List of works - Thomas Force

17 Beta-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overload

scientific article

17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling

scientific article published on 2 September 2004

A novel cardioprotective p38-MAPK/mTOR pathway ⬇️

scientific article published on October 2, 2011

A novel preclinical strategy for identifying cardiotoxic kinase inhibitors and mechanisms of cardiotoxicity

scientific article published on 13 October 2011

Activation of the Ste20-like oxidant stress response kinase-1 during the initial stages of chemical anoxia-induced necrotic cell death. Requirement for dual inputs of oxidant stress and increased cytosolic [Ca2+]

scientific article published on 01 November 1997

Acute reduction in functional infarct expansion with late coronary reperfusion: assessment with quantitative two-dimensional echocardiography

scientific article published on 01 January 1988

Advancing the research mission in an academic department: the creation of a center for translational medicine.

scientific article published on August 2010

Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue

scientific article published on 3 February 2016

CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation

scientific article

CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy ⬇️

scientific article published on July 15, 2012

Calcified left atrial mass associated with mitral valve prolapse

scientific article published on 01 June 1986

Calcineurin Promotes Protein Kinase C and c-Jun NH2-terminal Kinase Activation in the Heart

scientific article published in Journal of Biological Chemistry

Calcineurin inhibitors and cardiac hypertrophy

scientific article published on 01 April 1999

Cancer genetics and the cardiotoxicity of the therapeutics.

scientific article published on January 2013

Cancer treatment-related cardiotoxicity: current state of knowledge and future research priorities

scientific article published on 10 September 2014

Cardiac Hypertrophy

scholarly article

Cardiac fibroblast glycogen synthase kinase-3β regulates ventricular remodeling and dysfunction in ischemic heart

scientific article published on 4 June 2014

Cardio-Oncology: How New Targeted Cancer Therapies and Precision Medicine Can Inform Cardiovascular Discovery

scientific article published on December 2015

Cardiomyocyte-specific deletion of Gsk3α mitigates post-myocardial infarction remodeling, contractile dysfunction, and heart failure

scientific article

Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes.

scientific article published on February 2011

Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.

scientific article

Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology

scientific article published on January 2011

Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice

scientific article

Cytosolic phospholipase A(2)α protects against ischemia/reperfusion injury in the heart.

scientific article

Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation

scientific article published on October 2008

Deletion of cytosolic phospholipase A2 promotes striated muscle growth

scientific article

Developing small molecules to inhibit kinases unkind to the heart: p38 MAPK as a case in point

scientific article published on January 2010

Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55.

scientific article published on 27 June 2013

Double-Edged Sword of the New Cancer Therapeutics ⬇️

scientific article published on March 26, 2012

Emerging paradigms in cardiomyopathies associated with cancer therapies

scientific article published on August 2013

Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival

scientific article published on 24 April 2003

Exercise testing and ambulatory monitoring in patients with preexcitation syndrome

scientific article published on 01 January 1981

Expert Consensus for Multimodality Imaging Evaluation of Adult Patients during and after Cancer Therapy: A Report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging

scientific article published on 01 September 2014

Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging

scientific article

GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice

scientific journal article

GSK-3α is a central regulator of age-related pathologies in mice

scientific article

Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stre

scientific article

Gene 33/RALT is induced by hypoxia in cardiomyocytes, where it promotes cell death by suppressing phosphatidylinositol 3-kinase and extracellular signal-regulated kinase survival signaling.

scientific article published on July 2006

Glycogen synthase kinase-3beta -- actively inhibiting hypertrophy

scientific article published on April 2007

Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy

scientific article

Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart

scientific article published on 11 March 2004

Glycogen synthase kinase-3beta regulates post-myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivo

scientific article

Glycogen synthase kinase-3α limits ischemic injury, cardiac rupture, post-myocardial infarction remodeling and death

scientific article

Glycogen-Synthase Kinase3beta/beta-catenin axis promotes angiogenesis through activation of vascular endothelial growth factor signaling in endothelial cells.

scientific article published on 20 January 2005

Group IVA Cytosolic Phospholipase A2 Regulates the G2-to-M Transition by Modulating the Activity of Tumor Suppressor SIRT2.

scientific article

Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction

scientific article

Highlights of the 2003 scientific sessions of the Heart Failure Society of America; Las Vegas, Nevada, September 21 to 24, 2003

scientific article published on 01 March 2004

Highlights of the 2004 scientific sessions of the Heart Failure Society of America, Toronto, Canada, September 12 to 15, 2004.

scientific article published in February 2005

Imatinib activates pathological hypertrophy by altering myocyte calcium regulation

scientific article published on 16 June 2014

Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes: implications for herceptin-induced cardiomyopathy

scientific article published in December 2004

Inhibitors of protein kinase signaling pathways: emerging therapies for cardiovascular disease.

scientific article published on March 2004

Integrin-linked kinase regulates endothelial cell survival and vascular development.

scientific article published on September 2004

Introduction to cardiotoxicity review series

scientific article published on 01 January 2010

Ischemia and reperfusion enhance ATF-2 and c-Jun binding to cAMP response elements and to an AP-1 binding site from the c-jun promoter

scientific article

Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy.

scientific article published on 14 March 2016

MICU1 motifs define mitochondrial calcium uniporter binding and activity.

scientific article published on 12 December 2013

Management of cardiac toxicity in patients receiving vascular endothelial growth factor signaling pathway inhibitors

scientific article published on February 2012

Mechanism-Based Engineering Against Anthracycline Cardiotoxicity ⬇️

scientific article published on June 11, 2013

Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale

scientific article

Mitogen-activated protein kinases and transcriptional responses in renal injury and repair

scientific article

Molecular mechanisms of cardiovascular toxicity of targeted cancer therapeutics.

scientific article published on January 2010

Molecular scaffolds regulate bidirectional crosstalk between Wnt and classical seven-transmembrane-domain receptor signaling pathways.

scientific article published on 31 July 2007

Nerve growth factor decreases soluble guanylate cyclase in rat pheochromocytoma PC12 cells

scientific article published on February 1997

Not all hypertrophy is created equal.

scientific article published in November 2007

PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production

scientific article published in July 2001

Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury

scientific article

Postextrasystolic potentiation during acute myocardial infarction: predicting presence of viable myocardium.

scientific article

Prevention of liver cancer cachexia-induced cardiac wasting and heart failure

scientific article published on 29 August 2013

Protein Kinase Signaling at the Crossroads of Myocyte Life and Death in Ischemic Heart Disease

scientific article

Recent insights into cardiac hypertrophy and left ventricular remodeling.

scientific article

Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1.

scientific article published in October 2003

Report on the international colloquium on cardio-oncology (rome, 12-14 march 2014)

scientific article

Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute.

scientific article

Role of integrin-linked kinase in leukocyte recruitment.

scientific article published on 20 February 2002

Role of phosphoinositide 3-kinase in monocyte recruitment under flow conditions

scientific article published on March 2001

SOK1 translocates from the Golgi to the nucleus upon chemical anoxia and induces apoptotic cell death.

scientific article published on 25 March 2008

Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death

scientific journal article

Sorafenib cardiotoxicity increases mortality after myocardial infarction.

scientific article

Spatial and temporal variability in the pattern of recovery of ventricular geometry and function after acute occlusion and reperfusion.

scientific article published in May 1994

Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth

scientific article (publication date: 15 April 2003)

Stretch-activated pathways and left ventricular remodeling.

scientific article

Stretch-induced mitogen-activated protein kinase activation and interleukin-8 production in type II alveolar cells

scientific article published on 01 July 1999

Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase

scientific article

Targeting GSK-3 family members in the heart: a very sharp double-edged sword

scientific article

The GCK II and III subfamilies of the STE20 group kinases.

scientific article published on January 2007

The GSK-3 family as therapeutic target for myocardial diseases ⬇️

scientific article

The Heart Failure Society of America in 2020: a vision for the future

scientific article published on February 2012

The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy

scientific article (publication date: June 2006)

The weakness of a big heart

scientific article published in March 2008

The year in heart failure 2005

scientific article published on 01 February 2006

Troponin I-Interacting Protein Kinase

Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development

scientific article published on 08 December 2008

Why do kinase inhibitors cause cardiotoxicity and what can be done about it?

scientific article published on September 2010

Wnt signaling exerts an antiproliferative effect on adult cardiac progenitor cells through IGFBP3

scientific article published on 27 October 2011

c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo

scientific article

p38 mitogen-activated protein kinase: a future target for heart failure therapy?

scientific article published on 12 July 2006

List of works by Thomas Force

17 Beta-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overload

17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling

A novel cardioprotective p38-MAPK/mTOR pathway ⬇️

A novel preclinical strategy for identifying cardiotoxic kinase inhibitors and mechanisms of cardiotoxicity

Activation of the Ste20-like oxidant stress response kinase-1 during the initial stages of chemical anoxia-induced necrotic cell death. Requirement for dual inputs of oxidant stress and increased cytosolic [Ca2+]

Acute reduction in functional infarct expansion with late coronary reperfusion: assessment with quantitative two-dimensional echocardiography

Advancing the research mission in an academic department: the creation of a center for translational medicine.

Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue

CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation

CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy ⬇️

Calcified left atrial mass associated with mitral valve prolapse

Calcineurin Promotes Protein Kinase C and c-Jun NH2-terminal Kinase Activation in the Heart

Calcineurin inhibitors and cardiac hypertrophy

Cancer genetics and the cardiotoxicity of the therapeutics.

Cancer treatment-related cardiotoxicity: current state of knowledge and future research priorities

Cardiac Hypertrophy

Cardiac fibroblast glycogen synthase kinase-3β regulates ventricular remodeling and dysfunction in ischemic heart

Cardio-Oncology: How New Targeted Cancer Therapies and Precision Medicine Can Inform Cardiovascular Discovery

Cardiomyocyte-specific deletion of Gsk3α mitigates post-myocardial infarction remodeling, contractile dysfunction, and heart failure

Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes.

Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.

Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology

Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice

Cytosolic phospholipase A(2)α protects against ischemia/reperfusion injury in the heart.

Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation

Deletion of cytosolic phospholipase A2 promotes striated muscle growth

Developing small molecules to inhibit kinases unkind to the heart: p38 MAPK as a case in point

Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55.

Double-Edged Sword of the New Cancer Therapeutics ⬇️

Emerging paradigms in cardiomyopathies associated with cancer therapies

Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival

Exercise testing and ambulatory monitoring in patients with preexcitation syndrome

Expert Consensus for Multimodality Imaging Evaluation of Adult Patients during and after Cancer Therapy: A Report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging

Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging

GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice

GSK-3α is a central regulator of age-related pathologies in mice

Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stre

Gene 33/RALT is induced by hypoxia in cardiomyocytes, where it promotes cell death by suppressing phosphatidylinositol 3-kinase and extracellular signal-regulated kinase survival signaling.

Glycogen synthase kinase-3beta -- actively inhibiting hypertrophy

Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy

Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart

Glycogen synthase kinase-3beta regulates post-myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivo

Glycogen synthase kinase-3α limits ischemic injury, cardiac rupture, post-myocardial infarction remodeling and death

Glycogen-Synthase Kinase3beta/beta-catenin axis promotes angiogenesis through activation of vascular endothelial growth factor signaling in endothelial cells.

Group IVA Cytosolic Phospholipase A2 Regulates the G2-to-M Transition by Modulating the Activity of Tumor Suppressor SIRT2.

Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction

Highlights of the 2003 scientific sessions of the Heart Failure Society of America; Las Vegas, Nevada, September 21 to 24, 2003

Highlights of the 2004 scientific sessions of the Heart Failure Society of America, Toronto, Canada, September 12 to 15, 2004.

Imatinib activates pathological hypertrophy by altering myocyte calcium regulation

Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes: implications for herceptin-induced cardiomyopathy

Inhibitors of protein kinase signaling pathways: emerging therapies for cardiovascular disease.

Integrin-linked kinase regulates endothelial cell survival and vascular development.

Introduction to cardiotoxicity review series

Ischemia and reperfusion enhance ATF-2 and c-Jun binding to cAMP response elements and to an AP-1 binding site from the c-jun promoter

Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy.

MICU1 motifs define mitochondrial calcium uniporter binding and activity.

Management of cardiac toxicity in patients receiving vascular endothelial growth factor signaling pathway inhibitors

Mechanism-Based Engineering Against Anthracycline Cardiotoxicity ⬇️

Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale

Mitogen-activated protein kinases and transcriptional responses in renal injury and repair

Molecular mechanisms of cardiovascular toxicity of targeted cancer therapeutics.

Molecular scaffolds regulate bidirectional crosstalk between Wnt and classical seven-transmembrane-domain receptor signaling pathways.

Nerve growth factor decreases soluble guanylate cyclase in rat pheochromocytoma PC12 cells

Not all hypertrophy is created equal.

PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production

Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury

Postextrasystolic potentiation during acute myocardial infarction: predicting presence of viable myocardium.

Prevention of liver cancer cachexia-induced cardiac wasting and heart failure

Protein Kinase Signaling at the Crossroads of Myocyte Life and Death in Ischemic Heart Disease

Recent insights into cardiac hypertrophy and left ventricular remodeling.

Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1.

Report on the international colloquium on cardio-oncology (rome, 12-14 march 2014)

Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute.

Role of integrin-linked kinase in leukocyte recruitment.

Role of phosphoinositide 3-kinase in monocyte recruitment under flow conditions

SOK1 translocates from the Golgi to the nucleus upon chemical anoxia and induces apoptotic cell death.

Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death

Sorafenib cardiotoxicity increases mortality after myocardial infarction.

Spatial and temporal variability in the pattern of recovery of ventricular geometry and function after acute occlusion and reperfusion.