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List of works by Emilio Hirsch

A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress

scientific article

A pro-inflammatory signature mediates FGF2-induced angiogenesis

article

A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation

scientific article

A selective role for phosphatidylinositol 3,4,5-trisphosphate in the Gi-dependent activation of platelet Rap1B.

scientific article published on 28 October 2002

A single cis-acting element in a short promoter segment of the gene encoding the interphotoreceptor retinoid-binding protein confers tissue-specific expression.

scientific article published on January 1995

Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases

scientific article published on 20 December 2012

Ablation of phosphoinositide 3-kinase-gamma reduces the severity of acute pancreatitis

scientific article

Activation of phosphatidylinositol 3-kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role of Pyk2 and c-Cbl.

scientific article

Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence

scientific article published in August 2004

Aging, disease and death of nerve cells

scientific article published on 01 September 1996

Airway inflammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases

scientific article published in April 2005

Akt activation by PHLPP1 ablation prevents pathological hypertrophy by promoting angiogenesis.

scientific article published on 23 December 2014

An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology

scientific article published on 16 November 2017

Analysis of regulatory regions of the ciliary neutrophic factor gene in transgenic mice

article

Analysis of the murine phosphoinositide 3-kinase gamma gene

scientific article

Anchoring proteins as regulators of signaling pathways.

scientific article

Angiogenesis in metabolic-vascular disease

scientific article

Are dopaminergic neurons selectively vulnerable to Parkinson's disease?

scientific article published on January 1993

ArhGAP15, a RacGAP, Acts as a Temporal Signaling Regulator of Mac-1 Affinity in Sterile Inflammation

scientific article published on 27 July 2020

Benign childhood epilepsy with centrotemporal spikes: is it always benign?

scientific article published on 01 October 2000

Better Understanding of Phosphoinositide 3-Kinase (PI3K) Pathways in Vasculature: Towards Precision Therapy Targeting Angiogenesis and Tumor Blood Supply

scientific article published in July 2016

Biochemistry of Parkinson's disease 28 years later: a critical review

scientific article

Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

scientific article published on 28 August 2005

Blockade of phosphatidylinositol 3-kinase PI3Kδ or PI3Kγ reduces IL-17 and ameliorates imiquimod-induced psoriasis-like dermatitis

scientific article

Brain somatostatin concentrations do not decrease in progressive supranuclear palsy

scientific article published on November 1987

CALming Down T Cell Acute Leukemia ⬇️

scientific article published on April 17, 2012

CC-chemokine ligand 16 induces a novel maturation program in human immature monocyte-derived dendritic cells

scientific article published on 01 November 2006

CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer.

scientific article published on 15 November 2007

CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration

scientific article

Cancer: natural-born killers unleashed.

scientific article

Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis

scientific article published on 17 April 2018

Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure

scientific article published on 08 April 2020

Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs. Novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart

scientific article published on 19 July 2020

Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology

scientific article published on January 2011

Cellular quantification of tyrosine hydroxylase in the rat brain by immunoautoradiography

scientific article published in August 1993

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

scientific article

Characterization of two antigens in parkinsonian Lewy bodies

scientific article

Choline acetyltransferase-like immunoreactivity in the hippocampal formation of control subjects and patients with Alzheimer's disease

scientific article published in January 1989

Ciliary Neurotrophic Factor Constitutively Expressed in the Nervous System of Transgenic Mice Protects Embryonic Dorsal Root Ganglion Neurons from Apoptosis

scientific article published on 01 March 1996

Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation

scientific article published on 27 February 2013

Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion

scientific article published in January 2006

Class II PI3K Functions in Cell Biology and Disease

scientific article published on 25 January 2019

Class II PI3Ks at the Intersection between Signal Transduction and Membrane Trafficking

scientific article published on 15 March 2019

Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH-dependent sympathetic drive

scientific article published on 18 November 2014

Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-alpha and Tfr2-beta isoforms in different tissues.

scientific article published on 23 February 2010

Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception

scientific article

Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation.

scientific article published in July 2015

Converging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage

scientific article published on 13 December 2019

Correction: p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation

scientific article published on 19 September 2016

Crossroads of PI3K and Rac pathways.

scientific article published on April 2015

Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase

scientific article published in September 2005

Cytokinetic Abscission: Phosphoinositides and ESCRTs Direct the Final Cut.

scientific article published on 17 April 2017

DDAH1 and DDAH2 polymorphisms associate with asymmetrical dimethylarginine plasma levels in erectile dysfunction patients but not in healthy controls

scientific article published on 05 August 2019

Data demonstrating the anti-oxidant role of hemopexin in the heart.

scientific article

Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain

scientific article

Defective dendrite elongation but normal fertility in mice lacking the Rho-like GTPase activator Dbl.

scientific article

Defective dendritic cell migration and activation of adaptive immunity in PI3Kgamma-deficient mice

scientific article

Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis

scientific article

Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice

scientific journal article

Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia

scientific article

Deficiency of cannabinoid receptor of type 2 worsens renal functional and structural abnormalities in streptozotocin-induced diabetic mice

scientific article published on 14 May 2014

Determination of positive and negative regulatory elements

scientific article published on 01 January 1999

Dietary ω-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease.

scientific article published on May 2015

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity

scientific article

Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits

scientific article published on 7 October 2016

Dissection of the interplay between class I PI3Ks and Rac signaling in phagocytic functions.

scientific article

Distinct effects of leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure

scientific article published on 17 January 2011

Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK.

scientific article published on November 2000

Distribution of semaphorin IV in adult human brain

scientific article

Dopaminergic and cholinergic lesions in progressive supranuclear palsy

scientific article published on November 1985

Dopaminergic innervation of the pallidum in the normal state, in MPTP-treated monkeys and in parkinsonian patients

scientific article published in December 2000

Downregulation of class II phosphoinositide 3-kinase PI3K-C2β delays cell division and potentiates the effect of docetaxel on cancer cell growth

scientific article published on 21 November 2019

Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration

scientific article published in January 2001

ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models

scientific article published on 23 February 2014

Editorial to the SI Leukocyte Adhesion and Migration

scientific article published on 11 January 2013

Elastin degradation and ensuing inflammation as emerging keys to atherosclerosis.

scientific article

Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis

scientific article

Erratum to: Regulating neutrophil apoptosis: new players enter the game [Trends in Immunology (2011) 32, 117–124]

scholarly article published in Trends in Immunology

Erratum: Corrigendum: A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation

scholarly article published in Nature Chemical Biology

Erratum: Corrigendum: Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis

scientific article published on 01 June 2016

Essential role of phosphoinositide 3-kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation.

scientific article

Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility.

scientific article

Experimental models of Parkinson's disease

scientific article published in January 2002

Expression of beta 1 integrin complexes on the surface of unfertilized mouse oocyte

scientific article published in April 1993

Expression of tachykinin NK2 receptor mRNA in human brain

scientific article published in April 2001

Familial cortical myoclonic tremor with epilepsy: the third locus (FCMTE3) maps to 5p.

scientific article

Fetal lungs of tenascin-C-deficient mice grow well, but branch poorly in organ culture.

scientific article published on 6 August 2003

Frontline Science: Coincidental null mutation of Csf2rα in a colony of PI3Kγ-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection

scientific article published on 28 July 2016

Functions of PDE3 Isoforms in Cardiac Muscle

scientific article published on 6 February 2018

Genetic Deletion and Pharmacological Inhibition of PI3K γ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease

scientific article published on 21 June 2015

Genetic analyses of integrin function in mice

scientific article published on October 1996

Genetic analysis of β1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules ⬇️

scientific article published on December 1, 1997

Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes

scientific article published on 11 February 2008

Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets.

scientific article

Green fluorescent protein as a reporter of gene expression in transgenic mice

scientific article published in May 1997

Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors.

scientific article

Guido Tarone (1951-2015).

scientific article published in June 2015

Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress.

scientific article

Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases

scientific article published on 27 February 2013

Heterocellular signalling and crosstalk in the heart in ischaemia and heart failure

scientific article published on 08 April 2014

High frequency of development of B cell lymphoproliferation and diffuse large B cell lymphoma in Dbl knock-in mice

scientific article published on 11 January 2011

How PI3K-derived lipids control cell division

scientific article

Hyper-activation of the Rho-GTPase Rac1 via disruption of ArhGAP15 results in reduced architectural and functional complexity

article by Giorgio R. Merlo et al published December 2015 in International Journal of Developmental Neuroscience

Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics.

scientific article

IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload.

scientific article published on 14 April 2011

Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.

scientific article published on 31 August 2017

Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrins

scientific article published in Nature

Importance of Phosphoinositide 3-Kinase γ in the Host Defense against Pneumococcal Infection

article

In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes

scientific article published on 16 April 2015

Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation.

scientific article published on 12 July 2007

Increase of valproate-induced hyperammonemia in normal subjects by carbohydrate intake

scientific article published on 01 November 1984

Inflaming attraction by RNA ⬇️

scientific article published on 05 September 2012

Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology

scientific article published on February 2009

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis

scientific article published in Nature Communications

Inhibition of neutrophil migration by hemopexin leads to increased mortality due to sepsis in mice

scientific article

Inhibitory role of the acute phase proteins on neutrophil migration in severe sepsis

scientific article published on 23 June 2009

Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.

scientific article published on April 2011

Integrin function and regulation in development.

scientific article

Integrin signalling: the tug-of-war in heart hypertrophy.

scientific article

Integrin subunit expression associated with epithelial-mesenchymal interactions during murine tooth development

article

Interaction of the heart and its close and distant neighbours: report of the Meeting of the ESC Working Groups Myocardial Function and Cellular Biology

scientific article published on 16 July 2013

Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family

scholarly article

Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice

scientific article

Involvement of phosphoinositide 3-kinase gamma, Rac, and PAK signaling in chemokine-induced macrophage migration

scientific article

Is differential regulation of mitochondrial transcripts in Parkinson's disease related to apoptosis?

scientific article published on May 1997

Isoform selective phosphoinositide 3-kinase gamma and delta inhibitors and their therapeutic potential

scientific article

Key role of PI3Kγ in monocyte chemotactic protein-1-mediated amplification of PDGF-induced aortic smooth muscle cell migration

scientific article published on July 2012

La inhibición de la PI3Kγ protege contra la miocardiopatía diabética en ratones

Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling.

scientific article published on 16 April 2015

Lack of phosphoinositide 3-kinase-gamma attenuates ventilator-induced lung injury

scientific article

Late onset heart failure after childhood chemotherapy

scientific article published on 01 March 2019

Leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure

scientific article

Leukocyte transmigration is modulated by chemokine-mediated PI3Kgamma-dependent phosphorylation of vimentin

scientific article published in April 2009

Lipids on the move: phosphoinositide 3-kinases in leukocyte function

scientific article

Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2.

scientific article

Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress

scientific journal article

Loss of beta1-integrin-deficient cells during the development of endoderm-derived epithelia

scientific article published on 25 November 2003

Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression

scientific article

Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis.

scientific article published on 18 April 2016

Magnetically enriched bone marrow-derived macrophages loadedin vitro with iron oxide can migrate to inflammation sites in mice

scientific article published on 01 February 2008

Measurement of PIP3 levels reveals an unexpected role for p110β in early adaptive responses to p110α-specific inhibitors in luminal breast cancer

scientific article published on 24 December 2014

Measuring PI3K lipid kinase activity

scientific article published on January 2012

Mechanisms of Anthracycline-Induced Cardiotoxicity: Is Mitochondrial Dysfunction the Answer?

scientific article published on 12 March 2020

Mechanisms underlying the cross-talk between heart and cancer

scientific article published on 06 July 2019

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

scientific article published on July 1988

Melusin is a new muscle-specific interactor for beta(1) integrin cytoplasmic domain

scientific article

Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction

scientific article published on 15 October 2013

Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload

scientific article

Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting.

scientific article published on 26 February 2018

Methods to measure the enzymatic activity of PI3Ks

scientific article published on January 2014

Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function

scientific article published in October 2017

Modulation of mu opioid receptor desensitization in peripheral sensory neurons by phosphoinositide 3-kinase gamma

scientific article published on 6 May 2010

Molecular mechanism of action of Pelargonidin-3-O-glucoside, the main anthocyanin responsible for the anti-inflammatory effect of strawberry fruits.

scientific article published on 7 December 2017

Monoclonal antibodies raised against Lewy bodies in brains from subjects with Parkinson's disease

scientific article published in October 1985

More than just kinases: the scaffolding function of PI3K.

scientific article published on January 2010

Morgana acts as an oncosuppressor in chronic myeloid leukemia.

scientific article published on 12 February 2015

Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis

scientific article

Motor neuron disease, parkinsonism and dementia. Report of a case with diffuse Lewy body-like intracytoplasmic inclusions

scientific article published in January 1987

Mouse myoblasts can fuse and form a normal sarcomere in the absence of beta1 integrin expression.

scientific article

Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction

scientific article published on 29 April 2019

Myocyte signalling in leucocyte recruitment to the heart

scientific article published on 05 February 2014

NADPH oxidases in heart failure: poachers or gamekeepers?

scientific article

Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma

scholarly article

Neurocan is dispensable for brain development

scientific article

Neuronal localization of copper-zinc superoxide dismutase protein and mRNA within the human hippocampus from control and Alzheimer's disease brains

scientific article published on 01 January 1991

New pre-clinical evidence of anti-inflammatory effect and safety of a substituted fluorophenyl imidazole

scientific article published on 19 January 2019

New signal transduction paradigms in anthracycline-induced cardiotoxicity.

scientific article published on 29 January 2016

New species of human tyrosine hydroxylase mRNA are produced in variable amounts in adrenal medulla and are overexpressed in progressive supranuclear palsy

scientific article published on July 1996

Nicotine, but not cotinine, partially protects dopaminergic neurons against MPTP-induced degeneration in mice

scientific article

Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response

scientific article

Noncatalytic function of PI3Kγ drives smooth muscle cell proliferation after arterial damage

scientific article published on 01 June 2020

Nonredundant role of CCRL2 in lung dendritic cell trafficking

scientific article

Normal skeletal development of mice lacking matrilin 1: redundant function of matrilins in cartilage?

scientific article

Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells

scientific article published on 16 June 2008

PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis

article

PI(3,4)P2 Signaling in Cancer and Metabolism

scientific article published on 31 March 2020

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation

scientific article published on 10 December 2021

PI3-Kinase-γ Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development

scientific article published on 6 October 2015

PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth

scientific article

PI3K Signaling in Tissue Hyper-Proliferation: From Overgrowth Syndromes to Kidney Cysts

scientific article published on 29 March 2017

PI3K and Calcium Signaling in Cardiovascular Disease

scientific article

PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function

scientific article

PI3K class II α: a novel regulator of vesicular trafficking at the base of the primary cilium.

scientific article published on 16 November 2012

PI3K in cancer–stroma interactions: bad in seed and ugly in soil ⬇️

scientific article published on July 29, 2013

PI3K inhibition in inflammation: Toward tailored therapies for specific diseases.

scientific article published on March 2010

PI3K keeps the balance between metabolism and cancer

scientific article published on 24 April 2012

PI3K kinase and scaffold functions in heart.

scientific article published on February 2010

PI3K p110γ deletion attenuates murine atherosclerosis by reducing macrophage proliferation but not polarization or apoptosis in lesions.

scientific article

PI3K signaling in the pathogenesis of obesity: The cause and the cure

scientific article

PI3K signaling: a crossroads of metabolic regulation

scientific article published on 01 July 2009

PI3K-C2α regulates Polycystin-2 ciliary entry to prevent kidney cyst formation.

scientific article published on 13 July 2015

PI3K-C2α: One enzyme for two products coupling vesicle trafficking and signal transduction.

scientific article published on 12 May 2015

PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling

scientific article published on 23 June 2015

PI3K/AKT signaling pathway and cancer: an updated review

scientific article published on 05 June 2014

PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress

scientific article published on 15 January 2020

PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells.

scientific article

PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway

scientific article

PI3Ks and small GTPases in neutrophil migration: two sides of the same coin

scientific article

PI3Kγ Inhibition Protects Against Diabetic Cardiomyopathy in Mice

scientific article

PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

article

PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism

scientific article published on 27 October 2011

PI3Kγ integrates cAMP and Akt signalling of the μ-opioid receptor.

scientific article

PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis.

scientific article

PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control

scientific article (publication date: 2013)

PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization

scientific article

Peri-implantation lethality in mice lacking the Sm motif-containing protein Lsm4

scientific journal article

Pharmacologic inhibition of phosphoinositide 3-kinase gamma (PI3Kγ) promotes infarct resorption and prevents adverse cardiac remodeling after myocardial infarction in mice

scientific article published on December 2010

Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio

scientific journal article

Phosphoinositide 3-Kinase Gamma Inhibition Protects from Anthracycline Cardiotoxicity and Reduces Tumor Growth.

scientific article published on 18 January 2018

Phosphoinositide 3-Kinase γ Restrains Neurotoxic Effects of Microglia After Focal Brain Ischemia.

scientific article

Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation

scientific article published on 13 August 2015

Phosphoinositide 3-kinase gamma controls autonomic regulation of the mouse heart through Gi-independent downregulation of cAMP level.

scientific article published in January 2005

Phosphoinositide 3-kinase gamma controls inflammation-induced myocardial depression via sequential cAMP and iNOS signalling

scientific article published on 2 September 2015

Phosphoinositide 3-kinase gamma gene knockout impairs postischemic neovascularization and endothelial progenitor cell functions

scientific article published on 25 October 2007

Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function

scientific article published in March 2002

Phosphoinositide 3-kinase gamma participates in T cell receptor-induced T cell activation.

scientific article

Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility

scientific article published in November 2003

Phosphoinositide 3-kinase gamma: a key modulator in inflammation and allergy

scientific article

Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development

scientific article published on 09 September 2008

Phosphoinositide 3-kinase p110γ in immunity

scientific article published on 28 July 2011

Phosphoinositide 3-kinase signalling in the vascular system.

scientific article

Phosphoinositide 3-kinase γ affects LPS-induced disturbance of blood-brain barrier via lipid kinase-independent control of cAMP in microglial cells

scientific article published on 18 July 2014

Phosphoinositide 3-kinase γ mediates microglial phagocytosis via lipid kinase-independent control of cAMP.

scientific article published on 29 December 2012

Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases

scientific journal article

Phosphoinositide 3-kinasegamma (PI3Kgamma) controls L-type calcium current (ICa,L) through its positive modulation of type-3 phosphodiesterase (PDE3).

scientific article published on February 2006

Phosphoinositide 3-kinases as a common platform for multi-hormone signaling.

scientific article published on August 2007

Phosphoinositide 3-kinases gamma and delta, linkers of coordinate C5a receptor-Fcgamma receptor activation and immune complex-induced inflammation

scientific article published on 11 September 2008

Phosphoinositide 3-kinases in health and disease

scientific article published on January 2012

Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment.

scientific article published on 27 May 2010

Phosphoinositide-3 kinase gamma kinase activity significantly contributes to the pathophysiology of sepsis and multiorgan failure

scientific article

Phosphoinositides and cardiovascular diseases.

scientific article published on January 2012

Phosphoinositides in cell proliferation and metabolism

scientific article published on 20 January 2020

Pi3ks In Diabetic Cardiomyopathy.

scientific article published on 22 June 2017

Plasma protein haptoglobin modulates renal iron loading

scientific article published on April 2005

Plasticity of afferent fibers to striatal neurons bearing D1 dopamine receptors in Parkinson's disease

scientific article

Platelet activation by von Willebrand factor requires coordinated signaling through thromboxane A2 and Fc gamma IIA receptor

scientific article (publication date: 13 July 2001)

Potential therapeutic applications of AKAP disrupting peptides

scientific article published on 01 December 2020

Present and future of PI3K pathway inhibition in cancer: perspectives and limitations

scientific article published on January 2011

Preventing and Treating Anthracycline Cardiotoxicity: New Insights

scientific article published on 06 October 2020

Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma

scientific article

Protumor Steering of Cancer Inflammation by p50 NF-κB Enhances Colorectal Cancer Progression.

scientific article published on 27 March 2018

Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kγ) contributes to ventilator-induced lung injury and edema

scientific article published on 19 August 2010

Quantitative autoradiography of tyrosine hydroxylase immunoreactivity in the rat brain

scientific article published in October 1991

Rab11 activity and PtdIns(3)P turnover removes recycling cargo from endosomes

scientific article published on 18 June 2018

Rab11 and phosphoinositides: A synergy of signal transducers in the control of vesicular trafficking

scientific article

Rac signal adaptation controls neutrophil mobilization from the bone marrow.

scientific article

Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.

scientific article

Reduced expression of brain-derived neurotrophic factor protein in Parkinson's disease substantia nigra

scientific article published in February 1999

Regional cerebral glucose metabolism in children with deterioration of one or more cognitive functions and continuous spike-and-wave discharges during sleep

scientific article published on 01 December 1995

Regulating neutrophil apoptosis: new players enter the game

scientific article published on 12 February 2011

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

scientific article

Relationship between asymmetric dimethylarginine, nitrite and genetic polymorphisms: Impact on erectile dysfunction therapy

scientific article published on 23 October 2017

Requirement for PI 3-kinase gamma in macrophage migration to MCP-1 and CSF-1.

scientific article published in October 2003

Resistance to thromboembolism in PI3Kgamma-deficient mice.

scientific article published on 9 July 2001

Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities.

scientific article published on 20 June 2018

Role and regulation of phosphatidylinositol 3-kinase β in platelet integrin α2β1 signaling.

scientific article

Role of phosphoinositide 3-kinase in the pathogenesis of acute pancreatitis

scientific article

Role of pontine nuclei damage in smooth pursuit impairment of progressive supranuclear palsy: a clinical-pathologic study

scientific article

Rule out of acute aortic dissection with plasma matrix metalloproteinase 8 in the emergency department

scientific article

Salvage pathways in heart rejuvenation

scientific article published on 01 July 2016

Selective Rac-1 inhibition protects from diabetes-induced vascular injury

scientific article published on 15 December 2005

Selective activation of Fyn/PI3K and p38 MAPK regulates IL-4 production in BMMC under nontoxic stress condition.

scientific article published on February 2007

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

scientific article

Signal transduction in inflammation. Perspective clues from the leukocyte-endothelium interface

Signal transduction in inflammation. Perspective clues from the leukocyte-endothelium interface

article published in 2005

Signaling Pathways Underlying Anthracycline Cardiotoxicity

scientific article published on 05 March 2020

Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing

scientific article published in January 2006

Signaling through PI3Kγ: a common platform for leukocyte, platelet and cardiovascular stress sensing

Smooth muscle cells-derived CXCL10 prevents endothelial healing through PI3Kγ-dependent T cells response

scientific article published on 01 February 2020

Somatic mosaicism of the CAG repeat expansion in spinocerebellar ataxia type 3/Machado-Joseph disease

scientific article published in January 1998

Somatostatin messenger RNA-containing neurons in Alzheimer's disease: an in situ hybridization study in hippocampus, parahippocampal cortex and frontal cortex

scientific article published in August 1994

Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate

scientific journal article

Specific PI3K isoform modulation in heart failure: lessons from transgenic mice

scientific article published on September 2011

Specific expression in brain and liver driven by the hemopexin promoter in transgenic mice

scientific article published in January 1996

Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5

scientific article published in Nature Communications

Subthalamotomy in parkinsonian monkeys. Behavioural and biochemical analysis

scientific article published in October 1996

Superoxide dismutase and Parkinson's disease

scientific article published in April 1990

Sustained release of PI3K inhibitor from PHA nanoparticles and in vitro growth inhibition of cancer cell lines.

scientific article published on February 2011

Synaptic plasticity in the caudate nucleus of patients with Parkinson's disease

scientific article published on June 1996

Taming the PI3K team to hold inflammation and cancer at bay.

scientific article published on 05 March 2008

Targeting PI3K in Cancer: Any Good News? ⬇️

scientific article published on 08 May 2013

Targeting PI3K signaling in cancer: Challenges and advances

scientific article published on 01 April 2019

Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response.

scientific article

Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology

scientific article

Targeting phosphoinositide 3-kinase gamma to fight inflammation and more

scientific article

The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors

scientific article published on 18 September 2015

The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation

scientific article published on 23 April 2015

The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation

scientific article

The Inhibition of Phosphoinositide-3 Kinases Induce Resolution of Inflammation in a Gout Model

scientific article published on 01 January 2018

The PI3K/Akt/mTOR pathway in polycystic kidney disease: A complex interaction with polycystins and primary cilium

scientific article published on 09 November 2019

The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions

scientific article published on 6 May 2011

The RhoA-associated protein Citron-N controls dendritic spine maintenance by interacting with spine-associated Golgi compartments.

scientific article published on 29 February 2008

The absence of functional PI3Kgamma prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice.

scientific article published on 27 March 2010

The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation

scientific article

The beta 1 integrin distal promoter is developmentally regulated in transgenic mice.

scientific article

The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation

scientific article published on 3 March 2010

The efficacy of levodopa treatment declines in the course of Parkinson's disease: do nondopaminergic lesions play a role?

scientific article published on January 1990

The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC.

scientific article published on 15 January 2018

The novel butyrate derivative phenylalanine-butyramide protects from doxorubicin-induced cardiotoxicity

scientific article published on 06 March 2019

The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion

article

The proline‐rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside‐in signaling ⬇️

scientific article published on February 1, 2013

The turtle and the rabbit story in a modern (PI3)key.

scientific article published on 7 December 2017

Therapeutic Targeting of PDEs and PI3K in Heart Failure with Preserved Ejection Fraction (HFpEF).

scientific article

Therapeutic applications of PI3K inhibitors in cardiovascular diseases

scientific article published on March 2013

Tissue-Specific KO of ECM Proteins

scientific article published on 01 January 2009

Tissue-specific KO of ECM proteins.

scientific article

Toward standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function

scientific article published on 04 May 2020

Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy

scientific article

Tumor-derived prostaglandin E2 promotes p50 NF-κB-dependent differentiation of monocytic MDSC

scientific article published on 07 April 2020

Twice upon a time: PI3K's secret double life exposed

scientific article

Two signalling hands for uPAR ⬇️

scientific article published on January 10, 2013

Tyrosine hydroxylase gene expression in human ventral mesencephalon: detection of tyrosine hydroxylase messenger RNA in neurites

scientific article published in April 1990

Tyrosine hydroxylase-like immunoreactivity in senile plaques is not related to the density of tyrosine hydroxylase-positive fibers in patients with Alzheimer's disease

scientific article published in March 1990

Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways

scientific article

Weakening link to colorectal cancer? ⬇️

scientific article published on October 25, 2001

[Neuronal death caused by apoptosis in Parkinson disease]

scientific article published on 01 September 1997

p110γ deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity

scientific article published on 02 July 2019

p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation

scientific article (publication date: 2016)

p130Cas mediates the transforming properties of the anaplastic lymphoma kinase

scientific article

αv Integrin subunit is predominantly located in nervous tissue and skeletal muscle during mouse development

article

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