/2 study of single-agent bortezomib in relapsed systemic AL amyloidosis

scientific article

Long-term results of a risk-adapted approach to melphalan conditioning in autologous peripheral blood stem cell transplantation for primary (AL) amyloidosis

scientific article published in December 2006

Lysine 58-cleaved beta2-microglobulin is not detectable by 2D electrophoresis in ex vivo amyloid fibrils of two patients affected by dialysis-related amyloidosis.

scientific article

Lysozyme: a paradigmatic molecule for the investigation of protein structure, function and misfolding.

scientific article

MASS-FIX may allow identification of patients at risk for light chain amyloidosis before the onset of symptoms

scientific article published on 21 September 2018

Malnutrition at diagnosis predicts mortality in patients with systemic immunoglobulin light-chain amyloidosis independently of cardiac stage and response to treatment.

scientific article published on 26 September 2013

Management of AL amyloidosis in 2020

scientific article published on 01 December 2020

Management of multiple myeloma and related-disorders: guidelines from the Italian Society of Hematology (SIE), Italian Society of Experimental Hematology (SIES) and Italian Group for Bone Marrow Transplantation (GITMO).

scientific article published on June 2004

Management of the elderly patient with AL amyloidosis

scientific article published on 23 May 2018

Management of treatment-emergent peripheral neuropathy in multiple myeloma.

scientific article published on 23 December 2011

Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis:insights into the timing of proteolysis

scientific article published on 20 September 2020

Mass spectrometry-based proteomics as a diagnostic tool when immunoelectron microscopy fails in typing amyloid deposits ⬇️

scientific article published on June 1, 2011

Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis

scientific article

Mechanisms of renal damage in plasma cell dyscrasias: an overview.

scientific article

Melphalan and dexamethasone with or without bortezomib in newly diagnosed AL amyloidosis: a matched case–control study on 174 patients

scientific article published on 25 July 2014

Metrological sharp shooting for plasma proteins and peptides: The need for reference materials for accurate measurements in clinical proteomics andin vitro diagnostics to generate reliable results

article

Micropolyspora faeni antigens of three commercial extracts

scientific article published on 01 February 1984

Midregional proadrenomedullin (MR-proADM) is a powerful predictor of early death in AL amyloidosis

scientific article published on 09 November 2011

Modulating the cardiotoxic behaviour of immunoglobulin light chain dimers through point mutations

scientific article published on 01 January 2019

Molecular and functional bases of self-antigen recognition in long-term persistent melanocyte-specific CD8+ T cells in one vitiligo patient

scientific article published in August 2003

Molecular imaging of misfolded protein pathology for early clues to involvement of the heart

scholarly article by Giampaolo Merlini et al published 3 July 2014 in European Journal of Nuclear Medicine and Molecular Imaging

Molecular mechanisms of amyloidosis

scientific article

Monitoring free light chains in serum using mass spectrometry

scientific article published on 01 June 2016

Monitoring safety and effectiveness of Tafamidis in transthyretin amyloidosis in Italy: a 3-year longitudinal multicenter study in a non-endemic area

scientific article published on 2 November 2015

Monoclonal IgM-related AL amyloidosis

scientific article published on June 2016

Monoclonal gammopathy of clinical significance: a novel concept with therapeutic implications

scholarly article by Jean-Paul Fermand et al published 4 October 2018 in Blood

Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management

scientific article

Multicentre versus single centre approach to rare diseases: The model of systemic light chain amyloidosis

article

Mutation and transcription analysis of transthyretin gene in Italian families with hereditary amyloidosis: a putative novel ‘hot spot’ in codon 47

article

Myeloma kidney: advances in molecular mechanisms of acute kidney injury open novel therapeutic opportunities

scientific article published in October 2012

N-terminal fragment of the type-B natriuretic peptide (NT-proBNP) contributes to a simple new frailty score in patients with newly diagnosed multiple myeloma

scientific article published on 10 August 2016

New Insights Into a Multifaceted Disease

scientific article published on 01 March 2019

New concepts in the treatment and diagnosis of amyloidosis

scientific article published on 8 January 2018

New criteria for response to treatment in immunoglobulin light chain amyloidosis based on free light chain measurement and cardiac biomarkers: impact on survival outcomes

scientific article published on 22 October 2012

New drugs and novel mechanisms of action in multiple myeloma in 2013: a report from the International Myeloma Working Group (IMWG)

scientific article

Nomenclature 2014: Amyloid fibril proteins and clinical classification of the amyloidosis

scientific article published on 29 September 2014

Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis.

scientific article published on 22 April 2016

Nonlymphoplasmacytic lymphomas associated with light-chain amyloidosis

scientific article published on 01 January 2020

Novel Therapies in Light Chain Amyloidosis.

scientific article published on 28 November 2017

Novel Type of Renal Amyloidosis Derived from Apolipoprotein-CII.

scientific article published on 13 June 2016

Novel challenges in the management of immunoglobulin light chain amyloidosis: from the bench to the bedside

scientific article published on 28 July 2020

Novel mitochondrial protein interactors of immunoglobulin light chains causing heart amyloidosis.

scientific article published on 28 July 2015

Novel strategies for the diagnosis and treatment of cardiac amyloidosis.

scientific article

Nutritional counseling improves quality of life and preserves body weight in systemic immunoglobulin light-chain (AL) amyloidosis.

scientific article published on 11 May 2015

Nutritional status independently affects quality of life of patients with systemic immunoglobulin light-chain (AL) amyloidosis.

scientific article published on 9 August 2011

Nutritional status of outpatients with systemic immunoglobulin light-chain amyloidosis 1

article by Riccardo Caccialanza et al published February 2006 in American Journal of Clinical Nutrition

Obstructive intramural coronary amyloidosis: a distinct phenotype of cardiac amyloidosis that can cause acute heart failure

scientific article published on 02 February 2006

Occurrence of monoclonal components in general practice: clinical implications

scientific article published on 01 April 1992

Oral melphalan and dexamethasone grants extended survival with minimal toxicity in AL amyloidosis: long-term results of a risk-adapted approach.

scientific article

Paraprotein Interference in an Assay of Conjugated Bilirubin

scientific article published on 01 June 2005

Pathogenesis of renal failure in multiple myeloma: any role of contrast media?

scientific article

Patient experience with hereditary and senile systemic amyloidoses: a survey from the Amyloidosis Research Consortium

scientific article published on 2 November 2015

Patients with AL amyloidosis and low free light-chain burden have distinct clinical features and outcome.

scientific article

Patients with light-chain amyloidosis and low free light-chain burden have distinct clinical features and outcome.

scientific article published on 25 May 2017

Patterns of relapse after upfront bortezomib therapy in AL amyloidosis

scientific article published on 01 March 2017

Peptichemio induction therapy in myelomatosis.

scientific article

Peptichemio, vincristine and prednisone versus melphalan and prednisone as induction therapy in multiple myeloma.

scientific article

Persistent efficacy of anakinra in patients with tumor necrosis factor receptor-associated periodic syndrome

scientific article

Pharmaceutical strategies against amyloidosis: old and new drugs in targeting a "protein misfolding disease".

scientific article published on April 2004

Pharmacokinetic Behavior of Rituximab

scientific article published on 01 December 2005

Pharmacokinetics of peptichemio in myeloma patients: release ofm-l-sarcolysin in vivo and in vitro

scientific article published on 01 January 1993

Plasma cell DNA content in multiple myeloma and related paraproteinemic disorders. Relationship with clinical and cytokinetic features

scientific article published on 01 January 1984

Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group

scientific article

Plasma neurofilament light chain: an early biomarker for hereditary ATTR amyloid polyneuropathy

scientific article published on 06 January 2020

Pomalidomide and dexamethasone grant rapid haematologic responses in patients with relapsed and refractory AL amyloidosis: a European retrospective series of 153 patients

scientific article published on 25 May 2020

Predicting survival in light chain amyloidosis

scientific article published on 01 July 2019

Presentation and outcome with second line treatment in AL amyloidosis previously sensitive to non-transplant therapies.

scientific article published on 3 November 2017

Prevalence and prognostic value of conduction disturbances at the time of diagnosis of cardiac AL amyloidosis.

scientific article published on 20 January 2013

Primary therapy of Waldenstrom macroglobulinemia (WM) with weekly bortezomib, low-dose dexamethasone, and rituximab (BDR): long-term results of a phase 2 study of the European Myeloma Network (EMN).

scientific article published on 4 September 2013

Prognostic factors in symptomatic Waldenstrom's macroglobulinemia

scientific article published on 01 April 2003

Prognostic markers and criteria to initiate therapy in Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia

scientific article (publication date: April 2003)

Prognostic role of clinical and laboratory criteria to identify early ventilator-associated pneumonia in brain injury

scientific article published on 10 April 2008

Prognostic validation of the international classification of immunoglobulin M gammopathies: a survival advantage for patients with immunoglobulin M monoclonal gammopathy of undetermined significance?

scientific article published in March 2005

Prognostic value of depressed midwall systolic function in cardiac light-chain amyloidosis

scientific article published on 01 May 2014

Prognostic value of fragmented QRS in cardiac AL amyloidosis

scientific article published on 27 June 2012

Prognostication of survival and progression to dialysis in AA amyloidosis

scientific article published on 01 March 2017

Protein Aggregation

scientific article published on 01 November 2001

Proteomic characterization of amyloid deposits in transthyretin amyloidosis associated with various mutations ⬇️

scientific article published on 01 June 2011

Proteomics Fundamentally Advance the Diagnosis and Management of Amyloidosis

scientific article published on 01 September 2020

Proteomics in protein misfolding diseases.

scientific article published in January 2009

Proteomics of beta2-microglobulin amyloid fibrils.

scientific article

Proteomics with Mass Spectrometry Imaging: Beyond Amyloid Typing

scientific article published in February 2018

Proteotoxicity in cardiac amyloidosis: amyloidogenic light chains affect the levels of intracellular proteins in human heart cells

scientific article

Publisher Correction: The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group

scientific article published on 01 February 2019

Rapid progression of familial amyloidotic polyneuropathy: a multinational natural history study

scientific article

Rare diseases and effective treatments: are we delivering?

scientific article

Reasoning with Effects of Clinical Guideline Actions Using OWL: AL Amyloidosis as a Case Study

article published in 2012

Recommendations for appropriate serum electrophoresis requests: the Italian approach

scientific article published in June 2013

Recommendations for the diagnosis and initial evaluation of patients with Waldenström Macroglobulinaemia: A Task Force from the 8th International Workshop on Waldenström Macroglobulinaemia

scientific article published on 05 July 2016

Redefining myeloma

scientific article published on 31 July 2012

Redirecting proteoxicity

scientific article published on 24 August 2020

Reducing the amyloid burden through immunotherapy: a major therapeutic advance

scientific article published on 11 March 2011

Regulated expression of amyloidogenic immunoglobulin light chains in mice

Reliable typing of systemic amyloidoses through proteomic analysis of subcutaneous adipose tissue.

scientific article published on 13 September 2011

Renal apolipoprotein A-I amyloidosis: a rare and usually ignored cause of hereditary tubulointerstitial nephritis

scientific article published on 12 October 2005

Reply to S. Girnius et al.

scientific article published in July 2013

Report from the Sixth International Workshop on Waldenström's Macroglobulinemia

scientific article published in February 2011

Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial

scientific article

Response assessment in Waldenström macroglobulinaemia: update from the VIth International Workshop

scientific article

Response to bendamustine is associated with a survival advantage in a heavily pretreated patients with AL amyloidosis

article

Reversal of nephrotic syndrome due to reactive amyloidosis (AA-type) after excision of localized Castleman's disease

article

Review: immunoglobulin light chain amyloidosis--the archetype of structural and pathogenic variability.

scientific article

Risk stratification in Waldenström macroglobulinemia

scientific article published on April 2012

SIE, SIES, GITMO evidence-based guidelines on novel agents (thalidomide, bortezomib, and lenalidomide) in the treatment of multiple myeloma

scientific article published on 04 April 2012

Salvage therapy with lenalidomide and dexamethasone in patients with advanced AL amyloidosis refractory to melphalan, bortezomib, and thalidomide

scientific article published on 30 April 2011

Scintigraphic imaging and turnover studies with iodine-131 labelled serum amyloid P component in systemic amyloidosis

scientific article

Seek and You Shall Find: Is Subclinical Amyloid More Common Than Expected?

scientific article published on 01 November 2018

Sequential response-driven bortezomib-based therapy followed by autologous stem cell transplant in AL amyloidosis

scientific article published on 01 September 2020

Serum N-terminal pro-brain natriuretic peptide is a sensitive marker of myocardial dysfunction in AL amyloidosis

scientific article published on 28 April 2003

Serum amyloid a and C-reactive protein independently predict the recurrences of atrial fibrillation after cardioversion in patients with preserved left ventricular function.

scientific article published in May 2012

Serum free light chain analysis in the diagnosis and management of multiple myeloma and related conditions

scientific article

Serum markers of myocardial damage in acute pancreatitis: a prospective time course study

scientific article published in May 2015

Serum prealbumin: an independent marker of short-term energy intake in the presence of multiple-organ disease involvement

scientific article

Serum-free light chain analysis: works in progress

article

Serum-free light-chain analysis in diagnosis and management of multiple myeloma and related conditions

scientific article

Severity and reversibility of cardiac dysfunction and residual concentration of amyloidogenic light chain predict overall survival of patients with AL amyloidosis who attain complete response

scientific article published on 01 March 2017

Shotgun protein profile of human adipose tissue and its changes in relation to systemic amyloidoses.

scientific article published on 21 October 2013

Simple, reliable detection of amyloid in fat aspirates using the fluorescent dye FSB: prospective study in 206 patients

scientific article published on 06 June 2019

Sjögren's syndrome and localized nodular cutaneous amyloidosis: Coincidence or a distinct clinical entity?

scientific article published on 01 July 2008

Standardizing plasma protein measurements worldwide: a challenging enterprise ⬇️

scientific article published on October 20, 2010

Stanniocalcin1 is a key mediator of amyloidogenic light chain induced cardiotoxicity

scientific article

Structural and functional characterization of three human immunoglobulin κ light chains with different pathological implications

scientific article published on 01 December 1996

Structural characterization of κ II Inc, a new amyloid immunoglobulin

scientific article published on 01 April 1989

Structure, function and amyloidogenic propensity of apolipoprotein A-I.

scientific article published on December 2006

Susceptibility to AA amyloidosis in rheumatic diseases: a critical overview

scientific article published on October 2009

Synergy of combined doxycycline/TUDCA treatment in lowering Transthyretin deposition and associated biomarkers: studies in FAP mouse models

scientific article

Systemic amyloidoses and proteomics: The state of the art.

scientific article published on 23 February 2016

Systemic amyloidoses: what an internist should know

scientific article

Systemic amyloidosis: novel therapies and role of biomarkers

scientific article published on 18 August 2016

Systemic cardiac amyloidoses: disease profiles and clinical courses of the 3 main types.

scientific article

Systemic immunoglobulin light chain amyloidosis

Systemic light chain amyloidosis: an update for treating physicians

scientific article published on 13 May 2013

TTR-related amyloid neuropathy: clinical, electrophysiological and pathological findings in 15 unrelated patients

scientific article

Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy

The Clinical Impact of Proteomics in Amyloid Typing

scientific article published in May 2021

The Diflunisal Trial: study accrual and drug tolerance

scientific article published on 2 May 2012

The Pavia Approach to Clinical Protein Analysis

The amyloidogenic light chain is a stressor that sensitizes plasma cells to proteasome inhibitor toxicity.

scientific article

The combination of high-sensitivity cardiac troponin T (hs-cTnT) at presentation and changes in N-terminal natriuretic peptide type B (NT-proBNP) after chemotherapy best predicts survival in AL amyloidosis

scientific article published on 19 July 2010

The combination of thalidomide and intermediate-dose dexamethasone is an effective but toxic treatment for patients with primary amyloidosis (AL).

scientific article published on 30 November 2004

The concurrency of several biophysical traits links immunoglobulin light chains with toxicity in AL amyloidosis

scientific article published on 01 January 2019

The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties

scientific article

The elusive pathogenesis of Schnitzler syndrome

scientific article published on 01 March 2018

The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group

scientific article published on 01 January 2019

The expanding spectrum of low-penetrance TNFRSF1A gene variants in adults presenting with recurrent inflammatory attacks: clinical manifestations and long-term follow-up

scientific article published on 12 December 2013

The impact of renal function on the clinical performance of FLC measurement in AL amyloidosis

scientific article published on 01 June 2016

The intracellular quality control system down-regulates the secretion of amyloidogenic apolipoprotein A-I variants: A possible impact on the natural history of the disease

scientific article published on 15 July 2010

The lung in amyloidosis.

scientific article published on 6 September 2017

The molecular interaction of 4'-iodo-4'-deoxydoxorubicin with Leu-55Pro transthyretin 'amyloid-like' oligomer leading to disaggregation

scientific article published in October 2000

The novel S59P mutation in the TNFRSF1A gene identified in an adult onset TNF receptor associated periodic syndrome (TRAPS) constitutively activates NF-κB pathway

scientific article published on 3 April 2015

The red cell distribution width (RDW): value and role in preterm, IUGR (intrauterine growth restricted), full-term infants.

scientific article

The repertoire of λ light chains causing predominant amyloid heart involvement and identification of a preferentially involved germline gene, IGLV1-44.

scientific article published on 8 November 2011

The second riboflavin-binding myeloma IgGλDOT I. Biochemical and functional characterization

article

The utility of MASS-FIX to detect and monitor monoclonal proteins in the clinic

scientific article

The workings of the amyloid diseases

scientific article published on January 2007

Therapeutic advances demand accurate typing of amyloid deposits

scientific article published on 01 August 2001

Therapy and management of systemic AL (primary) amyloidosis.

scientific article published on November 2006

Topological investigation of amyloid fibrils obtained from beta2-microglobulin.

scientific article

Transplantation vs. conventional-dose therapy for amyloidosis

scientific article published on March 2011

Transthyretin deposition in the eye in the era of effective therapy for hereditary ATTRV30M amyloidosis

scientific article published on 24 January 2019

Treating advanced cardiac damage in light chain amyloidosis: still an unmet need

scientific article published in September 2014

Treatment of AL amyloidosis with bendamustine: a study of 122 patients

scientific article published on 14 August 2018

Treatment of IgM-associated AL amyloidosis with the combination of rituximab, bortezomib, and dexamethasone.

scientific article published in February 2011

Treatment of patients with advanced cardiac AL amyloidosis with oral melphalan, dexamethasone, and thalidomide

scientific article

Treatment recommendations for patients with Waldenström macroglobulinemia (WM) and related disorders: IWWM-7 consensus

scientific article

Treatment recommendations from the Eighth International Workshop on Waldenström's Macroglobulinemia

scientific article published on 18 July 2016

Treatment with oral melphalan plus dexamethasone produces long-term remissions in AL amyloidosis

scientific article published on 01 July 2007

Tubulointerstitial nephritis is a dominant feature of hereditary apolipoprotein A-I amyloidosis

scientific article published on 7 January 2015

Ultrastructural organization of ex vivo amyloid fibrils formed by the apolipoprotein A-I Leu174Ser variant: an atomic force microscopy study

Update on recommendations for assessing response from the Third International Workshop on Waldenstrom's Macroglobulinemia

scientific article

Update on treatment recommendations from the Fourth International Workshop on Waldenstrom's Macroglobulinemia

scientific article published on December 2008

Update on treatment recommendations from the Third International Workshop on Waldenstrom's macroglobulinemia

scientific article published on 12 January 2006

Urinary albumin to creatinine ratio in diagnosis and risk stratification of renal AL amyloidosis

scientific article published on 01 March 2017

Utility of biochemical markers in the follow-up of heart transplant recipients

scientific article published in December 2003

Utility of bisphosphonates in treating bone metastases

scientific article published on December 1996

Variable presentations of TTR-related familial amyloid polyneuropathy in seventeen patients.

scientific article published in June 2011

Vascular alterations in apolipoprotein A-I amyloidosis (Leu75Pro). A case-control study.

scientific article published on 21 July 2015

Waldenstrom's macrogloblinemia/ lymphoplasmacytic lymphoma

scientific article published on January 2008

Waldenström Macroglobulinemia

scientific article published on 05 August 2014

Weekly and twice-weekly bortezomib in patients with systemic AL amyloidosis: results of a phase 1 dose-escalation study

scientific article

What is new in diagnosis and management of light chain amyloidosis?

scientific article published on 6 April 2016

When should treatment of AL amyloidosis start at relapse? Early, to prevent organ progression

scientific article published on 01 January 2019

Zebrafish model of amyloid light chain cardiotoxicity: regeneration versus degeneration

scientific article published on 15 March 2019

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