List of works - Almer M van der Sloot

A novel classification system to predict the pathogenic effects of CHD7 missense variants in CHARGE syndrome.

scientific article

A novel genetic selection system for improved enantioselectivity of Bacillus subtilis lipase A.

scientific article

An improved understanding of TNFL/TNFR interactions using structure-based classifications

scientific article published on 11 July 2012

At Long Last, a C-Terminal Bookend for the Ubiquitin Code

scientific article published on 01 May 2018

Building blocks for protein interaction devices.

scientific article

Computational design of TNF ligand-based protein therapeutics

scientific article published on January 2011

Computational design of peptide ligands

scientific article published on 12 February 2011

DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design

scientific article

Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity.

scientific article published on 8 June 2015

Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor

scholarly article

Engineering of weak helper interactions for high-efficiency FRET probes

scientific article published in September 2013

Enhancement of antitumor properties of rhTRAIL by affinity increase toward its death receptors.

scientific article

Evaluating CHARGE syndrome in congenital hypogonadotropic hypogonadism patients harboring CHD7 variants

scientific article published on 16 November 2017

Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity.

scientific article published on 3 November 2017

Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL ⬇️

scientific article published on January 2, 2012

Loop grafting of Bacillus subtilis lipase A: inversion of enantioselectivity.

scientific article published in August 2008

Mutational analysis of a key residue in the substrate specificity of a cephalosporin acylase

scientific article

Protein design in biological networks: from manipulating the input to modifying the output

scientific article published on 02 July 2009

Protein design with fragment databases

scientific article published on 16 June 2011

RET-familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src/JAK/STAT3 pathway, independent of glial cell line-derived neurotrophic factor.

scientific article published on March 2005

RGD-avidin-biotin pretargeting to alpha v beta 3 integrin enhances the proapoptotic activity of TNF alpha related apoptosis inducing ligand (TRAIL).

scientific article

Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants.

scientific article

Synthetic Genomics: Rewriting the Genome Chromosome by Chromosome.

scientific article published in May 2017

T-RMSD: a fine-grained, structure-based classification method and its application to the functional characterization of TNF receptors

scientific article published on 13 May 2010

Targeting AML through DR4 with a novel variant of rhTRAIL

scientific article

List of works by Almer M van der Sloot

A novel classification system to predict the pathogenic effects of CHD7 missense variants in CHARGE syndrome.

A novel genetic selection system for improved enantioselectivity of Bacillus subtilis lipase A.

An improved understanding of TNFL/TNFR interactions using structure-based classifications

At Long Last, a C-Terminal Bookend for the Ubiquitin Code

Building blocks for protein interaction devices.

Computational design of TNF ligand-based protein therapeutics

Computational design of peptide ligands

DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design

Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity.

Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor

Engineering of weak helper interactions for high-efficiency FRET probes

Enhancement of antitumor properties of rhTRAIL by affinity increase toward its death receptors.

Evaluating CHARGE syndrome in congenital hypogonadotropic hypogonadism patients harboring CHD7 variants

Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity.

Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL ⬇️

Loop grafting of Bacillus subtilis lipase A: inversion of enantioselectivity.

Mutational analysis of a key residue in the substrate specificity of a cephalosporin acylase

Protein design in biological networks: from manipulating the input to modifying the output

Protein design with fragment databases

RET-familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src/JAK/STAT3 pathway, independent of glial cell line-derived neurotrophic factor.

RGD-avidin-biotin pretargeting to alpha v beta 3 integrin enhances the proapoptotic activity of TNF alpha related apoptosis inducing ligand (TRAIL).

Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants.

Synthetic Genomics: Rewriting the Genome Chromosome by Chromosome.

T-RMSD: a fine-grained, structure-based classification method and its application to the functional characterization of TNF receptors

Targeting AML through DR4 with a novel variant of rhTRAIL