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List of works by Paul A. Lapchak

3alpha-OL-5-beta-pregnan-20-one hemisuccinate, a steroidal low-affinity NMDA receptor antagonist improves clinical rating scores in a rabbit multiple infarct ischemia model: synergism with tissue plasminogen activator

scientific article published on 21 November 2005

4-((1E)-2-(5-(4-hydroxy-3-methoxystyryl-)-1-phenyl-1H-pyrazoyl-3-yl) vinyl)-2-methoxy-phenol) (CNB-001) Does Not Regulate Human Recombinant Protein-Tyrosine Phosphatase1B (PTP1B) Activity in vitro

scientific article published on September 2014

A Series of Novel Neuroprotective Blood Brain Barrier Penetrating Flavonoid Drugs to Treat Acute Ischemic Stroke ⬇️

scientific article published on January 1, 2012

A blinded, randomized study of L-arginine in small clot embolized rabbits

scientific article

A cost-effective rabbit embolic stroke bioassay: insight into the development of acute ischemic stroke therapy

scientific article

A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy?

scientific article

A new embolus injection method to evaluate intracerebral hemorrhage in New Zealand white rabbits

scientific article published on 21 June 2010

A novel approach to screening for new neuroprotective compounds for the treatment of stroke

scientific article published on 9 August 2007

A novel method to promote behavioral improvement and enhance mitochondrial function following an embolic stroke.

scientific article

Adenoviral vector-mediated GDNF gene therapy in a rodent lesion model of late stage Parkinson's disease

scientific article

Advances in hemorrhagic stroke therapy: conventional and novel approaches

scientific article published on September 2007

Advances in ischemic stroke treatment: neuroprotective and combination therapies

scientific article

BDNF and trkB mRNA expression in the hippocampal formation of aging rats

scientific article published in March 1993

BDNF and trkB mRNA expression in the rat hippocampus following entorhinal cortex lesions.

scientific article published in February 1993

BDNF mRNA expression in the developing rat brain following kainic acid-induced seizure activity.

scientific article published in June 1992

Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes

scientific article

Binding sites for [3H]AF-DX 116 and effect of AF-DX 116 on endogenous acetylcholine release from rat brain slices

scientific article published in September 1989

Biology of glial cell line-derived neurotrophic factor (GDNF): implications for the use of GDNF to treat Parkinson's disease

scientific article published on September 1996

CNB-001 reduces paraplegia in rabbits following spinal cord ischemia

scientific article published on 01 December 2019

CNB-001, a pleiotropic drug is efficacious in embolized agyrencephalic New Zealand white rabbits and ischemic gyrencephalic cynomolgus monkeys

scientific article published on 04 December 2018

Carbamylated erythropoietin to treat neuronal injury: new development strategies

scientific article published in August 2008

CeeTox™ Analysis of CNB-001 a Novel Curcumin-Based Neurotrophic/Neuroprotective Lead Compound to Treat Stroke: Comparison with NXY-059 and Radicut

scientific article published on March 2011

Characterization and possible role of growth factor and lymphokine receptors in the regulation of cholinergic function in the mammalian brain.

scientific article published in January 1989

Characterization of N-[3H]methylcarbamylcholine binding sites and effect of N-methylcarbamylcholine on acetylcholine release in rat brain

scientific article published on 01 July 1988

Characterization of [3H]AF-DX 116 binding sites in the rat brain: evidence for heterogeneity of muscarinic-M2 receptor sites

scientific article published on 01 January 1989

Characterization of a fibrin glue-GDNF slow-release preparation

scientific article

Cholinergic regulation of hippocampal brain-derived neurotrophic factor mRNA expression: evidence from lesion and chronic cholinergic drug treatment studies

scientific article published in February 1993

Cholinergic regulation of vasoactive intestinal peptide content and release in rat frontal cortex and hippocampus

scientific article

Chronic estradiol treatment alters central cholinergic function in the female rat: effect on choline acetyltransferase activity, acetylcholine content, and nicotinic autoreceptor function

scientific article published in August 1990

Chronic intranigral administration of brain-derived neurotrophic factor produces striatal dopaminergic hypofunction in unlesioned adult rats and fails to attenuate the decline of striatal dopaminergic function following medial forebrain bundle trans

scientific article published in April 1993

Coadministration of NXY-059 and tenecteplase six hours following embolic strokes in rabbits improves clinical rating scores

scientific article published in August 2004

Comparison of TNK with wild-type tissue plasminogen activator in a rabbit embolic stroke model

scientific article published in March 2001

Comparison of Tenecteplase with Alteplase on clinical rating scores following small clot embolic strokes in rabbits

scientific article published in January 2004

Comparison of the post-embolization effects of tissue-plasminogen activator and simvastatin on neurological outcome in a clinically relevant rat model of acute ischemic stroke ⬇️

scientific article published on July 29, 2010

Compensatory elevation of acetylcholine synthesis in vivo by cholinergic neurons surviving partial lesions of the septohippocampal pathway

scientific article published in September 1991

Continuous monitoring of changes in plasma nitrite following cerebral ischemia in a rabbit embolic stroke model

scientific article published on June 2011

Critical early thrombolytic and endovascular reperfusion therapy for acute ischemic stroke victims: a call for adjunct neuroprotection.

scientific article

Cytoprotective Drug-Tissue Plasminogen Activator Protease Interaction Assays: Screening of Two Novel Cytoprotective Chromones.

scientific article

Data Standardization and Quality Management

scientific article

De-Risking of Stilbazulenyl Nitrone (STAZN), a Lipophilic Nitrone to Treat Stroke Using a Unique Panel of In Vitro Assays

scientific article published on June 2011

Dehydroepiandrosterone sulfate is neuroprotective in a reversible spinal cord ischemia model: possible involvement of GABA(A) receptors

scientific article published on August 2000

Delayed treatment with a novel neurotrophic compound reduces behavioral deficits in rabbit ischemic stroke

scientific article

Development of the Nitrone‐Based Spin Trap Agent NXY‐059 to Treat Acute Ischemic Stroke ⬇️

scientific article published on January 1, 2003

Development of transcranial sonothrombolysis as an alternative stroke therapy: incremental scientific advances toward overcoming substantial barriers

scientific article published on March 2013

Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer's disease.

scientific article published in June 1988

Differential alterations of cortical cholinergic and neurotensin markers following ibotenic acid lesions of the nucleus basalis magnocellularis

scientific article published in June 1993

Distribution of [125I]nerve growth factor in the rat brain following a single intraventricular injection: correlation with the topographical distribution of trkA messenger RNA-expressing cells

scientific article

Distribution of neurotensin receptors in mammalian brain. What it is telling us about its interactions with other neurotransmitter systems

scientific article published on January 1, 1992

Dose response to intraventricular glial cell line-derived neurotrophic factor administration in parkinsonian monkeys ⬇️

scientific article published on September 1, 1997

Dose-specific effect of simvastatin on hypoxia-induced HIF-1α and BACE expression in Alzheimer's disease cybrid cells.

scientific article

Drug-like property profiling of novel neuroprotective compounds to treat acute ischemic stroke: guidelines to develop pleiotropic molecules

scientific article published on June 2013

Ebselen, a seleno-organic antioxidant, is neuroprotective after embolic strokes in rabbits: synergism with low-dose tissue plasminogen activator

scientific article published on 10 July 2003

Edaravone (Radicut), a free radical scavenger, is a potentially useful addition to thrombolytic therapy in patients with acute ischemic stroke

scientific article published on 29 August 2012

Effect of chronic nicotine treatment on nicotinic autoreceptor function and N-[3H]methylcarbamylcholine binding sites in the rat brain

scientific article published on 01 February 1989

Effect of estradiol treatment on β-endorphin content and release in the female rat hypothalamus ⬇️

scientific article published on July 19, 1991

Effect of internal carotid artery reperfusion in combination with Tenecteplase on clinical scores and hemorrhage in a rabbit embolic stroke model

scientific article

Effect of recombinant human nerve growth factor on presynaptic cholinergic function in rat hippocampal slices following partial septohippocampal lesions: measures of [3H]acetylcholine synthesis, [3H]acetylcholine release and choline acetyltransferas

scientific article published in January 1991

Effect of the Pleiotropic Drug CNB-001 on Tissue Plasminogen Activator (tPA) Protease Activity in vitro: Support for Combination Therapy to Treat Acute Ischemic Stroke.

scientific article

Effects of aging on nicotinic and muscarinic autoreceptor function in the rat brain: relationship to presynaptic cholinergic markers and binding sites

scientific article published on September 1990

Effects of chronic basic fibroblast growth factor administration to rats with partial fimbrial transections on presynaptic cholinergic parameters and muscarinic receptors in the hippocampus: comparison with nerve growth factor

scientific article

Effects of chronic intraventricular nerve growth factor treatment on vasoactive intestinal peptide and neuropeptide Y levels in the hippocampal formation and cerebral cortex following fimbrial transections

scientific article published in August 1994

Effects of chronic nerve growth factor treatment on hippocampal [3H]cytisine/nicotinic binding sites and presynaptic nicotinic receptor function following fimbrial transections

scientific article

Effects of intrathecal administration of a cell permeant caspase inhibitor, boc-D-fluoromethylketone (BDFMK), on behavioral deficits following spinal cord ischemia: a dose-response analysis

scientific article

Effects of the spin trap agent disodium- [tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) on intracerebral hemorrhage in a rabbit Large clot embolic stroke model: combination studies with tissue plasminogen activator

scientific article

Efficacy and safety profile of the carotenoid trans sodium crocetinate administered to rabbits following multiple infarct ischemic strokes: a combination therapy study with tissue plasminogen activator

scientific article

Emerging Therapies: Pleiotropic Multi-target Drugs to Treat Stroke Victims ⬇️

scientific article published on June 1, 2011

Emerging pharmacology of nerve growth factor

scientific article

Enhanced delivery of [125I]glial cell line-derived neurotrophic factor to the rat CNS following osmotic blood-brain barrier modification

scientific article published on December 1996

Erythropoietin molecules to treat acute ischemic stroke: a translational dilemma!

scientific article

Evidence that somatostatin enhances endogenous acetylcholine release in the rat hippocampus

scientific article

Fast neuroprotection (fast-NPRX) for acute ischemic stroke victims: the time for treatment is now.

scientific article

Functional recovery in parkinsonian monkeys treated with GDNF

scientific article

GDNF triggers fiber outgrowth of fetal ventral mesencephalic grafts from nigra to striatum in 6-OHDA-lesioned rats

scientific article published on November 1996

Genome response to tissue plasminogen activator in experimental ischemic stroke

scientific article

Glial cell line-derived neurotrophic factor attenuates behavioural deficits and regulates nigrostriatal dopaminergic and peptidergic markers in 6-hydroxydopamine-lesioned adult rats: comparison of intraventricular and intranigral delivery

scientific article published on May 1997

Glial cell line-derived neurotrophic factor improves survival of ventral mesencephalic grafts to the 6-hydroxydopamine lesioned striatum.

scientific article published on August 1997

Glial cell line-derived neurotrophic factor induces the dopaminergic and cholinergic phenotype and increases locomotor activity in aged Fischer 344 rats

scientific article published on April 1997

Glial cell line-derived neurotrophic factor protects midbrain dopamine neurons from the lethal action of the weaver gene: a quantitative immunocytochemical study

scientific article published on August 1999

Glial cell line-derived neurotrophic factor reverses motor impairment in 16-17 month old rats.

scientific article published on June 1996

Glial cell line-derived neurotrophic factor-levodopa interactions and reduction of side effects in parkinsonian monkeys

scientific article published on August 1997

Glial cell line-derived neurotrophic factor: a novel therapeutic approach to treat motor dysfunction in Parkinson's disease

scientific article published on March 1997

Glial cell line-derived neurotrophic factor: distribution and pharmacology in the rat following a bolus intraventricular injection

scientific article published on January 1997

Growth factors and lymphokines: modulators of cholinergic neuronal activity

scientific article published on August 1991

Heterogeneous binding of [3H]4-DAMP to muscarinic cholinergic sites in the rat brain: evidence from membrane binding and autoradiographic studies

scientific article published in November 1991

Immunoautoradiographic localization of interleukin 2-like immunoreactivity and interleukin 2 receptors (Tac antigen-like immunoreactivity) in the rat brain

scientific article published in January 1991

Induction of immune system mediators in the hippocampal formation in Alzheimer's and Parkinson's diseases: selective effects on specific interleukins and interleukin receptors.

scientific article published in August 1994

Insulin-like growth factor-1 (somatomedin-C) receptors in the rat brain: distribution and interaction with the hippocampal cholinergic system

scientific article published on 01 April 1989

Interleukin-2 interacts with opioid neuroregulatory systems in the rat hippocampus

scientific article

Interleukin-2 regulates monoamine and opioid peptide release from the hypothalamus

scientific article

Intracerebroventricular glial cell line-derived neurotrophic factor improves motor function and supports nigrostriatal dopamine neurons in bilaterally 6-hydroxydopamine lesioned rats

scientific article published on May 1997

Intravenous xenogeneic human cardiosphere-derived cell extracellular vesicles (exosomes) improves behavioral function in small-clot embolized rabbits

scientific article published on 14 June 2018

J-147 a Novel Hydrazide Lead Compound to Treat Neurodegeneration: CeeTox(™) Safety and Genotoxicity Analysis

scientific article

Localization of interleukin-2 immunoreactivity and interleukin-2 receptors in the rat brain: interaction with the cholinergic system

scientific article

Memantine, an uncompetitive low affinity NMDA open-channel antagonist improves clinical rating scores in a multiple infarct embolic stroke model in rabbits.

scientific article published on 13 April 2006

Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke.

scientific article published in December 2000

Methodology of motor evoked potentials in a rabbit model

scientific article published on 20 May 2015

Microplasmin: a novel thrombolytic that improves behavioral outcome after embolic strokes in rabbits

scientific article published on 01 September 2002

Molecular mechanism of inverse regulation of hepatic alpha-1 and beta-2-adrenergic receptors

scientific article published on 01 January 1985

Muscarinic receptor subtypes in human neurodegenerative disorders: focus on Alzheimer's disease.

scientific article published on December 1989

N-[3H]methylcarbamylcholine binding sites in the rat and human brain: relationship to functional nicotinic autoreceptors and alterations in Alzheimer's disease.

scientific article published on January 1989

NGF suppression of weight gain in adult female rats correlates with decreased hypothalamic cholecystokinin levels

scientific article published in August 1994

Nerve growth factor pharmacology: application to the treatment of cholinergic neurodegeneration in Alzheimer's disease

scientific article

Neuroprotection by the selective cyclooxygenase-2 inhibitor SC-236 results in improvements in behavioral deficits induced by reversible spinal cord ischemia

scientific article

Neuroprotective and neurotrophic curcuminoids to treat stroke: a translational perspective

scientific article published on January 2011

Neuroprotective effects of the spin trap agent disodium-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) in a rabbit small clot embolic stroke model: combination studies with the thrombolytic tissue plasminogen activator

scientific article published in May 2002

Neurotensin regulation of endogenous acetylcholine release from rat cerebral cortex: effect of quinolinic acid lesions of the basal forebrain

scientific article published on October 1990

Neurotensin regulation of endogenous acetylcholine release from rat striatal slices is independent of dopaminergic tone

scientific article published in February 1991

Neurotrophins and Neurotrophin Receptors in Adult Brain Plasticity

scientific article published in October 1992

Neurotrophins in the central nervous system

scientific article published on 01 January 1992

Novel curcumin derivative CNB-001 mitigates obesity-associated insulin resistance.

scientific article published on 18 February 2014

Opiate receptor-mediated inhibition of acetylcholine release from mammalian brain: tissue- and species-dependence

scientific article

Pharmacological activities of glial cell line-derived neurotrophic factor (GDNF): preclinical development and application to the treatment of Parkinson's disease

scientific article published on June 1997

Pharmacological characterization of glial cell line-derived neurotrophic factor (GDNF): implications for GDNF as a therapeutic molecule for treating neurodegenerative diseases

scientific article published on November 1996

Pharmacological effects of the spin trap agents N-t-butyl-phenylnitrone (PBN) and 2,2,6, 6-tetramethylpiperidine-N-oxyl (TEMPO) in a rabbit thromboembolic stroke model: combination studies with the thrombolytic tissue plasminogen activator

scientific article

Pharmacological stimulation reveals recombinant human nerve growth factor-induced increases of in vivo hippocampal cholinergic function measured in rats with partial fimbrial transections

scientific article published in October 1992

Pharmacology of caffeinol in embolized rabbits: clinical rating scores and intracerebral hemorrhage incidence

scientific article published in August 2004

Preclinical development of neurosteroids as neuroprotective agents for the treatment of neurodegenerative diseases

scientific article

Presynaptic cholinergic mechanisms in the rat cerebellum: evidence for nicotinic, but not muscarinic autoreceptors

scientific article published on December 1989

Prosaptide exacerbates ischemia-induced behavioral deficits in vivo; an effect that does not involve mitogen-activated protein kinase activation

scientific article published in January 2000

Protective effects of nerve growth factor and brain-derived neurotrophic factor on basal forebrain cholinergic neurons in adult rats with partial fimbrial transections

scientific article

RIGOR guidelines: escalating STAIR and STEPS for effective translational research

scientific article published on 5 September 2012

Recommendations and practices to optimize stroke therapy: developing effective translational research programs

scientific article

Recommendations for preclinical research in hemorrhagic transformation

scientific article

Reducing bleeding complications after thrombolytic therapy for stroke: clinical potential of metalloproteinase inhibitors and spin trap agents

scientific article

Regionally specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid

scientific article (publication date: 1992)

Regulation of endogenous acetylcholine release from mammalian brain slices by opiate receptors: hippocampus, striatum and cerebral cortex of guinea-pig and rat

scientific article published on 01 January 1989

Regulation of hippocampal muscarinic receptor function by chronic nerve growth factor treatment in adult rats with fimbrial transections

scientific article published in March 1993

Resolving the negative data publication dilemma in translational stroke research

scientific article

Safety profile of transcranial near-infrared laser therapy administered in combination with thrombolytic therapy to embolized rabbits.

scientific article

Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator

scientific article

Sisyphus and translational stroke research

scientific article published in October 2012

Spin Trap Agents: A New Approach to Stroke Therapy

scientific article published on 01 May 2002

Stroke Cytoprotection: Can Repeating History with New Expectations Really Be the Path to Success in Stroke Research?

scientific article published in March 2017

Synergistic Effect of AJW200, a von Willebrand Factor Neutralizing Antibody with Low Dose (0.9 mg/mg) Thrombolytic Therapy Following Embolic Stroke in Rabbits

scientific article published on April 2013

Systemic interleukin-1 beta decreases brain-derived neurotrophic factor messenger RNA expression in the rat hippocampal formation

scientific article

Taking a light approach to treating acute ischemic stroke patients: transcranial near-infrared laser therapy translational science ⬇️

scientific article published on November 1, 2010

The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor simvastatin reduces thrombolytic-induced intracerebral hemorrhage in embolized rabbits

scientific article published on 23 September 2009

The High Cost of Stroke and Stroke Cytoprotection Research.

scientific article published on 30 December 2016

The lipophilic multifunctional antioxidant edaravone (radicut) improves behavior following embolic strokes in rabbits: a combination therapy study with tissue plasminogen activator

scientific article

The many faces of erythropoietin: from erythropoiesis to a rational neuroprotective strategy--correspondence

scientific article published in October 2008

The neuroactive steroid 3-alpha-ol-5-beta-pregnan-20-one hemisuccinate, a selective NMDA receptor antagonist improves behavioral performance following spinal cord ischemia

scientific article

The nonpeptide glycoprotein IIb/IIIa platelet receptor antagonist SM-20302 reduces tissue plasminogen activator-induced intracerebral hemorrhage after thromboembolic stroke

scientific article published in January 2002

The phenylpropanoid micronutrient chlorogenic acid improves clinical rating scores in rabbits following multiple infarct ischemic strokes: synergism with tissue plasminogen activator

scientific article published on 16 March 2007

Therapeutic Potential for Nerve Growth Factor in Alzheimer's Disease: Insights from Pharmacological Studies Using Lesioned Central Cholinergic Neurons ⬇️

scientific article published on 01 April 1992

Therapeutic potential of platelet glycoprotein IIb/IIIa receptor antagonists in the management of ischemic stroke.

scientific article published on January 2003

Therapeutic window for nonerythropoietic carbamylated-erythropoietin to improve motor function following multiple infarct ischemic strokes in New Zealand white rabbits.

scientific article published on 16 August 2008

Topographical distribution of [125I]-glial cell line-derived neurotrophic factor in unlesioned and MPTP-lesioned rhesus monkey brain following a bolus intraventricular injection

scientific article published on April 1998

Transcranial Near-Infrared Laser Therapy for Stroke: How to Recover from Futility in the NEST-3 Clinical Trial.

scientific article published on January 2016

Transcranial Near-Infrared Laser Transmission (NILT) Profiles (800 nm): Systematic Comparison in Four Common Research Species

scientific article published on 3 June 2015

Transcranial infrared laser therapy improves clinical rating scores after embolic strokes in rabbits.

scientific article

Transcranial near infrared laser treatment (NILT) increases cortical adenosine-5'-triphosphate (ATP) content following embolic strokes in rabbits

scientific article

Transcranial near-infrared laser therapy applied to promote clinical recovery in acute and chronic neurodegenerative diseases ⬇️

scientific article published on January 1, 2012

Transcranial near-infrared light therapy improves motor function following embolic strokes in rabbits: an extended therapeutic window study using continuous and pulse frequency delivery modes

scientific article published on 12 July 2007

Translational Stroke Research Guideline Projections: The 20/20 Standards

scientific article published on 06 April 2017

Translational Stroke Research Opportunities and a Strategy to Develop Effective Cytoprotection

scientific article published on 8 March 2017

Tumor necrosis factor-alpha is involved in thrombolytic-induced hemorrhage following embolic strokes in rabbits

scientific article published on 17 July 2007

Vasoactive intestinal peptide increases acetylcholine synthesis by rat hippocampal slices

scientific article published in January 1988

ret receptor tyrosine kinase immunoreactivity is altered in glial cell line-derived neurotrophic factor-responsive neurons following lesions of the nigrostriatal and septohippocampal pathways

scientific article published on September 1997

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