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List of works by Giovanni Palladini

A Caenorhabditis elegans-based assay recognizes immunoglobulin light chains causing heart amyloidosis

scientific article

A European collaborative study of cyclophosphamide, bortezomib, and dexamethasone in upfront treatment of systemic AL amyloidosis

scientific article published on 18 May 2015

A European collaborative study of treatment outcomes in 346 patients with cardiac stage III AL amyloidosis.

scientific article

A modified high-dose dexamethasone regimen for primary systemic (AL) amyloidosis

scientific article published on 01 June 2001

A multicenter phase II trial of 4'-iodo-4'deoxydoxorubicin (IDOX) in primary amyloidosis (AL).

scientific article

A new genetic variant of hereditary apolipoprotein A-I amyloidosis: a case-report followed by discussion of diagnostic challenges and therapeutic options

scientific article published on 21 January 2019

A novel AbetaPP mutation exclusively associated with cerebral amyloid angiopathy

scientific article published in October 2005

A novel approach for the purification and proteomic analysis of pathogenic immunoglobulin free light chains from serum.

scientific article published on 4 January 2011

A patient with AL amyloidosis with negative free light chain results.

scientific article published in June 2016

A phase 1/2 study of the oral proteasome inhibitor ixazomib in relapsed or refractory AL amyloidosis.

scientific article published on 26 May 2017

A phase 2 trial of pomalidomide and dexamethasone rescue treatment in patients with AL amyloidosis.

scientific article published on 27 January 2017

A phase II trial of cyclophosphamide, lenalidomide and dexamethasone in previously treated patients with AL amyloidosis.

scientific article published on 14 September 2012

A practical approach to the diagnosis of systemic amyloidoses.

scientific article published on 30 January 2015

A staging system for renal outcome and early markers of renal response to chemotherapy in AL amyloidosis

article

A strategy for synthesis of pathogenic human immunoglobulin free light chains in E. coli

scientific article

A validated composite organ and hematologic response model for early assessment of treatment outcomes in light chain amyloidosis

scientific article published on 14 April 2020

AL amyloidosis associated with IgM monoclonal protein: a distinct clinical entity

scientific article published in March 2009

ATR-FTIR Spectroscopy Supported by Multivariate Analysis for the Characterization of Adipose Tissue Aspirates from Patients Affected by Systemic Amyloidosis

scientific article published on 04 February 2019

Advantages of the lognormal approach to determining reference change values for N-terminal propeptide B-type natriuretic peptide

scientific article published on 3 December 2011

Amyloidosis: is a cure possible?

scientific article published on June 2008

Analysis of V(lambda)-J(lambda) expression in plasma cells from primary (AL) amyloidosis and normal bone marrow identifies 3r (lambdaIII) as a new amyloid-associated germline gene segment

scientific article

Association of melphalan and high-dose dexamethasone is effective and well tolerated in patients with AL (primary) amyloidosis who are ineligible for stem cell transplantation.

scientific article

BDR in newly diagnosed patients with WM: final analysis of a phase 2 study after a minimum follow-up of 6 years

scientific article published on 21 November 2016

Best use of cardiac biomarkers in patients with AL amyloidosis and renal failure

scientific article published on 3 March 2012

Bevacizumab treatment followed by maintenance in life-threatening POEMS syndrome

scientific article published on 19 January 2013

Biochemical markers in early diagnosis and management of systemic amyloidoses.

scientific article

Bortezomib in a phase 1 trial for patients with relapsed AL amyloidosis: cardiac responses and overall effects

article

Bortezomib in the treatment of AL amyloidosis: targeted therapy?

scientific article published in October 2007

Bortezomib with or without dexamethasone in primary systemic (light chain) amyloidosis

scientific article published on 19 January 2010

Bortezomib-induced paralytic ileus is a potential gastrointestinal side effect of this first-in-class anticancer proteasome inhibitor

scientific article published on 01 July 2007

Cardiac Light Chain Amyloidosis: The Role of Metal Ions in Oxidative Stress and Mitochondrial Damage.

scientific article published on 28 January 2017

Characterization of immunoglobulin variable regions of two human pathogenic monoclonal cryocrystalglobulins

scientific article published on 18 October 2007

Circulating amyloidogenic free light chains and serum N-terminal natriuretic peptide type B decrease simultaneously in association with improvement of survival in AL.

scientific article published on 24 January 2006

Circulating free light chain measurement in the diagnosis, prognostic assessment and evaluation of response of AL amyloidosis: comparison of Freelite and N latex FLC assays

scientific article published on 27 March 2017

Clinical aspects of systemic amyloid diseases.

scientific article

Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity

scientific article published in December 2017

Consensus guidelines for the conduct and reporting of clinical trials in systemic light-chain amyloidosis

scientific article published on 05 April 2012

Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient

scientific article published on 20 March 2019

Current treatment of AL amyloidosis

scientific article published on August 2009

Diagnostic and prognostic value of low QRS voltages in cardiac AL amyloidosis.

scientific article published on 20 January 2013

Diagnostic challenges of amyloidosis in Waldenström macroglobulinemia

scientific article published on 07 March 2013

Disease profile and differential diagnosis of hereditary transthyretin-related amyloidosis with exclusively cardiac phenotype: an Italian perspective.

scientific article

Doxycycline plus tauroursodeoxycholic acid for transthyretin amyloidosis: a phase II study

scientific article

Efficacy and safety of once-weekly and twice-weekly bortezomib in patients with relapsed systemic AL amyloidosis: results of a phase 1/2 study

scientific article published on 11 May 2011

Eight novel loci implicate shared genetic etiology in multiple myeloma, AL amyloidosis, and monoclonal gammopathy of unknown significance

scientific article published on 06 November 2019

End-stage renal failure due to amyloidosis and recurrent fever on dialysis--is there a link?

scientific article

Enlightening light chain deposition disease

scientific article published in December 2015

European Collaborative Study Defining Clinical Profile Outcomes and Novel Prognostic Criteria in Monoclonal Immunoglobulin M-Related Light Chain Amyloidosis

scientific article

First report of systemic reactive (AA) amyloidosis in a patient with the hyperimmunoglobulinemia D with periodic fever syndrome

scientific article published on September 2004

Genome-wide association study of clinical parameters in immunoglobulin light chain amyloidosis in three patient cohorts.

scientific article published on 4 July 2017

Genome-wide association study of immunoglobulin light chain amyloidosis in three patient cohorts: comparison with myeloma.

scientific article published on 27 December 2016

Growth Differentiation Factor 15 Is a New Biomarker for Survival and Renal Outcomes in Light Chain (AL) Amyloidosis

scientific article published on 31 January 2018

Identification and quantification of urinary monoclonal proteins by capillary electrophoresis in AL amyloidosis.

scientific article published in March 2017

Identification of Amyloidogenic Light Chains Requires the Combination of Serum-Free Light Chain Assay with Immunofixation of Serum and Urine

scientific article published on 08 January 2009

Impaired osteoblastogenesis in a murine model of dominant osteogenesis imperfecta: a new target for osteogenesis imperfecta pharmacological therapy. ⬇️

scientific article

Importance of the echocardiographic evaluation of right ventricular function in patients with AL amyloidosis

scientific article published on 22 June 2007

In situ characterization of protein aggregates in human tissues affected by light chain amyloidosis: a FTIR microspectroscopy study.

scientific article published on 04 July 2016

Indicators of profound hematologic response in AL amyloidosis: complete response remains the goal of therapy

scientific article published on 01 September 2020

Insights into the regulation of immunoglobulin light chain gene rearrangements via analysis of the kappa light chain locus in lambda myeloma

scientific article published in July 2004

Light Chain Amyloidosis.

scientific article published in March 2018

Light chain amyloidosis 2012: a new era.

scientific article published on 07 January 2013

Light chain amyloidosis: the heart of the problem

scientific article published on October 2013

Liver biopsy discloses a new apolipoprotein A-I hereditary amyloidosis in several unrelated Italian families

scientific article

Long-term follow-up from a phase 1/2 study of single-agent bortezomib in relapsed systemic AL amyloidosis

scientific article

Malnutrition at diagnosis predicts mortality in patients with systemic immunoglobulin light-chain amyloidosis independently of cardiac stage and response to treatment.

scientific article published on 26 September 2013

Management of the elderly patient with AL amyloidosis

scientific article published on 23 May 2018

Melphalan and dexamethasone with or without bortezomib in newly diagnosed AL amyloidosis: a matched case–control study on 174 patients

scientific article published on 25 July 2014

Midregional proadrenomedullin (MR-proADM) is a powerful predictor of early death in AL amyloidosis

scientific article published on 09 November 2011

Multicentre versus single centre approach to rare diseases: The model of systemic light chain amyloidosis

article

N-terminal fragment of the type-B natriuretic peptide (NT-proBNP) contributes to a simple new frailty score in patients with newly diagnosed multiple myeloma

scientific article published on 10 August 2016

New concepts in the treatment and diagnosis of amyloidosis

scientific article published on 8 January 2018

New criteria for response to treatment in immunoglobulin light chain amyloidosis based on free light chain measurement and cardiac biomarkers: impact on survival outcomes

scientific article published on 22 October 2012

Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis.

scientific article published on 22 April 2016

Novel Therapies in Light Chain Amyloidosis.

scientific article published on 28 November 2017

Novel strategies for the diagnosis and treatment of cardiac amyloidosis.

scientific article

Nutritional counseling improves quality of life and preserves body weight in systemic immunoglobulin light-chain (AL) amyloidosis.

scientific article published on 11 May 2015

Nutritional status independently affects quality of life of patients with systemic immunoglobulin light-chain (AL) amyloidosis.

scientific article published on 9 August 2011

Oral melphalan and dexamethasone grants extended survival with minimal toxicity in AL amyloidosis: long-term results of a risk-adapted approach.

scientific article

Outcome of Patients With Newly Diagnosed Systemic Light-Chain Amyloidosis Associated With Deletion of 17p

scientific article published on 25 July 2018

Ovarian hyperstimulation syndrome in systemic amyloidosis.

scientific article published on 16 January 2014

Paraneoplastic Cushing's syndrome and nephrotic syndrome in a patient with disseminated small cell lung cancer

scientific article published on 01 February 2008

Patients with AL amyloidosis and low free light-chain burden have distinct clinical features and outcome.

scientific article

Patients with light-chain amyloidosis and low free light-chain burden have distinct clinical features and outcome.

scientific article published on 25 May 2017

Patterns of relapse after upfront bortezomib therapy in AL amyloidosis

scientific article published on 01 March 2017

Presentation and outcome with second line treatment in AL amyloidosis previously sensitive to non-transplant therapies.

scientific article published on 3 November 2017

Prevalence and prognostic value of conduction disturbances at the time of diagnosis of cardiac AL amyloidosis.

scientific article published on 20 January 2013

Primary therapy of Waldenstrom macroglobulinemia (WM) with weekly bortezomib, low-dose dexamethasone, and rituximab (BDR): long-term results of a phase 2 study of the European Myeloma Network (EMN).

scientific article published on 4 September 2013

Prognostic factors in symptomatic Waldenstrom's macroglobulinemia

scientific article published on 01 April 2003

Prognostic value of depressed midwall systolic function in cardiac light-chain amyloidosis

scientific article published on 01 May 2014

Prognostic value of fragmented QRS in cardiac AL amyloidosis

scientific article published on 27 June 2012

Prognostication of survival and progression to dialysis in AA amyloidosis

scientific article published on 01 March 2017

Protein Aggregation

scientific article published on 01 November 2001

Proteotoxicity in cardiac amyloidosis: amyloidogenic light chains affect the levels of intracellular proteins in human heart cells

scientific article

Rationale, application and clinical qualification for NT-proBNP as a surrogate end point in pivotal clinical trials in patients with AL amyloidosis

scientific article

Regulated expression of amyloidogenic immunoglobulin light chains in mice

Reliable typing of systemic amyloidoses through proteomic analysis of subcutaneous adipose tissue.

scientific article published on 13 September 2011

Renal involvement in systemic amyloidosis--an Italian retrospective study on epidemiological and clinical data at diagnosis.

scientific article

Renal involvement in systemic amyloidosis: an Italian collaborative study on survival and renal outcome

scientific article published on 19 October 2007

Reply to S. Girnius et al.

scientific article published in July 2013

Response to bendamustine is associated with a survival advantage in a heavily pretreated patients with AL amyloidosis

article

Salvage therapy with lenalidomide and dexamethasone in patients with advanced AL amyloidosis refractory to melphalan, bortezomib, and thalidomide

scientific article published on 30 April 2011

Serum N-terminal pro-brain natriuretic peptide is a sensitive marker of myocardial dysfunction in AL amyloidosis

scientific article published on 28 April 2003

Serum prealbumin: an independent marker of short-term energy intake in the presence of multiple-organ disease involvement

scientific article

Serum-free light-chain analysis in diagnosis and management of multiple myeloma and related conditions

scientific article

Severity and reversibility of cardiac dysfunction and residual concentration of amyloidogenic light chain predict overall survival of patients with AL amyloidosis who attain complete response

scientific article published on 01 March 2017

Shotgun protein profile of human adipose tissue and its changes in relation to systemic amyloidoses.

scientific article published on 21 October 2013

Simple, reliable detection of amyloid in fat aspirates using the fluorescent dye FSB: prospective study in 206 patients

scientific article published on 06 June 2019

Sjögren's syndrome and localized nodular cutaneous amyloidosis: Coincidence or a distinct clinical entity?

scientific article published on 01 July 2008

Stanniocalcin1 is a key mediator of amyloidogenic light chain induced cardiotoxicity

scientific article

Systemic amyloidoses and proteomics: The state of the art.

scientific article published on 23 February 2016

Systemic amyloidoses: what an internist should know

scientific article

Systemic cardiac amyloidoses: disease profiles and clinical courses of the 3 main types.

scientific article

Systemic immunoglobulin light chain amyloidosis

Systemic light chain amyloidosis: an update for treating physicians

scientific article published on 13 May 2013

The amyloidogenic light chain is a stressor that sensitizes plasma cells to proteasome inhibitor toxicity.

scientific article

The combination of high-sensitivity cardiac troponin T (hs-cTnT) at presentation and changes in N-terminal natriuretic peptide type B (NT-proBNP) after chemotherapy best predicts survival in AL amyloidosis

scientific article published on 19 July 2010

The combination of thalidomide and intermediate-dose dexamethasone is an effective but toxic treatment for patients with primary amyloidosis (AL).

scientific article published on 30 November 2004

The elusive pathogenesis of Schnitzler syndrome

scientific article published on 01 March 2018

The impact of renal function on the clinical performance of FLC measurement in AL amyloidosis

scientific article published on 01 June 2016

The lung in amyloidosis.

scientific article published on 6 September 2017

The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition.

scientific article published on 22 January 2009

The repertoire of λ light chains causing predominant amyloid heart involvement and identification of a preferentially involved germline gene, IGLV1-44.

scientific article published on 8 November 2011

The workings of the amyloid diseases

scientific article published on January 2007

Therapeutic advances demand accurate typing of amyloid deposits

scientific article published on 01 August 2001

Transplantation vs. conventional-dose therapy for amyloidosis

scientific article published on March 2011

Treating advanced cardiac damage in light chain amyloidosis: still an unmet need

scientific article published in September 2014

Treatment of AL amyloidosis with bendamustine: a study of 122 patients

scientific article published on 14 August 2018

Treatment of IgM-associated AL amyloidosis with the combination of rituximab, bortezomib, and dexamethasone.

scientific article published in February 2011

Treatment of patients with advanced cardiac AL amyloidosis with oral melphalan, dexamethasone, and thalidomide

scientific article

Treatment with oral melphalan plus dexamethasone produces long-term remissions in AL amyloidosis

scientific article published on 01 July 2007

Unusual manifestations of disseminated neoplasia at presentation: right-sided heart failure due to a massive cardiac metastasis and autoimmune thrombocytopenia in pleomorphic rhabdomyosarcoma of the adult

scientific article

Update on treatment of light chain amyloidosis

scientific article

Urinary albumin to creatinine ratio in diagnosis and risk stratification of renal AL amyloidosis

scientific article published on 01 March 2017

What is new in diagnosis and management of light chain amyloidosis?

scientific article published on 6 April 2016

When should treatment of AL amyloidosis start at relapse? Early, to prevent organ progression

scientific article published on 01 January 2019

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