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List of works by Gordon C. Jayson

A Longitudinal Investigation of Psychological Disorders in Patients Prior and Subsequent to a Diagnosis of Ovarian Cancer

scientific article published on 01 June 2010

A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides

scientific article

A longitudinal investigation of posttraumatic stress disorder in patients with ovarian cancer

scientific article published on 16 December 2010

A novel discharge pathway for patients with advanced cancer requiring home parenteral nutrition

scientific article published on 21 April 2019

A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours

scientific article

A phase I and pharmacokinetic study of OSI-7904L, a liposomal thymidylate synthase inhibitor in combination with oxaliplatin in patients with advanced colorectal cancer

scientific article published on 23 May 2007

A phase I study to determine the safety, pharmacokinetics and pharmacodynamics of a dual VEGFR and FGFR inhibitor, brivanib, in patients with advanced or metastatic solid tumors

scientific article

A phase I trial of bryostatin 1 in patients with advanced malignancy using a 24 hour intravenous infusion.

scientific article

A phase II trial evaluating two schedules of sagopilone (ZK-EPO), a novel epothilone, in patients with platinum-resistant ovarian cancer

scientific article published on 03 March 2011

A phase II trial of bryostatin 1 in patients with non-Hodgkin's lymphoma.

scientific article

A phase II trial of bryostatin-1 administered by weekly 24-hour infusion in recurrent epithelial ovarian carcinoma

scientific article published on October 2003

A phase IIA study of the topoisomerase I inhibitor, exatecan mesylate (DX-8951f), administered at two different dose schedules in patients with platinum- and taxane-resistant/refractory ovarian cancer

scientific article published in October 2004

A randomized phase II trial of interleukin 2 and interleukin 2-interferon alpha in advanced renal cancer.

scientific article

A two-part phase II study of cediranib in patients with advanced solid tumours: the effect of food on single-dose pharmacokinetics and an evaluation of safety, efficacy and imaging pharmacodynamics.

scientific article published in December 2010

Accessing cancer services in North West England: the Chinese population.

scientific article published on 7 January 2014

Alpha-v integrins as therapeutic targets in oncology.

scientific article published on October 2007

An Outpatient, Dose-Intense, Intravenous Cisplatin and Oral Etoposide Regimen for the Treatment of Advanced, Platinum-Resistant Ovarian Cancer

scientific article published in March 2018

An audit of primary surgical treatment for women with ovarian cancer referred to a cancer centre.

scientific article published on May 1999

Angiogenese-Hemmung durch Proteine, Peptide und «small molecules»: Klinischer Einsatz

scientific article published on 03 October 2005

Angiogenesis as a target for the treatment of ovarian cancer

scientific article published on September 2013

Angiogenesis as a therapeutic target in cancer

scientific article published on 01 August 2008

Antiangiogenic drugs in ovarian cancer.

scientific article

Antiangiogenic therapy in oncology: current status and future directions

scientific article published on 4 February 2016

Antiangiogenic therapy--evolving view based on clinical trial results.

scientific article published on 14 February 2012

Assessment and management of diarrhea following VEGF receptor TKI treatment in patients with ovarian cancer

scientific article published on 4 April 2018

Assessment of antiangiogenic and antivascular therapeutics using MRI: recommendations for appropriate methodology for clinical trials.

scientific article published in January 2003

Basic fibroblast growth factor increases the multiplication and migration of a serum-free derivative of CACO-2 but does not affect differentiation

scientific article published on 01 November 1994

Better life expectancy in women with BRCA2 compared with BRCA1 mutations is attributable to lower frequency and later onset of ovarian cancer

scientific article published in June 2008

Binding of endostatin to endothelial heparan sulphate shows a differential requirement for specific sulphates.

scientific article

Biomarkers and response to bevacizumab--response

scientific article published in February 2014

Biomarkers of angiogenesis and their role in the development of VEGF inhibitors

scientific article published on 15 December 2009

Blockade of platelet-derived growth factor receptor-beta by CDP860, a humanized, PEGylated di-Fab', leads to fluid accumulation and is associated with increased tumor vascularized volume.

scientific article

Breath-hold perfusion and permeability mapping of hepatic malignancies using magnetic resonance imaging and a first-pass leakage profile model

scientific article published in April 2002

Bryostatin 1-tamoxifen combinations show synergistic effects on the inhibition of growth of P388 cells in vitro.

scientific article

Carcinomatous meningitis in patients with breast cancer. An aggressive disease variant

scientific article published on 01 December 1994

Carcinomatous meningitis in solid tumours

scientific article

Carcinosarcoma of the ovary.

scientific article

Cediranib in patients with relapsed platinum-sensitive ovarian cancer (ICON6): a randomised, double-blind, placebo-controlled phase 3 trial.

scientific article

Chemotherapy for ovarian cancer--a consensus statement on standard practice. ⬇️

scientific article published on December 1998

Comparison of normal tissue R1 and R*2 modulation by oxygen and carbogen

scientific article published in January 2009

Comparison of the performance of tracer kinetic model-driven registration for dynamic contrast enhanced MRI using different models of contrast enhancement.

scientific article published in September 2006

Continuous infusion of 5-fluorouracil with alpha 2b interferon for advanced colorectal carcinoma

scientific article

Coordinated modulation of the fibroblast growth factor dual receptor mechanism during transformation from human colon adenoma to carcinoma

scientific article published on 01 July 1999

Cross-Visit Tumor Sub-segmentation and Registration with Outlier Rejection for Dynamic Contrast-Enhanced MRI Time Series Data

scientific article published on 01 January 2010

DCE-MRI model selection for investigating disruption of microvascular function in livers with metastatic disease

scientific article published on 10 October 2011

Dealing with loss: food and eating in women with ovarian cancer on parenteral nutrition

scientific article published on 06 February 2020

Development of a modified hollow fibre assay for studying agents targeting the tumour neovasculature.

scientific article published on May 2005

Development of antiangiogenic agents for ovarian cancer.

scientific article published on January 2008

Discharging Women with Advanced Ovarian Cancer on Home Parenteral Nutrition: Making and Implementing the Decision

scientific article published on 07 January 2020

Do Imaging Biomarkers Relate to Outcome in Patients Treated with VEGF Inhibitors? ⬇️

scientific article published on October 23, 2012

Doctor, does this mean I'm going to starve to death?

scientific article

Does clinical trial participation improve outcomes in patients with ovarian cancer?

scientific article

Dynamic contrast-enhanced MRI in clinical trials of antivascular therapies

scientific article published on 14 February 2012

Dynamics of circulating vascular endothelial growth factor-A predict benefit from antiangiogenic cediranib in metastatic or recurrent cervical cancer patients

scientific article published on 13 April 2019

Early versus delayed treatment of relapsed ovarian cancer (MRC OV05/EORTC 55955): a randomised trial

scientific article

Endothelial heparan sulfate 6-O-sulfation levels regulate angiogenic responses of endothelial cells to fibroblast growth factor 2 and vascular endothelial growth factor.

scientific article

Enhancing fraction predicts clinical outcome following first-line chemotherapy in patients with epithelial ovarian carcinoma.

scientific article published in October 2007

Evaluation of hypertension and proteinuria as markers of efficacy in antiangiogenic therapy for metastatic colorectal cancer

scientific article published in May 2014

Experimentally-derived functional form for a population-averaged high-temporal-resolution arterial input function for dynamic contrast-enhanced MRI.

scientific article published in November 2006

First gram-scale synthesis of a heparin-related dodecasaccharide.

scientific article

Heparan sulfate proteoglycans and cancer.

scientific article

Heparan sulfate undergoes specific structural changes during the progression from human colon adenoma to carcinoma in vitro.

scientific article published in January 1998

Heparan sulphate synthetic and editing enzymes in ovarian cancer

scientific article

Heparanase gene haplotype (CGC) is associated with stage of disease in patients with ovarian carcinoma

article

Heparin octasaccharides inhibit angiogenesis in vivo.

scientific article published on November 2005

High-performance liquid chromatographic assay for the novel antitumor drug, bryostatin-1, incorporating a serum extraction technique ⬇️

scientific article published on May 8, 1998

Home parenteral nutrition for people with inoperable malignant bowel obstruction

Hypoxia increases heparanase-dependent tumor cell invasion, which can be inhibited by antiheparanase antibodies

scientific article published on June 2004

Identification of early predictive imaging biomarkers and their relationship to serological angiogenic markers in patients with ovarian cancer with residual disease following cytotoxic therapy

scientific article published on 29 March 2010

Imaging angiogenesis of genitourinary tumors.

scientific article published on 19 January 2010

Imaging biomarker roadmap for cancer studies ⬇️

scientific article

Imaging tumor vascular heterogeneity and angiogenesis using dynamic contrast-enhanced magnetic resonance imaging.

scientific article published on June 2007

Immunomodulation in patients receiving intravenous Bryostatin 1 in a phase I clinical study: comparison with effects of Bryostatin 1 on lymphocyte function in vitro

scientific article published on 01 October 1994

Impact of laparotomy and liver resection on the peritoneal concentrations of fibroblast growth factor 2, vascular endothelial growth factor and hepatocyte growth factor

scientific article published on 26 October 2005

Improved Survival from Ovarian Cancer in Patients Treated in Phase III Trial Active Cancer Centres in the UK. ⬇️

scientific article published on 9 July 2016

Indexed distribution analysis for improved significance testing of spatially heterogeneous parameter maps: application to dynamic contrast-enhanced MRI biomarkers

scientific article published in March 2014

Inhibition of FGFR2 and FGFR1 increases cisplatin sensitivity in ovarian cancer

scientific article

Inhibition of carboplatin-induced DNA interstrand cross-link repair by gemcitabine in patients receiving these drugs for platinum-resistant ovarian cancer.

scientific article

Intra-tumoural microvessel density in human solid tumours.

scientific article

Is the toxicity of anti-angiogenic drugs predictive of outcome? A review of hypertension and proteinuria as biomarkers of response to anti-angiogenic therapy

scientific article published on 30 January 2012

Issues on fit-for-purpose validation of a panel of ELISAs for application as biomarkers in clinical trials of anti-Angiogenic drugs.

scientific article

Lymphatic vessel density, microvessel density and lymphangiogenic growth factor expression in colorectal cancer

scientific article published on 01 November 2007

Malignant bowel obstruction in advanced ovarian cancer.

scientific article published on 18 January 2017

Metallothionein expression in epithelial ovarian cancer: effect of chemotherapy and prognostic significance.

scientific article

Method validation and preliminary qualification of pharmacodynamic biomarkers employed to evaluate the clinical efficacy of an antisense compound (AEG35156) targeted to the X-linked inhibitor of apoptosis protein XIAP.

scientific article published on July 2006

Mixed-effects modeling of clinical DCE-MRI data: application to colorectal liver metastases treated with bevacizumab.

scientific article

Modular synthesis of heparin-related tetra-, hexa- and octasaccharides with differential o-6 protections: programming for regiodefined 6-o-modifications.

scientific article published on 9 April 2015

Molecular imaging of antiangiogenic agents.

scientific article

Molecular phenotyping of a UK population: defining the human serum metabolome

scientific article

Neoadjuvant chemotherapy versus debulking surgery in advanced tubo-ovarian cancers: pooled analysis of individual patient data from the EORTC 55971 and CHORUS trials

scientific article published on 06 November 2018

Novel phase I trial design to evaluate the addition of cediranib or selumetinib to preoperative chemoradiotherapy for locally advanced rectal cancer: the DREAMtherapy trial

scientific article published on 21 June 2019

Oligosaccharides as anti-angiogenic agents

scientific article published on 01 March 2008

Oral melphalan as a treatment for platinum-resistant ovarian cancer.

scientific article published on June 2003

Organ-specific effects of oxygen and carbogen gas inhalation on tissue longitudinal relaxation times

scientific article published in September 2007

Outcomes after multiple lines of chemotherapy for platinum-resistant epithelial cancers of the ovary, peritoneum, and fallopian tube

scientific article published on January 2011

Ovarian cancer

scholarly article

Ovarian cancer cell heparan sulfate 6-O-sulfotransferases regulate an angiogenic program induced by heparin-binding epidermal growth factor (EGF)-like growth factor/EGF receptor signaling

scientific article

PARP inhibitors in BRCA mutation-associated ovarian cancer

scientific article published on 04 December 2014

PARP inhibitors in platinum-sensitive high-grade serous ovarian cancer

scientific article published on 20 February 2018

Paclitaxel plus platinum-based chemotherapy versus conventional platinum-based chemotherapy in women with relapsed ovarian cancer: the ICON4/AGO-OVAR-2.2 trial

scientific article published in June 2003

Palliative home parenteral nutrition in patients with ovarian cancer and malignant bowel obstruction: experiences of women and family caregivers

scientific article published on 29 December 2019

Pazopanib and Fosbretabulin in recurrent ovarian cancer (PAZOFOS): A multi-centre, phase 1b and open-label, randomised phase 2 trial

scientific article published on 10 January 2020

Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer

scientific article published on 22 March 2016

Phase I evaluation of CDP791, a PEGylated di-Fab' conjugate that binds vascular endothelial growth factor receptor 2.

scientific article

Phase I evaluation of a fully human anti-alphav integrin monoclonal antibody (CNTO 95) in patients with advanced solid tumors.

scientific article published on April 2007

Phase I investigation of recombinant anti-human vascular endothelial growth factor antibody in patients with advanced cancer

scientific article published on 22 January 2005

Phase II trial of combretastatin A4 phosphate, carboplatin, and paclitaxel in patients with platinum-resistant ovarian cancer.

scientific article

Phase II trial of tamoxifen and goserelin in recurrent epithelial ovarian cancer

scientific article published on September 2005

Phase III randomized trial of docetaxel-carboplatin versus paclitaxel-carboplatin as first-line chemotherapy for ovarian carcinoma.

scientific article

Plasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancer

scientific article published in Nature Communications

Platelet-derived growth factor receptor (PDGFR): a target for anticancer therapeutics.

scientific article

Pre-operative Plasma Levels of Vascular Endothelial Growth Factor A, C and D in Patients with Colorectal Cancer

scientific article published on 01 August 2005

Preclinical evaluation of the pharmacodynamic properties of 2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone

scientific article

Predicting response to bevacizumab in ovarian cancer: a panel of potential biomarkers informing treatment selection

scientific article

Preliminary study of oxygen-enhanced longitudinal relaxation in MRI: a potential novel biomarker of oxygenation changes in solid tumors

scientific article published on 26 March 2009

Prevalence of germline pathogenic BRCA1/2 variants in sequential epithelial ovarian cancer cases

scientific article published on 25 January 2019

Primary chemotherapy versus primary surgery for newly diagnosed advanced ovarian cancer (CHORUS): an open-label, randomised, controlled, non-inferiority trial.

scientific article published on 19 May 2015

Profiling heparan sulfate proteoglycans in ovarian carcinoma.

scientific article published in March 2005

Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor: insights from imaging

scientific article

Quantifying heterogeneity in dynamic contrast-enhanced MRI parameter maps

scientific article published on 01 January 2007

Quantitative angiogenesis assays in vivo--a review.

scientific article published in January 2004

Quantitative imaging biomarkers in the clinical development of targeted therapeutics: current and future perspectives

scientific article published on August 2008

Quantitative multiplexed quantum dot immunohistochemistry.

scientific article published on 11 July 2008

Randomised phase II study of cisplatin-etoposide versus infusional carboplatin in advanced non-small-cell lung cancer and mesothelioma.

scientific article

Randomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer.

scientific article

Randomized trial of two intravenous schedules of the topoisomerase I inhibitor liposomal lurtotecan in women with relapsed epithelial ovarian cancer: a trial of the national cancer institute of Canada clinical trials group.

scientific article

Regulation of fibroblast growth factor-2 activity by human ovarian cancer tumor endothelium

scientific article published on June 2005

Reproducibility of quantitative dynamic contrast-enhanced MRI in newly presenting glioma

scientific article published in March 2003

Requirement for expert histopathological assessment of ovarian cancer and borderline tumors

scientific article

Review of recent trials of chemotherapy for advanced breast cancer: studies excluding taxanes

scientific article published on November 1997

Scalable Synthesis ofl-Iduronic Acid Derivatives via Stereocontrolled Cyanohydrin Reaction for Synthesis of Heparin-Related Disaccharides

scientific article published on 01 October 2009

Screening tool for malignant bowel obstruction in relapsed, metastatic ovarian cancer

scientific article published on 21 March 2019

Segregation of late outgrowth endothelial cells into functional endothelial CD34- and progenitor-like CD34+ cell populations

scientific article published on October 2014

Single-agent paclitaxel in advanced non-small cell lung cancer: single-center phase II study using a 3-hour administration schedule.

scientific article

Small-molecule-induced clustering of heparan sulfate promotes cell adhesion.

scientific article published on 17 July 2013

Social support, anxiety and depression after chemotherapy for ovarian cancer: a prospective study

scientific article published in November 2004

Stage- and CA125-related survival in patients with epithelial ovarian cancer treated at a cancer center

scientific article

Standard chemotherapy with or without bevacizumab for women with newly diagnosed ovarian cancer (ICON7): overall survival results of a phase 3 randomised trial ⬇️

scientific article

Synthesis and scalable conversion of L-iduronamides to heparin-related di- and tetrasaccharides

scientific article

Synthesis of a heparin-related GlcN-IdoA sulfation-site variable disaccharide library and analysis by Raman and ROA spectroscopy

scientific article

Synthesis of l-Iduronic Acid Derivatives via [3.2.1] and [2.2.2] l-Iduronic Lactones from Bulk Glucose-Derived Cyanohydrin Hydrolysis: A Reversible Conformationally Switched Superdisarmed/Rearmed Lactone Route to Heparin Disaccharides

scientific article published on 07 April 2015

Synthetic Site-Selectively Mono-6-O-Sulfated Heparan Sulfate Dodecasaccharide Shows Anti-Angiogenic Properties In Vitro and Sensitizes Tumors to Cisplatin In Vivo

scientific article

Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology.

scientific article

Synthetic heparan sulfate oligosaccharides inhibit endothelial cell functions essential for angiogenesis

scientific article

Systematic analysis of circulating soluble angiogenesis-associated proteins in ICON7 identifies Tie2 as a biomarker of vascular progression on bevacizumab ⬇️

scientific article published on 28 June 2016

Targeted anti-vascular therapies for ovarian cancer: current evidence ⬇️

scientific article

Technology evaluation: VEGF Trap (cancer), Regeneron/sanofi-aventis.

scientific article

The Best Guess Approach to Phase I Trial Design

article

The Neoadjuvant Approach in the Treatment of Patients with Advanced Epithelial Ovarian Carcinoma

scientific article published on 01 March 2007

The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations.

scientific article published on May 2005

The clinical potential of antiangiogenic fragments of extracellular matrix proteins

scientific article

The combination of circulating Ang1 and Tie2 levels predicts progression-free survival advantage in bevacizumab-treated patients with ovarian cancer

scientific article

The development of anti-angiogenic heparan sulfate oligosaccharides

scientific article published on 01 December 2014

The ethical and scientific case for phase 2C clinical trials

scientific article published in May 2010

The interval from surgery to chemotherapy in the treatment of advanced epithelial ovarian carcinoma

scientific article published on 29 March 2006

The morphogenic properties of oligomeric endostatin are dependent on cell surface heparan sulfate

scientific article published on 15 February 2006

The treatment of nephrotic syndrome caused by primary (light chain) amyloid with vincristine, doxorubicin and dexamethasone ⬇️

scientific article published on September 1, 1998

Thrombosis in ovarian cancer: a case control study.

scientific article published on 21 January 2014

VEGF inhibitors and advanced ovarian cancer

scientific article published on 10 October 2011

Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy.

scientific article

Vascular endothelial growth factors and receptors in colorectal cancer: Implications for anti-angiogenic therapy

scientific article published on 01 January 2006

Weekly paclitaxel in the treatment of recurrent ovarian carcinoma

scientific article published on 01 January 2007

Weekly platinum chemotherapy for recurrent ovarian cancer

scientific article published on January 2002

p53 And related proteins in epithelial ovarian cancer

scientific article published on 01 December 2000

‘Fit-for-purpose’ validation of SearchLight multiplex ELISAs of angiogenesis for clinical trial use

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