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List of works by David William Andrews

5-aminolevulinic acid for quantitative seek-and-treat of high-grade dysplasia in Barrett's esophagus cellular models

scientific article published on February 2015

A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection.

scientific article published on 05 April 2017

A Versatile Cell Death Screening Assay Using Dye-Stained Cells and Multivariate Image Analysis

scientific article published on 30 September 2015

A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes

scientific article published on May 1994

A reference library for assigning protein subcellular localizations by image-based machine learning

scientific article published on 01 March 2020

A single nucleotide is a sufficient 5' untranslated region for translation in an eukaryotic in vitro system.

scientific article

A site-specific, membrane-dependent cleavage event defines the membrane binding domain of FtsY.

scientific article

A stop transfer sequence recognizes receptors for nascent chain translocation across the endoplasmic reticulum membrane

scientific article published on 01 December 1986

A structure for the signal sequence binding protein SRP54: 3D reconstruction from STEM images of single molecules

scientific article published on 01 July 1994

After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.

scientific article published on 10 March 2014

An amino-terminal domain containing hydrophobic and hydrophilic sequences binds the signal recognition particle receptor alpha subunit to the beta subunit on the endoplasmic reticulum membrane.

scientific article published in June 1995

Apoptosis: embedded in membranes

scientific article published on 26 August 2010

Assembly of Bcl-2 into microsomal and outer mitochondrial membranes

scientific article published on 01 April 1994

At the onset of transformation polyomavirus middle-T recruits shc and src to a perinuclear compartment coincident with condensation of endosomes

scientific article published on August 1998

Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2

scientific article

Automatic selection of molecular images from dark field electron micrographs

scientific article published on 01 January 1986

BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models

scientific article published on 17 September 2020

BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes

scientific article

BH3-only proteins: Orchestrators of apoptosis

scientific article published on 10 December 2010

BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response

scientific article

Bacterial transmembrane proteins that lack N-terminal signal sequences

scientific article

Bax forms an oligomer via separate, yet interdependent, surfaces

scientific article

Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

scientific article

Bax homodimerization is not required for Bax to accelerate chemotherapy-induced cell death

scientific article published on December 1996

Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif

scientific article

Bcl-2 changes conformation to inhibit Bax oligomerization

scientific article published on 27 April 2006

Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax

scientific article

Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types

scientific article

Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts

scientific article published on June 1999

Bcl-XL inhibits membrane permeabilization by competing with Bax.

scientific article

Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line

scientific article (publication date: 23 August 2006)

Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry

scientific article

Bid: a Bax-like BH3 protein.

scientific article published on December 2008

Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2

scientific article published on 12 March 2019

Both the 5' untranslated region and the sequences surrounding the start site contribute to efficient initiation of translation in vitro

scientific article published on May 1991

Cell-free analysis of tail-anchor protein targeting to membranes

scientific article published on April 2007

Chemical and biosynthetic evolution of the antimycin-type depsipeptides

scientific article published on November 2013

Circumvention of fluorophore photobleaching in fluorescence fluctuation experiments: a beam scanning approach

scientific article

Closing in on the link between apoptosis and autophagy

scientific article published on 17 December 2010

Conformational Heterogeneity of Bax Helix 9 Dimer for Apoptotic Pore Formation

scientific article published on 06 July 2016

Construction of defined polytopic integral transmembrane proteins. The role of signal and stop transfer sequence permutations

scientific article

Creation of deletion, insertion and substitution mutations using a single pair of primers and PCR

scientific article published on 01 February 1996

Cytoplasmic O-glycosylation prevents cell surface transport of E-cadherin during apoptosis

scientific article

Delivery of a secretable adenosine deaminase through microcapsules--a novel approach to somatic gene therapy

scientific article published in December 1994

Development of dimeric modulators for anti-apoptotic Bcl-2 proteins

scientific article published on 30 October 2007

Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells

scientific article

Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax

scientific article published on 01 May 2015

Distinct pathways mediate the sorting of tail-anchored proteins to the plastid outer envelope

scientific article

Drugs targeting Bcl-2 family members as an emerging strategy in cancer

scientific article published on 08 September 2010

During apoptosis bcl-2 changes membrane topology at both the endoplasmic reticulum and mitochondria

scientific article published on May 2004

Electron microscopic visualization of the sidechains of the poly-L-lysine alpha helix

scientific article published on 01 January 1983

Electron microscopy of the poly-L-lysine alpha-helix

scientific article published on January 1982

Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes

scientific article published on May 2007

Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event

scientific article published in April 2001

Endoplasmic reticulum protein BIK binds to and inhibits mitochondria-localized antiapoptotic proteins

scientific article published in 2023

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Evidence Implicating Immunological Host Effects in the Efficacy of Metronomic Low-Dose Chemotherapy

scientific article published on 28 August 2016

Evidence for multiple mechanisms for membrane binding and integration via carboxyl-terminal insertion sequences

scientific article published on 01 July 1997

Evidence that the middle T antigen of polyomavirus interacts with the membrane skeleton

scientific article published on August 1993

Examining protein translocation in cell-free systems and microinjected Xenopus oocytes

scientific article published on 01 October 1989

Examining the molecular mechanism of bcl-2 family proteins at membranes by fluorescence spectroscopy

scientific article published on 01 January 2014

FimH can directly activate human and murine natural killer cells via TLR4

scientific article

FtsY binds to the Escherichia coli inner membrane via interactions with phosphatidylethanolamine and membrane proteins

scientific article published on 15 May 2001

GIMAP5 regulates mitochondrial integrity from a distinct subcellular compartment

scientific journal article

Genome-wide analysis of Homo sapiens, Arabidopsis thaliana, and Saccharomyces cerevisiae reveals novel attributes of tail-anchored membrane proteins

scientific article published on 11 November 2019

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

scientific article published on 17 April 2009

High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells

scientific article published on 13 June 2016

High-speed multifocal array scanning using refractive window tilting

scientific article published on 2 September 2015

Hydrophobic-domain-dependent protein-protein interactions mediate the localization of GPAT enzymes to ER subdomains

scientific article published on 8 February 2011

Identification of the endoplasmic reticulum targeting signal in vesicle-associated membrane proteins.

scientific article

Image-Based Analysis of Protein Stability

scientific article published on 27 November 2019

Improving drug discovery using image-based multiparametric analysis of the epigenetic landscape

scientific article published on 22 October 2019

Inhibition of p53 transcriptional activity by Bcl-2 requires its membrane-anchoring domain

scientific article published on March 1999

Interaction of the full-length Bax protein with biomimetic mitochondrial liposomes: a small-angle neutron scattering and fluorescence study.

scientific article published on 15 October 2011

Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis

scientific article

Interactions of pro-apoptotic BH3 proteins with anti-apoptotic Bcl-2 family proteins measured in live MCF-7 cells using FLIM FRET.

scientific article published on 16 August 2012

Interstitial cells of Cajal generate a rhythmic pacemaker current

scientific article published on July 1998

Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells.

scientific article

Lipid Droplet-Associated Proteins (LDAPs) Are Required for the Dynamic Regulation of Neutral Lipid Compartmentation in Plant Cells.

scientific article published on 19 February 2016

Mechanisms of action of Bcl-2 family proteins

scientific article published on April 2013

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

scientific article

Membrane-bound fatty acid desaturases are inserted co-translationally into the ER and contain different ER retrieval motifs at their carboxy termini

scientific article published in January 2004

MiRNA-106a and prostate cancer radioresistance: a novel role for LITAF in ATM regulation.

scientific article

Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state

scientific article published on 10 January 2012

Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis

scientific article (publication date: April 2000)

Molecular Pathways: Leveraging the BCL-2 Interactome to Kill Cancer Cells--Mitochondrial Outer Membrane Permeabilization and Beyond

scientific article published on 02 April 2015

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid

scientific article published on 5 June 2014

Multiple post-translational modifications regulate E-cadherin transport during apoptosis

scientific article published on 28 February 2012

Negatively charged residues in the IgM stop-transfer effector sequence regulate transmembrane polypeptide integration

scientific article published on 01 November 1999

Neuronal cell life, death, and axonal degeneration as regulated by the BCL-2 family proteins

scientific article published on 08 November 2020

New insights into the targeting of a subset of tail-anchored proteins to the outer mitochondrial membrane

scientific article published on 4 September 2014

Novel targeting signals mediate the sorting of different isoforms of the tail-anchored membrane protein cytochrome b5 to either endoplasmic reticulum or mitochondria

scientific article

Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit

scientific article (publication date: September 2000)

Optimizing the acquisition and analysis of confocal images for quantitative single-mobile-particle detection.

scientific article

Peak emission wavelength and fluorescence lifetime are coupled in far-red, GFP-like fluorescent proteins

scientific article published in PLoS ONE

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance.

scientific article

Photodamage to multiple Bcl-xL isoforms by photodynamic therapy with the phthalocyanine photosensitizer Pc 4.

scientific article published on December 2003

Pores of no return

scientific article published on 20 November 2014

Problems with Co-Funding in Canada

scientific article published in Science

Protein origami for beginners

scientific article

Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning

scientific article published on 22 February 2021

Regulating cell death at, on, and in membranes.

scientific article

Regulation of Ca2+-induced permeability transition by Bcl-2 is antagonized by Drpl and hFis1

scientific article

Regulation of acidification and apoptosis by SHP-1 and Bcl-2

scientific article

Removing bias against membrane proteins in interaction networks

scientific article

Saccharomyces cerevisiae peroxisomal thiolase is imported as a dimer.

scientific article published in October 1994

Sequences beyond the cleavage site influence signal peptide function.

scientific article

Shedding light on apoptosis at subcellular membranes

scientific article published on December 2012

Site-directed mutagenesis by inverse PCR.

scientific article

Small molecules reveal an alternative mechanism of Bax activation.

scientific article

Stability and function of the Sec61 translocation complex depends on the Sss1p tail-anchor sequence

scientific article

Still embedded together binding to membranes regulates Bcl-2 protein interactions.

scientific article published on 19 July 2010

Streak camera crosstalk reduction using a multiple delay optical fiber bundle

scientific article published in January 2012

Suppression of IP3-mediated calcium release and apoptosis by Bcl-2 involves the participation of protein phosphatase 1

scientific article published on 28 July 2006

Switching the model: a concerted mechanism for GTPases in protein targeting

scientific article published on May 1997

TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL

scientific article

Tamoxifen and ICI 182,780 increase Bcl-2 levels and inhibit growth of breast carcinoma cells by modulating PI3K/AKT, ERK and IGF-1R pathways independent of ERalpha

scientific article

Targeting of passenger protein domains to multiple intracellular membranes

scientific article published on May 1994

The 3' untranslated region of bovine preprolactin contains a transferable non-poly(A) mRNA sequence that prolongs translation

scientific article

The C-terminus of cytochrome b5 confers endoplasmic reticulum specificity by preventing spontaneous insertion into membranes

scientific article published on February 2007

The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase

scientific article published on 01 April 2022

The apoptotic pore on mitochondria: are we breaking through or still stuck?

scientific article published on February 2014

The beta-subunit of the signal recognition particle receptor is a novel GTP-binding protein without intrinsic GTPase activity

scientific article published on 19 May 2003

The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells

scientific article published on 24 January 2020

The cotranslational integration of membrane proteins into the phospholipid bilayer is a multistep process

scientific article published on 01 May 1996

The environment of nascent secretory and membrane proteins at the endoplasmic reticulum membrane during translocation and integration

scientific article published on 01 January 1995

The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma

scientific article published on 14 July 2020

The proapoptotic protein tBid forms both superficially bound and membrane-inserted oligomers.

scientific article published on May 2014

The relative biological effectiveness of low-dose mammography quality X rays in the human breast MCF-10A cell line

scientific article published on 23 December 2014

The role of the N region in signal sequence and signal-anchor function

scientific article

The signal recognition particle receptor alpha subunit assembles co-translationally on the endoplasmic reticulum membrane during an mRNA-encoded translation pause in vitro.

scientific article

The structure of Escherichia coli signal recognition particle revealed by scanning transmission electron microscopy.

scientific article

The translocon: more than a hole in the ER membrane?

scientific article published on 01 October 1996

The use of FLIM-FRET for the detection of mitochondria-associated protein interactions

scientific article published on January 2015

There is more to life and death than mitochondria: Bcl-2 proteins at the endoplasmic reticulum

scientific article published on March 2004

Transport across membranes: a question of navigation.

scientific article

Tunable hydrogel thin films from reactive synthetic polymers as potential two-dimensional cell scaffolds

scientific article published on 12 May 2015

Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove

scientific article published on 01 December 2018

Using Förster-Resonance Energy Transfer to Measure Protein Interactions Between Bcl-2 Family Proteins on Mitochondrial Membranes

scientific article published on 01 January 2016

tBid elicits a conformational alteration in membrane-bound Bcl-2 such that it inhibits Bax pore formation

scientific article published on 27 September 2006

tBid undergoes multiple conformational changes at the membrane required for Bax activation

scientific article

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